Hemagglutinin protein of wild-type measles virus activates Toll-like receptor 2 signaling

Journal of Virology

Volumn 76, Issue 17, 2002, Pages 8729-8736

  Bieback, Karen ^a   Lien, Egil ^a   Klagge, Ingo M ^a   Avota, Elita ^a   Schneider Schaulies, Jürgen ^a   Paul Duprex, W ^a   Wagner, Herrmann ^a   Kirschning, Carsten J ^a   Ter Meulen, Volker ^a   Schneider Schaulies, Sibylle ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ASPARAGINE; CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; TOLL LIKE RECEPTOR 2; VIRUS HEMAGGLUTININ;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; MEASLES VIRUS; MONOCYTE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION; VIRUS PATHOGENESIS;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENS, CD; ANTIGENS, CD46; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; HEMAGGLUTININS, VIRAL; HUMANS; INTERLEUKIN-6; MACROPHAGES; MEASLES VACCINE; MEASLES VIRUS; MEMBRANE GLYCOPROTEINS; MICE; MONOCYTES; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTORS; VACCINES, ATTENUATED;

EID: 0036340341     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.17.8729-8736.2002     Document Type: Article

References (66)

1. Production of hybridoma growth factor by human monocytes
2. Toll-like receptors: Critical proteins linking innate and acquired immunity
3. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
4. Toll-like receptor 2-mediated NF-κB activation requires a RacI-dependent pathway
5. CBL and LAT phosphorylation
6. Natural measles causes prolonged suppression of interleukin-12 production
7. Measles virus infection in rhesus macaques: Altered immune responses and comparison of the virulence of six different virus strains
8. Disruption of Akt kinase activation is important for immunosuppression induced by measles virus
9. Mapping amino acids of the measles virus hemagglutinin responsible for receptor (CD46) downregulation
10. Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments production of inflammatory cytokines
11. A46R and A52R from vaccinia virus are antagonists of host IL-1 and Toll-like receptor signaling
12. Toll-like receptors: Molecular mechanisms of the mammalian immune response
13. Failure of measles virus to activate nuclear factor-κB in neuronal cells: Implications on the immune response to viral infections in the central nervous system
14. The human CD46 molecule is a receptor for measles virus (Edmonston strain)
15. CD150 (SLAM) is a receptor for measles virus but is not involved in contact-mediated proliferation inhibition of lymphocytes
16. Infection of monocytes during measles
17. Apoptosis as a cause of death in measles virus-infected cells
18. Human Toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide
19. Measles virus suppresses cell-mediated immunity by interfering with the survival and function of dendritic cells
20. Immune responses during measles virus infection
21. Differential CD4 T cell activation in measles
22. Measles virus infects human dendritic cells and blocks their allostimulatory properties for CD4+ T cells
23. Measles virus activates NF-κB and STAT transcription factors and production of IFN-α/β and IL-6 in the human epithelial cell line A549
24. A Toll-like receptor recognizes bacterial DNA
25. Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2
26. CDw150 (SLAM) is a receptor for a lymphotropic strain of measles virus and may account for the immunosuppressive properties of this virus
27. A single amino acid change in the hemagglutinin protein of measles virus determines its ability to bind CD46 and reveals another receptor on marmoset B cells
28. A recombinant measles vaccine virus expressing wild-type glycoproteins: Consequences for viral spread and cell tropism
29. Mechanism of suppression of cell-mediated immunity by measles virus
30. Human receptor for measles virus (CD46) enhances nitric oxide production and restricts virus replication in mouse macrophages by modulating the production of alpha/beta inter-feron
31. Virus interactions with dendritic cells
32. Measles virus-induced promotion of dendritic cell maturation by soluble mediators does not overcome the immunosuppressive activity of viral glycoproteins on the cell surface
33. Signaling lymphocyte activation molecule is expressed on mature CD83+ dendritic cells and is upregulated by IL-1β
34. Functional modulation of human macrophages through CD46 (measles virus receptor): Production of IL-12 p40 and nitric oxide in association with recruitment of protein-tyrosine phosphatase SHIP-1 to CD46
35. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
36. Sequence and structure alignment of paramyxoviridae attachment proteins and discovery of enzymatic activity for a morbillivirus hemagglutinin
37. Identification of two amino acids in the hemagglutinin glycoprotein of measles virus (MV) that govern hemadsorption, HeLa cell fusion, and CD46 downregulation: Phenotypic markers that differentiate vaccine and wild-type MV strains
38. Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators
39. Measles virus infection enhances IL-1 beta but reduces tumor necrosis factor-alpha expression in human monocytes
40. An essential role of the NF-κB/Toll like receptor pathway in induction of inflammatory and tissue repair gene expression by necrotic cells
41. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
42. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products
43. Clinical isolates of measles virus use CD46 as a cellular receptor
44. Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis induced macrophage responses
45. Induction of the measles virus receptor SLAM (CD150) on monocytes
46. Evasion of host defenses by measles virus: Wild-type measles virus infection interferes with induction of alpha/beta interferon production
47. Adaptation of wild-type measles virus to CD46 receptor usage
48. The hemagglutinin protein is an important determinant for measles virus tropism for dendritic cells in vitro and immuno-suppression in vivo
49. Measles viruses of throat swabs from measles patients use signaling lymphocytic activation molecule (CDw150) but not 46 as a cellular receptor
50. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
51. Murine retroviruses activate B cells via interaction with Toll-like receptor 4
52. Endotoxin tolerance
53. Measles virus induced immunosuppression: Targets and effector mechanisms
54. Induction of maturation of human blood dendritic cell precursors by measles virus is associated with immunosuppression
55. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor 2
56. Measles virus induces abnormal differentiation of CD40-ligand activated human dendritic cells
57. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
58. Discrimination of bacterial lipopropteins by Toll-like receptor 6
59. SLAM (CDw150) is a cellular receptor for measles virus
60. Monkeys in measles research
61. Regulation of Toll-like receptors in human monocytes and dendritic cells
62. Changes in cytokine production after measles virus vaccination: Predominant production of IL-4 suggests induction of a Th2 response
63. Measles virus-induced immunosuppression in vitro is independent of complex glycosylation of viral glycoproteins and hemifusion
64. Toll-like receptor 2 is required for innate, but not acquired host defense to Borrelia burgdorferi
65. Recognition of gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
66. CD46/CD3 costimulation induces morphological changes of human T cells and activation of Vav, Rac, and extracellular signal-related kinase mitogen-activated protein kinase