Advances in immunology: Innate immunity

New England Journal of Medicine

Volumn 343, Issue 5, 2000, Pages 338-344

  Medzhitov, R ^a   Janeway C , Jr ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR; ANTIGEN; CELL SURFACE RECEPTOR; DROSOPHILA PROTEIN; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TOLL LIKE RECEPTOR;

ANTIGEN RECOGNITION; COMPLEMENT SYSTEM; HOST RESISTANCE; HUMAN; IMMUNOMODULATION; IMMUNOREACTIVITY; IMMUNOREGULATION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ANIMAL; CELLULAR IMMUNITY; COMPLEMENT ACTIVATION; EVOLUTION; IMMUNOLOGY; INNATE IMMUNITY;

ANIMALS; ANTIGENS; COMPLEMENT ACTIVATION; DROSOPHILA PROTEINS; EVOLUTION; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, NATURAL; MEMBRANE GLYCOPROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; TOLL-LIKE RECEPTORS;

EID: 0034601309     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200008033430506     Document Type: Review

References (28)

1. Approaching the asymptote? Evolution and revolution in immunology
2. The immune system evolved to discriminate infectious nonself from nonifectious self
3. Innate immunity: Impact on the adaptive immune response
4. The instructive role of innate immunity in the acquired immune response
5. The collectins in innate immunity
6. The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity
7. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
8. Protection from lethal gram-positive infection by macrophage scavenger receptor-dependent phagocytosis
9. The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein
10. Drosophila Toll and IL-1 receptor
11. A conserved signaling pathway: The Drosophila Toll-dorsal pathway
12. NK-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses
13. Phylogenetic perspectives in innate immunity
14. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
15. Signaling mechanisms in the antimicrobial host defense of Drosophila
16. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
17. A family of human receptors structurally related to Drosophila Toll
18. Innate immunity: The virtues of a nonclonal system of recognition
19. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
20. Endotoxin-tolerant mice have mutations in Toll-like receptor 4
21. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
22. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
23. Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages
24. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
25. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
26. Cutting edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a Toll-like receptor 2- and MyD88-dependent signaling pathway
27. Tlr4: Central component of the sole mammalian LPS sensor
28. Endotoxin and IL-1 hyporesponsiveness in a patient with recurrent bacterial infections