Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

Nature Immunology

Volumn 1, Issue 5, 2000, Pages 398-401

  Kurt Jones, Evelyn A ^a,b   Popova, Lana ^b   Kwinn, Laura ^b   Haynes, Lia M ^c   Jones, Les P ^c   Tripp, Ralph A ^c   Walsh, Edward E ^d   Freeman, Mason W ^e   Golenbock, Douglas T ^f   Anderson, Larry J ^c   Finberg, Robert W ^a,b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^d UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; CD14 ANTIGEN; CELL SURFACE RECEPTOR; CYTOKINE; DROSOPHILA PROTEIN; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; TLR4 PROTEIN, HUMAN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; VIRUS FUSION PROTEIN;

ANIMAL; ARTICLE; BIOSYNTHESIS; GENETICS; HUMAN; IMMUNOLOGY; IN VITRO STUDY; LUNG; METABOLISM; MONONUCLEAR CELL; MOUSE; MOUSE MUTANT; PATHOGENICITY; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; VIROLOGY; VIRUS INFECTION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD14; CYTOKINES; DROSOPHILA PROTEINS; HUMANS; INFLAMMATION MEDIATORS; LEUKOCYTES, MONONUCLEAR; LUNG; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; RECEPTORS, CELL SURFACE; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; VIRAL FUSION PROTEINS;

EID: 5944261457     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/80833     Document Type: Article

References (41)

1. Ulevitch, R. J. Recognition of bacterial endotoxins by receptor-dependent mechanisms. Adv. Immunol. 53, 267-289 (1993).
2. Wright, S. D., Ramos, R. A., Tobias, P. S., Ulevitch, R. J. & Mathison, J. C. CD14, a receptor for complexes of lipopotysaccharide (LPS) and LPS binding protein. Science 249, 1431-1433 (1990).
3. Pugin, J. et al. CD14 is a pattern recognition receptor. Immunity 1, 509-516 (1994).
4. Savedra, R., Jr. Delude, R. L., Ingalls, R. R., Fenton, M. J. & Golenbock, D. T. Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endotoxin signaling system. J. Immunol. 157, 2549-2554 (1996).
5. Chow, J. C., Young, D.W., Golenbock, D.T., Christ, W. J. & Gusovsky, F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J. Biol. Chem. 274, 10689-10692 (1999).
6. Shimazu, R. et al. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med 189, 1777-1782 (1999).
7. Yang, R. -B. et al. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 395, 284-288 (1998).
8. Kirschning, C. J., Wesche, H., Merrill Ayres, T. & Rothe, M. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J. Exp. Med. 188, 2091-2097 (1998).
9. Heine, H. et al. Cutting edge: cells that carry a null allele for Toll-like receptor 2 are capable of responding to endotoxin. J. Immunol. 162, 6971-6975 (1999).
10. Yoshimura, A. et al. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol. 163, 1-5 (1999).
11. Means, T. K. et al. The CD 14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for toll-like receptors. J. Immunol. 163, 6748-4755 (1999).
12. Means, T. K. et al. Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J. Immunol. 163, 3920-3927 (1999).
13. Schwandner, R., Dziarski, R., Wesche, H., Rothe, M. & Kirschning, C. J. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J. Biol. Chem. 274, 17406-17409 (1999).
14. Hirschfeld, M. et al. Cutting edge: inflammatory signaling by borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J. Immunol. 163, 2382-2386 (1999).
15. Lien, E. et at Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J. Biol. Chem. 274, 33419-33425 (1999).
16. Brightbill, H. D. et at Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285, 732-736 (1999).
17. Aliprantis, A. O. et al. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285, 736-739 (1999).
18. Heilman, C. A. From the National Institute of Allergy and Infectious Diseases and the World Health Organization. Respiratory syncytial and parainfluenza viruses. J. Infect. Dis. 161, 402-406 (1990).
19. Hall, C. B. et al. Respiratory syncytial viral infection in children with compromised immune function. N. Engl. J. Med 315, 77-81 (1986).
20. Alwan, W. H., Kozlowska, W. J. & Openshaw, P. J. Distinct types of lung disease caused by functional subsets of antiviral T cells. J. Exp. Med. 179, 81-89 (1994).
21. Prince, G. A. et al. Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactiva ted virus. J. Virol. 57, 721-728 (1986).
22. Waris, M. E., Tsou, C., Erdman, D. D., Day, D. B. & Anderson, L. J. Priming with live respiratory syncytial virus (RSV) prevents the enhanced pulmonary inflammatory response seen after RSV challenge in BALB/c mice immunized with formalin-inactivated RSV. J. Virol. 71, 6935-6939 (1997).
23. Graham, B. S. et al. Priming immunization determines T helper cytokine mRNA expression patterns in lungs of mice challenged with respiratory syncytial virus. J. Immunol. 151, 2032-2040 (1993).
24. Anderson, L. J. & Heilman, C. A. Protective and disease-enhancing immune responses to respiratory syncytial virus. J. Infect. Dis. 171, 1-7 (1995).
25. Cavaillon, J. M. & Haeffner-Cavaillon, N. Polymyxin-B inhibition of LPS-induced interleukin-1 secretion by human monocytes is dependent upon the LPS origin. Mol. Immunol. 23, 965-969 (1986).
26. Poltorak, A. et al. Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene. Science 282, 2085-2088 (1998).
27. Hoshino, K. et al. Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product. J. Immunol. 162, 3749-3752 (1999).
28. Qureshi, S. T. et al. Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4). J. Exp. Med. 189, 615-625 (1999).
29. Haynes, L. M. et al. Involvement of Toll-like Receptor-4 in Innate Immunity to Respiratory Syncytial Virus. J. Immunol. (submitted, 2000).
30. Rock, F. L., Hardiman, G., Timans, J. C., Kastelein, R. A. & Bazan, J. F. A family of human receptors structurally related to Drosophila Toll. Proc. Natl Acad. Sci. USA 95, 588-593 (1998).
31. Medzhitov, R., Preston-Hurlburt, P. & Janeway, C. A., Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388, 394-397 (1997).
32. Chaudhary, P. M. et al. Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. Blood 91, 4020-4027 (1998).'
33. Belvin, M. P. & Anderson, K. V. A conserved signaling pathway: the Drosophila toll-dorsal pathway. Ann. Rev. Cell Dev. Biol. 12, 393-416 (1996).
34. Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J. M. & Hoffmann, J. A. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86, 973-983 (1996).
35. Meister, M., Lemaitre, B. & Hoffmann, J. A. Antimicrobial peptide defense in Drosophila. Bioessoys 19, 1019-1026 (1997).
36. Williams, M. J., Rodriguez, A., Kimbrell, D. A.& Eldon, E. D. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. EMBO J. 16, 6120-6130 (1997).
37. Takeuchi, O. et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11, 443-451 (1999).
38. Solomon, K. R. et al. Heterotrimeric G proteins physically associated with the lipopolysaccharide receptor CD14 modulate both In vivo and In vitro responses to lipopolysaccharide. J. Clin. Invest. 102, 2019-2027 (1998).
39. Walsh, E. E., Brandriss, M. W. & Schlesinger, J. J. Purification and characterization of the respiratory syncytial virus fusion protein. J. Gen. Virol. 66, 409-415 (1985).
40. Graham, B. S., Perkins, M. D., Wright, P. F. & Karzon, D. T. Primary respiratory syncytial virus infection in mice. J. Med. Virol. 26, 153-162 (1988).
41. Tripp, R. A., Jones, L., Anderson, L. J. & Brown, M. P. CD40 Ligand (CD154) Enhances the Th1 and Antibody Responses to Respiratory Syncytial Virus in the BALB/c Mouse. J. Immunol. 164, 5913-5921 (2000).