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Volumn 146, Issue 1, 2007, Pages 255-264

Mutation of superoxide dismutase elevates reactive species: Comparison of nitration and oxidation of proteins in different brain regions of transgenic mice with amyotrophic lateral sclerosis

Author keywords

cerebellar cortex; hypoglossal nucleus; motor cortex; nitric oxide; protein carbonyl content; protein bound nitrotyrosine

Indexed keywords

3 NITROTYROSINE; COPPER ZINC SUPEROXIDE DISMUTASE;

EID: 34247485859     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2007.01.028     Document Type: Article
Times cited : (37)

References (57)
  • 1
    • 0028971936 scopus 로고
    • Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis
    • Abe K., Pan L.H., Watanabe M., Kato T., and Itoyama Y. Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis. Neurosci Lett 199 (1995) 152-154
    • (1995) Neurosci Lett , vol.199 , pp. 152-154
    • Abe, K.1    Pan, L.H.2    Watanabe, M.3    Kato, T.4    Itoyama, Y.5
  • 2
    • 0034099564 scopus 로고    scopus 로고
    • Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase
    • Alexander G.M., Deitch J.S., Seeburger J.L., Del Valle L., and Heiman-Patterson T.D. Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase. J Neurochem 74 (2000) 1666-1673
    • (2000) J Neurochem , vol.74 , pp. 1666-1673
    • Alexander, G.M.1    Deitch, J.S.2    Seeburger, J.L.3    Del Valle, L.4    Heiman-Patterson, T.D.5
  • 3
    • 0033018506 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • Almer G., Vukosavic S., Romero N., and Przedborski S. Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem 72 (1999) 2415-2425
    • (1999) J Neurochem , vol.72 , pp. 2415-2425
    • Almer, G.1    Vukosavic, S.2    Romero, N.3    Przedborski, S.4
  • 4
    • 0031784348 scopus 로고    scopus 로고
    • Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • Andrus P.K., Fleck T.J., Gurney M.E., and Hall E.D. Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem 71 (1998) 2041-2048
    • (1998) J Neurochem , vol.71 , pp. 2041-2048
    • Andrus, P.K.1    Fleck, T.J.2    Gurney, M.E.3    Hall, E.D.4
  • 5
    • 12244312473 scopus 로고    scopus 로고
    • Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: reduction by Mn (III) tetrakis (4-benzoic acid) porphyrin
    • Bao F., DeWitt D.S., Prough D.S., and Liu D. Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: reduction by Mn (III) tetrakis (4-benzoic acid) porphyrin. J Neurosci Res 71 (2003) 220-227
    • (2003) J Neurosci Res , vol.71 , pp. 220-227
    • Bao, F.1    DeWitt, D.S.2    Prough, D.S.3    Liu, D.4
  • 10
    • 0018406568 scopus 로고
    • Rapid isolation of carcinogen-bound DNA and RNA by hydroxyapatite chromatography
    • Beland F.A., Dooley K.L., and Casciano D.A. Rapid isolation of carcinogen-bound DNA and RNA by hydroxyapatite chromatography. J Chromatogr 174 (1979) 177-186
    • (1979) J Chromatogr , vol.174 , pp. 177-186
    • Beland, F.A.1    Dooley, K.L.2    Casciano, D.A.3
  • 12
    • 0031868461 scopus 로고    scopus 로고
    • Elevated "hydroxyl radical" generation in vivo in an animal model of amyotrophic lateral sclerosis
    • Bogdanov M.B., Ramos L.E., Xu Z., and Beal M.F. Elevated "hydroxyl radical" generation in vivo in an animal model of amyotrophic lateral sclerosis. J Neurochem 71 (1998) 1321-1324
    • (1998) J Neurochem , vol.71 , pp. 1321-1324
    • Bogdanov, M.B.1    Ramos, L.E.2    Xu, Z.3    Beal, M.F.4
  • 13
    • 0027359334 scopus 로고
    • Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis
    • Bowling A.C., Schulz J.B., Brown Jr. R.H., and Beal M.F. Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis. J Neurochem 61 (1993) 2322-2325
    • (1993) J Neurochem , vol.61 , pp. 2322-2325
    • Bowling, A.C.1    Schulz, J.B.2    Brown Jr., R.H.3    Beal, M.F.4
  • 14
    • 0030806228 scopus 로고    scopus 로고
    • Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant
    • Bruijn L.I., Beal M.F., Becher M.W., Schulz J.B., Wong P.C., Price D.L., and Cleveland D.W. Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant. Proc Natl Acad Sci U S A 94 (1997) 7606-7611
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 7606-7611
    • Bruijn, L.I.1    Beal, M.F.2    Becher, M.W.3    Schulz, J.B.4    Wong, P.C.5    Price, D.L.6    Cleveland, D.W.7
  • 15
    • 18144398928 scopus 로고    scopus 로고
    • Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: possible multifunctional role in the pathogenesis
    • Casoni F., Basso M., Massignan T., Gianazza E., Cheroni C., Salmona M., Bendotti C., and Bonetto V. Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: possible multifunctional role in the pathogenesis. J Biol Chem 280 (2005) 16295-16304
    • (2005) J Biol Chem , vol.280 , pp. 16295-16304
    • Casoni, F.1    Basso, M.2    Massignan, T.3    Gianazza, E.4    Cheroni, C.5    Salmona, M.6    Bendotti, C.7    Bonetto, V.8
  • 16
    • 0029991827 scopus 로고    scopus 로고
    • Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study
    • Chou S.M., Wang H.S., and Komai K. Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study. J Chem Neuroanat 10 (1996) 249-258
    • (1996) J Chem Neuroanat , vol.10 , pp. 249-258
    • Chou, S.M.1    Wang, H.S.2    Komai, K.3
  • 17
    • 0036391077 scopus 로고    scopus 로고
    • Cu/Zn superoxide dismutase (SOD1) mutations associated with familial amyotrophic lateral sclerosis (ALS) affect cellular free radical release in the presence of oxidative stress
    • Cookson M.R., Menzies F.M., Manning P., Eggett C.J., Figlewicz D.A., McNeil C.J., and Shaw P.J. Cu/Zn superoxide dismutase (SOD1) mutations associated with familial amyotrophic lateral sclerosis (ALS) affect cellular free radical release in the presence of oxidative stress. Amyotroph Lateral Scler Other Motor Neuron Disord 3 (2002) 75-85
    • (2002) Amyotroph Lateral Scler Other Motor Neuron Disord , vol.3 , pp. 75-85
    • Cookson, M.R.1    Menzies, F.M.2    Manning, P.3    Eggett, C.J.4    Figlewicz, D.A.5    McNeil, C.J.6    Shaw, P.J.7
  • 24
    • 0026647763 scopus 로고
    • Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress
    • Floyd R.A., and Carney J.M. Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann Neurol 32 Suppl (1992) S22-S27
    • (1992) Ann Neurol , vol.32 , Issue.SUPPL
    • Floyd, R.A.1    Carney, J.M.2
  • 26
    • 0030050727 scopus 로고    scopus 로고
    • Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis
    • Gurney M.E., Cutting F.B., Zhai P., Doble A., Taylor C.P., Andrus P.K., and Hall E.D. Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Ann Neurol 39 (1996) 147-157
    • (1996) Ann Neurol , vol.39 , pp. 147-157
    • Gurney, M.E.1    Cutting, F.B.2    Zhai, P.3    Doble, A.4    Taylor, C.P.5    Andrus, P.K.6    Hall, E.D.7
  • 27
    • 0032127330 scopus 로고    scopus 로고
    • Relationship of oxygen radical-induced lipid peroxidative damage to disease onset and progression in a transgenic model of familial ALS
    • Hall E.D., Andrus P.K., Oostveen J.A., Fleck T.J., and Gurney M.E. Relationship of oxygen radical-induced lipid peroxidative damage to disease onset and progression in a transgenic model of familial ALS. J Neurosci Res 53 (1998) 66-77
    • (1998) J Neurosci Res , vol.53 , pp. 66-77
    • Hall, E.D.1    Andrus, P.K.2    Oostveen, J.A.3    Fleck, T.J.4    Gurney, M.E.5
  • 28
    • 0017702532 scopus 로고
    • Subnanomole-range amino acid analysis
    • Hare P.E. Subnanomole-range amino acid analysis. Methods Enzymol 47 (1977) 3-18
    • (1977) Methods Enzymol , vol.47 , pp. 3-18
    • Hare, P.E.1
  • 29
    • 0031554894 scopus 로고    scopus 로고
    • Quantitation of protein-bound 3-nitrotyrosine and 3,4-dihydroxyphenylalanine by high-performance liquid chromatography with electrochemical array detection
    • Hensley K., Maidt M.L., Pye Q.N., Stewart C.A., Wack M., Tabatabaie T., and Floyd R.A. Quantitation of protein-bound 3-nitrotyrosine and 3,4-dihydroxyphenylalanine by high-performance liquid chromatography with electrochemical array detection. Anal Biochem 251 (1997) 187-195
    • (1997) Anal Biochem , vol.251 , pp. 187-195
    • Hensley, K.1    Maidt, M.L.2    Pye, Q.N.3    Stewart, C.A.4    Wack, M.5    Tabatabaie, T.6    Floyd, R.A.7
  • 30
    • 0036062628 scopus 로고    scopus 로고
    • Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis
    • Hensley K., Floyd R.A., Gordon B., Mou S., Pye Q.N., Stewart C.A., West M., and Williamson K. Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. J Neurochem 82 (2002) 365-374
    • (2002) J Neurochem , vol.82 , pp. 365-374
    • Hensley, K.1    Floyd, R.A.2    Gordon, B.3    Mou, S.4    Pye, Q.N.5    Stewart, C.A.6    West, M.7    Williamson, K.8
  • 31
    • 19444374567 scopus 로고    scopus 로고
    • Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice
    • Holasek S.S., Wengenack T.M., Kandimalla K.K., Montano C., Gregor D.M., Curran G.L., and Poduslo J.F. Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice. Brain Res 1045 (2005) 185-198
    • (2005) Brain Res , vol.1045 , pp. 185-198
    • Holasek, S.S.1    Wengenack, T.M.2    Kandimalla, K.K.3    Montano, C.4    Gregor, D.M.5    Curran, G.L.6    Poduslo, J.F.7
  • 32
    • 0031020172 scopus 로고    scopus 로고
    • Bright and dark sides of nitric oxide in ischemic brain injury
    • Iadecola C. Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci 20 (1997) 132-139
    • (1997) Trends Neurosci , vol.20 , pp. 132-139
    • Iadecola, C.1
  • 34
    • 4544377971 scopus 로고    scopus 로고
    • Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis
    • Kiaei M., Bush A.I., Morrison B.M., Morrison J.H., Cherny R.A., Volitakis I., Beal M.F., and Gordon J.W. Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci 24 (2004) 7945-7950
    • (2004) J Neurosci , vol.24 , pp. 7945-7950
    • Kiaei, M.1    Bush, A.I.2    Morrison, B.M.3    Morrison, J.H.4    Cherny, R.A.5    Volitakis, I.6    Beal, M.F.7    Gordon, J.W.8
  • 35
    • 0035868484 scopus 로고    scopus 로고
    • Protein and DNA oxidation in spinal injury: neurofilaments: an oxidation target
    • Leski M.L., Bao F., Wu L., Qian H., Sun D., and Liu D. Protein and DNA oxidation in spinal injury: neurofilaments: an oxidation target. Free Radic Biol Med 30 (2001) 613-624
    • (2001) Free Radic Biol Med , vol.30 , pp. 613-624
    • Leski, M.L.1    Bao, F.2    Wu, L.3    Qian, H.4    Sun, D.5    Liu, D.6
  • 37
    • 0027194540 scopus 로고
    • A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
    • Lipton S.A., Choi Y.B., Pan Z.H., Lei S.Z., Chen H.S., Sucher N.J., Loscalzo J., Singel D.J., and Stamler J.S. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364 (1993) 626-632
    • (1993) Nature , vol.364 , pp. 626-632
    • Lipton, S.A.1    Choi, Y.B.2    Pan, Z.H.3    Lei, S.Z.4    Chen, H.S.5    Sucher, N.J.6    Loscalzo, J.7    Singel, D.J.8    Stamler, J.S.9
  • 38
    • 0028596337 scopus 로고
    • An experimental model combining microdialysis with electrophysiology, histology, and neurochemistry for studying excitotoxicity in spinal cord injury. Effect of NMDA and kainate
    • Liu D. An experimental model combining microdialysis with electrophysiology, histology, and neurochemistry for studying excitotoxicity in spinal cord injury. Effect of NMDA and kainate. Mol Chem Neuropathol 23 (1994) 77-92
    • (1994) Mol Chem Neuropathol , vol.23 , pp. 77-92
    • Liu, D.1
  • 39
    • 0028006013 scopus 로고
    • Hydroxyl radicals generated in vivo kill neurons in the rat spinal cord: electrophysiological, histological, and neurochemical results
    • Liu D., Yang R., Yan X., and McAdoo D.J. Hydroxyl radicals generated in vivo kill neurons in the rat spinal cord: electrophysiological, histological, and neurochemical results. J Neurochem 62 (1994) 37-44
    • (1994) J Neurochem , vol.62 , pp. 37-44
    • Liu, D.1    Yang, R.2    Yan, X.3    McAdoo, D.J.4
  • 40
    • 0028897694 scopus 로고
    • Paraquat-a superoxide generator-kills neurons in the rat spinal cord
    • Liu D., Yang J., Li L., and McAdoo D.J. Paraquat-a superoxide generator-kills neurons in the rat spinal cord. Free Radic Biol Med 18 (1995) 861-867
    • (1995) Free Radic Biol Med , vol.18 , pp. 861-867
    • Liu, D.1    Yang, J.2    Li, L.3    McAdoo, D.J.4
  • 41
    • 0032764587 scopus 로고    scopus 로고
    • The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids
    • Liu D., Wen J., Liu J., and Li L. The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids. FASEB J 13 (1999) 2318-2328
    • (1999) FASEB J , vol.13 , pp. 2318-2328
    • Liu, D.1    Wen, J.2    Liu, J.3    Li, L.4
  • 42
    • 0032819394 scopus 로고    scopus 로고
    • Elevation of hydrogen peroxide after spinal cord injury detected by using the Fenton reaction
    • Liu D., Liu J., and Wen J. Elevation of hydrogen peroxide after spinal cord injury detected by using the Fenton reaction. Free Radic Biol Med 27 (1999) 478-482
    • (1999) Free Radic Biol Med , vol.27 , pp. 478-482
    • Liu, D.1    Liu, J.2    Wen, J.3
  • 43
    • 0033793219 scopus 로고    scopus 로고
    • The role of reactive nitrogen species in secondary spinal cord injury: formation of nitric oxide, peroxynitrite, and nitrated protein
    • Liu D., Ling X., Wen J., and Liu J. The role of reactive nitrogen species in secondary spinal cord injury: formation of nitric oxide, peroxynitrite, and nitrated protein. J Neurochem 75 (2000) 2144-2154
    • (2000) J Neurochem , vol.75 , pp. 2144-2154
    • Liu, D.1    Ling, X.2    Wen, J.3    Liu, J.4
  • 44
    • 0034999442 scopus 로고    scopus 로고
    • Prostaglandin release by spinal cord injury mediates production of hydroxyl radical, malondialdehyde and cell death: a site of the neuroprotective action of methylprednisolone
    • Liu D., Li L., and Augustus L. Prostaglandin release by spinal cord injury mediates production of hydroxyl radical, malondialdehyde and cell death: a site of the neuroprotective action of methylprednisolone. J Neurochem 77 (2001) 1036-1047
    • (2001) J Neurochem , vol.77 , pp. 1036-1047
    • Liu, D.1    Li, L.2    Augustus, L.3
  • 45
    • 0031768025 scopus 로고    scopus 로고
    • Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • Liu R., Althaus J.S., Ellerbrock B.R., Becker D.A., and Gurney M.E. Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis. Ann Neurol 44 (1998) 763-770
    • (1998) Ann Neurol , vol.44 , pp. 763-770
    • Liu, R.1    Althaus, J.S.2    Ellerbrock, B.R.3    Becker, D.A.4    Gurney, M.E.5
  • 46
    • 0023654594 scopus 로고
    • N-substituted 1-cyanobenz[f]isoindole: evaluation of fluorescence efficiencies of a new fluorogenic label for primary amines and amino acids
    • Matuszewski B.K., Givens R.S., Srinivasachar K., Carlson R.G., and Higuchi T. N-substituted 1-cyanobenz[f]isoindole: evaluation of fluorescence efficiencies of a new fluorogenic label for primary amines and amino acids. Anal Chem 59 (1987) 1102-1105
    • (1987) Anal Chem , vol.59 , pp. 1102-1105
    • Matuszewski, B.K.1    Givens, R.S.2    Srinivasachar, K.3    Carlson, R.G.4    Higuchi, T.5
  • 47
    • 0025612247 scopus 로고
    • Nitrotyrosine as a new marker for endogenous nitrosation and nitration of proteins
    • Ohshima H., Friesen M., Brouet I., and Bartsch H. Nitrotyrosine as a new marker for endogenous nitrosation and nitration of proteins. Food Chem Toxicol 28 (1990) 647-652
    • (1990) Food Chem Toxicol , vol.28 , pp. 647-652
    • Ohshima, H.1    Friesen, M.2    Brouet, I.3    Bartsch, H.4
  • 50
    • 0034659123 scopus 로고    scopus 로고
    • Increased reactive oxygen species in familial amyotrophic lateral sclerosis with mutations in SOD1
    • Said Ahmed M., Hung W.Y., Zu J.S., Hockberger P., and Siddique T. Increased reactive oxygen species in familial amyotrophic lateral sclerosis with mutations in SOD1. J Neurol Sci 176 (2000) 88-94
    • (2000) J Neurol Sci , vol.176 , pp. 88-94
    • Said Ahmed, M.1    Hung, W.Y.2    Zu, J.S.3    Hockberger, P.4    Siddique, T.5
  • 51
    • 23144448320 scopus 로고    scopus 로고
    • Molecular and cellular pathways of neurodegeneration in motor neurone disease
    • Shaw P.J. Molecular and cellular pathways of neurodegeneration in motor neurone disease. J Neurol Neurosurg Psychiatry 76 (2005) 1046-1057
    • (2005) J Neurol Neurosurg Psychiatry , vol.76 , pp. 1046-1057
    • Shaw, P.J.1
  • 52
    • 23844538993 scopus 로고    scopus 로고
    • The pathobiology of amyotrophic lateral sclerosis: a proteinopathy?
    • Strong M.J., Kesavapany S., and Pant H.C. The pathobiology of amyotrophic lateral sclerosis: a proteinopathy?. J Neuropathol Exp Neurol 64 (2005) 649-664
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 649-664
    • Strong, M.J.1    Kesavapany, S.2    Pant, H.C.3
  • 53
    • 0034033626 scopus 로고    scopus 로고
    • Increased cerebrospinal fluid and serum nitrite and nitrate levels in amyotrophic lateral sclerosis
    • Taskiran D., Sagduyu A., Yuceyar N., Kutay F.Z., and Pogun S. Increased cerebrospinal fluid and serum nitrite and nitrate levels in amyotrophic lateral sclerosis. Int J Neurosci 101 (2000) 65-72
    • (2000) Int J Neurosci , vol.101 , pp. 65-72
    • Taskiran, D.1    Sagduyu, A.2    Yuceyar, N.3    Kutay, F.Z.4    Pogun, S.5
  • 54
    • 0033524950 scopus 로고    scopus 로고
    • Increase in oxidized NO products and reduction in oxidized glutathione in cerebrospinal fluid from patients with sporadic form of amyotrophic lateral sclerosis
    • Tohgi H., Abe T., Yamazaki K., Murata T., Ishizaki E., and Isobe C. Increase in oxidized NO products and reduction in oxidized glutathione in cerebrospinal fluid from patients with sporadic form of amyotrophic lateral sclerosis. Neurosci Lett 260 (1999) 204-206
    • (1999) Neurosci Lett , vol.260 , pp. 204-206
    • Tohgi, H.1    Abe, T.2    Yamazaki, K.3    Murata, T.4    Ishizaki, E.5    Isobe, C.6
  • 55
    • 0033064535 scopus 로고    scopus 로고
    • Administration of nitric oxide synthase inhibitors does not alter disease course of amyotrophic lateral sclerosis SOD1 mutant transgenic mice
    • Upton-Rice M.N., Cudkowicz M.E., Mathew R.K., Reif D., and Brown Jr. R.H. Administration of nitric oxide synthase inhibitors does not alter disease course of amyotrophic lateral sclerosis SOD1 mutant transgenic mice. Ann Neurol 45 (1999) 413-414
    • (1999) Ann Neurol , vol.45 , pp. 413-414
    • Upton-Rice, M.N.1    Cudkowicz, M.E.2    Mathew, R.K.3    Reif, D.4    Brown Jr., R.H.5
  • 56
    • 5644242311 scopus 로고    scopus 로고
    • Activation of programmed cell death markers in ventral horn motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in a transgenic mouse model
    • Wengenack T.M., Holasek S.S., Montano C.M., Gregor D., Curran G.L., and Poduslo J.F. Activation of programmed cell death markers in ventral horn motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in a transgenic mouse model. Brain Res 1027 (2004) 73-86
    • (2004) Brain Res , vol.1027 , pp. 73-86
    • Wengenack, T.M.1    Holasek, S.S.2    Montano, C.M.3    Gregor, D.4    Curran, G.L.5    Poduslo, J.F.6
  • 57
    • 9644273779 scopus 로고    scopus 로고
    • Inflammatory mediators and growth factors in the spinal cord of G93A SOD1 rats
    • Xie Y., Weydt P., Howland D.S., Kliot M., and Moller T. Inflammatory mediators and growth factors in the spinal cord of G93A SOD1 rats. Neuroreport 15 (2004) 2513-2516
    • (2004) Neuroreport , vol.15 , pp. 2513-2516
    • Xie, Y.1    Weydt, P.2    Howland, D.S.3    Kliot, M.4    Moller, T.5


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