Triggering the interferon antiviral response through an IKK-related pathway

Science

Volumn 300, Issue 5622, 2003, Pages 1148-1151

  Sharma, Sonia ^a   TenOever, Benjamin R ^a   Grandvaux, Nathalie ^a   Zhou, Guo Ping ^a   Lin, Rongtuan ^a,b   Hiscott, John ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; COMPOSITION; INTERFERONS;

ANTIVIRAL RESPONSE;

VIRUSES;

I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 7; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR;

RESPONSE ANALYSIS; VIRAL DISEASE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; HUMAN; HUMAN CELL; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; VIRUS INFECTION;

CELL LINE; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, VIRAL; HEPACIVIRUS; HUMANS; I-KAPPA B KINASE; INTERFERON REGULATORY FACTOR-3; INTERFERON REGULATORY FACTOR-7; INTERFERON TYPE I; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0038363463     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1081315     Document Type: Article

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26. The authors thank G. Sen (Cleveland), J. Bell (Ottawa), and I. Julkunen (Helsinki) for reagents, and S. Richard and members of the Molecular Oncology Group, Lady Davis Institute, McGill University. Supported by grants from the Canadian Institutes of Health Research (CIHR), the National Cancer Institute of Canada, with funds from the Canadian Cancer Society and the Canadian Network for Vaccines and Immunotherapeutics. S.S. was supported by a CIHR studentship, B.R.tO. by a National Science and Engineering Research Council studentship, N.G. by a Fonds de ia Recherche en Santé du Quebec (FRSQ) postdoctoral fellowship, R.L. by an FRSQ Chercheur Boursier, and J.H. by a CIHR Senior Scientist award.