Subversion of the innate immune system by a retrovirus

Nature Immunology

Volumn 4, Issue 6, 2003, Pages 573-578

  Jude, Brooke A ^a   Pobezinskaya, Yelena ^a   Bishop, Jennifer ^a   Parke, Susannah ^a   Medzhitov, Ruslan M ^b   Chervonsky, Alexander V ^a   Golovkina, Tatyana V ^a  

^a JACKSON LABORATORY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 10; TOLL LIKE RECEPTOR 4; VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; HOST RESISTANCE; IMMUNE RESPONSE; IMMUNE SYSTEM; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RETROVIRUS; SIGNAL TRANSDUCTION; VIRUS RECOMBINANT; VIRUS RESISTANCE; VIRUS STRAIN; VIRUS SURVIVAL; VIRUS VIRULENCE; WILD TYPE;

ANIMALS; CROSSES, GENETIC; CYTOTOXICITY TESTS, IMMUNOLOGIC; INTERLEUKIN-10; MAMMARY TUMOR VIRUS, MOUSE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; RETROVIRIDAE INFECTIONS; SELECTION (GENETICS); SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TUMOR VIRUS INFECTIONS;

EID: 0037502208     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni926     Document Type: Article

References (38)

1. Tortorella, D., Gewurz, B.E., Furman, M.H., Schust, D.J. & Ploegh, H.L. Viral subversion of the immune system. Annu. Rev. Immunol. 18, 861-926 (2000).
2. Bowie, A. et al. A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling. Proc. Natl. Acad Sci. USA 97, 10162-10167 (2000).
3. Preston, B.D. & Dougherty, J.P. Mechanisms of retroviral mutation. Trends Microbiol. 4, 16-21 (1996).
4. Hu, W.S. & Temin, H.M. Genetic consequences of packaging two RNA genomes in one retroviral particle: pseudodiploidy and high rate of genetic recombination, Proc. Natl. Acad. Sci. USA 87, 1556-1560 (1990).
5. Domingo, E. & Holland, J.J. RNA virus mutations and fitness for survival. Annu. Rev. Microbiol. 51, 151-178 (1997).
6. Outzen, H.C., Corrow, D. & Shultz, L.D. Attenuation of exogenous murine mammary tumor virus virulence in the C3H/HeJ mouse substrain bearing the Lps mutation. J. Natl. Cancer Inst. 75, 917-923 (1985).
7. Hook, L.M., Agafonova, Y., Ross, S.R., Turner, S.J. & Golovkina, T.V. Genetics of mouse mammary tumor virus-induced mammary tumors: linkage of tumor induction to the gag gene. J. Virol. 74, 8876-8883 (2000).
8. Coffin, J.M. Retroviridae: the viruses and their replication. Fundamental Virology (eds. Fields, B.N., Howley, P.M. & Knipe, D.M.) 763-844 (Raven Press, New York, NY, 1996).
9. MacDonald, H.R. et al. T-cell reactivity and tolerance to Mlsa-encoded antigens. Immunol. Rev. 107, 89-108 (1989).
10. + T cells are required to stimulate B cells after infection with mouse mammary tumor virus. J. Exp. Med. 177, 359-366 (1993).
11. Acha-Orbea, H. & MacDonald, H.R. Superantigens of mouse mammary tumor virus. Annu. Rev. Immunol. 13, 459-486 (1995).
12. Golovkina, T.V., Dudley, J.P. & Ross, S.R. B and T cells are required for mouse mammary tumor virus spread within the mammary gland. J. Immunol. 161, 2375-2382 (1998).
13. Golovkina, T.V., Jaffe, A. & Ross, S.R. Coexpression of exogenous and endogenous mouse mammary tumor virus RNA in vivo results in viral recombination and broadens the virus host range. J. Virol. 68, 5019-5026 (1994).
14. Golovkina, T.V., Dudley, J.P., Jaffe, A.B. & Ross, S.R. Mouse mammary tumor viruses with functional superantigen genes are selected during in vivo infection. Proc. Natl. Acad. Sci. USA 92, 4828-4832 (1995).
15. Marrack, P., Kushnir, E. & Kappler, J. A maternally inherited superantigen encoded by mammary tumor virus. Nature 349, 524-526 (1991).
16. Golovkina, T.V., Chervonsky, A.V., Dudley, J.P. & Ross, S.R. Transgenic mouse mammary tumor virus superantigen expression prevents viral infection. Cell 69, 637-645 (1992).
17. Held, W. et al. Superantigen-induced immune stimulation amplifies mouse mammary tumor virus infection and allows virus transmission. Cell 74, 529-540 (1993).
18. Glode, L.M. & Rosenstreich, D.L. Genetic control of B cell activation by bacterial lipopolysaccharide is mediated by multiple distinct genes or alleles. J. Immunol. 117, 2061-2066 (1976).
19. Vogel, S.N. et al. Cutting edge: functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for a dominant negative mutation. J. Immunol. 162, 5666-5670 (1999)
20. Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085-2088 (1998).
21. Hoshino, K. et al. Cutting edge: toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162, 3749-3752 (1999).
22. Qureshi, S.T. et al. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J. Exp. Med. 189, 615-625 (1999).
23. Pucillo, C., Cepeda, R. & Hodes, R.J. Expression of a MHC class II transgene determines both superantigenicity and susceptibility to mammary tumor virus infection. J. Exp. Med. 178, 1441-1445 (1993).
24. + T cells. Science 248, 1227-1230 (1990).
25. Rassa, J.C., Meyers, J.L., Zhang, Y., Kudaravalli, R. & Ross, S.R. Murine retroviruses activate B cells via interaction with toll-like receptor 4. Proc. Natl. Acad. Sci. USA 99, 2281-2286 (2002).
26. Moore, K.W., de Waal Malefyt, R., Coffman, R.L. & O'Garra, A. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19, 683-765 (2001).
27. Sing, A., Roggenkamp, A., Geiger, A.M. & Heesemann, J. Yersinia enterocolitica evasion of the host innate immune response by V antigen-induced IL-10 production of macrophages is abrogated in IL-10-deficient mice. J. Immunol. 168, 1315-1321 (2002).
28. Eaton, K.A., Mefford, M. & Thevenot, T. The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J. Immunol. 166, 7456-7461 (2001).
29. Akridge, R.E., Oyafuso, L.K. & Reed, S.G. IL-10 is induced during HIV-1 infection and is capable of decreasing viral replication in human macrophages. J. Immunol. 153, 5782-5789 (1994).
30. Fleming, S.B., McCaughan, C.A., Andrews, A.E,, Nash, A.D. & Mercer, A.A. A homolog of interleukin-10 is encoded by the poxvirus orf virus. J. Virol. 71, 4857-4861 (1997).
31. Spencer, J.V. et al. Potent immunosuppressive activities of cytomegalovirus-encoded interleukin-10. J. Virol. 76, 1285-1292 (2002).
32. Sing, A. et al. Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression. J. Exp. Med. 196, 1017-1024 (2002).
33. Beutner, J., Kraus, E., Kitamura, D., Rajewsky, K. & Huber, B.T. B cells are essential for murine mammary tumor virus transmission, but not for presentation of endogenous superantigens. J. Exp. Med. 179, 1457-1466 (1994).
34. Mombaerts, P. et al. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 360, 225-231 (1992).
35. Kitamura, D., Roes, J., Kuhn, R. & Rajewsky, K. A B-cell deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature 350, 423 (1991).
36. Mombaerts, P. et al. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869-877 (1992).
37. + T cells. Science 248, 1227-1230 (1990).
38. Mach N. et al. Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand. Cancer Res. 60, 3239-3246 (2000).