Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

Science

Volumn 300, Issue 5625, 2003, Pages 1584-1587

  Girardin, Stephen E ^a   Boneca, Ivo G ^a   Carneiro, Leticia A M ^a   Antignac, Aude ^a   Jéhanno, Muguette ^a   Viala, Jérôme ^a   Tedin, Karsten ^b   Taha, Muhamed Kheir ^a   Labigne, Agnès ^a   Zähringer, Ulrich ^c   Coyle, Anthony J ^d   DiStefano, Peter S ^d   Bertin, John ^d   Sansonetti, Philippe J ^a   Philpott, Dana J ^a  

^a INSTITUT PASTEUR   (France)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c RESEARCH CENTER BORSTEL   (Germany)

^d MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; MOLECULES; ORGANIC ACIDS;

BACTERIAL SENSING;

BACTERIA;

BACTERIAL PROTEIN; CELL PROTEIN; DIAMINOPIMELIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MURAMIC ACID; MUROPEPTIDE; N ACETYLGLUCOSAMINE; PEPTIDOGLYCAN; PROTEIN NOD1; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

BIOCHEMISTRY; MICROBIOLOGY;

ARTICLE; BACTERIAL INFECTION; EPITHELIUM CELL; GRAM NEGATIVE BACTERIUM; IMMUNITY; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MOTIF; TRANSCRIPTION INITIATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; ANIMALS; ANTIGENS, DIFFERENTIATION; CARRIER PROTEINS; CELL LINE; CYTOPLASM; EPITHELIAL CELLS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; IMMUNITY, NATURAL; INTERLEUKIN-8; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOPOLYSACCHARIDES; MICE; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; NOD1 SIGNALING ADAPTOR PROTEIN; NOD2 SIGNALING ADAPTOR PROTEIN; OLIGOPEPTIDES; PEPTIDOGLYCAN; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TRISACCHARIDES;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 0038615855     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1084677     Document Type: Article

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33. We thank M. Mavris for critical reading of the manuscript; the PTR/TLR group at the Institut Pasteur for helpful discussions; those individuals who donated bacterial strains, plasmids, and bacterial products; R. Athman for advice on primary cell cultures; M. Parmier for plasmid preparations; and the PT3 technical platform at the Institut Pasteur for mass spectrometry analyses. Supported by a Programme Transversal de Recherche grant from the Institut Pasteur (S.E.G., D.J.P.); a grant from Danone Vitapole, Paris (S.E.G.); a postdoctoral fellowship from the Fundação para a Ciência e a Tecnologia, Portugal (I.G.B.); and a studentship from CAPES/MEC, Brazil (L.A.M.C.). P.J.S. is a Howard Hughes International Research Scholar.