Regulation of lung injury and repair by Toll-like receptors and hyaluronan

Nature Medicine

Volumn 11, Issue 11, 2005, Pages 1173-1179

  Jiang, Dianhua ^a   Liang, Jiurong ^a   Fan, Juan ^a   Yu, Shuang ^a   Chen, Suping ^a   Luo, Yi ^b   Prestwich, Glenn D ^b   Mascarenhas, Marcella M ^c   Garg, Hari G ^c   Quinn, Deborah A ^c   Homer, Robert J ^a   Goldstein, Daniel R ^a   Bucala, Richard ^a   Lee, Patty J ^a   Medzhitov, Ruslan ^a   Noble, Paul W ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; HYALURONIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MIGRATION; CELL SURFACE; CELL SURVIVAL; CYTOKINE PRODUCTION; DEGRADATION; EPITHELIUM CELL; INFLAMMATION; INFLAMMATORY CELL; ISOLATION PROCEDURE; LUNG INJURY; MACROPHAGE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; STIMULATION;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELLS, CULTURED; CHEMOKINES; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; HYALURONIC ACID; LUNG; MACROPHAGES, PERITONEAL; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR WEIGHT; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; WOUND HEALING;

ANIMALIA;

EID: 30744462300     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1315     Document Type: Article

References (40)

1. Teder, P. et al. Resolution of lung inflammation by CD44. Science 296, 155-158 (2002).
2. Fraser, J.R., Laurent, T.C. & Laurent, U.B. Hyaluronan: its nature, distribution, functions and turnover. J. Intern. Med. 242, 27-33 (1997).
3. Aruffo, A., Stamenkovic, I., Melnick, M., Underhill, C.B. & Seed, B. CD44 is the principal cell surface receptor for hyaluronate. Cell 61, 1303-1313 (1990).
4. Termeer, C. et al. Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J. Exp. Med. 195, 99-111 (2002).
5. Taylor, K.R. et al. Hyaluronan fragments stimulate endothelial recognition of injury through TLR4. J. Biol. Chem. 279, 17079-17084 (2004).
6. Jameson, J.M., Cauvi, G., Sharp, L.L., Witherden, D.A. & Havran, W.L. {gamma}{delta} T cell-induced hyaluronan production by epithelial cells regulates inflammation. J. Exp. Med. 201, 1269-1279 (2005).
7. Adamson, I.Y. & Bowden, D.H. The pathogenesis of bloemycin-induced pulmonary fibrosis in mice. Am. J. Pathol. 77, 185-197 (1974).
8. Bozic, C.R. et al. Expression and biologic characterization of the murine chemokine KC. J. Immunol. 154, 6048-6057 (1995).
9. Heeckeren, A. et al. Excessive inflammatory response of cystic fibrosis mice to bronchopulmonary infection with Pseudomonas aeruginosa. J. Clin. Invest. 100, 2810-2815 (1997).
10. Mehrad, B. et al. CXC chemokine receptor-2 ligands are necessary components of neutrophil-mediated host defense in invasive pulmonary aspergillosis. J. Immunol. 163, 6086-6094 (1999).
11. Clark, J.M. & Lambertsen, C.J. Pulmonary oxygen toxicity: a review. Pharmacol. Rev. 23, 37-133 (1971).
12. van Asbeck, B.S. et al. Protection against lethal hyperoxia by tracheal insufflation of erythrocytes: role of red cell glutathione. Science 227, 756-759 (1985).
13. Kawasaki, M. et al. Protection from lethal apoptosis in lipopolysaccharide-induced acute lung injury in mice by a caspase inhibitor. Am. J. Pathol. 157, 597-603 (2000).
14. Kuwano, K. et al. Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor. Am. J. Physiol. Lung Cell. Mol. Physiol. 280, L316-L325 (2001).
15. Mummert, M.E., Mohamadzadeh, M., Mummert, D.I., Mizumoto, N. & Takashima, A. Development of a peptide inhibitor of hyaluronan-mediated leukocyte trafficking. J. Exp. Med. 192, 769-779 (2000).
16. Camenisch, T.D. et al. Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. J. Clin. Invest. 106, 349-360 (2000).
17. Zhu, Z., Ma, B., Homer, R.J., Zheng, T. & Elias, J.A. Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice. J. Biol. Chem. 276, 25222-25229 (2001).
18. Rice, W.R. et al. Maintenance of the mouse type II cell phenotype in vitro. Am. J. Physiol. Lung Cell. Mol. Physiol. 283, L256-L264 (2002).
19. Beg, A.A. & Baltimore, D. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 274, 782-784 (1996).
20. Van Antwerp, D.J., Martin, S.J., Kafri, T., Green, D.R. & Verma, I.M. Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 274, 787-789 (1996).
21. Zhang, X.Y., Shimura, S., Masuda, T., Saitoh, H. & Shirato, K. Antisense oligonucleotides to NF-kappaB improve survival in bleomycin-induced pneumopathy of the mouse. Am. J. Respir. Crit. Care Med. 162, 1561-1568 (2000).
22. Kuwano, K. et al. Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. J. Clin. Invest. 104, 13-19 (1999).
23. Pierce, J.W. et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J. Biol. Chem. 272, 21096-21103 (1997).
24. Dai, Y. et al. Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells. Blood 103, 2761-2770 (2004).
25. Noble, P.W., Lake, F.R., Henson, P.M. & Riches, D.W. Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages. J. Clin. Invest. 91, 2368-2377 (1993).
26. Hodge-Dufour, J. et al. Induction of IL-12 and chemokines by hyaluronan requires adhesion-dependent priming of resident but not elicited macrophages. J. Immunol. 159, 2492-2500 (1997).
27. Albertine, K.H. et al. Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Am. J. Pathol. 161, 1783-1796 (2002).
28. Chapman, H.A. Disorders of lung matrix remodeling. J. Clin. Invest. 113, 148-157 (2004).
29. Armstrong, L. et al. Expression of functional toll-like receptor-2 and -4 on alveolar epithelial cells. Am. J. Respir. Cell Mol. Biol. 31, 241-245 (2004).
30. Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. & Medzhitov, R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118, 229-241 (2004).
31. Luo, Y. & Prestwich, G.D. Synthesis and selective cytotoxicity of a hyaluronic acid-antitumor bioconjugate. Bioconjug. Chem. 10, 755-763 (1999).
32. Mascarenhas, M.M. et al. Low molecular weight hyaluronan from stretched lung enhances interleukin-8 expression. Am. J. Respir. Cell Mol. Biol. 30, 51-60 (2004).
33. Kawai, T., Adachi, O., Ogawa, T., Takeda, K. & Akira, S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11, 115-122 (1999).
34. Takeuchi, O. et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11, 443-451 (1999).
35. Takeuchi, O. et al. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 169, 10-14 (2002).
36. Alexopoulou, L., Holt, A.C., Medzhitov, R. & Flavell, R.A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413, 732-738 (2001).
37. Hayashi, F. et al. The innate immune response to bacterial flagell in is mediated by Toll-like receptor 5. Nature 410, 1099-1103 (2001).
38. Hemmi, H. et al. A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745 (2000).
39. Horton, M.R., Burdick, M.D., Strieter, R.M., Bao, C. & Noble, P.W. Regulation of hyaluronan-induced chemokine gene expression by IL-10 and IFN-gamma in mouse macrophages. J. Immunol. 160, 3023-3030 (1998).
40. Noble, P.W., McKee, C.M., Cowman, M. & Shin, H.S. Hyaluronan fragments activate an NF-kappa B/I-kappa B alpha autoregulatory loop in murine macrophages. J. Exp. Med. 183, 2373-2378 (1996).