TIRAP: An adapter molecule in the Toll signaling pathway

Nature Immunology

Volumn 2, Issue 9, 2001, Pages 835-841

  Horng, Tiffany ^a   Barton, Gregory M ^a   Medzhitov, Ruslan ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; DOUBLE STRANDED RNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; RNA BINDING PROTEIN; TOLL LIKE RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; DOWNSTREAM PROCESSING; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MICROBIAL METABOLISM; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, DIFFERENTIATION; CELL DIFFERENTIATION; CELL LINE; CLONING, MOLECULAR; CPG ISLANDS; DENDRITIC CELLS; DROSOPHILA PROTEINS; EIF-2 KINASE; HSP40 HEAT-SHOCK PROTEINS; HUMANS; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; MYELOID DIFFERENTIATION FACTOR 88; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, INTERLEUKIN-1; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 9; TOLL-LIKE RECEPTORS;

EID: 0035555301     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni0901-835     Document Type: Article

References (19)

1. Toll-like receptors in the induction of the innate immune response
2. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
3. A Toll-like receptor recognizes bacterial DNA
4. The Toll-receptor family and control of innate immunity
5. Unresponsiveness of MyD88-deficient mice to endotoxin
6. Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88
7. Endotoxin-induced maturation of myd88-deficient dendritic cells
8. Targeted disruption of the MyD88 gene results in loss of IL-1-and IL- 18-mediated function
9. Cutting edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway
10. The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin
11. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
12. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
13. Structural basis for signal transduction by the Toll/interleukin-I receptor domains
14. The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins
15. PACT, a protein activator of the interferon-induced protein kinase, PKR
16. Trojan peptides: The penetration system for intracellular delivery
17. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
18. Toll-like receptor 2-mediated NF-κ B activation requires a Racl-dependent pathway
19. A human homologue of the Drosophilia Toll protein signals activation of adaptive immunity