Toll-like receptor 3 promotes cross-priming to virus-infected cells

Nature

Volumn 433, Issue 7028, 2005, Pages 887-892

  Schulz, Oliver ^a   Diebold, Sandra S ^a   Chen, Margaret ^b,c   Näslund, Tanja I ^b   Nolte, Martijn A ^a   Alexopoulou, Lena ^d,e   Azuma, Yasu Taka ^d   Flavell, Richard A ^d   Liljeström, Peter ^b,c   Reis E Sousa, Caetano ^a  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^b KAROLINSKA INSTITUTE   (Sweden)

^c SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; ANTIGENS; PROTEINS; RNA; VIRUSES;

ANTIGEN-PRESENTING CELLS (APC); CROSS-PENETRATION; CROSS-PRIMING; DENDRITIC CELLS;

CELLS;

B7 ANTIGEN; BETA INTERFERON; CANCER VACCINE; CD40 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; DOUBLE STRANDED RNA; INTERLEUKIN 12; INTERLEUKIN 6; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; OVALBUMIN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TUMOR NECROSIS FACTOR ALPHA; CELL SURFACE RECEPTOR; MEMBRANE PROTEIN; POLYINOSINIC POLYCYTIDYLIC ACID; TOLL LIKE RECEPTOR;

MEDICINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; CANCER IMMUNOTHERAPY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; ENCEPHALOMYOCARDITIS VIRUS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IN VITRO STUDY; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMLIKI FOREST ALPHAVIRUS; SPLEEN CELL; ULTRAVIOLET IRRADIATION; VERO CELL; VIRUS INFECTION; ANIMAL; ANTIGEN PRESENTATION; C57BL MOUSE; CERCOPITHECUS; CROSS PRESENTATION; ENDOSOME; GENETICS; IMMUNOLOGY; METABOLISM; PHYSIOLOGY;

ANIMALS; ANTIGEN PRESENTATION; CARDIOVIRUS INFECTIONS; CERCOPITHECUS AETHIOPS; CROSS-PRIMING; DENDRITIC CELLS; ENCEPHALOMYOCARDITIS VIRUS; ENDOSOMES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; OVALBUMIN; POLY I-C; RECEPTORS, CELL SURFACE; RNA, DOUBLE-STRANDED; RNA, MESSENGER; T-LYMPHOCYTES, CYTOTOXIC; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTORS; VERO CELLS;

EID: 20044382430     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03326     Document Type: Article

References (30)

1. Heath, W. R. et al. Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunol. Rev. 199, 9-26 (2004).
2. Fonteneau, J. F. et al. Activation of influenza virus-specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunity. Blood 101, 3520-3526 (2003).
3. Salio, M., Palmowski, M. J., Atzberger, A., Hermans, I. F. & Cerundolo, V. CpG-matured murine plasmacytoid dendritic cells are capable of in vivo priming of functional CD8 T cell responses to endogenous but not exogenous antigens. J. Exp. Med. 199, 567-579 (2004).
4. Allan, R. S. et al. Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells. Science 301, 1925-1928 (2003).
5. Smith, C. M. et al. Cutting edge: conventional CD8alpha(+) dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1. J. Immunol. 170, 4437-4440 (2003).
6. Belz, G. T. et al. Cutting edge: conventional CD8alpha(+) dendritic cells are generally involved in priming CTL immunity to viruses. J. Immunol. 172, 1996-2000 (2004).
7. den Haan, J. M., Lehar, S. M. & Bevan, M. J. CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo. J. Exp. Med. 192, 1685-1696 (2000).
8. Valdez, Y. et al. Major histocompatibility complex class II presentation of cell-associated antigen is mediated by CD8alpha + dendritic cells in vivo. J. Exp. Med. 195, 683-694 (2002).
9. Iyoda, T. et al. The CD8(+) dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J. Exp. Med. 195, 1289-1302 (2002).
10. + dendritic cells is attributable to their ability to internalise dead cells. Immunology 107, 183-189 (2002).
11. Belz, G. T. et al. The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J. Exp. Med. 196, 1099-1104 (2002).
12. Liu, K. et al. Immune tolerance after delivery of dying cells to dendritic cells in situ. J. Exp. Med. 196, 1091-1097 (2002).
13. Le Bon, A. et al. Cross-priming of CD8 + T cells stimulated by virus-induced type I interferon. Nature Immunol. 4, 1009-1015 (2003).
14. Alexopoulou, L., Holt, A. C., Medzhitov, R. & Flavell, R. A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413, 732-738 (2001).
15. + DC correlates with unresponsiveness to imidazoquinolines. Eur. J. Immunol. 33, 827-833 (2003).
16. Kaufman, R. J. Double-stranded RNA-activated protein kinase mediates virus-induced apoptosis: a new role for an old actor. Proc. Natl Acad. Sci. USA 96, 11693-11695 (1999).
17. Harshyne, L. A., Watkins, S. C., Gambotto, A. & Barratt-Boyes, S. M. Dendritic cells acquire antigens from live cells for cross-presentation to CTL. J. Immunol. 166, 3717-3723 (2001).
18. Helwig, F. & Schmidt, E. A filter-passing agent producing interstitial myocarditis in anthropoid apes and small animals. Science 102, 31-33 (1945).
19. Strauss, J. H. & Strauss, E. G. The alphaviruses; gene expression, replication, and evolution. Microbiol. Rev. 58, 491-562 (1994).
20. Smerdou, C. & Liljestrom, P. Two-helper RNA system for production of recombinant Semliki forest virus particles. J. Virol. 73, 1092-1098 (1999).
21. Diebold, S. S. et al. Viral infection switches non-plasmacytoid dendritic cells into high interferon producers. Nature 424, 324-328 (2003).
22. Freigang, S., Egger, D., Bienz, K., Hengartner, H. & Zinkernagel, R. M. Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming. Proc. Natl Acad. Sci. USA 100, 13477-13482 (2003).
23. Edelmann, K. H. et al. Does Toll-like receptor 3 play a biological role in virus infections? Virology 322, 231-238 (2004).
24. Crozat, K. & Beutler, B. TLR7: A new sensor of viral infection. Proc. Natl Acad. Sci. USA 101, 6835-6836 (2004).
25. Muzio, M. et al. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J. Immunol. 164, 5998-6004 (2000).
26. Tabeta, K. et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl Acad. Sci. USA 101, 3516-3521 (2004).
27. Melief, C. J. Regulation of cytotoxic T lymphocyte responses by dendritic cells: peaceful coexistence of cross-priming and direct priming? Eur. J. Immunol. 33, 2645-2654 (2003).
28. Reis e Sousa, C. Toll-like receptors and dendritic cells: for whom the bug tolls. Semin. Immunol. 16, 27-34 (2004).
29. Hoebe, K. & Beutler, B. LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins. J. Endotoxin Res. 10, 130-136 (2004).
30. Katze, M. G., He, Y. & Gale, M. Viruses and interferon: A fight for supremacy. Nature Rev. Immunol. 2, 675-687 (2002).