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Volumn 409, Issue 3, 2008, Pages 623-633

Post-translational modifications of adiponectin: Mechanisms and functional implications

Author keywords

Adipokine; Adiponectin; Insulin sensitivity; Metabolic syndrome; Obesity

Indexed keywords

DISEASES; HYDROXYLATION; MOLECULAR MASS; MOLECULAR STRUCTURE; OLIGOMERS; TISSUE;

EID: 38949125405     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20071492     Document Type: Review
Times cited : (329)

References (102)
  • 1
    • 34247857663 scopus 로고    scopus 로고
    • Obesity, inflammation, and insulin resistance
    • Shoelson, S. E., Herrero, L. and Naaz, A. (2007) Obesity, inflammation, and insulin resistance. Gastroenterology 132, 2169-2180
    • (2007) Gastroenterology , vol.132 , pp. 2169-2180
    • Shoelson, S.E.1    Herrero, L.2    Naaz, A.3
  • 2
    • 13244284806 scopus 로고    scopus 로고
    • Adiponectin: Journey from an adipocyte secretory protein to biomarker of the metabolic syndrome
    • Trujillo, M. E. and Scherer, P. E. (2005) Adiponectin: journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J. Intern. Med. 257, 167-175
    • (2005) J. Intern. Med , vol.257 , pp. 167-175
    • Trujillo, M.E.1    Scherer, P.E.2
  • 3
    • 17544382289 scopus 로고    scopus 로고
    • AdipoQ is a novel adipose-specific gene dysregulated in obesity
    • Hu, E., Liang, P. and Spiegelman, B. M. (1996) AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 271, 10697-10703
    • (1996) J. Biol. Chem , vol.271 , pp. 10697-10703
    • Hu, E.1    Liang, P.2    Spiegelman, B.M.3
  • 4
    • 0029980285 scopus 로고    scopus 로고
    • cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1)
    • Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y. and Matsubara, K. (1996) cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1). Biochem. Biophys. Res. Commun. 221, 286-289
    • (1996) Biochem. Biophys. Res. Commun , vol.221 , pp. 286-289
    • Maeda, K.1    Okubo, K.2    Shimomura, I.3    Funahashi, T.4    Matsuzawa, Y.5    Matsubara, K.6
  • 5
    • 0029836585 scopus 로고    scopus 로고
    • Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma
    • Nakano, Y., Tobe, T., Choi-Miura, N. H., Mazda, T. and Tomita, M. (1996) Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J. Biochem. (Tokyo) 120, 803-812
    • (1996) J. Biochem. (Tokyo) , vol.120 , pp. 803-812
    • Nakano, Y.1    Tobe, T.2    Choi-Miura, N.H.3    Mazda, T.4    Tomita, M.5
  • 6
    • 0028787490 scopus 로고
    • A novel serum protein similar to C1q, produced exclusively in adipocytes
    • Scherer, P. E., Williams, S., Fogliano, M., Baldini, G. and Lodish, H. F. (1995) A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 270, 26746-26749
    • (1995) J. Biol. Chem , vol.270 , pp. 26746-26749
    • Scherer, P.E.1    Williams, S.2    Fogliano, M.3    Baldini, G.4    Lodish, H.F.5
  • 9
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • Xu, A., Wang, Y., Keshaw, H., Xu, L. Y., Lam, K. S. and Cooper, G. J. (2003) The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J. Clin. Invest. 112, 91-100
    • (2003) J. Clin. Invest , vol.112 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.5    Cooper, G.J.6
  • 10
    • 27144457438 scopus 로고    scopus 로고
    • Adiponectin protects against myocardial ischemia-repertusion injury through AMPK- and COX-2-dependent mechanisms
    • Shibata, R., Sato, K., Pimentel, D. R., Takemura, Y., Kihara, S., Ohashi, K., Funahashi, T., Ouchi, N. and Walsh, K. (2005) Adiponectin protects against myocardial ischemia-repertusion injury through AMPK- and COX-2-dependent mechanisms. Nat. Med. 11, 1096-1103
    • (2005) Nat. Med , vol.11 , pp. 1096-1103
    • Shibata, R.1    Sato, K.2    Pimentel, D.R.3    Takemura, Y.4    Kihara, S.5    Ohashi, K.6    Funahashi, T.7    Ouchi, N.8    Walsh, K.9
  • 11
    • 33746516349 scopus 로고    scopus 로고
    • Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice
    • Shore, S. A., Terry, R. D., Flynt, L., Xu, A. and Hug, C. (2006) Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J. Allergy Clin. Immunol. 118, 389-395
    • (2006) J. Allergy Clin. Immunol , vol.118 , pp. 389-395
    • Shore, S.A.1    Terry, R.D.2    Flynt, L.3    Xu, A.4    Hug, C.5
  • 12
    • 33845806853 scopus 로고    scopus 로고
    • Adiponectin modulates the glycogen synthase kinase-3β/β-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice
    • Wang, Y., Lam, J. B., Lam, K. S., Liu, J., Lam, M. C., Hoo, R. L., Wu, D., Cooper, G. J. and Xu, A. (2006) Adiponectin modulates the glycogen synthase kinase-3β/β-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice. Cancer Res. 66, 11462-11470
    • (2006) Cancer Res , vol.66 , pp. 11462-11470
    • Wang, Y.1    Lam, J.B.2    Lam, K.S.3    Liu, J.4    Lam, M.C.5    Hoo, R.L.6    Wu, D.7    Cooper, G.J.8    Xu, A.9
  • 13
    • 34247365935 scopus 로고    scopus 로고
    • Adiponectin as a negative regulator in obesity-related mammary carcinogenesis
    • Wang, Y., Lam, K. S. and Xu, A. (2007) Adiponectin as a negative regulator in obesity-related mammary carcinogenesis. Cell Res. 17, 280-282
    • (2007) Cell Res , vol.17 , pp. 280-282
    • Wang, Y.1    Lam, K.S.2    Xu, A.3
  • 14
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • Kadowaki, T., Yamauchi, T., Kubota, N., Hara, K., Ueki, K. and Tobe, K. (2006) Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Invest. 116, 1784-1792
    • (2006) J. Clin. Invest , vol.116 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3    Hara, K.4    Ueki, K.5    Tobe, K.6
  • 15
    • 0037983775 scopus 로고    scopus 로고
    • Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes
    • Wu, X., Motoshima, H., Mahadev, K., Stalker, T. J., Scalia, R. and Goldstein, B. J. (2003) Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes 52, 1355-1363
    • (2003) Diabetes , vol.52 , pp. 1355-1363
    • Wu, X.1    Motoshima, H.2    Mahadev, K.3    Stalker, T.J.4    Scalia, R.5    Goldstein, B.J.6
  • 16
    • 0036851817 scopus 로고    scopus 로고
    • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    • Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K. et al. (2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med. 8, 1288-1295
    • (2002) Nat. Med , vol.8 , pp. 1288-1295
    • Yamauchi, T.1    Kamon, J.2    Minokoshi, Y.3    Ito, Y.4    Waki, H.5    Uchida, S.6    Yamashita, S.7    Noda, M.8    Kita, S.9    Ueki, K.10
  • 17
    • 0347379841 scopus 로고    scopus 로고
    • Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity: Different oligomers activate different signal transduction pathways
    • Tsao, T. S., Tomas, E., Murrey, H. E., Hug, C., Lee, D. H., Ruderman, N. B., Heuser, J. E. and Lodish, H. F. (2003) Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity: different oligomers activate different signal transduction pathways. J. Biol. Chem. 278, 50810-50817
    • (2003) J. Biol. Chem , vol.278 , pp. 50810-50817
    • Tsao, T.S.1    Tomas, E.2    Murrey, H.E.3    Hug, C.4    Lee, D.H.5    Ruderman, N.B.6    Heuser, J.E.7    Lodish, H.F.8
  • 19
    • 33745222085 scopus 로고    scopus 로고
    • Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex
    • Wang, Y., Lam, K. S., Chan, L., Chan, K. W., Lam, J. B., Lam, M. C., Hoo, R. C., Mak, W. W., Cooper, G. J. and Xu, A. (2006) Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex. J. Biol. Chem. 281, 16391-16400
    • (2006) J. Biol. Chem , vol.281 , pp. 16391-16400
    • Wang, Y.1    Lam, K.S.2    Chan, L.3    Chan, K.W.4    Lam, J.B.5    Lam, M.C.6    Hoo, R.C.7    Mak, W.W.8    Cooper, G.J.9    Xu, A.10
  • 20
    • 34248147538 scopus 로고    scopus 로고
    • Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells
    • Cheng, K. K., Lam, K. S., Wang, Y., Huang, Y., Carling, D., Wu, D., Wong, C. and Xu, A. (2007) Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabetes 56, 1387-1394
    • (2007) Diabetes , vol.56 , pp. 1387-1394
    • Cheng, K.K.1    Lam, K.S.2    Wang, Y.3    Huang, Y.4    Carling, D.5    Wu, D.6    Wong, C.7    Xu, A.8
  • 24
    • 33845592201 scopus 로고    scopus 로고
    • Adipose tissue-derived factors: Impact on health and disease
    • Trujillo, M. E. and Scherer, P. E. (2006) Adipose tissue-derived factors: impact on health and disease. Endocr. Rev. 27, 762-778
    • (2006) Endocr. Rev , vol.27 , pp. 762-778
    • Trujillo, M.E.1    Scherer, P.E.2
  • 25
    • 0037205414 scopus 로고    scopus 로고
    • Hydroxylation and glycosylate of the four conserved lysine residues in the collagenous domain of adiponectin: Potential role in the modulation of its insulin-sensitizing activity
    • Wang, Y., Xu, A., Knight, C., Xu, L. Y. and Cooper, G. J. (2002) Hydroxylation and glycosylate of the four conserved lysine residues in the collagenous domain of adiponectin: potential role in the modulation of its insulin-sensitizing activity. J. Biol. Chem. 277, 19521-19529
    • (2002) J. Biol. Chem , vol.277 , pp. 19521-19529
    • Wang, Y.1    Xu, A.2    Knight, C.3    Xu, L.Y.4    Cooper, G.J.5
  • 26
    • 10644228562 scopus 로고    scopus 로고
    • Proteomic and functional characterization of endogenous adiponectin purified from fetal bovine serum
    • Wang, Y., Lu, G., Wong, W. P., Vliegenthart, J. F., Gerwig, G. J., Lam, K. S., Cooper, G. J. and Xu, A. (2004) Proteomic and functional characterization of endogenous adiponectin purified from fetal bovine serum. Proteomics 12, 3933-3942
    • (2004) Proteomics , vol.12 , pp. 3933-3942
    • Wang, Y.1    Lu, G.2    Wong, W.P.3    Vliegenthart, J.F.4    Gerwig, G.J.5    Lam, K.S.6    Cooper, G.J.7    Xu, A.8
  • 27
    • 33745664785 scopus 로고    scopus 로고
    • Adiponectin multimerisation is dependent on conserved lysines in the collagenous domain: Evidence for regulation of multimerisation by alterations in post-translational modifications
    • Richards, A. A., Stephens, T., Charlton, H. K., Jones, A., Macdonald, G. A., Prins, J. B. and Whitehead, J. P. (2006) Adiponectin multimerisation is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerisation by alterations in post-translational modifications. Mol. Endocrinol. 20, 1673-1687
    • (2006) Mol. Endocrinol , vol.20 , pp. 1673-1687
    • Richards, A.A.1    Stephens, T.2    Charlton, H.K.3    Jones, A.4    Macdonald, G.A.5    Prins, J.B.6    Whitehead, J.P.7
  • 29
    • 0036861267 scopus 로고    scopus 로고
    • The third activity for lysyl hydroxylase 3: Galactosylation of hydroxylysyl residues in collagens in vitro
    • Wang, C., Luosujarvi, H., Heikkinen, J., Risteli, M., Uitto, L. and Myllyla, R. (2002) The third activity for lysyl hydroxylase 3: galactosylation of hydroxylysyl residues in collagens in vitro. Matrix Biol. 21, 559-566
    • (2002) Matrix Biol , vol.21 , pp. 559-566
    • Wang, C.1    Luosujarvi, H.2    Heikkinen, J.3    Risteli, M.4    Uitto, L.5    Myllyla, R.6
  • 30
    • 3142761477 scopus 로고    scopus 로고
    • T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin
    • Hug, C., Wang, J., Ahmad, N. S., Bogan, J. S., Tsao, T. S. and Lodish, H. F. (2004) T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc. Natl. Acad. Sci. U.S.A. 101, 10308-10313
    • (2004) Proc. Natl. Acad. Sci. U.S.A , vol.101 , pp. 10308-10313
    • Hug, C.1    Wang, J.2    Ahmad, N.S.3    Bogan, J.S.4    Tsao, T.S.5    Lodish, H.F.6
  • 31
    • 0035800745 scopus 로고    scopus 로고
    • Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein, adipo Q
    • Sato, C., Yasukawa, Z., Honda, N., Matsuda, T. and Kitajima, K. (2001) Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein, adipo Q. J. Biol. Chem. 276, 28849-28856
    • (2001) J. Biol. Chem , vol.276 , pp. 28849-28856
    • Sato, C.1    Yasukawa, Z.2    Honda, N.3    Matsuda, T.4    Kitajima, K.5
  • 32
    • 0037119375 scopus 로고    scopus 로고
    • Oligomerization state-dependent activation of NF-κB signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30)
    • Tsao, T. S., Murrey, H. E., Hug, C., Lee, D. H. and Lodish, H. F. (2002) Oligomerization state-dependent activation of NF-κB signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30). J. Biol. Chem. 277, 29359-29362
    • (2002) J. Biol. Chem , vol.277 , pp. 29359-29362
    • Tsao, T.S.1    Murrey, H.E.2    Hug, C.3    Lee, D.H.4    Lodish, H.F.5
  • 33
    • 0141924849 scopus 로고    scopus 로고
    • Impaired multimerization of human adiponectin mutants associated with diabetes: Molecular structure and multimer formation of adiponectin
    • Waki, H., Yamauchi, T., Kamon, J., Ito, Y., Uchida, S., Kita, S., Hara, K., Hada, Y., Vasseur, F., Froguel, P. et al. (2003) Impaired multimerization of human adiponectin mutants associated with diabetes: molecular structure and multimer formation of adiponectin. J. Biol. Chem. 278, 40352-40363
    • (2003) J. Biol. Chem , vol.278 , pp. 40352-40363
    • Waki, H.1    Yamauchi, T.2    Kamon, J.3    Ito, Y.4    Uchida, S.5    Kita, S.6    Hara, K.7    Hada, Y.8    Vasseur, F.9    Froguel, P.10
  • 34
    • 24044479055 scopus 로고    scopus 로고
    • Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes
    • Xu, A., Chan, K. W., Hoo, R. L., Wang, Y., Tan, K. C., Zhang, J., Chen, B., Lam, M. C., Tse, C., Cooper, G. J. and Lam, K. S. (2005) Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J. Biol. Chem. 280, 18073-18080
    • (2005) J. Biol. Chem , vol.280 , pp. 18073-18080
    • Xu, A.1    Chan, K.W.2    Hoo, R.L.3    Wang, Y.4    Tan, K.C.5    Zhang, J.6    Chen, B.7    Lam, M.C.8    Tse, C.9    Cooper, G.J.10    Lam, K.S.11
  • 35
    • 0032510463 scopus 로고    scopus 로고
    • The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor
    • Shapiro, L. and Scherer, P. E. (1998) The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr. Biol. 8, 335-338
    • (1998) Curr. Biol , vol.8 , pp. 335-338
    • Shapiro, L.1    Scherer, P.E.2
  • 36
    • 0037984387 scopus 로고    scopus 로고
    • Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin: Implications for metabolic regulation and bioactivity
    • Pajvani, U. B., Du, X., Combs, T. P., Berg, A. H., Rajala, M. W., Schulthess, T., Engel, J., Brownlee, M. and Scherer, P. E. (2003) Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin: implications for metabolic regulation and bioactivity. J. Biol. Chem. 278, 9073-9085
    • (2003) J. Biol. Chem , vol.278 , pp. 9073-9085
    • Pajvani, U.B.1    Du, X.2    Combs, T.P.3    Berg, A.H.4    Rajala, M.W.5    Schulthess, T.6    Engel, J.7    Brownlee, M.8    Scherer, P.E.9
  • 37
    • 24044538551 scopus 로고    scopus 로고
    • Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization dependent manner
    • Wang, Y., Lam, K. S., Xu, J. Y., Lu, G., Xu, L. Y., Cooper, G. J. and Xu, A. (2005) Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization dependent manner. J. Biol. Chem. 280, 18341-18347
    • (2005) J. Biol. Chem , vol.280 , pp. 18341-18347
    • Wang, Y.1    Lam, K.S.2    Xu, J.Y.3    Lu, G.4    Xu, L.Y.5    Cooper, G.J.6    Xu, A.7
  • 38
    • 33847109769 scopus 로고    scopus 로고
    • The oligomeric structure of high molecular weight adiponectin
    • Suzuki, S., Wilson-Kubalek, E. M., Wert, D., Tsao, T. S. and Lee, D. H. (2007) The oligomeric structure of high molecular weight adiponectin. FEBS Lett. 581, 809-814
    • (2007) FEBS Lett , vol.581 , pp. 809-814
    • Suzuki, S.1    Wilson-Kubalek, E.M.2    Wert, D.3    Tsao, T.S.4    Lee, D.H.5
  • 39
    • 11144355637 scopus 로고    scopus 로고
    • Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity
    • Pajvani, U. B., Hawkins, M., Combs, T. P., Rajala, M. W., Doebber, T., Berger, J. P., Wagner, J. A., Wu, M., Knopps, A., Xiang, A. H. et al. (2004) Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J. Biol. Chem. 279, 12152-12162
    • (2004) J. Biol. Chem , vol.279 , pp. 12152-12162
    • Pajvani, U.B.1    Hawkins, M.2    Combs, T.P.3    Rajala, M.W.4    Doebber, T.5    Berger, J.P.6    Wagner, J.A.7    Wu, M.8    Knopps, A.9    Xiang, A.H.10
  • 40
  • 41
    • 33745813610 scopus 로고    scopus 로고
    • A novel ELISA system for selective measurement of human adiponectin multimers by using proteases
    • Ebinuma, H., Miyazaki, O., Yago, H., Hara, K., Yamauchi, T. and Kadowaki, T. (2006) A novel ELISA system for selective measurement of human adiponectin multimers by using proteases. Clin. Chim. Acta 372, 47-53
    • (2006) Clin. Chim. Acta , vol.372 , pp. 47-53
    • Ebinuma, H.1    Miyazaki, O.2    Yago, H.3    Hara, K.4    Yamauchi, T.5    Kadowaki, T.6
  • 42
    • 34547642346 scopus 로고    scopus 로고
    • Improved ELISA for selective measurement of adiponectin multimers and identification of adiponectin in human cerebrospinal fluid
    • Ebinuma, H., Miida, T., Yamauchi, T., Hada, Y., Hara, K., Kubota, N. and Kadowaki, T. (2007) Improved ELISA for selective measurement of adiponectin multimers and identification of adiponectin in human cerebrospinal fluid. Clin. Chem. 53, 1541-1544
    • (2007) Clin. Chem , vol.53 , pp. 1541-1544
    • Ebinuma, H.1    Miida, T.2    Yamauchi, T.3    Hada, Y.4    Hara, K.5    Kubota, N.6    Kadowaki, T.7
  • 44
    • 34547609888 scopus 로고    scopus 로고
    • Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: Differential regulation from nondiabetic subjects
    • Basu, R., Pajvani, U. B., Rizza, R. A. and Scherer, P. E. (2007) Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: differential regulation from nondiabetic subjects. Diabetes 56, 2174-2177
    • (2007) Diabetes , vol.56 , pp. 2174-2177
    • Basu, R.1    Pajvani, U.B.2    Rizza, R.A.3    Scherer, P.E.4
  • 46
    • 33846847854 scopus 로고    scopus 로고
    • High-molecular weight adiponectin isoforms increase after biliopancreatic diversion in obese subjects
    • Salani, B., Briatore, L., Andraghetti, G., Adami, G. F., Maggi, D. and Cordera, R. (2006) High-molecular weight adiponectin isoforms increase after biliopancreatic diversion in obese subjects. Obesity 14, 1511-1514
    • (2006) Obesity , vol.14 , pp. 1511-1514
    • Salani, B.1    Briatore, L.2    Andraghetti, G.3    Adami, G.F.4    Maggi, D.5    Cordera, R.6
  • 47
    • 33749843974 scopus 로고    scopus 로고
    • Circulating concentrations of high-molecular-weight adiponectin are increased following Roux-en-Y gastric bypass surgery
    • Swarbrick, M. M., Austrheim-Smith, I. T., Stanhope, K. L., Van Loan, M. D., Ali, M. R., Wolfe, B. M. and Havel, P. J. (2006) Circulating concentrations of high-molecular-weight adiponectin are increased following Roux-en-Y gastric bypass surgery. Diabetologia 49, 2552-2558
    • (2006) Diabetologia , vol.49 , pp. 2552-2558
    • Swarbrick, M.M.1    Austrheim-Smith, I.T.2    Stanhope, K.L.3    Van Loan, M.D.4    Ali, M.R.5    Wolfe, B.M.6    Havel, P.J.7
  • 48
    • 34248197560 scopus 로고    scopus 로고
    • Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention
    • Wang, Z. V., Schraw, T. D., Kim, J. Y., Khan, T., Rajala, M. W., Follenzi, A. and Scherer, P. E. (2007) Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Mol. Cell. Biol. 27, 3716-3731
    • (2007) Mol. Cell. Biol , vol.27 , pp. 3716-3731
    • Wang, Z.V.1    Schraw, T.D.2    Kim, J.Y.3    Khan, T.4    Rajala, M.W.5    Follenzi, A.6    Scherer, P.E.7
  • 49
    • 33644760456 scopus 로고    scopus 로고
    • Adiponectin multimeric complexes and the metabolic syndrome trait cluster
    • Lara-Castro, C., Luo, N., Wallace, P., Klein, R. L. and Garvey, W. T. (2006) Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes 55, 249-259
    • (2006) Diabetes , vol.55 , pp. 249-259
    • Lara-Castro, C.1    Luo, N.2    Wallace, P.3    Klein, R.L.4    Garvey, W.T.5
  • 50
    • 33845482288 scopus 로고    scopus 로고
    • High molecular weight, rather than total, adiponectin levels better reflect metabolic abnormalities associated with childhood obesity
    • Araki, S., Dobashi, K., Kubo, K., Asayama, K. and Shirahata, A. (2006) High molecular weight, rather than total, adiponectin levels better reflect metabolic abnormalities associated with childhood obesity. J. Clin. Endocrinol. Metab. 91, 5113-5116
    • (2006) J. Clin. Endocrinol. Metab , vol.91 , pp. 5113-5116
    • Araki, S.1    Dobashi, K.2    Kubo, K.3    Asayama, K.4    Shirahata, A.5
  • 51
    • 33644829597 scopus 로고    scopus 로고
    • High molecular weight adiponectin correlates with insulin sensitivity in patients with hepatitis C genotype 3, but not genotype 1 infection
    • Wang, A. Y., Hickman, I. J., Richards, A. A., Whitehead, J. P., Prins, J. B. and Macdonald, G. A. (2005) High molecular weight adiponectin correlates with insulin sensitivity in patients with hepatitis C genotype 3, but not genotype 1 infection. Am. J. Gastroenterol. 100, 2717-2723
    • (2005) Am. J. Gastroenterol , vol.100 , pp. 2717-2723
    • Wang, A.Y.1    Hickman, I.J.2    Richards, A.A.3    Whitehead, J.P.4    Prins, J.B.5    Macdonald, G.A.6
  • 52
    • 35948959366 scopus 로고    scopus 로고
    • Total and high molecular weight (HMW) but not trimeric or hexameric forms of adiponectin correlate with markers of the metabolic syndrome and liver injury in Thai subjects
    • Liu, Y., Retnakaran, R., Hanley, A., Tungtrongchit, R., Shaw, C. and Sweeney, G. (2007) Total and high molecular weight (HMW) but not trimeric or hexameric forms of adiponectin correlate with markers of the metabolic syndrome and liver injury in Thai subjects. J. Clin. Endocrinol. Metab. 92, 4313-4318
    • (2007) J. Clin. Endocrinol. Metab , vol.92 , pp. 4313-4318
    • Liu, Y.1    Retnakaran, R.2    Hanley, A.3    Tungtrongchit, R.4    Shaw, C.5    Sweeney, G.6
  • 53
    • 33745854236 scopus 로고    scopus 로고
    • Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome
    • Hara, K., Horikoshi, M., Yamauchi, T., Yago, H., Miyazaki, O., Ebinuma, H., Imai, Y., Nagai, R. and Kadowaki, T. (2006) Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care 29, 1357-1362
    • (2006) Diabetes Care , vol.29 , pp. 1357-1362
    • Hara, K.1    Horikoshi, M.2    Yamauchi, T.3    Yago, H.4    Miyazaki, O.5    Ebinuma, H.6    Imai, Y.7    Nagai, R.8    Kadowaki, T.9
  • 55
    • 33846993043 scopus 로고    scopus 로고
    • Decreased high-molecular-weight adiponectin in gestational diabetes: Implications for the pathophysiology of Type 2 diabetes
    • Retnakaran, R., Connelly, P. W., Maguire, G., Sermer, M., Zinman, B. and Hanley, A. J. (2007) Decreased high-molecular-weight adiponectin in gestational diabetes: implications for the pathophysiology of Type 2 diabetes. Diabetes Med. 24, 245-252
    • (2007) Diabetes Med , vol.24 , pp. 245-252
    • Retnakaran, R.1    Connelly, P.W.2    Maguire, G.3    Sermer, M.4    Zinman, B.5    Hanley, A.J.6
  • 56
    • 33749540415 scopus 로고    scopus 로고
    • Decreased total and high molecular weight adiponectin are independent risk factors for the development of type 2 diabetes in Japanese-Americans
    • Nakashima, R., Kamei, N., Yamane, K., Nakanishi, S., Nakashima, A. and Kohno, N. (2006) Decreased total and high molecular weight adiponectin are independent risk factors for the development of type 2 diabetes in Japanese-Americans. J.Clin. Endocrinol. Metab. 91, 3873-3877
    • (2006) J.Clin. Endocrinol. Metab , vol.91 , pp. 3873-3877
    • Nakashima, R.1    Kamei, N.2    Yamane, K.3    Nakanishi, S.4    Nakashima, A.5    Kohno, N.6
  • 57
    • 34547670934 scopus 로고    scopus 로고
    • High molecular weight adiponectin as a predictor of long-term clinical outcome in patients with coronary artery disease
    • Inoue, T., Kotooka, N., Morooka, T., Komoda, H., Uchida, T., Aso, Y., Inukai, T., Okuno, T. and Node, K. (2007) High molecular weight adiponectin as a predictor of long-term clinical outcome in patients with coronary artery disease. Am. J. Cardiol. 100, 569-574
    • (2007) Am. J. Cardiol , vol.100 , pp. 569-574
    • Inoue, T.1    Kotooka, N.2    Morooka, T.3    Komoda, H.4    Uchida, T.5    Aso, Y.6    Inukai, T.7    Okuno, T.8    Node, K.9
  • 58
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • Berg, A. H., Combs, T. P., Du, X., Brownlee, M. and Scherer, P. E. (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med. 7, 947-953
    • (2001) Nat. Med , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 60
    • 33646346627 scopus 로고    scopus 로고
    • Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor γ agonists
    • Nawrocki, A. R., Rajala, M. W., Tomas, E., Pajvani, U. B., Saha, A. K., Trumbauer, M. E., Pang, Z., Chen, A. S., Ruderman, N. B., Chen, H. et al. (2006) Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor γ agonists. J. Biol. Chem. 281, 2654-2660
    • (2006) J. Biol. Chem , vol.281 , pp. 2654-2660
    • Nawrocki, A.R.1    Rajala, M.W.2    Tomas, E.3    Pajvani, U.B.4    Saha, A.K.5    Trumbauer, M.E.6    Pang, Z.7    Chen, A.S.8    Ruderman, N.B.9    Chen, H.10
  • 62
    • 0035852760 scopus 로고    scopus 로고
    • Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
    • Fruebis, J., Tsao, T. S., Javorschi, S., Ebbets-Reed, D., Erickson, M. R., Yen, F. T., Bihain, B. E. and Lodish, H. F. (2001) Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl. Acad. Sci. U.S.A. 98, 2005-2010
    • (2001) Proc. Natl. Acad. Sci. U.S.A , vol.98 , pp. 2005-2010
    • Fruebis, J.1    Tsao, T.S.2    Javorschi, S.3    Ebbets-Reed, D.4    Erickson, M.R.5    Yen, F.T.6    Bihain, B.E.7    Lodish, H.F.8
  • 68
    • 0242581695 scopus 로고    scopus 로고
    • Adiponectin stimulates production of nitric oxide in vascular endothelial cells
    • Chen, H., Montagnani, M., Funahashi, T., Shimomura, I. and Quon, M. J. (2003) Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J. Biol. Chem. 278, 45021-45026
    • (2003) J. Biol. Chem , vol.278 , pp. 45021-45026
    • Chen, H.1    Montagnani, M.2    Funahashi, T.3    Shimomura, I.4    Quon, M.J.5
  • 69
    • 0035957040 scopus 로고    scopus 로고
    • Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages
    • Ouchi, N., Kihara, S., Arita, Y., Nishida, M., Matsuyama, A., Okamoto, Y., Ishigami, M., Kuriyama, H., Kishida, K., Nishizawa, H. et al. (2001) Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 103, 1057-1063
    • (2001) Circulation , vol.103 , pp. 1057-1063
    • Ouchi, N.1    Kihara, S.2    Arita, Y.3    Nishida, M.4    Matsuyama, A.5    Okamoto, Y.6    Ishigami, M.7    Kuriyama, H.8    Kishida, K.9    Nishizawa, H.10
  • 70
    • 33748310586 scopus 로고    scopus 로고
    • Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: Evidence for involvement of a cAMP signaling pathway
    • Ouedraogo, R., Wu, X., Xu, S. Q., Fuchsel, L., Motoshima, H., Mahadev, K., Hough, K., Scalia, R. and Goldstein, B. J. (2006) Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway. Diabetes 55, 1840-1846
    • (2006) Diabetes , vol.55 , pp. 1840-1846
    • Ouedraogo, R.1    Wu, X.2    Xu, S.Q.3    Fuchsel, L.4    Motoshima, H.5    Mahadev, K.6    Hough, K.7    Scalia, R.8    Goldstein, B.J.9
  • 75
    • 30544453791 scopus 로고    scopus 로고
    • Adiponectin as a growth inhibitor in prostate cancer cells
    • Bub, J. D., Miyazaki, T. and Iwamoto, Y. (2006) Adiponectin as a growth inhibitor in prostate cancer cells. Biochem. Biophys. Res. Commun. 340, 1158-1166
    • (2006) Biochem. Biophys. Res. Commun , vol.340 , pp. 1158-1166
    • Bub, J.D.1    Miyazaki, T.2    Iwamoto, Y.3
  • 77
    • 34548359051 scopus 로고    scopus 로고
    • Glycosylation of human adiponectin affects its conformation and stability
    • Peake, P. W., Hughes, J. T., Shen, Y. and Charlesworth, J. A. (2007) Glycosylation of human adiponectin affects its conformation and stability. J. Mol. Endocrinol. 39, 45-52
    • (2007) J. Mol. Endocrinol , vol.39 , pp. 45-52
    • Peake, P.W.1    Hughes, J.T.2    Shen, Y.3    Charlesworth, J.A.4
  • 78
    • 0038293399 scopus 로고    scopus 로고
    • Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: Evidence for independent roles of age and sex
    • Cnop, M., Havel, P. J., Utzschneider, K. M., Carr, D. B., Sinha, M. K., Boyko, E. J., Retzlaff, B. M., Knopp, R. H., Brunzell, J. D. and Kahn, S. E. (2003) Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 46, 459-469
    • (2003) Diabetologia , vol.46 , pp. 459-469
    • Cnop, M.1    Havel, P.J.2    Utzschneider, K.M.3    Carr, D.B.4    Sinha, M.K.5    Boyko, E.J.6    Retzlaff, B.M.7    Knopp, R.H.8    Brunzell, J.D.9    Kahn, S.E.10
  • 81
    • 0033538869 scopus 로고    scopus 로고
    • Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4
    • Bogan, J. S. and Lodish, H. F. (1999) Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. J. Cell Biol. 146, 609-620
    • (1999) J. Cell Biol , vol.146 , pp. 609-620
    • Bogan, J.S.1    Lodish, H.F.2
  • 82
    • 34249861029 scopus 로고    scopus 로고
    • Gender differences of oligomers and total adiponectin during puberty: A cross-sectional study of 859 Danish school children
    • Andersen, K. K., Frystyk, J., Wolthers, O. D., Heuck, C. and Flyvbjerg, A. (2007) Gender differences of oligomers and total adiponectin during puberty: a cross-sectional study of 859 Danish school children. J. Clin. Endocrinol. Metab. 92, 1857-1862
    • (2007) J. Clin. Endocrinol. Metab , vol.92 , pp. 1857-1862
    • Andersen, K.K.1    Frystyk, J.2    Wolthers, O.D.3    Heuck, C.4    Flyvbjerg, A.5
  • 83
    • 0038307297 scopus 로고    scopus 로고
    • Androgens and cardiovascular disease
    • Liu, P. Y., Death, A. K. and Handelsman, D. J. (2003) Androgens and cardiovascular disease. Endocr. Rev. 24, 313-340
    • (2003) Endocr. Rev , vol.24 , pp. 313-340
    • Liu, P.Y.1    Death, A.K.2    Handelsman, D.J.3
  • 84
    • 1442263876 scopus 로고    scopus 로고
    • Androgens are necessary for the development of fructose-induced hypertension
    • Song, D., Arikawa, E., Galipeau, D., Battell, M. and McNeill, J. H. (2004) Androgens are necessary for the development of fructose-induced hypertension. Hypertension 43, 667-672
    • (2004) Hypertension , vol.43 , pp. 667-672
    • Song, D.1    Arikawa, E.2    Galipeau, D.3    Battell, M.4    McNeill, J.H.5
  • 86
    • 0036068133 scopus 로고    scopus 로고
    • Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance
    • Bluher, M., Michael, M. D., Peroni, O. D., Ueki, K., Carter, N., Kahn, B. B. and Kahn, C. R. (2002) Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev. Cell 3, 25-38
    • (2002) Dev. Cell , vol.3 , pp. 25-38
    • Bluher, M.1    Michael, M.D.2    Peroni, O.D.3    Ueki, K.4    Carter, N.5    Kahn, B.B.6    Kahn, C.R.7
  • 88
    • 34249693131 scopus 로고    scopus 로고
    • Paradoxical elevation of high-molecular weight adiponectin in acquired extreme insulin resistance due to insulin receptor antibodies
    • Semple, R. K., Halberg, N. H., Burling, K., Soos, M. A., Schraw, T., Luan, J., Cochran, E. K., Dunger, D. B., Wareham, N. J., Scherer, P. E. et al. (2007) Paradoxical elevation of high-molecular weight adiponectin in acquired extreme insulin resistance due to insulin receptor antibodies. Diabetes 56, 1712-1717
    • (2007) Diabetes , vol.56 , pp. 1712-1717
    • Semple, R.K.1    Halberg, N.H.2    Burling, K.3    Soos, M.A.4    Schraw, T.5    Luan, J.6    Cochran, E.K.7    Dunger, D.B.8    Wareham, N.J.9    Scherer, P.E.10
  • 91
    • 8744234072 scopus 로고    scopus 로고
    • Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess
    • Lam, K. S., Xu, A., Tan, K. C., Wong, L.-C. and Tam, S. C. (2004) Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess. J. Clin. Endocrinol. Metab. 89, 5772-5778
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , pp. 5772-5778
    • Lam, K.S.1    Xu, A.2    Tan, K.C.3    Wong, L.-C.4    Tam, S.C.5
  • 92
    • 4243645912 scopus 로고    scopus 로고
    • Induction of adipocyte complement-related protein of 30 kilodaltons by PPARγ agonists: A potential mechanism of insulin sensitization
    • Combs, T. P., Wagner, J. A., Berger, J., Doebber, T., Wang, W. J., Zhang, B. B., Tanen, M., Berg, A. H., O'Rahilly, S., Savage, D. B. et al. (2002) Induction of adipocyte complement-related protein of 30 kilodaltons by PPARγ agonists: a potential mechanism of insulin sensitization. Endocrinology 143, 998-1007
    • (2002) Endocrinology , vol.143 , pp. 998-1007
    • Combs, T.P.1    Wagner, J.A.2    Berger, J.3    Doebber, T.4    Wang, W.J.5    Zhang, B.B.6    Tanen, M.7    Berg, A.H.8    O'Rahilly, S.9    Savage, D.B.10
  • 95
    • 0037677767 scopus 로고    scopus 로고
    • Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors
    • Iwaki, M., Matsuda, M., Maeda, N., Funahashi, T., Matsuzawa, Y., Makishima, M. and Shimomura, I. (2003) Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 52, 1655-1663
    • (2003) Diabetes , vol.52 , pp. 1655-1663
    • Iwaki, M.1    Matsuda, M.2    Maeda, N.3    Funahashi, T.4    Matsuzawa, Y.5    Makishima, M.6    Shimomura, I.7
  • 98
    • 34347338702 scopus 로고    scopus 로고
    • Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-Lα
    • Qiang, L., Wang, H. and Farmer, S. R. (2007) Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-Lα. Mol. Cell. Biol. 27, 4698-4707
    • (2007) Mol. Cell. Biol , vol.27 , pp. 4698-4707
    • Qiang, L.1    Wang, H.2    Farmer, S.R.3
  • 99
    • 0025146994 scopus 로고
    • Secretion of immunoglobulin M assembly intermediates in the presence of reducing agents
    • Alberini, C. M., Bet, P., Milstein, C. and Sitia, R. (1990) Secretion of immunoglobulin M assembly intermediates in the presence of reducing agents. Nature 347, 485-487
    • (1990) Nature , vol.347 , pp. 485-487
    • Alberini, C.M.1    Bet, P.2    Milstein, C.3    Sitia, R.4
  • 101
    • 33646349753 scopus 로고    scopus 로고
    • Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles
    • Xie, L., Boyle, D., Sanford, D., Scherer, P. E., Pessin, J. E. and Mora, S. (2006) Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles. J. Biol. Chem. 281, 7253-7259
    • (2006) J. Biol. Chem , vol.281 , pp. 7253-7259
    • Xie, L.1    Boyle, D.2    Sanford, D.3    Scherer, P.E.4    Pessin, J.E.5    Mora, S.6


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