The glucose-6-phosphatase system

Biochemical Journal

Volumn 362, Issue 3, 2002, Pages 513-532

  Van Schaftingen, Emile ^a   Gerin, Isabelle ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Gluconeogenesis; Glucose 6 phosphate; Glycogen; Glycogen storage disease; Transporter

Indexed keywords

BIOLOGICAL MEMBRANES; BIOLOGICAL ORGANS; GENES; GLUCOSE; HYDROLYSIS; PROTEINS;

STARVATION;

ENZYMES;

COMPLEMENTARY DNA; CYCLIC AMP; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATE; GLUCOSE TRANSPORTER; GLYCOGEN;

AMINO ACID SEQUENCE; ANIMAL TISSUE; CATALYSIS; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME PURIFICATION; GLUCONEOGENESIS; GLUCOSE TRANSPORT SYSTEM; GLYCOGEN STORAGE DISEASE; HUMAN; HUMAN TISSUE; HYDROLYSIS; MODEL; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION ANALYSIS; REGULATORY MECHANISM; REVIEW; SEQUENCE ANALYSIS; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; ANIMALS; ENDOPLASMIC RETICULUM; GLUCOSE-6-PHOSPHATASE; HUMANS; ISOENZYMES; KIDNEY; KINETICS; LIVER; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA; ARION;

EID: 0037086660     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3620513     Document Type: Review

References (266)

1. The role of glucose-1-phosphate in the formation of blood sugar and synthesis of glycogen in the liver
2. Le système hexose-phosphatasique. I. Existence d'une glucose-6-phosphatase spécifique dans le foie
3. Le système hexose-phosphatasique. III. Localisation intra-cellulaire des ferments par centrifugation fractionnée
4. Glucose-6-phosphatase of the liver in glycogen storage disease
5. On the involvement of a glucose 6-phosphate transport system in the function of microsomal glucose 6-phosphatase
6. A new variant of glycogen storage disease type I probably due to a defect in the glucose-6-phosphate transport system
7. Glucose-6-phosphatase structure, regulation, and function: An update
8. New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system
9. Le système hexose-phosphatasique. IV. Spécificité de la glucose-6-phosphatase
10. The specificity of glucose 6-phosphatase of intact liver microsomes
11. Evidence for the common identity of glucose 6-phosphatase, inorganic pyrophosphatase, and pyrophosphate-glucose phosphotransferase
12. Modifications of hydrolytic and synthetic activities of liver microsomal glucose 6-phosphatase
13. The mechanism of glucose-6-phosphatase
14. Carbamyl phosphate: Glucose phosphotransferase activity of hepatic microsomal glucose 6-phosphatase at physiological pH
15. Metabolic regulation by multifunctional glucose-6-phosphatase
16. Phosphorylation of glucose in isolated rat hepatocytes. Sigmoidal kinetics explained by the activity of glucokinase alone
17. Detection and characterization of the phosphorylated form of microsomal glucose-6-phosphatase
18. Protein-bound phosphoryl histidine: A probable intermediate in the microsomal glucose-6-phosphatase-inorganic pyrophosphatase reaction
19. The phosphohydrolase component of the hepatic microsomal glucose-6-phosphatase system is a 36.5-kilodalton polypeptide
20. Le systéme hexose-phosphatasique. V. Influence de divers agents sur l'activité et la stabilité de la glucose-6-phosphatase
21. Kinetics of the glucose 6-phosphate-glucose exchange activity and glucose inhibition of glucose 6-phosphatase of intact and disrupted rat liver microsomes
22. Evidence for the participation of independent translocation for phosphate and glucose 6-phosphate in the microsomal glucose-6-phosphatase system. Interactions of the system with orthophosphate, inorganic pyrophosphate, and carbamyl phosphate
23. Vanadium - An element in search of a role
24. Vanadate: A potent inhibitor of multifunctional glucose-6-phosphatase
25. Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate
26. Tungstate: A potent inhibitor of multifunctional glucose-6-phosphatase
27. Unsaturated fatty acids associated with glycogen may inhibit glucose-6-phosphatase in rat liver
28. Fatty acyl-CoA esters inhibit glucose-6-phosphatase in rat liver microsomes
29. Mechanisms by which fatty-acyl-CoA esters inhibit or activate glucose-6-phosphatase in intact and detergent-treated rat liver microsomes
30. Liver microsomal glucose-8-phosphatase is competitively inhibited by the lipid products of phosphatidylinositol-3-kinase
31. Glucose-6-phosphatase catalytic enzyme inhibitors: Synthesis and in vitro evaluation of novel 4,5,6,7-tetrahydrothieno[3,2-c]- and -[2,3-c]pyridines
32. N,N-dibenzyl-N′-benzylidenehydrazines: Potent competitive glucose-6-phosphatase catalytic enzyme inhibitors
33. Le système hexose-phosphatasique. VI. Essai de démembrement des microsomes porteurs de glucose-6-phosphatase
34. Identification and purification of a liver microsomal glucose 6-phosphatase
35. Is thermostability of glucose-6-phosphatase indeed dependent on a stabilizing protein?
36. The purification of a detergent-soluble glucose-6-phosphatase from rat liver
37. Genetic control of morphogenetic and biochemical differentiation: Lethal albino deletions in the mouse
38. Isolation and characterization of mouse hepatocyte lines carrying a lethal albino deletion
39. Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes
40. Isolation of the gene for murine glucose-6-phosphatase, the enzyme deficient in glycogen storage disease type 1A
41. Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum
42. Mutations in the glucose-6-phosphatase gene that cause glycogen storage disease type 1a
43. Identification of mutations in the gene for glucose-6-phosphatase, the enzyme deficient in glycogen storage disease type1a
44. Isolation of a cDNA for the catalytic subunit of rat liver glucose-6-phosphatase: Regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP
45. Isolation and nucleotide sequence of canine glucose-6-phosphatase mRNA: Identification of mutation in puppies with glycogen storage disease type Ia
46. Isolation and sequencing of cDNA clones coding for the catalytic unit of glucose-6-phosphatase from two haplochromine cichlid fishes
47. Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein
48. Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene
49. Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes
50. Identification of a novel phosphatase sequence motif
51. An unexpected structural relationship between integral membrane phosphatases and soluble haloperoxidases
52. From phosphatases to vanadium peroxidases: A similar architecture of the active site
53. X-ray structure of a vanadium-containing enzyme: Chloroperoxidase from the fungus Curvularia inaequalis
54. Transmembrane topology of glucose-6-phosphatase
55. Structure-function analysis of human glucose-6-phosphatase, the enzyme deficient in glycogen storage disease type 1a
56. A new model for the membrane topology of glucose-6-phosphatase: The enzyme involved in von Gierke disease
57. Asparagine-linked oligosaccharides are localized to a luminal hydrophilic loop in human glucose-6-phosphatase
58. Gluconeogenesis and related aspects of glycolysis
59. 3H]glucose in isolated rat hepatocytes: A study of the contributions of glucokinase and glucose-6-phosphatase
60. Extracellular metabolites in suspensions of isolated hepatocytes
61. Glucose 6-phosphate hydrolysis is activated by glucagon in a low temperature-sensitive manner
62. Reduced sensitivity of the hepatic adenylate cyclase-cyclic AMP system to glucagon during sustained hormonal stimulation
63. Control of gluconeogenesis in liver. 3. Effects of L-lactate, pyruvate, fructose, glucagon, epinephrine, and adenosine 3′,5′monophosphate on gluconeogenic intermediates in the perfused rat liver
64. Inhibition of glucagon effects in perfused rat liver by (+)decanoylcarnitine
65. Control of gluconeogenesis in rat liver cells. I. Kinetics of the individual enzymes and the effect of glucagon
66. The control of glycogen metabolism in the liver
67. Acyl-CoA-binding protein from cow. Binding characteristics and cellular and tissue distribution
68. The inhibition of rat liver glucokinase by palmitoyl-CoA
69. Stimulation of glucose phosphorylation by fructose in isolated rat hepatocytes
70. Phosphatidylinositol 3-kinase translocates onto liver endoplasmic reticulum and may account for the inhibition of glucose-6-phosphatase during refeeding
71. Le système hexose-phosphatasique. II. - Répartition de l'activité glucose-6-phosphatasique dans les tissus
72. Glucose-6-phosphatase activity in islets from ob/ob and lean mice and the effect of dexamethasone
73. Glucose-6-phosphatase in human jejunal mucosa: Properties demonstrating the specific character of the enzyme activity
74. Development and regulation of glucose-6-phosphatase gene expression in rat liver, intestine, and kidney: In vivo and in vitro studies in cultured fetal hepatocytes
75. The glucose-6-phosphatase gene is expressed in human and rat small intestine: Regulation of expression in fasted and diabetic rats
76. Rat small intestine is an insulin-sensitive gluconeogenic organ
77. New data and concepts on glutamine and glucose metabolism in the gut
78. Low levels of glucose-6-phosphate hydrolysis in the sarcoplasmic reticulum of skeletal muscle: Involvement of glucose-6-phosphatase
79. Astrocytic glucose-6-phosphatase and the permeability of brain microsomes to glucose 6-phosphate
80. Metabolic pathways for glucose in astrocytes
81. Glucose-6-phosphatase is present in normal and pre-eclamptic placental trophoblasts: Ultrastructural enzyme-histochemical evidence
82. Glucose production by the human placenta in vivo
83. Cloning and characterization of cDNAs encoding a candidate glycogen storage disease type 1b protein in rodents
84. Expression and distribution of glucose-6-phosphatase catalytic subunit messenger RNA and its changes in the diabetic state
85. The hormonal regulation of enzymes in prenatal and postnatal rat liver. Effects of adenosine 3′,5′-(cyclic)-monophosphate
86. Ontogeny of the murine glucose-6-phosphatase system
87. Conformational change of the catalytic subunit of glucose-6-phosphatase in rat liver during the fetal-to-neonatal transition
88. Studies of liver glucose 6-phosphatase. III. Solubilization and properties of the enzyme from normal and diabetic rats
89. The role of hepatic glucose-6-phosphatase in the regulation of carbohydrate metabolism
90. Liver glucose-6-phosphatase and pyrophosphate-glucose phosphotransferase: Effects of fasting
91. Regulation of rat liver glucose-6-phosphatase gene expression in different nutritional and hormonal states: Gene structure and 5′-flanking sequence
92. Differential time course of liver and kidney glucose-6-phosphatase activity during long-term fasting in rat correlates with differential time course of messenger RNA level
93. Effect of acute diabetes on rat hepatic glucose-6-phosphatase activity and its messenger RNA level
94. Studies on carbohydrate metabolism in rat liver slices. VI. Hormonal factors influencing glucose-6-phosphatase
95. Parallel changes in vivo in microsomal inorganic pyrophosphatase, pyrophosphate-glucose phosphotransferase and glucose-phosphatase activities
96. Selective tonic inhibition of G-6-Pase catalytic subunit, but not G-6-P transporter, gene expression by insulin in vivo
97. A multicomponent insulin response sequence mediates a strong repression of mouse glucose-6-phosphatase gene transcription by insulin
98. Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: Transcription factor FKHR binds the insulin response sequence
99. Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells
100. Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity
101. Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin
102. Insulin-regulated gene expression
103. Liver microsomal glucose 6-phosphatase, inorganic pyrophosphatase, and pyrophosphate-glucose phosphotransferase. IV. Effects of adrenalectomy and cortisone administration on activities assayed in the absence and presence of deoxycholate
104. Induction of glucose 6-phosphatase in cultured hepatoma cells by dexamethasone
105. Cloning and sequencing of the 5′ region of the human glucose-6-phosphatase gene: Transcriptional regulation by cAMP, insulin and glucocorticoids in H4IIE hepatoma cells
106. Hepatocyte nuclear factor 1alpha is an accessory factor required for activation of glucose-6-phosphatase gene transcription by glucocorticoids
107. Protein kinase A phosphorylates hepatocyte nuclear factor-6 and stimulates glucose-6-phosphatase catalytic subunit gene transcription
108. Identification of a cAMP response element within the glucose-6-phosphatase hydrolytic subunit gene promoter which is involved in the transcriptional regulation by cAMP and glucocorticoids in H4IIE hepatoma cells
109. Differential role of hepatocyte nuclear factor-1 in the regulation of glucose-6-phosphatase catalytic subunit gene transcription by cAMP in liver- and kidney-derived cell lines
110. Stimulation of glucose-6-phosphatase gene expression by glucose and fructose-2,6-bisphosphate
111. Regulation of the glucose-6-phosphatase gene by glucose occurs by transcriptional and post-transcriptional mechanisms. Differential effect of glucose and xylitol
112. Glucose regulates in vivo glucose-6-phosphatase gene expression in the liver of diabetic rats
113. Upregulation of hepatic glucose 6-phosphatase gene expression in rats treated with an inhibitor of glucose-6-phosphate translocase
114. Acute inhibition of hepatic glucose-6-phosphatase does not affect gluconeogenesis but directs gluconeogenic flux toward glycogen in fasted rats. A pharmacological study with the chlorogenic acid derivative S4048
115. Induction of hepatic glucose-6-phosphatase gene expression by lipid infusion
116. Phorbol ester-induced activation of mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase and extracellular-signal-regulated protein kinase decreases glucose-6-phosphatase gene expression
117. 5-Aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase
118. Inhibition by AICA riboside of gluconeogenesis in isolated rat hepatocytes
119. Microsomal membrane permeability and the hepatic glucose-6-phosphatase system. Interactions of the system with D-mannose 6-phosphate and D-mannose
120. The requirement for membrane integrity in the inhibition of hepatic glucose 6-phosphatase by sulfhydryl reagents and taurocholate
121. Three thiol groups are important for the activity of the liver microsomal glucose-6-phosphatase system. Unusual behavior of one thiol located in the glucose-6-phosphate translocase
122. The fine structural localization of glucose-6-phosphatase in rat liver
123. Differentiation of endoplasmic reticulum in hepatocytes. I. Glucose-6-phosphate distribution in situ
124. Measurement of glucose 6-phosphate penetration into liver microsomes. Confirmation of substrate transport in the glucose-6-phosphatase system
125. A direct evidence for defect in glucose-6-phosphate transport system in hepatic microsomal membrane of glycogen storage disease type 1B
126. Glycogen storage disease type 1B: A new model of genetic disorders involving the transport system of intracellular membrane
127. Rapid kinetics of liver microsomal glucose-6-phosphatase. Evidence for tight-coupling between glucose-6-phosphate transport and phosphohydrolase activity
128. Demonstration of a metabolically active glucose-6-phosphate pool in the lumen of liver microsomal vesicles
129. A conformational model for the human liver microsomal glucose-6-phosphatase system: Evidence from rapid kinetics and detects in glycogen storage disease type 1
130. Glucose-6-phosphatase dependent substrate transport in the glycogen storage disease type-1a mouse
131. Probing into the function of the gene product responsible for glycogen storage disease type 1b
132. Novel arguments in favor of the substrate-transport model of glucose-6-phosphatase
133. Evidence for a membrane exchangeable glucose pool in the functioning of rat liver glucose-6-phosphatase
134. An integrated view of the kinetics of glucose and phosphate transport, and of glucose 6-phosphate transport and hydrolysis in intact rat liver microsomes
135. Ionic permeability of isolated muscle sarcoplasmic reticulum and liver endoplasmic reticulum vesicles
136. Permeability of rat liver microsomal membrane to glucose 6-phosphate
137. Direct evidence for the involvement of two glucose 6-phosphate-binding sites in the glucose-6-phosphatase activity of intact liver microsomes. Characterization of T1, the microsomal glucose 6-phosphate transport protein by a direct binding assay
138. Effect of two inhibitors of anion transport on the hydrolysis of glucose 6-phosphate by rat liver microsomes. Covalent modification of the glucose 6-P transport component
139. 3H]ethane-2, 2′-disulfonic acid
140. Structural requirements for the stability and microsomal transport activity of the human glucose 6-phosphate transporter
141. Time-dependent inhibition of glucose 6-phosphatase by 3-mercaptopicolinic acid
142. Protease inhibitors but not proteases inhibit the glucose-6-phosphatase of native rat liver microsomes
143. Chlorogenic acid and hydroxynitrobenzaldehyde: New inhibitors of hepatic glucose 6-phosphatase
144. Chlorogenic acid and synthetic chlorogenic acid derivatives: Novel inhibitors of hepatic glucose-6-phosphate translocase
145. Chlorogenic acid analogue S 3483: A potent competitive inhibitor of the hepatic and renal glucose-6-phosphatase systems
146. Pharmacodynamic profile of a novel inhibitor of the hepatic glucose-6-phosphatase system
147. Alterations of carbohydrate and lipid intermediary metabolism during inhibition of glucose-6-phosphatase in rats
148. Plasma glucose levels are reduced in rats and mice treated with an inhibitor of glucose-6-phosphate translocase
149. Effects of 3-mercaptopicolinic acid and a derivative of chlorogenic acid (S-3483) on hepatic and islet glucose-6-phosphatase activity
150. Identification of protein components of the microsomal glucose 6-phosphate transporter by photoaffinity labelling
151. Kodaistatins, novel inhibitors of glucose-6-phosphate translocase T1 from Aspergillus terreus thom DSM 11247. Isolation and structural elucidation
152. The chemical structure of mumbaistatin, a novel glucose-6-phosphate translocase inhibitor produced by Streptomyces sp. DSM 11641
153. Ion-coupled transport and transporters
154. Reconstitution of the hexose phosphate translocator from the envelope membranes of wheat endosperm amyloplasts
155. Nucleotide sequence and transcriptional startpoint of the glpT gene of Escherichia coli: Extensive sequence homology of the glycerol-3-phosphate transport protein with components of the hexose-6-phosphate transport system
156. Nucleotide sequence of the uhp region of Escherichia coli
157. Role of uhp genes in expression of the Escherichia coli sugar-phosphate transport system
158. Anion-exchange mechanisms in bacteria
159. Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type 1b
160. Initial sequencing and analysis of the human genome
161. Mammalian and bacterial sugar transport proteins are homologous
162. Structure and mutation analysis of the glycogen storage disease type 1b gene
163. Genomic structure of the human glucose 6-phosphate translocase gene and novel mutations in the gene of a Japanese patient with glycogen storage disease type 1b
164. Structure of the gene mutated in glycogen storage disease type 1b
165. Inactivation of the glucose 6-phosphate transporter causes glycogen storage disease type 1b
166. Glycogen storage disease type 1b: Structural and mutational analysis of the microsomal glucose-6-phosphate transporter gene
167. A different isoform of the transport protein mutated in the glycogen storage disease 1b is expressed in brain
168. A gene on chromosome 11q23 coding for a putative glucose-6-phosphate translocase is mutated in glycogen-storage disease types 1b and 1c
169. Quantitative analysis of glucose-6-phosphate translocase gene expression in various human tissues and haematopoietic progenitor cells
170. Human variant glucose-6-phosphate transporter is active in microsomal transport
171. Transmembrane topology of human glucose 6-phosphate transporter
172. A maior superfamily of transmembrane facilitators that catalyse uniport, symport and antiport
173. Glucose-6-phosphate transporter and receptor functions of the glucose 6-phosphatase system analyzed from a consensus defined by multiple alignments
174. Glucose-6-phosphatase in the insulin secreting cell line INS-1
175. Ontogeny of the catalytic subunit and putative glucose-6-phosphate transporter proteins of the rat microsomal liver glucose-6-phosphatase system
176. Diabetes affects similarly the catalytic subunit and putative glucose-6-phosphate translocase of glucose-6-phosphatase
177. Up-regulation of liver glucose-6-phosphatase in rats fed with a Pi-deficient diet
178. Distinct hormone stimulation and counteraction by insulin of the expression of the two components of glucose 6-phosphatase in HepG2 cells
179. +-P(i) cotransporter mRNA and immunoreactive protein in X-linked Hyp mice
180. A molecular link between the common phenotypes of type 1 glycogen storage disease and HNF1alpha-null mice
181. Glucose 6-phosphate transport in fibroblast microsomes from glycogen storage disease type 1b patients: Evidence for multiple glucose 6-phosphate transport systems
182. m mannose-6-phosphatase as a criterion for microsomal integrity
183. Liver microsomal transport of glucose-6-phosphate, glucose, and phosphate in type 1 glycogen storage disease
184. Purification and characterization of the phosphate/hydroxyl ion antiport protein from rat liver mitochondria
185. +-dependent phosphate cotransporters: The NaPi protein families
186. The identification of T2; the phosphate/pyrophosphate transport protein of the hepatic microsomal glucose-6-phosphatase system
187. The putative glucose 6-phosphate translocase gene is mutated in essentially all cases of glycogen storage disease type Inon-a
188. Mutations in the glucose-6-phosphate transporter (G6PT) gene in patients with glycogen storage diseases type 1b and 1c
189. Molecular diagnosis of type 1c glycogen storage disease
190. The glucose transporter family: Structure, function and tissue-specific expression
191. Facilitative glucose transporters
192. Cloning and expression analysis of a novel member of the facilitative glucose transporter family SLC2A9 (GLUT9)
193. Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes
194. GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst
195. Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: A candidate gene for NIDDM susceptibility
196. Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells
197. Kinetics of 3-O-methyl-D-glucose transport in isolated rat hepatocytes
198. Identification and characterization of a hepatic microsomal glucose transport protein. T3 of the glucose-6-phosphatase system?
199. Cloning and expression of a hepatic microsomal glucose transport protein. Comparison with liver plasma-membrane glucose-transport protein GLUT 2
200. A re-evaluation of GLUT 7
201. Evidence for two types of rat liver microsomes with differing permeability to glucose and other small molecules
202. Heterogeneity of glucose transport in rat liver microsomal vesicles
203. Permeability of liver microsomal membranes to glucose
204. Evidence that the transit of glucose into liver microsomes is not required for functional glucose-6-phosphatase
205. Normal hepatic glucose production in the absence of GLUT2 reveals an alternative pathway for glucose release from hepatocytes
206. Mutations in GLUT2, the gene for the liver-type glucose transporter, in patients with Fanconi-Bickel syndrome
207. Localization and characteristics of hexose 6-phosphate dehydrogenase (glucose dehydrogenase)
208. Latency of microsomal hexose-6-phosphate dehydrogenase activity
209. Intramembraneous localization of rat liver microsomal hexose-6-phosphate dehydrogenase and membrane permeability to its substrates
210. Hexose-6-phosphate dehydrogenase: Distribution in rat tissues and effect of diet, age and steroids
211. Isolation and the complete amino acid sequence of lumenal endoplasmic reticulum glucose-6-phosphate dehydrogenase
212. Human hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) encoded at 1p36: Coding sequence and expression
213. Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway
214. The purification of 11 beta-hydroxysteroid dehydrogenase from mouse liver microsomes
215. Purification and properties of a metyrapone-reducing enzyme from mouse liver microsomes
216. Ultrastructural demonstration of thioredoxin and thioredoxin reductase in rat hepatocytes
217. Glucose-6-phosphate oxidation pathway in rat-liver microsomal vesicles. Stimulation under oxidative stress
218. Calcium sequestration activity in rat liver microsomes. Evidence for a cooperation of calcium transport with glucose-6-phosphatase
219. 2+ uptake by rat kidney microsomes
220. On a possible role for glucose-6-phosphatase in the regulation of liver cell cytosolic calcium concentration
221. 2+ sequestration are mutually enhanced in microsomes from liver, brain, and heart
222. Topography of glycosylation reactions in the endoplasmic reticulum
223. The LPP1 and DPP1 gene products account for most of the isoprenoid phosphate phosphatase activities in Saccharomyces cerevisiae
224. Glycogen storage diseases
225. Genetic basis of glycogen storage disease type 1a: Prevalent mutations at the glucose-6-phosphatase locus
226. Molecular genetics of type I glycogen storage disease
227. Glycogen storage disease type Ia: Recent experience with mutation analysis, a summary of mutations reported in the literature and a newly developed diagnostic flow chart
228. Correction of glycogen storage disease type 1a in a mouse model by gene therapy
229. Canine model and genomic structural organization of glycogen storage disease type Ia (GSD Ia)
230. Studies of liver glycogenoses, with particular reference to the metabolism of intravenously administered glycerol
231. Type Ib glycogen storage disease is caused by a defect in the glucose-6-phosphate translocase of the microsomal glucose-6-phosphatase system
232. Molecular analysis of glycogen storage disease type Ib: Identification of a prevalent mutation among Japanese patients and assignment of a putative glucose-6-phosphate translocase gene to chromosome 11
233. Glycogen storage disease type Ib without neutropenia
234. Inherited disorders of phagocyte killing
235. Defective neutrophil and monocyte functions in glycogen storage disease type Ib: A literature review
236. Neutropenia, neutrophil dysfunction, and inflammatory bowel disease in glycogen storage disease type Ib: Results of the European Study on Glycogen Storage Disease type I
237. MR imaging of bone marrow in glycogen storage disease type IB in children and young adults
238. Neutropenia and impaired neutrophil migration in type IB glycogen storage disease
239. Impaired metabolic function and signaling defects in phagocytic cells in glycogen storage disease type 1b
240. Impaired carbohydrate metabolism of polymorphonuclear leukocytes in glycogen storage disease Ib
241. Deficient glucose phosphorylation as a possible common denominator and its relation to abnormal leucocyte function, in glycogen storage disease 1b patients
242. Hexose uptake and transport in polymorphonuclear leukocytes from patients with glycogen storage disease Ib
243. Glucose-6-phosphatase mutation G188R confers an atypical glycogen storage disease type 1b phenotype
244. Type Ic, a novel glycogenosis. Underlying mechanism
245. Analysis of human hepatic microsomal glucose-6-phosphatase in clinical conditions where the T2 pyrophosphate/phosphate transport protein is absent
246. Mutations in the glucose-6-phosphatase gene are associated with glycogen storage disease types 1a and 1aSP but not 1b and 1c
247. Type-1c glycogen storage disease is not caused by mutations in the glucose-6-phosphate transporter gene
248. Diagnosis of type 1a and 1c glycogen storage diseases in adults
249. Molecular pathology of glucose-6-phosphatase
250. Diagnosis of type 1B and 1C glycogen storage disease
251. The gene for glycogen-storage disease type 1b maps to chromosome 11q23
252. Localisation of the gene for glycogen storage disease type 1c by homozygosity mapping to 11q
253. How many forms of glycogen storage disease type I?
254. Glycogen storage diseases
255. Diagnosis of a novel glycogen storage disease: Type 1aSP
256. Metabolic impact of adenovirus-mediated overexpression of the glucose-6-phosphatase catalytic subunit in hepatocytes
257. Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase
258. Overexpression of the P46 (T1) translocase component of the glucose-6-phosphatase complex in hepatocytes impairs glycogen accumulation via hydrolysis of glucose 1-phosphate
259. Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats
260. Evidence for changes in the conformational status of rat liver microsomal glucose-6-phosphate: Phosphohydrolase during detergent-dependent membrane modification. Effect of p-mercuribenzoate and organomercurial agarose gel on glucose-6-phosphatase of native and detergent-modified microsomes
261. Interaction of mannose-6-phosphate with the hysteretic transition in glucose-6-phosphate hydrolysis in intact liver microsomes
262. Glucose-6-phosphatase specificity after membrane solubilization by detergent treatment
263. Glucose 6-phosphate and mannose 6-phosphate are equally and more actively hydrolyzed by glucose 6-phosphatase during hysteretic transition within intact microsomal membrane than after detergent treatment
264. Effects of basic proteins of low molecular weight on the phosphohydrolase and phosphotransferase activities of microsomal glucose-6-phosphatase in adult monkey hepatocytes
265. The mechanism of histone activation of the hepatic microsomal glucose-6-phosphatase system: A novel method to assay glucose-6-phosphatase activity
266. Glucose transport and glucose 6-phosphate hydrolysis in intact rat liver microsomes