Metyrapone prevents cortisone-induced preadipocyte differentiation by depleting luminal NADPH of the endoplasmic reticulum

Biochemical Pharmacology

Volumn 76, Issue 3, 2008, Pages 382-390

  Marcolongo, Paola ^a   Senesi, Silvia ^a   Gava, Barbara ^a   Fulceri, Rosella ^a   Sorrentino, Vincenzo ^a   Margittai, Éva ^b   Lizák, Beáta ^b   Csala, Miklós ^b   Bánhegyi, Gábor ^a,b   Benedetti, Angelo ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

11 Hydroxysteroid dehydrogenase type 1; Adipogenesis; Endoplasmic reticulum; Metyrapone; NADPH NADP+

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTISONE; DEXAMETHASONE; FAT DROPLET; METYRAPONE; OXIDOREDUCTASE; PYRIDINE NUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ADIPOCYTE; ADIPOGENESIS; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; FLUOROMETRY; HUMAN; HUMAN CELL; LIVER MICROSOME; MEMBRANE PERMEABILITY; MESENCHYMAL STEM CELL; MICROSOME MEMBRANE; NONHUMAN; OXIDATION; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROADIPOCYTE; RAT; REDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; CORTISONE; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; FIBROBLASTS; HUMANS; MALE; MESENCHYMAL STEM CELLS; METYRAPONE; MICE; MICROSOMES, LIVER; NADP; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 46649087941     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.05.027     Document Type: Article

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