Essential role of mda-5 in type I IFN responses to polyriboinosinic: polyribocytidylic acid and encephalomyocarditis picornavirus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 22, 2006, Pages 8459-8464

  Gitlin, Leonid ^a   Barchet, Winfried ^a   Gilfillan, Susan ^a   Cella, Marina ^a   Beutler, Bruce ^b   Flavell, Richard A ^c   Diamond, Michael S ^a   Colonna, Marco ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Innate immunity; Virus

Indexed keywords

DOUBLE STRANDED RNA; GENE PRODUCT; HELICASE; INTERFERON; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN MDA 5; RETINOIC ACID; RETINOIC ACID INDUCED PROTEIN 1; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG; VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL PATHWAY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENCEPHALOMYOCARDITIS VIRUS; ENDOSOME; GENE FUNCTION; HOST RESISTANCE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA ANALYSIS; VIRUS DETECTION; VIRUS INFECTION; VIRUS PATHOGENESIS; VIRUS REPLICATION;

ANIMALS; BONE MARROW CELLS; CARDIOVIRUS INFECTIONS; CELL DIFFERENTIATION; CELLS, CULTURED; DEAD-BOX RNA HELICASES; DENDRITIC CELLS; DISEASE SUSCEPTIBILITY; ENCEPHALOMYOCARDITIS VIRUS; INTERFERON TYPE I; MACROPHAGES; MICE; MICE, KNOCKOUT; POLYNUCLEOTIDES; RNA HELICASES; SURVIVAL RATE;

PICORNAVIRIDAE; RNA VIRUSES;

EID: 33744791510     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0603082103     Document Type: Article

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