The receptor for heat shock protein 60 on macrophages is saturable, specific, and distinct from receptors for other heat shock proteins

Journal of Immunology

Volumn 168, Issue 2, 2002, Pages 569-576

  Habich, C ^a   Baumgart, K ^a   Kolb, H ^a   Burkart, V ^a  

^a LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; ANTIGEN; CD14 ANTIGEN; GLYCOPROTEIN GP 96; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BINDING SITE; BONE MARROW; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOCYTOSIS; FLOW CYTOMETRY; FLUORESCENCE; HEATING; HUMAN; IMMUNOREGULATION; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STEREOSPECIFICITY;

EID: 0037080218     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.2.569     Document Type: Article

References (34)

1. Chaperone-mediated protein folding
2. Heat-shock proteins as molecular chaperones
3. Molecular chaperones
4. The mitochondrial chaperonin hsp60 is required for its own assembly
5. Immunocytochemical localization of heat-shock protein 60-related protein in β-cell secretory granules and its altered distribution in non-obese diabetic mice
6. Insulitis-caused redistribution of heat-shock protein HSP60 inside β-cells correlates with induction of HSP60 autoantibodies
7. Surface expression by mononuclear phagocytes of an epitope shared with mycobacterial heat shock protein 60
8. Immunoelectron microscopic localization of the 60-kDa heat shock chaperonin protein (Hsp60) in mammalian cells
9. Cell surface localization of the 60 kDa heat shock chaperonin protein (hsp60) in mammalian cells
10. T lymphocytes of rheumatoid arthritis patients show augmented reactivity to a fraction of mycobacteria cross-reactive with cartilage
11. Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65
12. Heat shock proteins and the immune response
13. The 65-kDa heat-shock protein in the pathogenesis, prevention and therapy of autoimmune arthritis and diabetes mellitus in rats and mice
14. Serum soluble heat shock protein 60 is elevated in subjects with atherosclerosis in a general population
15. Induction of heat shock protein in monocytic cells by oxidized low density lipoprotein
16. Do heat shock proteins control the balance of T-cell regulation in inflammatory diseases?
17. Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages
18. Human 60-kDa heat-shock protein: A danger signal to the innate immune system
19. Heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex
20. Endocytosed heat shock protein 60s use TLR2 and TLR4 to activate the Toll/interleukin-1 receptor signaling pathway in innate immune cells
21. Toll-like receptors; their physiological role and signal transduction system
22. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
23. CD91: A receptor for heat shock protein gp96
24. + cells
25. Characterization of a receptor for heat shock protein 70 on macrophages and monocytes
26. CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin
27. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
28. Purification of two forms of colony-stimulating factor from mouse L-cell-conditioned medium
29. Vascular smooth muscle-derived relaxing factor (MDRF) and its close similarity to nitric oxide
30. The physiology of transferrin and transferrin receptors
31. The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells
32. Cutting exige: Receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells
33. HSP70 stimulates cytokine production through a CD14-depefident pathway, demonstrating its dual role as a chaperone and cytokine
34. Heat shock protein (HSP)60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cells