The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Nature

Volumn 410, Issue 6832, 2001, Pages 1099-1103

  Hayashi, Fumitaka ^a   Smith, Kelly D ^a   Ozinsky, Adrian ^b   Hawn, Thomas R ^b,c   Yi, Eugene C ^b   Goodlett, David R ^b   Eng, Jimmy K ^b   Akira, Shizuo ^d   Underhill, David M ^b   Aderem, Alan ^b  

^a Department of Immunology ^*

^b INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CELL CULTURE; CYTOLOGY; GENES; PATHOLOGY; PROTEINS; TUMORS;

PATHOGENS;

IMMUNOLOGY;

ADAPTOR PROTEIN; COMPLEMENTARY DNA; FLAGELLIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 5; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CHO CELL; CYTOKINE PRODUCTION; ESCHERICHIA COLI; FLAGELLUM; GENE DELETION; GRAM NEGATIVE BACTERIUM; IMMUNE RESPONSE; LISTERIA MONOCYTOGENES; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN FAMILY; RECEPTOR INTRINSIC ACTIVITY; SEQUENCE ANALYSIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, DIFFERENTIATION; CHO CELLS; CRICETINAE; DROSOPHILA PROTEINS; ESCHERICHIA COLI; FLAGELLIN; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; IMMUNITY, NATURAL; LISTERIA MONOCYTOGENES; MEMBRANE GLYCOPROTEINS; MICE; MOLECULAR SEQUENCE DATA; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RECOMBINANT FUSION PROTEINS; TOLL-LIKE RECEPTOR 5; TOLL-LIKE RECEPTORS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; LISTERIA MONOCYTOGENES; MAMMALIA; NEGIBACTERIA; POSIBACTERIA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0035953543     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35074106     Document Type: Article

References (30)

1. Toll-like receptors in the induction of the innate immune response
2. Toll-like receptors: Molecular mechanisms of the mammalian immune response
3. Innate immune recognition: Mechanisms and pathways
4. The biology of Toll-like receptors
5. In vitro induction of cecropin genes - An immune response in a Drosophila blood cell line
6. FLS2: An LRR receptor-like kinase involved in the perception of file bacterial elicitor flagellin, in Arabidopsis
7. Potent immunoregulatory effects of Salmonella typhi flagella on antigenic stimulation of human peripheral blood mononuclear cells
8. Salmonella typhi flagella are potent inducers of proinflammatory cytokine secretion by human monocytes
9. Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells
10. High-affinity interaction between gram-negative flagellin and a cell surface polypeptide results in human monocyte activation
11. Induction of cytokine synthesis by flagella from gram-negative bacteria may be dependent on the activation or differentiation state of human monocytes
12. MyD88 is an adaptor protein in the hToll/IL- 1 receptor family signaling pathways
13. A family of human receptors structurally related to Drosophila Toll
14. Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: Evidence for a multi-gene receptor family in humans
15. Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: Sequence and mRNA expression studies in Salmonella- susceptible MOLF/Ei mice
16. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: Selective expression of TLR3 in dendritic cells
17. Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
18. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
19. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
20. An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database
21. Temperature-dependent expression of flagella of Listeria monocytogenes studied by electron microscopy, SDS-PAGE and western blotting
22. Studies on H-O variants in Salmonella in relation to phase variation
23. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
24. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
25. Salmonella flagellin fused with a linear epitope of colonization factor antigen I (CFA/I) can prime antibody responses against homologous and heterologous fimbriae of enterotoxigenic Escherichia coli
26. Immune responses to epitopes inserted in Salmonella flagellin
27. Locations of terminal segments of flagellin in the filament structure and their roles in polymerization and polymorphism
28. Method for the isolation of highly purified Salmonella flagellins
29. Protein identification, with a single accurate mass of a cysteine-containing peptide and constrained database searching
30. Targeted disruption of the MyD88 gene results in loss of IL-l- and IL-18-mediated function