A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease

Journal of Experimental Medicine

Volumn 198, Issue 10, 2003, Pages 1563-1572

  Hawn, Thomas R ^a,b   Verbon, Annelies ^c,d   Lettinga, Kamilla D ^c   Zhao, Lue Ping ^e,f   Li, Shuying Sue ^e   Laws, Richard J ^e   Skerrett, Shawn J ^a   Beutler, Bruce ^g   Schroeder, Lea ^b   Nachman, Alex ^b   Ozinsky, Adrian ^b   Smith, Kelly D ^a,b   Aderem, Alan ^b  

^a UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^b INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^e USA   (United States)

^f Enodar Biologic Corporation   (United States)

^g SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Bacterial infections; Genetic markers; Genetic predisposition to disease; Immunity; Inflammation

Indexed keywords

CYTOKINE; FLAGELLIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 5; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHINESE HAMSTER; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; EMBRYO; FIBROBLAST; FLAGELLATE; GENETIC PREDISPOSITION; HUMAN; HUMAN CELL; KIDNEY CELL; LEGIONELLA PNEUMOPHILA; LEGIONNAIRE DISEASE; LIGAND BINDING; LUNG ADENOCARCINOMA; LUNG ALVEOLUS EPITHELIUM; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; STOP CODON;

CODON, TERMINATOR; FLAGELLIN; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LEGIONNAIRES' DISEASE; MEMBRANE GLYCOPROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 5; TOLL-LIKE RECEPTORS;

EID: 10744226016     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20031220     Document Type: Article

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