Pattern recognition by toll-like receptors

Advances in Experimental Medicine and Biology

Volumn 653, Issue , 2009, Pages 15-34

  Bauer, Stefan ^a   Müller, Thomas ^b   Hamm, Svedana ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; PATTERN RECOGNITION RECEPTOR; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 9; CYTOKINE; LIGAND; PROTEIN KINASE;

ADAPTIVE IMMUNITY; ARTICLE; AUTOIMMUNITY; CELLULAR DISTRIBUTION; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; HOST RESISTANCE; HUMAN; IMMUNOSTIMULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; SIGNAL TRANSDUCTION; ANIMAL; BACTERIUM; CHEMISTRY; FUNGUS; IMMUNOLOGY; METABOLISM; PARASITE; REVIEW; VIRUS;

MAMMALIA;

ANIMALS; AUTOIMMUNITY; BACTERIA; CYTOKINES; FUNGI; HUMANS; INTERFERONS; LIGANDS; PARASITES; PROTEIN KINASES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; VIRUSES;

EID: 70350511427     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-0901-5_2     Document Type: Article

References (202)

1. Medzhitov R, Janeway Jr CA. Innate immunity: The virtues of a nondonal system of recognition. Cell 1997; 91:295-298. (Pubitemid 27467959)
2. Janeway Jr CA, Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002; 20:197-216. (Pubitemid 34293424)
3. Rock FL, Hardiman G, Timans JC et al. A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci USA 1998; 95:588-593. (Pubitemid 28083787)
4. Anderson KY, Bokla L, Nusslein-Volhard C. Establishment of dorsal-ventral polarity in the Drosophila embryo: The induction of polarity by the Toll gene product. Cell 1985; 42:791-798. (Pubitemid 16083720)
5. Lemaitre B, Nicolas E, Michaut L et al. The dorsoventral regulatory gene cassette spatzle/Tolll cactus controls the potent antifungal response in Drosophila adults. Cell 1996; 86:973-983. (Pubitemid 26336801)
6. Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol 2005; 17:1-14.
7. Tabeta K, Georgel P, Janssen E et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci USA 2004; 101:3516-3521. (Pubitemid 38338227)
8. Medzhitov R, Janeway Jr C. Innate immunity. N Engl J Med 2000; 343:338-344.
9. Alexander C, Rietschel ET. Bacterial lipopolysaccharides and innate immunity. J Endotoxin Res 2001; 7:167-202. (Pubitemid 32894573)
10. Poltorak A, He X, Smirnova I et al. Defective LPS signaling in C3H/HeJ and C57BLlI0ScCr mice: Mutations in Tlr4 gene. Science 1998; 282:2085-2088. (Pubitemid 29001265)
11. Heumann D, Lauener R, Ryffel B. The dual role of LBP and CD14 in response to Gram-negative bacteria or Gram-negative compounds. J Endotoxin Res 2003; 9:381-384. (Pubitemid 38035602)
12. Shimazu R, Akashi S, Ogata H et al. MD-2 a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 1999; 189:1777-1782. (Pubitemid 29272694)
13. Girard R, Pedron T, Uematsu S et al. Lipopolysaccharides from Lcgionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2. J Cell Sci 2003; 116:293-302. (Pubitemid 36163870)
14. Werts C, Tapping RI, Mathison JC et al. Leptospiral lipopolysaccharide activates cells through a TLR2-dependcnt mechanism. Nat Immunol 2001; 2:346-352. (Pubitemid 33706346)
15. Akamine M, Higa F, Arakaki N et al. Differential roles of Toll-like receptors 2 and 4 in in vitro responses of macrophages to Lcgionella pneumophila. Infect Immun 2005; 73:352-361. (Pubitemid 40041127)
16. Asai Y, Hashimoto M, Fletcher HM et al. Lipopolysaccharide preparation extracted from Porphyromonas gingivalis lipoprotein-deficient mutant shows a marked decrease in toll-like receptor 2-mediated signaling. Infect Immun 2005: 73:2157-2163. (Pubitemid 40470815)
17. Takeuchi O, Hoshino K, Kawai T et al. Differential roles of TLR2 and TIM in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 1999; 11:443-451. (Pubitemid 29504199)
18. Schwandner R, Dziarski R, Wesche H et al. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chern 1999; 274:17406-17409.
19. Alexopoulou L, Thomas V, Schnare M et al. Hypotesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TIR2-deficient mice. Nat Med 2002; 8:878-884.
20. Ozinsky A, Underhill DM, Fontenot JD et al. The repertoire for partern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci USA 2000; 97:13766-13771.
21. Takeuchi O, Sato S, Horiuchi T et al. Curting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol 2002; 169:10-14. (Pubitemid 34686113)
22. Takeuchi O, Kawai T, Muhlradt PF et al. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol 2001; 13:933-940. (Pubitemid 32685205)
23. Buwitt-Beckmann U, Heine H, Wiesmuller KH et al. TIR1- and TLR6-indepcndent recognition of bacteriallipopeptides. J Biol Chern 2006; 281:9049-9057.
24. Michelsen KS, Aicher A, Mohaupt M et al. The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid arc inducers of DC maturation and require TLR2. J Biol Chern 2001; 276:25680-25686.
25. Travassos LH, Girardin SE, Philpott DJ et al. Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition. EMBO Rep 2004; 5:1000-1006. (Pubitemid 39534459)
26. Chamaillard M, Hashimoto M, Horie Y et al. An essential role for NODI in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol 2003; 4:702-707. (Pubitemid 36874448)
27. Girardin SE, Boncca IG, Carneiro Y et al. Nod1 detects a unique muropeptide from Gram-negative bacterial peptidoglycan. Science 2003; 300:1584-1587. (Pubitemid 36682892)
28. Girardin SE, Boneca IG, Viala J et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chern 2003: 278:8869-8872. (Pubitemid 36800360)
29. Inohara N, Ogura Y, Fontalba A et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chern 2003; 278:5509-5512. (Pubitemid 36800790)
30. Echchannaoui H, Bachmann P, Letiembre M et al. Regulation of Streptococcus pneumoniae distribution by Toll-like receptor 2 in vivo. Immunobiology 2005; 210:229-236. (Pubitemid 41025164)
31. Takeuchi O, Hoshino K, Akira S. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol 2000; 165:5392-5396.
32. Woods JP, Frelinger JA, Warrack G et al. Mouse genetic locus Lps influences susceptibility to Neisseria meningitidis infection. Infect Immun 1988; 56:1950-1955.
33. Weinstein DL, Lissner CR, Swanson RN et al. Macrophage defect and inflammatory cell recruitment dysfunction in Salmonella susceptible C3H/HeJ mice. Cell Immunol 1986; 102:68-77. (Pubitemid 17171341)
34. Bernheiden M, Heinrich JM, Minigo G et al. LBP CD14 TLR4 and the mutine innate immune response to a peritoneal Salmonella infection. J Endotoxin Res 2001; 7:447-450. (Pubitemid 34048529)
35. Zhang D, Zhang G, Hayden MS et al. A toll-like receptor that prevents infection by uropathogenic bacteria. Science 2004; 303:1522-1526. (Pubitemid 38314423)
36. Hayashi F, Smith KD, Ozinsky A. et al. The innate immune response to bacterial f1agellin is mediated by Toll-like receptor 5. Nature 2001; 410:1099-1103. (Pubitemid 32391041)
37. Smith KD, Andersen-Nissen E, Hayashi F et al. Toll-like receptor 5 recognizes a conserved site on f1agellin required for protofilament formation and bacterial motiliry. Nat Immunol 2003; 4:1247-1253. (Pubitemid 37540694)
38. Gewirtz AT, Navas TA, Lyons S et al. Cutting edge: Bacterial flagcllin activates basolaterallyexpressed TLR5 to induce epithelial proinflammatory gene expression. J Immunol 2001; 167:1882-1885. (Pubitemid 32747491)
39. Means TK, Hayashi F, Smith KD et al. The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J Immunol 2003; 170:5165-5175. (Pubitemid 36554749)
40. Cabral ES, Gelderblom H, Hornung RL et al. Borrelia burgdorferi lipoprotein-mediated TLR2 stimulation causes the down-regulation of TLR5 in human monocytes. J Infect Dis 2006; 193:849-859.
41. Subramanian N, Qadti A. Lysophospholipid sensing triggers secretion of flagellin from pathogenic salmonella. Nat Immunol 2006; 7:583-589. (Pubitemid 43797339)
42. Hawn TR, Verbon A, Lettinga KD et al. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med 2003; 198:1563-1572. (Pubitemid 37467170)
43. Andersen-Nissen E, Smith KD, Strobe KL et al. Evasion of Toll-like receptor 5 by flagellated bacteria. Proc Natl Acad Sci USA 2005; 102:9247-9252. (Pubitemid 40923549)
44. Tokunaga T, Yamamoto H, Shimada S et al. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation physicochemical characterization and antitumor activity. J Natl Cancer Inst 1984; 72:955-962. (Pubitemid 14131740)
45. Krieg AM, Yi AK, Matson S et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995; 374:546-549.
46. Wagner H. Toll meets bactetial CpG-DNA. Immunity 2001; 14:499-502.
47. Kalis C, Gumenscheimer M, Fteudenberg N et al. Requirement for TLR9 in the immunomodulatoty activity of Propionibacterium acnes. J Immunol 2005; 174:4295-4300. (Pubitemid 40396011)
48. Kurt-Jones EA, Popova L, Kwinn L, et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratoty syncytial virus. Nat Immunol 2000; 1:398-401.
49. Haynes LM, Moore DD, Kurt-Jones EA et al. Involvement of toll-like receptor 4 in innate immunity to respiratoty syncytial virus. J Virol 2001; 75:10730-10737. (Pubitemid 33031542)
50. Rassa JC, Meyers JL, Zhang Y. et al. Murine retroviruses activate B cells via interaction with toll-like receptor 4. Proc Natl Acad Sci USA 2002; 99:2281-2286. (Pubitemid 34169052)
51. Jude BA, Pobezinskaya Y, Bishop J et al. Subversion of the innate immune system by a retrovirus. Nat Immunol 2003; 4:573-578. (Pubitemid 36701341)
52. Ehl S, Bischoff R, Ostler T et al. The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratoty syncytial virus. Eur J Immunol 2004; 34:1146-1153. (Pubitemid 39255994)
53. Burzyn D, Rassa JC, Kim D et al. Toll-like receptor 4-dependent activation of dendritic cells by a retrovirus. J Virol 2004; 78:576-584. (Pubitemid 38067579)
54. Bieback K, Lien E, Klagge IM et al. Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signaling. J Virol 2002; 76:8729-8736. (Pubitemid 34864068)
55. Atavalli RN, Hu S, Rowen TN et al. Cutting edge: TLR2-mediated proinflammatory cytokine and chemokine production by microglial cells in response to herpes simplex virus. J Immunol 2005; 175:4189-4193. (Pubitemid 41361951)
56. Kurt-Jones EA, Chan M, Zhou S et al. Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci USA 2004; 101:1315-1320. (Pubitemid 38182686)
57. Compton T, Kurt-Jones EA, Boehme KW et al. Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J Virol 2003; 77:4588-4596. (Pubitemid 36402808)
58. Garcia-Sastre A, Biron CA. Type 1 interferons and the virus-host relationship: A lesson in detente. Science 2006; 312:879-882. (Pubitemid 43727313)
59. Lund J, Saw A, Akira S et al. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 2003; 198:513-520. (Pubitemid 36976063)
60. Krug A, French AR, Barchet W et al. TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 2004; 21:107-119. (Pubitemid 38925271)
61. Hochrein H, Schlatter B, O'Keeffe M et al. Hetpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and -independent pathways. Proc Natl Acad Sci USA 2004; 101:11416-11421. (Pubitemid 39038361)
62. Krug A, Luker GD, Barchet W et al. Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood 2004; 103:1433-1437. (Pubitemid 38168659)
63. Siegal FP, Kadowaki N, Shodell M et al. The nature of the principal type 1 interferon-producing cells in human blood. Science 1999; 284:1835-1837.
64. Malmgaard L, Mekhjorsen J, Bowie AG et al. Viral activation of macrophages through TLR-dependent and -independent pathways. J Immunol 2004; 173:6890-6898. (Pubitemid 39541076)
65. Heil F, Hemmi H, Hochrein H et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 2004; 303:1526-1529. (Pubitemid 38314424)
66. Diebold SS, Kaisho T, Hemmi H et al. Innate antiviral responses by means of TLR7-mediated recognition of single-srranded RNA. Science 2004; 303:1529-1531. (Pubitemid 38314425)
67. Lund JM, Alexopoulou L, Sato A et al. Recognition of single-srranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci USA, 2004, 101:5598-5603. (Pubitemid 38481202)
68. Kato H, Sato S, Yoneyama M et al. Cell type-specific involvement of RIG-I in antiviral response. Immunity 2005; 23:19-28. (Pubitemid 41019654)
69. Triantafilou K, Orthopoulos G, Vakakis E et al. Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent. Cell Microbiol 2005; 7:1117-1126. (Pubitemid 41030937)
70. Triantafilou K, Vakakis E, Orthopoulos G et al. TLR8 and TLR7 are involved in the host's immune response to human parechovirus 1. Eur J Immunol 2005; 35:2416-2423. (Pubitemid 41179762)
71. Chuang TH, Ulevitch RJ. Cloning and characterization of a sub-fiunily of human toll-like receptors: hTLR7 hTLR8 and hTLR9. Eur Cytokine Netw 2000; 11:372-378. (Pubitemid 32268894)
72. Du X, Poltorak A, Wei Y. et al. Three novel mammalian toll-like receptors: Gene structure expression and evolution. Eur Cytokine Netw 2000; 11:362-371. (Pubitemid 32268893)
73. Hemmi H, Kaisho T, Takeuchi O et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 2002; 3:196-200. (Pubitemid 34141451)
74. Jurk M, Heil F, VollmerJ et al. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat Immunol 2002; 3:499. (Pubitemid 34669818)
75. Heil F, Ahmad-Nejad P, Hemmi H et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7 8 and 9 subfamily. Eur J Immunol 2003; 33:2987-2997. (Pubitemid 37428331)
76. Lee J, Chuang TH, Redecke V et al. Molecular basis for the immunostimulatoty activity of guanine nucleoside analogs: Activation of Toll-like receptor 7. Proc Natl Acad Sci USA, 2003, 100:6646-6651. (Pubitemid 36666635)
77. Yoneyama M, Kikuchi M, Natsukawa T et al. The RNA helicase RIG-I has an essential function in double-srranded RNA-induced innate antiviral responses. Nat Immunol 2004; 5:730-737. (Pubitemid 39023305)
78. Gitlin L, Barchet W, Gilfillan S et al. Essential role of mda-5 in type I IFN responses to polytiboinosinic:polytibocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci USA, 2006. 103: 8459-8464 (Pubitemid 43838477)
79. Kato H, Takeuchi O, Sato S et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006; 441:101-105.
80. Yang K, Puel A, Zhang S et al. Human TLR-7- -8- and -9-mediated induction of IFN-alphalbeta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses. Immunity 2005; 23:465-478. (Pubitemid 41587887)
81. Alexopoulou L, Holt AC, Medzhitov R et al. Recognition of double-stranded RNA and aaivation of NF-kappaB by Toll-like receptor 3. Nature 2001; 413:732-738. (Pubitemid 33009951)
82. Matsumoto M, Funami K, Oshiumi H et al. Toll-like receptor 3: A link between toll-like receptor interferon and viruses. Microbiol Immunol 2004; 48:147-154. (Pubitemid 38405076)
83. Edelmann KH, Richardson-Burns S, Alexopoulou L. et al. Does Toll-like receptor 3 playa biological role in virus infections? Virology 2004; 322:231-238. (Pubitemid 38521138)
84. Wang T, Town T, Alexopoulou L et al. Toll-like receptor 3 mediates West Nile virus entty into the brain causing lethal encephalitis. Nat Med 2004; 10:1366-1373. (Pubitemid 40022719)
85. Schulz O, Diebold SS, Chen M et al. Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature 2005; 433:887-892. (Pubitemid 40314900)
86. Loseke S, Grage-Griebenow E, Heine H et al. In vitro-generated viral double-srranded RNA in contrast to polyinosinic: Polycyridylic acid induces interferon-alpha in human plasmacytoid dendritic cells. Scand J Immunol 2006; 63:264-274.
87. Underhill DM, Ozinsky A, Hajjar AM et al. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 1999; 401:811-815.
88. Netea MG, Van der Graaf CA, Vonk AG et al. The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. J Infect Dis 2002; 185:1483-1489. (Pubitemid 34507972)
89. Meier A, Kirschning CJ, Nikolaus T et al. Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages. Cell Microbiol 2003; 5:561-570. (Pubitemid 36939595)
90. Jouault T, Ibata-Ombena S, Takeuchi O et al. Candida albicans phospholipomannan is sensed through toll-like receptors. J Infea Dis 2003; 188:165-172. (Pubitemid 36829757)
91. Levitz SM. Interactions of Toll-like receptors with fungi. Microbes Infect 2004; 6:1351-1355. (Pubitemid 41110576)
92. Netea MG, Sutmuller R, Hermann C et al. Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-I0 and regulatory T cells. J Immunol 2004; 172:3712-3718. (Pubitemid 38337955)
93. Netea MG, Warris A, Van der Meer JW et al. Aspergillus fumigatus evades immune recognition during germination through loss of toll-like receptor-4-mediated signal transduction. J Infect Dis 2003; 188:320-326. (Pubitemid 36898166)
94. Gantner BN, Simmons RM, Canavera SJ et al. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med 2003; 197:1107-1117. (Pubitemid 36570066)
95. Brown GD. Dectin-1: A signalling nonTLR pattern-recognition receptor. Nat Rev Immunol 2006; 6:33-43. (Pubitemid 43279751)
96. Brown GD, Taylor PR, Reid DM et al. Dectin-1 is a major beta-glucan receptor on macrophages. J Exp Med 2002; 196:407-412. (Pubitemid 34875669)
97. Rogers NC, Slack EC, Edwards AD et al. Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immuniry 2005; 22:507-517. (Pubitemid 40545115)
98. Gantner BN, Simmons RM, Underhill DM. Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. EMBO J 2005; 24:1277-1286. (Pubitemid 40516610)
99. Campos MA, Almeida IC, Takeuchi O et al. Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite. J Immunol 2001; 167:416-423. (Pubitemid 32567807)
100. Mun HS, Aosai F, Norose K et al. TLR2 as an essential molecule for protective immuniry against Toxoplasma gondii infection. Int Immunol 2003; 15:1081-1087. (Pubitemid 37063207)
101. de Veer MJ, Curtis JM, Baldwin TM et al. MyD88 is essential for clearance of Leishmania major: Possible role for lipophosphoglycan and Toll-like receptor 2 signaling. Eur J Immunol 2003; 33:2822-2831. (Pubitemid 37337148)
102. Kropf P, Freudenberg MA, Modolell M et al. Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major. Infect Immun 2004; 72:1920-1928. (Pubitemid 38419902)
103. Oliveira AC, Peixoto JR, de Arruda LB et al. Expression of functional TLR4 confers proinflammatory responsiveness to Ttypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi. J Immunol 2004; 173:5688-5696. (Pubitemid 39392157)
104. Yarovinsky F, Zhang D, Andersen JF et al. TLRll activation of dendritic cells by a protozoan profilin-like protein. Science 2005; 308:1626-1629. (Pubitemid 40807512)
105. Pichyangkul S, Yongvanitchit K, Kum-arb U et al. Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a Toll-like receptor 9-dependent pathway. J Immunol 2004; 172:4926-4933. (Pubitemid 38456417)
106. Coban C, Ishii KJ, Kawai T et al. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J Exp Med 2005; 201:19-25. (Pubitemid 40130079)
107. Wagner H. The immunobiology of the TLR9 subfamily. Trends Immunol 2004; 25:381-386. (Pubitemid 38780955)
108. Latz E, Schoenemeyer A, Visintin A et al. TLR9 signals afrer translocating from the ER to CpG DNA in the lysosome. Nat Immunol 2004; 5:190-198. (Pubitemid 38208361)
109. Leifer CA, Kennedy MN, Mazzoni A et al. TLR9 is localized in the endoplasmic reticulum prior to stimulation. J Immunol 2004; 173:1179-1183. (Pubitemid 38924294)
110. Rutz M, Metzger J, Gellert T et al. Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. Eur J Immunol 2004; 34:2541-2550. (Pubitemid 39302811)
111. Yi AK, Peckham OW, Ashman RF et al. CpG DNA rescues B cells from apoptosis by activating NFkappaB and preventing mitochondrial membrane potential disruption via a chloroquine-sensitive pathway. Int Immunol 1999; 11:2015-2024.
112. Hacker H, Mischak H, Miethke T et al. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activiry and is preceded by nonspecific endocytosis and endosomal maturation. EMBO J 1998; 17:6230-6240. (Pubitemid 28497796)
113. Funami K, Matsumoto M, Oshiumi H et al. The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling. Int Immunol 2004; 16:1143-1154. (Pubitemid 39136731)
114. Nishiya T, Kajita E, Miwa S et al. TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements. J Biol Chern 2005; 280:37107-37117. (Pubitemid 41587795)
115. Kajita E, Nishiya T, Miwa S. The transmembrane domain directs TLR9 to intracellular compartments that contain TLR3. Biochem Biophys Res Commun 2006; 343:578-584.
116. Barton GM, Kagan JC, Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol 2006; 7:49-56. (Pubitemid 41823868)
117. Kariko K, Buckstein M, Ni H et al. Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA. Immunity 2005; 23:165-175. (Pubitemid 41169286)
118. Ishii KJ, Akira S. TLR ignores methylated RNA? Immunity 2005; 23:111-113. (Pubitemid 41169280)
119. Leadbetter EA, Rifkin IR. Hohlbaum AM et al. Chrornatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 2002; 416:603-607. (Pubitemid 34406754)
120. Viglianti GA, Lau CM, Hanley TM et al. Activation of autoreactive B cells by CpG dsDNA. Immuniry 2003; 19:837-847. (Pubitemid 37542304)
121. Beg AA. Endogenous ligands of Toll-like receptors: Implications for regulating inflammatory and immune responses. Trends Immunol 2002; 23:509-512. (Pubitemid 35223541)
122. Seong SY, Matzinger P. Hydrophobicity: An ancient damage-associated molecular pattern that initiates innate immune responses. Nat Rev Immunol 2004; 4:469-478. (Pubitemid 38745558)
123. Vabulas RM, Ahmad-Nejad P, da Costa C et al. Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the tollJinterleukin-1 receptor signaling pathway in innate immune cells. J Biol Chern 2001; 276:31332-31339. (Pubitemid 37385004)
124. Vabulas RM, Braedel S, Hilf N et al. The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway. J Biol Chern 2002; 277:20847-20853. (Pubitemid 34967392)
125. Habich C, Baumgart K, Kolb H et al. The receptor for heat shock protein 60 on macrophages is saturable specific and distinct from receptors for other heat shock proteins. J Immunol 2002; 168:569-576. (Pubitemid 34049555)
126. Vabulas RM, Ahmad-Nejad P, Ghose S et al. HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chern 2002; 277:15107-15112. (Pubitemid 34952589)
127. Flohe SB, Bruggemann J, Lendemans S et al. Human heat shock protein 60 induces maturation of dendritic cells versus a Th1-promoting phenotype. J Immunol 2003; 170:2340-2348. (Pubitemid 36245620)
128. Multhoff G. Heat shock proteins in immunity. Handb Exp Pharmacol 2006; 279-304.
129. Smiley ST, King JA, Hancock WW. Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol 2001; 167:2887-2894. (Pubitemid 32768923)
130. Guillot L, Balloy V, McCormack FX et al. Cutting edge: The immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4. J Immunol 2002; 168:5989-5992. (Pubitemid 34620010)
131. Okamura Y, Watari M, Jerud ES et al. The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chern 2001; 276:10229-10233.
132. Johnson GB, Brunn GJ, Kodaira Y et al. Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J Immunol 2002; 168:5233-5239. (Pubitemid 34495991)
133. Termeer C, Benedix F, Sleeman J et al. Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med 2002; 195:99-111. (Pubitemid 34074500)
134. Biragyn A, Ruffini PA, Leifer CA et al. Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science 2002; 298:1025-1029. (Pubitemid 35247310)
135. Park JS, Svetkauskaite D, He Q et al. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem 2004; 279:7370-7377. (Pubitemid 38294612)
136. Gao B, Tsan MF. Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophages. J Biol Chern 2003; 278:22523-22529. (Pubitemid 36830307)
137. Gao B, Tsan MF. Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor alpha release by murine macrophages. J Biol Chern 2003; 278:174-179. (Pubitemid 36043559)
138. Liu B, Dai J, Zheng H et al. Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases. Proc Natl Acad Sci USA 2003; 100:15824-15829. (Pubitemid 38021074)
139. Elias D, Reshef T, Birk OS et al. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci USA 1991; 88:3088-3091. (Pubitemid 21916564)
140. Pockley AG. Heat shock proteins inflammation and cardiovascular disease. Circulation 2002; 105:1012-1017. (Pubitemid 34184583)
141. Pope RM, Lovis RM, Gupta RS. Activation of synovial fluid T lymphocytes by 60-kd heat-shock proteins in patients with inflammatory synovitis. Arthritis Rheum 1992; 35:43-48.
142. Jiang D, Liang J, Fan J et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med 2005; 11:1173-1179. (Pubitemid 43093664)
143. Ronnblom L, Aim GV. Systemic lupus erythematosus and the type I interferon system. Arthritis ResTher 2003; 5:68-75. (Pubitemid 36849752)
144. Migliorini P, Baldini C, Rocchi Vet al. Anti-Sm and anti-RNP antibodies. Autoimmunity 2005; 38:47-54. (Pubitemid 40515003)
145. Leadbetter EA, Rifkin IR, Marshak-Rothstein A Toll-like receptors and activation of autoreactive B cells. CUrt Dir Autoimmun 2003; 6:105-122.
146. Boule MW, Broughton C, Mackay F et al. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med 2004; 199:1631-1640. (Pubitemid 38821996)
147. Lau CM, Broughton C, Tabor AS et al. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med 2005; 202:1171-1177. (Pubitemid 41586947)
148. Means TK, Larz E, Hayashi F et al. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Invest 2005; 115:407-417. (Pubitemid 40385482)
149. Vollmer J, Tluk S, Schmitz C et al. Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J Exp Med 2005; 202:1575-1585. (Pubitemid 41746603)
150. Barrat FJ, Meeker T, Gregorio J et al. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 2005; 202: 1131-1139. (Pubitemid 41464506)
151. Savarese E, Chae OW, Trowil Z, Sch S et al. U1 small nuclear ribonucleoprotein immune complexes induce type 1 interferon in plasmacytoid dendritic cells through TLR7. Blood 2006; 107:3229-3234.
152. Christensen SR, Kashgarian M, Alexopoulou L et al. Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J Exp Med 2005; 202:321-331. (Pubitemid 41043827)
153. Wu X, Peng SL. Toll-like receptor 9 signaling ptotects against murine lupus. Arthritis Rheum 2006; 54:336-342. (Pubitemid 43122217)
154. Yasuda K, Rutz M, Schlatter B et al. CpG motif-independent activation of TLR9 upon endosomal translocation of "natural" phosphodiester DNA. Eur J Immunol 2006; 36:431-436. (Pubitemid 43257466)
155. Cabral AR, Alarcon-Segovia D. Autoantibodies in systemic lupus erythematosus. Curr Opin Rheumatol 1997; 9:387-392. (Pubitemid 27437935)
156. Pisitkun P, Deane JA, Difilippantonio MJ et al. Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 2006; 312:1669-72. (Pubitemid 43902669)
157. O'Neill LA. How Toll-like receptors signal: What we know and what we don't know. CUrt Opin Immunol 2006; 18:3-9. (Pubitemid 43049641)
158. O'Neill LA, Greene C. Signal transduction pathways activated by the IL-1 receptor family: Ancient signaling machinery in mammals insects and plants. J Leukoc Biol 1998; 63:650-657. (Pubitemid 28274824)
159. Medzhitov R, Preston-Hurlburt P, Janeway Jr CA. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997; 388:394-397. (Pubitemid 27334820)
160. Wesche H, Henzel WJ, Shillinglaw W et al. MyD88: An adapter that recruits IRAK to the IL-1 receptor complex. Immunity 1997; 7:837-847. (Pubitemid 28064897)
161. Burns K, Martinon F, Esslinger C et al. MyD88 an adapter protein involved in interleukin-1 signaling. J Biol Chern 1998; 273:12203-12209. (Pubitemid 28240584)
162. Adachi O, Kawai T, Takeda K et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 1998; 9:143-150. (Pubitemid 28361303)
163. Medzhitov R, Preston-Hurlburt P, Kopp E et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell 1998; 2:253-258. (Pubitemid 128373651)
164. Horng T, Barton GM, Medzhitov R. TlRAP: An adapter molecule in the Toll signaling pathway. Nat Immunol 2001; 2:835-841.
165. Fitzgerald KA, Palsson-McDermott EM, Bowie AG et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 2001; 413:78-83. (Pubitemid 32843491)
166. Yamamoto M, Sato S, Mori K et al. Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol 2002; 169:6668-6672. (Pubitemid 36899248)
167. Oshiumi H, Matsumoto M, Funarni K et al. TlCAM-1 an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol 2003; 4:161-167. (Pubitemid 36193018)
168. Yamamoto M, Sato S, Hemmi H et al. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol 2003; 4: 1144-1150. (Pubitemid 37428043)
169. Cao Z, Xiong J, Takeuchi M et al. TRAF6 is a signal transducer for interleukin-1. Nature 1996; 383:443-446. (Pubitemid 26330834)
170. Muzio M, Natoli G, Saccani S et al. The human toll signaling pathway: Divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J Exp Med 1998; 187:2097-2101. (Pubitemid 28285580)
171. Li S, Strelow A, Fontana EJ et al. IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase. Proc Nad Acad Sci VSA 2002; 99:5567-5572. (Pubitemid 34411589)
172. Wang C, Deng L, Hong M et al. TAKI is a ubiquitin-dependent kinase of MKK and IKK. Nature 2001; 412:346-351. (Pubitemid 32694385)
173. Hacker H, Redecke V, Blagoev B et al. Specificity in Toll-like receptor yignaling through distinct effector functions of TRAF3 and TRAF6. Nature. 2006; 439:204-207. (Pubitemid 43083141)
174. Oganesyan G, Saha SK, Guo B et al. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature 2006; 439:208-211. (Pubitemid 43083142)
175. Takaoka A, Yanai H, Kondo S et al. Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature 2005; 434:243-249. (Pubitemid 40388058)
176. Hoebe K, Du X, Georgel P et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signaling. Nature 2003; 424:743-748. (Pubitemid 37021696)
177. Yamamoto M, Sato S, Hemmi H et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 2003; 301:640-643. (Pubitemid 36927946)
178. Meylan E, Burns K, Hofmann K et al. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol 2004; 5:503-507. (Pubitemid 38660462)
179. Fitzgerald KA, Rowe DC, Barnes BJ et al. LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med 2003; 198:1043-1055. (Pubitemid 37248620)
180. Sharma S, Tenoever BR, Grandvaux N et al. Triggering the interferon antiviral response through an IKK-relared pathway. Science 2003; 300:1148-1151. (Pubitemid 36583100)
181. Honda K, Yanai H, Negishi H et al. IRF-7 is the master regulator of type-1 interferon-dependent immune responses. Nature 2005; 434:772-777. (Pubitemid 44739521)
182. Sakaguchi S, Negishi H, Asagiri M et al. Essential role of IRF-3 in lipopolysaccharide-induced interferon-beta gene expression and endotoxin shock. Biochem Biophys Res Commun 2003; 306:860-866. (Pubitemid 36776210)
183. Honda K, Yanai H, Mizutani T et al. Role of a uansductional- transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc Natl Acad Sci USA 2004; 101:15416-15421. (Pubitemid 39441556)
184. Kawai T, Sato S, Ishii KJ et al. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol 2004; 5:1061-1068. (Pubitemid 41057726)
185. Uematsu S, Sato S, Yamamoto M et al. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor {TLR)7- and TLR9-mediated interferon-{alpha} induction. J Exp Med 2005; 201:915-923. (Pubitemid 40524461)
186. Hoshino K, Sugiyama T, Matsumoto M et al. IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature 2006; 440:949-953.
187. Kobe B, Deisenhofer J. Proteins with leucine-rich repeats. Curr Opin Suuct Biol 1995; 5:409-416.
188. Bell JK, Mullen GE, Leifer CA et al. Leucine-rich repeats and pathogen recognition in Toll-like receptors. Trends Immunol 2003; 24:528-533. (Pubitemid 37205203)
189. Bell JK, Botos I, Hall PR et al. The molecular structure of the Toll-like receptor 3 ligand-binding domain. Proc Natl Acad Sci USA 2005; 102:10976-10980. (Pubitemid 41105978)
190. Choe J, Kelker MS, Wilson IA. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science 2005; 309:581-585. (Pubitemid 41033635)
191. Bell JK, Askins J, Hall PR et al. The dsRNA binding site of human Toll-like receptor 3. Proc Natl Acad Sci USA 2006; 103:8792-8797. (Pubitemid 43878098)
192. Kaisho T, Akira S. Regulation of dendritic cell function through toll-like receptors. Curr Mol Med 2003; 3:759-771. (Pubitemid 37536880)
193. Sivori S, Falco M, Della CM et al. CpG and double-stranded RNA uigger human NK cells by Toll-like receptors: Induction of cytokine release and cytotoxicity against tumors and dendritic cells. Proc Natl Acad Sci USA 2004; 101:10116-10121. (Pubitemid 38891204)
194. Parker LC, Whyte MK, Dower SK et al. The expression and roles of Toll-like receptors in the biology of the human neutrophil. J Leukoc Biol 2005; 77:886-892. (Pubitemid 40770839)
195. Nagase H, Okugawa S, Ota Y et al. Expression and function of Toll-like receptors in eosinophils: Activation by Toll-like receptor 7 ligand. J Immunol 2003; 171:3977-3982. (Pubitemid 37238671)
196. Krishnaswamy G, Ajitawi O, Chi DS. The human mast cell: An overview. Methods Mol Biol 2006; 315:13-34.
197. Ruprecht CR, Lanzavecchia A. Toll-like receptor stimulation as a third signal required for activation of human naive B cells. Eur J Immunol 2006; 36:810-816.
198. Pasare C, Medzhitov R. Control of B-cell responses by Toll-like receptors. Nature 2005; 438:364-368. (Pubitemid 41643953)
199. Xu D, Komai-Koma M, Liew FY. Expression and function of Toll-like receptor on T cells. Cell Immunol 2005; 233:85-89. (Pubitemid 41074059)
200. Pasare C, Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003; 299:1033-1036. (Pubitemid 36222922)
201. Peng G, Guo Z, Kiniwa Y et al. Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science 2005; 309:1380-1384. (Pubitemid 41209366)
202. Sutmuller RP, den Brok MH, Kramer M et al. Toll-like receptor 2 controls expansion and function of regulatory T cells. J Clin Invest 2006; 116:485-494. (Pubitemid 43228366)