11β-Hydroxysteroid Dehydrogenases in the Brain: Two Enzymes Two Roles

Annals of the New York Academy of Sciences

Volumn 1007, Issue , 2003, Pages 357-366

  Holmes, Megan C ^a,c   Yau, Joyce L W ^a   Kotelevtsev, Yuri ^a   Mullins, John J ^b   Seckl, Jonathan R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

11 hydroxysteroid dehydrogenases; Cerebellum; Glucocorticoids; HPA axis; Programming

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; BRAIN ENZYME; CORTICOSTEROID RECEPTOR; CORTICOSTERONE; DEHYDROCORTICOSTERONE; GENE PRODUCT; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; ISOENZYME; MINERALOCORTICOID RECEPTOR; STEROID;

AGING; BRAIN; BRAIN ELECTROPHYSIOLOGY; BRAIN METABOLISM; CELL DIVISION; CELL LEVEL; CONFERENCE PAPER; GENE DELETION; HORMONAL REGULATION; HORMONE ACTION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; KNOCKOUT MOUSE; METABOLISM; NERVE CELL NECROSIS; NEUROTRANSMISSION; NONHUMAN; PHENOTYPE; POSTNATAL DEVELOPMENT; PRENATAL DEVELOPMENT; PROTEIN FUNCTION; REGULATORY MECHANISM; STEROID METABOLISM; TRANSCRIPTION REGULATION;

EID: 1342309154     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1286.035     Document Type: Conference Paper

References (38)

1. BROWN, R.W., K.E. CHAPMAN, Y. KOTELEVTSEV, et al. 1996. Cloning and production of antisera to human placental 11β-hydroxysteroid dehydrogenase type 2. Biochem. J. 313: 1007-1017.
2. MOISAN, M.-P., J.R. SECKL & C.R.W. EDWARDS. 1990. 11-hydroxysteroid dehydrogenase bioactivity and messenger RNA expression in rat forebrain: localization in hypothalamus, hippocampus and cortex. Endocrinology 127: 1450-1455.
3. SECKL, J.R. & B.R. WALKER. 2001. Minireview: 11 beta-hydroxysteroid dehydrogenase type 1 - a tissue-specific amplifier of glucocorticoid action. Endocrinology 142: 1371-1376.
4. TEELUCKSINGH, S., R. BENEDIKTSSON, R.S. LINDSAY, et al. 1991. Liquorice. Lancet 337: 1549.
5. MONDER, C. 1991. Corticosteroids, kidneys, sweet roots and dirty drugs. Mol. Cell. Endocrinol. 78: C95-C98.
6. KOTELEVTSEV, Y., M.C. HOLMES, A. BURCHELL, et al. 1997. 11 beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc. Natl. Acad. Sci. USA 94: 14924-14929.
7. MORTON, N.M., M.C. HOLMES, C. FIEVET, et al. 2001. Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11 beta-hydroxysteroid dehydrogenase type 1 null mice. J. Biol. Chem. 276: 41293-41300.
8. DIAZ, R., R.W. BROWN & J.R. SECKL. 1998. Distinct ontogeny of glucocorticoid and mineralocorticoid receptor and 11β-hydroxysteroid dehydrogenase types I and II mRNAs in the fetal rat brain suggest a complex control of glucocorticoid actions. J. Neurosci. 18: 2570-2580.
9. HUNDERTMARK, S., A. DILL, A. EBERT, et al. 2002. Foetal lung maturation in 11 beta-hydroxysteroid dehydrogenase type 1 knockout mice. Horm. Metab. Res. 34: 545-549.
10. HARRIS, H.J., Y. KOTELEVTSEV, J.J. MULLINS, et al. 2001. Intracellular regeneration of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary- adrenal axis: analysis of 11 beta-HSD-1-deficient mice. Endocrinology 142: 114-120.
11. YAU, J.L.W., J. NOBLE, C.J. KENYON, et al. 2001. Lack of tissue glucocorticoid reactivation in 11 beta-hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments. Proc. Natl. Acad. Sci. USA 98: 4716-4721.
12. JAMIESON, P.M., E. FUCHS, G. FLUGGE, et al. 1997. Attenuation of hippocampal 11 beta-hydroxysteroid dehydrogenase type 1 by chronic psychosocial stress in the tree shrew. Stress 2: 123-132.
13. SECKL, J.R. 1997. 11 beta-hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action? Front. Neuroendocrinol. 18: 49-99.
14. SAPOLSKY, R.M., L.C. KREY & B.S. MCEWEN. 1986. The neuroendocrinology of stress and ageing. The glucocorticoid cascade hypothesis. Endocr. Rev. 7: 284-301.
15. RAJAN, V., C.R.W. EDWARDS & J.R. SECKL. 1996. 11β- hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity. J. Neurosci. 16: 65-70.
16. LANDFIELD, P.W., R.K. BASKIN & T.A. PITLER, 1981. Brain aging correlates: retardation by hormonal-pharmacological treatments. Science 214: 581-584.
17. LANDFIELD, P.W., J.C. WAYMIRE & G. LYNCH. 1978. Hippocampal aging and adrenocorticoids: quantitative correlations. Science 202: 1098-1102.
18. YAU, J.L.W. & J.R. SECKL. 2001. 11 Beta-hydroxysteroid dehydrogenase type I in the brain; thickening the glucocorticoid soup. Mol. Psychiatr. 6: 611-614.
19. BARF, T., J. VALLGARDA, R. EMOND, et al. 2002. Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11 beta-hydroxysteroid dehydrogenase type 1. J. Med. Chem. 45: 3813-3815.
20. ALBERTS, P., L. ENGBLOM, N. EDLING, et al. 2002. Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia 45: 1528-1532.
21. EDWARDS, C.R.W., P.M. STEWART, D. BURT, et al. 1988. Localisation of 11β-hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor. Lancet ii: 986-989.
22. WHITE, P.C., T. MUNE & A.K. AGARWAL. 1997. 11 Beta-hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocr. Rev. 18: 135-156.
23. ROBSON, A.C., C.M. LECKIE, J.R. SECKL, et al. 1998. 11 Beta-hydroxysteroid dehydrogenase type 2 in the postnatal and adult rat brain. Mol. Brain Res. 61: 1-10.
24. ROLAND, B.L., K.X.Z. LI & J.W. FUNDER. 1995. Hybridization histochemical localization of 11β-hydroxysteroid dehydrogenase type 2 in rat brain. Endocrinology 136: 4697-4700.
25. ROWLAND, N.E. & M.J. FREGLY. 1988. Sodium appetite: species and strain differences and role of renin-angiotensin-aldostyerone system. Appetite 11: 143-178.
26. GOMEZ-SANCHEZ, E.P. 1986. Intracerebroventricular infusion of aldosterone induces hypertension in rats. Endocrinology 118: 819-823.
27. GOMEZ-SANCHEZ, E.P. & C.E. GOMEZ-SANCHEZ. 1992. Central hypertensinogenic effects of glycyrrhizic acid and carbenoxolone. Am. J. Physiol. 263: E1125-E1130.
28. BROWN, R.W., R. DIAZ, A.C. ROBSON, et al. 1996. The ontogeny of 11β-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor gene expression reveal intricate control of glucocorticoid action in development. Endocrinology 137: 794-797.
29. BOHN, M.C. 1980. Granule cell genesis in the hippocampus of rats treated neonatally with hydrocortisone. Neuroscience 5: 2003-2012.
30. BOHN, M.C. & J.M. LAUDER. 1978. The effects of neonatal hydrocortisone on rat cerebellar development: an autoradiographic and light microscopic study. Dev. Neurosci. 1: 250-266.
31. MATTHEWS, S.G. 2002. Early programming of the hypothalamo-pituitary- adrenal axis. Trends Endocrinol. Metab. 13: 373-380.
32. WELBERG, L.A.M. & J.R. SECKL. 2001. Prenatal stress, glucocorticoids and the programming of the brain. J. Neuroendocrinol. 13: 113-128.
33. WEINSTOCK, M. 2001. Alterations induced by gestational stress in brain morphology and behaviour of the offspring. Prog. Neurobiol. 65: 427-451.
34. WELBERG, L.A.M., J.R. SECKL & M.C. HOLMES. 2001. Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: Possible implications for behaviour. Neuroscience 104: 71-79.
35. MACCARI, S., P.V. PIAZZA, M. KABBAJ, et al. 1995. Adoption reverses the long-term impairment in glucocorticoid feedback induced by prenatal stress. J. Neurosci. 15: 110-116.
36. WELBERG, L.A., J.R. SECKL & M.C. HOLMES. 2000. Inhibition of 11 beta-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring. Eur. J. Neurosci. 12: 1047-1054.
37. JOHNSTONE, H.A., A. WIGGER, A.J. DOUGLAS, et al. 2000. Attenuation of hypothalamic-pituitary-adrenal axis stress responses in late pregnancy: changes in feedforward and feedback mechanisms. J. Neuroendocrinol. 12: 811-822.
38. VENIHAKI, M., A. CARRIGAN, P. DIKKES, et al. 2000. Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency. Proc. Natl. Acad. Sci. USA 97: 7336-7341.