VKORC1 and the Vitamin K Cycle

Vitamins and Hormones

Volumn 78, Issue , 2008, Pages 23-33

  Garcia, Andrea A ^a   Reitsma, Pieter H ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 40949088051     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0083-6729(07)00002-7     Document Type: Review

References (35)

1. Bell R.G., and Matschiner J.T. Vitamin K activity of phylloquinone oxide. Arch. Biochem. Biophys. 141 (1970) 473-476
2. Binkley N.C., Krueger D.C., Kawahara T.N., Engelke J.A., Chappell R.J., and Suttie J.W. A high phylloquinone intake is required to achieve maximal osteocalcin gamma-carboxylation. Am. J. Clin. Nutr. 76 (2002) 1055-1060
3. Buitenhuis H.C., Soute B.A., and Vermeer C. Comparison of the vitamins K1, K2 and K3 as cofactors for the hepatic vitamin K-dependent carboxylase. Biochim. Biophys. Acta 1034 (1990) 170-175
4. Cain D., Hutson S.M., and Wallin R. Assembly of the warfarin-sensitive vitamin K 2,3-epoxide reductase enzyme complex in the endoplasmic reticulum membrane. J. Biol. Chem. 272 (1997) 29068-29075
5. D'Andrea G., D'Ambrosio R.L., Di Perna P., Chetta M., Santacroce R., Brancaccio V., Grandone E., and Margaglione M. A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin. Blood 105 (2005) 645-649
6. Fregin A., Rost S., Wolz W., Krebsova A., Muller C.R., and Oldenburg J. Homozygosity mapping of a second gene locus for hereditary combined deficiency of vitamin K-dependent clotting factors to the centromeric region of chromosome 16. Blood 100 (2002) 3229-3232
7. Furie B., and Furie B.C. The molecular basis of blood coagulation. Cell 53 (1988) 505-518
8. Furie B., Bouchard B.A., and Furie B.C. Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid. Blood 93 (1999) 1798-1808
9. Guenthner T.M., Cai D., and Wallin R. Co-purification of microsomal epoxide hydrolase with the warfarin-sensitive vitamin K1 oxide reductase of the vitamin K cycle. Biochem. Pharmacol. 55 (1998) 169-175
10. Kohn M.H., and Pelz H.J. A gene-anchored map position of the rat warfarin-resistance locus, Rw, and its orthologs in mice and humans. Blood 96 (2000) 1996-1998
11. Kulman J.D., Harris J.E., Xie L., and Davie E.W. Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues. Proc. Natl. Acad. Sci. USA 98 (2001) 1370-1375
12. Li T., Chang C.Y., Jin D.Y., Lin P.J., Khvorova A., and Stafford D.W. Identification of the gene for vitamin K epoxide reductase. Nature 427 (2004) 541-544
13. Li T., Lange L.A., Li X., Susswein L., Bryant B., Malone R., Lange E.M., Huang T.Y., Stafford D.W., and Evans J.P. Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation. J. Med. Genet. 43 (2006) 740-744
14. Miyata M., Kudo G., Lee Y.H., Yang T.J., Gelboin H.V., Fernandez-Salguero P., Kimura S., and Gonzalez F.J. Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene. J. Biol. Chem. 274 (1999) 23963-23968
15. Morris D.P., Stevens R.D., Wright D.J., and Stafford D.W. Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate. J. Biol. Chem. 270 (1995) 30491-30498
16. Oldenburg J., Bevans C.G., Muller C.R., and Watzka M. Vitamin K epoxide reductase complex subunit 1 (VKORC1): The key protein of the vitamin K cycle. Antioxid. Redox Signal. 8 (2006) 347-353
17. Pelz H.J., Rost S., Hunerberg M., Fregin A., Heiberg A.C., Baert K., MacNicoll A.D., Prescott C.V., Walker A.S., Oldenburg J., and Muller C.R. The genetic basis of resistance to anticoagulants in rodents. Genetics 170 (2005) 1839-1847
18. Price P.A., Faus S.A., and Williamson M.K. Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves. Arterioscler. Thromb. Vasc. Biol. 18 (1998) 1400-1407
19. Reitsma P.H., van der Heijden J.F., Groot A.P., Rosendaal F.R., and Buller H.R. A C1173T dimorphism in the VKORC1 gene determines coumarin sensitivity and bleeding risk. PLoS Med. 2 (2005) e312
20. Rieder M.J., Reiner A.P., Gage B.F., Nickerson D.A., Eby C.S., McLeod H.L., Blough D.K., Thummel K.E., Veenstra D.L., and Rettie A.E. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N. Engl. J. Med. 352 (2005) 2285-2293
21. Robertson H.M. Genes encoding vitamin-K epoxide reductase are present in Drosophila and trypanosomatid protists. Genetics 168 (2004) 1077-1080
22. Rombouts E.K., Rosendaal F.R., and van der Meer F.J. The effect of vitamin K supplementation on anticoagulant treatment. J. Thromb. Haemost. 4 (2006) 691-692
23. Rost S., Fregin A., Ivaskevicius V., Conzelmann E., Hortnagel K., Pelz H.J., Lappegard K., Seifried E., Scharrer I., Tuddenham E.G., Muller C.R., Strom T.M., et al. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature 427 (2004) 537-541
24. Rost S., Fregin A., Koch D., Compes M., Muller C.R., and Oldenburg J. Compound heterozygous mutations in the gamma-glutamyl carboxylase gene cause combined deficiency of all vitamin K-dependent blood coagulation factors. Br. J. Haematol. 126 (2004) 546-549
25. Sadler J.E. Medicine: K is for koagulation. Nature 427 (2004) 493-494
26. Sconce E., Khan T., Mason J., Noble F., Wynne H., and Kamali F. Patients with unstable control have a poorer dietary intake of vitamin K compared to patients with stable control of anticoagulation. Thromb. Haemost. 93 (2005) 872-875
27. Spronk H.M., Soute B.A., Schurgers L.J., Thijssen H.H., De Mey J.G., and Vermeer C. Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. J. Vasc. Res. 40 (2003) 531-537
28. Stafford D.W. The vitamin K cycle. J. Thromb. Haemost. 3 (2005) 1873-1878
29. Tie J., Wu S.M., Jin D., Nicchitta C.V., and Stafford D.W. A topological study of the human gamma-glutamyl carboxylase. Blood 96 (2000) 973-978
30. Tie J.K., Nicchitta C., von Heijne G., and Stafford D.W. Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation. J. Biol. Chem. 280 (2005) 16410-16416
31. Wadelius M., Chen L.Y., Downes K., Ghori J., Hunt S., Eriksson N., Wallerman O., Melhus H., Wadelius C., Bentley D., and Deloukas P. Common VKORC1 and GGCX polymorphisms associated with warfarin dose. Pharmacogenomics. J. 5 (2005) 262-270
32. Wajih N., Sane D.C., Hutson S.M., and Wallin R. The inhibitory effect of calumenin on the vitamin K-dependent gamma-carboxylation system. Characterization of the system in normal and warfarin-resistant rats. J. Biol. Chem. 279 (2004) 25276-25283
33. Wajih N., Hutson S.M., and Wallin R. Disulfide-dependent protein folding is linked to operation of the vitamin K cycle in the endoplasmic reticulum. A protein disulfide isomerase-VKORC1 redox enzyme complex appears to be responsible for vitamin K1 2,3-epoxide reduction. J. Biol. Chem. 282 (2007) 2626-2635
34. Wallin R., and Hutson S.M. Warfarin and the vitamin K-dependent gamma-carboxylation system. Trends Mol. Med. 10 (2004) 299-302
35. Wallin R., Sane D.C., and Hutson S.M. Vitamin K2, 3-epoxide reductase and the vitamin K-dependent gamma-carboxylation system. Thromb. Res. 108 (2002) 221-226