Hexose-6-phosphate dehydrogenase: Linking endocrinology and metabolism in the endoplasmic reticulum

Journal of Molecular Endocrinology

Volumn 42, Issue 4, 2009, Pages 283-289

  Bánhegyi, Gábor ^a,b   Csala, Miklós ^b   Benedetti, Angelo ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; FATTY ACID; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; GALACTOSE 6 PHOSPHATE DEHYDROGENASE; GALACTOSE-6-PHOSPHATE DEHYDROGENASE; GLUCOSE 6 PHOSPHATE; OXIDOREDUCTASE;

ADIPOSE TISSUE; CELL LEVEL; CELL METABOLISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; GLUCONEOGENESIS; GLUCOSE TRANSPORT; GLYCOLYSIS; HORMONAL REGULATION; HUMAN; INSULIN RESISTANCE; METABOLISM; MUSCLE TISSUE; NONHUMAN; NUTRIENT LOADING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; ANIMAL; ENDOCRINE SYSTEM; ENDOPLASMIC RETICULUM; PHYSIOLOGY;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; CARBOHYDRATE DEHYDROGENASES; ENDOCRINE SYSTEM; ENDOPLASMIC RETICULUM; GLUCOCORTICOIDS; GLUCOSE-6-PHOSPHATE; HUMANS;

EID: 67449161934     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1677/JME-08-0156     Document Type: Review

References (66)

1. Atanasov AG, Nashev LG, Schweizer RA, Frick C & Odermatt A 2004 Hexose-6-phosphate dehydrogenase determines the reaction direction of 11b-hydroxysteroid dehydrogenase type 1 as an oxoreductase. FEBS Letters 571 129-133.
2. Atanasov AG, Nashev LG, Gelman L, Legeza B, Sack R, Portmann R & Odermatt A 2008 Direct protein-protein interaction of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the endoplasmic reticulum lumen. Biochimica et Biophysica Acta 1783 1536-1543.
3. Balazs Z, Nashev LG, Chandsawangbhuwana C, Baker ME & Odermatt A 2008 Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11β-hydroxysteroid dehydrogenase 1. Molecular and Cellular Endocrinology (doi: 10.1016/ j.mce.2008.10.021).
4. Banhegyi G, Benedetti A, Fulceri R & Senesi S 2004 Cooperativity between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the lumen of the endoplasmic reticulum. Journal of Biological Chemistry 279 27017-27021.
5. Banhegyi G, Benedetti A, Csala M & Mandl J 2007 Stress on redox. FEBS Letters 581 3634-3640.
6. Basu R, Singh R, Basu A, Johnson CM & Rizza RA 2006 Effect of nutrient ingestion on total-body and splanchnic cortisol production in humans. Diabetes 55 667-674.
7. Belkaid A, Copland IB, Massillon D & Annabi B 2006 Silencing of the human microsomal glucose-6-phosphate translocase induces glioma cell death: potential new anticancer target for curcumin. FEBS Letters 580 3746-3752.
8. Beutler E & Morrison M 1967 Localization and characteristics of hexose 6-phosphate dehydrogenase (glucose dehydrogenase). Journal of Biological Chemistry 242 5289-5293.
9. Bujalska IJ, Draper N, Michailidou Z, Tomlinson JW, White PC, Chapman KE, Walker EA & Stewart PM 2005 Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11β-hydroxysteroid dehydrogenase type 1. Journal of Molecular Endocrinology 34 675-684.
10. Bujalska IJ, Hewitt KN, Hauton D, Lavery GG, Tomlinson JW, Walker EA & Stewart PM 2008 Lack of hexose-6-phosphate dehydrogenase impairs lipid mobilization from mouse adipose tissue. Endocrinology 149 2584-2591.
11. Chang-Chen KJ, Mullur R & Bernal-Mizrachi E 2008 β-Cell failure as a complication of diabetes. Reviews in Endocrine and Metabolic Disorders 9 329-343.
12. Chapman KE & Seckl JR 2008 11β-HSD1, inflammation, metabolic disease and age-related cognitive (dys)function. Neurochemical Research 33 624-636.
13. Clarke JL & Mason PJ 2003 Murine hexose-6-phosphate dehydrogenase: a bifunctional enzyme with broad substrate specificity and 6-phosphogluconolactonase activity. Archives of Biochemistry and Biophysics 415 229-234.
14. Collard F, Collet JF, Gerin I, Veiga-da-Cunha M & Van Schaftingen E 1999 Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway(1). FEBS Letters 459 223-226.
15. Csala M, Banhegyi G & Benedetti A 2006 Endoplasmic reticulum: a metabolic compartment. FEBS Letters 580 2160-2165.
16. Czegle I, Piccirella S, Senesi S, Csala M, Mandl J, Banhegyi G, Fulceri R & Benedetti A 2006 Cooperativity between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum. Molecular and Cellular Endocrinology 248 24-25.
17. Denton RM, Yorke RE & Randle PJ 1966 Measurement of concentrations of metabolites in adipose tissue and effects of insulin, alloxan-diabetes and adrenaline. Biochemical Journal 100 407-419.
18. + ratio in liver and pancreas are dependent on the severity of hyperglycemia in rat. Life Sciences 78 2601-2607.
19. Dimitriadis G, Leighton B, Parry-Billings M, Sasson S, Young M, Krause U, Bevan S, Piva T, Wegener G & Newsholme EA 1997 Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle. Biochemical Journal 321 707-712.
20. Dzyakanchuk AA, Balazs Z, Nashev LG, Amrein KE & Odermatt A 2008 11β-Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP(+) and is stimulated by extracellular glucose. Molecular and Cellular Endocrinology (doi: 10.1016/ jmce.2008.08.009).
21. Hems DA & Brosnan JT 1971 Effects of metabolic acidosis and starvation on the content of intermediary metabolites in rat kidney. Biochemical Journal 123 391-397.
22. Hewitt KN, Walker EA & Stewart PM 2005 Minireview: hexose-6-phosphate dehydrogenase and redox control of 11β-hydroxysteroid dehydrogenase type 1 activity. Endocrinology 146 2539-2543.
23. Hotamisligil GS 2005 Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes 54 S73-S78.
24. Hou ZQ, Li HL, Gao L, Pan L, Zhao JJ & Li GW 2008 Involvement of chronic stresses in rat islet and INS-1 cell glucotoxicity induced by intermittent high glucose. Molecular and Cellular Endocrinology 291 71-78.
25. Hult M, Elleby B, Shafqat N, Svensson S, Rane A, Jornvall H, Abrahmsen L & Oppermann U 2004 Human and rodent type 1 11β-hydroxysteroid dehydrogenases are 7β-hydroxycholesterol dehydrogenases involved in oxysterol metabolism. Cellular and Molecular Life Sciences 61 992-999.
26. Kardon T, Senesi S, Marcolongo P, Legeza B, Banhegyi G, Mandl J, Fulceri R & Benedetti A 2008 Maintenance of luminal NADPH in the endoplasmic reticulum promotes the survival of human neutrophil granulocytes. FEBS Letters 582 1809-1815.
27. Lavery GG, Walker EA, Draper N, Jeyasuria P, Marcos J, Shackleton CH, Parker KL, White PC & Stewart PM 2006 Hexose-6-phosphate dehydrogenase knock-out mice lack 11β-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation. Journal of Biological Chemistry 281 6546-6551.
28. Lavery GG, Hauton D, Hewitt KN, Brice SM, Sherlock M, Walker EA & Stewart PM 2007 Hypoglycemia with enhanced hepatic glycogen synthesis in recombinant mice lacking hexose-6-phosphate dehydrogenase. Endocrinology 148 6100-6106.
29. Lavery GG, Walker EA, Turan N, Rogoff D, Ryder JW, Shelton JM, Richardson JA, Falciani F, White PC, Stewart PM et al. 2008 Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy. Journal of Biological Chemistry 283 8453-8461.
30. Leuzzi R, Banhegyi G, Kardon T, Marcolongo P, Capecchi PL, Burger HJ, Benedetti A & Fulceri R 2003 Inhibition of microsomal glucose-6-phosphate transport in human neutrophils results in apoptosis: a potential explanation for neutrophil dysfunction in glycogen storage disease type 1b. Blood 101 2381-2387.
31. Lewis-Tuffin LJ & Cidlowski JA 2006 The physiology of human glucocorticoid receptor β (hGRβ) and glucocorticoid resistance. Annals of the New York Academy of Sciences 1069 1-9.
32. Luu-The V 2001 Analysis and characteristics of multiple types of human 17β-hydroxysteroid dehydrogenase. Journal of Steroid Biochemistry and Molecular Biology 76 143-151.
33. Marcolongo P, Piccirella S, Senesi S, Wunderlich L, Gerin I, Mandl J, Fulceri R, Banhegyi G & Benedetti A 2007 The glucose-6-phosphate transporter-hexose-6-phosphate dehydrogenase-11β-hydroxysteroid dehydrogenase type 1 system of the adipose tissue. Endocrinology 148 2487-2495.
34. Mason PJ, Stevens D, Diez A, Knight SW, Scopes DA & Vulliamy TJ 1999 Human hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) encoded at 1p36: coding sequence and expression. Blood Cells, Molecules & Diseases 25 30-37.
35. Morton NM & Seckl JR 2008 11β-Hydroxysteroid dehydrogenase type 1 and obesity. Frontiers of Hormone Research 36 146-164.
36. Mziaut H, Korza G, Hand AR, Gerard C & Ozols J 1999 Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11β-hydroxysteroid dehydrogenase and the 50-kDa esterase. Journal of Biological Chemistry 274 14122-14129.
37. Nashev LG, Chandsawangbhuwana C, Balazs Z, Atanasov AG, Dick B, Frey FJ, Baker ME & Odermatt A 2007 Hexose-6-phosphate dehydrogenase modulates 11β-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7β-hydroxy-neurosteroids. PLoS ONE 2 e561.
38. Odermatt A, Arnold P, Stauffer A, Frey BM & Frey FJ 1999 The N-terminal anchor sequences of 11β-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane. Journal of Biological Chemistry 274 28762-28770.
39. + ratio on the activities of hexose-6-phosphate dehydrogenase and glucose-6-phosphate dehydrogenase. Biochimica et Biophysica Acta 662 318-325.
40. Ozols J 1993 Isolation and the complete amino acid sequence of lumenal endoplasmic reticulum glucose-6-phosphate dehydrogenase. PNAS 90 5302-5306.
41. Ozols J 1995 Lumenal orientation and post-translational modifications of the liver microsomal 11β-hydroxysteroid dehydrogenase. Journal of Biological Chemistry 270 2305-2312.
42. + ratio. Diabetologia 51 101-109.
43. Piccirella S, Czegle I, Lizak B, Margittai E, Senesi S, Papp E, Csala M, Fulceri R, Csermely P, Mandl J et al. 2006 Uncoupled redox systems in the lumen of the endoplasmic reticulum. Pyridine nucleotides stay reduced in an oxidative environment. Journal of Biological Chemistry 281 4671-4677.
44. Pierotti S, Gandini L, Lenzi A & Isidori AM 2008 Pre-receptorial regulation of steroid hormones in bone cells: insights on glucocorticoid-induced osteoporosis. Journal of Steroid Biochemistry and Molecular Biology 108 292-299.
45. Pollak N, Dolle C & Ziegler M 2007 The power to reduce: pyridine nucleotides - small molecules with a multitude of functions. Biochemical Journal 402 205-218.
46. Randle PJ 1998 Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes/Metabolism Reviews 14 263-283.
47. Randle PJ, Garland PB, Hales CN & Newsholme EA 1963 The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1 785-789.
48. Rizza RA, Mandarino LJ & Gerich JE 1982 Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action. Journal of Clinical Endocrinology and Metabolism 54 131-138.
49. Rogoff D, Ryder JW, Black K, Yan Z, Burgess SC, McMillan DR & White PC 2007 Abnormalities of glucose homeostasis and the hypothalamic-pituitary-adrenal axis in mice lacking hexose-6-phosphate dehydrogenase. Endocrinology 148 5072-5080.
50. van Schaftingen E & Gerin I 2002 The glucose-6-phosphatase system. Biochemical Journal 362 513-532.
51. Schweizer RA, Zurcher M, Balazs Z, Dick B & Odermatt A 2004 Rapid hepatic metabolism of 7-ketocholesterol by 11β-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme. Journal of Biological Chemistry 279 18415-18424.
52. Sekar N, Qian S & Shechter Y 1998 Vanadate elevates lipogenicity of starved rat adipose tissue: mechanism of action. Endocrinology 139 2514-2518.
53. Stahn C, Lowenberg M, Hommes DW & Buttgereit F 2007 Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists. Molecular and Cellular Endocrinology 275 71-78.
54. Stimson RH & Walker BR 2007 Glucocorticoids and 11β-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome. Minerva Endocrinologica 32 141-159.
55. Swali A, Walker EA, Lavery GG, Tomlinson JW & Stewart PM 2008 11β-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets. Diabetologia 51 2003-2011.
56. Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M & Stewart PM 2004 11β-Hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. Endocrine Reviews 25 831-866.
57. Tomlinson JW, Finney J, Hughes BA, Hughes SV & Stewart PM 2008 Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss. Diabetes 57 1536-1543.
58. Wake DJ, Homer NZ, Andrew R & Walker BR 2006 Acute in vivo regulation of 11β-hydroxysteroid dehydrogenase type 1 activity by insulin and intralipid infusions in humans. Journal of Clinical Endocrinology and Metabolism 91 4682-4688.
59. Walker EA, Ahmed A, Lavery GG, Tomlinson JW, Kim SY, Cooper MS, Ride JP, Hughes BA, Shackleton CH, McKiernan P et al. 2007 11β-Hydroxysteroid dehydrogenase type 1 regulation by intracellular glucose 6-phosphate provides evidence for a novel link between glucose metabolism and hypothalamo-pituitary-adrenal axis function. Journal of Biological Chemistry 282 27030-27036.
60. Wamil M, Andrew R, Chapman KE, Street J, Morton NM & Seckl JR 2008 7-Oxysterols modulate glucocorticoid activity in adipocytes through competition for 11β-hydroxysteroid dehydrogenase type 1. Endocrinology 149 5905-5918.
61. Wang H, Kouri G & Wollheim CB 2005 ER stress and SREBP-1 activation are implicated in β-cell glucolipotoxicity. Journal of Cell Science 118 3905-3915.
62. Wei Y, Wang D, Topczewski F & Pagliassotti MJ 2006 Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. American Journal of Physiology 291 E275-E281.
63. White PC, Rogoff D, McMillan DR & Lavery GG 2007 Hexose 6-phosphate dehydrogenase (H6PD) and corticosteroid metabolism. Molecular and Cellular Endocrinology 265-266 89-92.
64. White PC, Rogoff D & McMillan DR 2008 Physiological roles of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase. Current Opinion in Pediatrics 20 453-457.
65. Yoshida H 2007 ER stress and diseases. FEBS Journal 274 630-658.
66. Zhang K & Kaufman RJ 2008 From endoplasmic-reticulum stress to the inflammatory response. Nature 454 455-462.