Immunology: Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function

Science

Volumn 309, Issue 5739, 2005, Pages 1380-1384

  Peng, Gyangyong ^a   Guo, Zhong ^a   Kiniwa, Yukiko ^a   Voo, Kui Shin ^a   Peng, Weiyi ^a   Fu, Tihui ^a   Wang, Daniel Y ^a   Li, Yanchun ^a   Wang, Helen Y ^a   Wang, Rong Fu ^a  

^a CENTER FOR CELL AND GENE THERAPY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; PROTEINS; TUMORS;

ANTITUMOR IMMUNITY; IMMUNE RESPONSES; TOLL-LIKE RECEPTORS (TLR); TREG CELLS;

IMMUNOLOGY;

ALPHA INTERFERON; CD4 ANTIGEN; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; INTERLEUKIN RECEPTOR ASSOCIATED KINASE 4; LIGAND; LIPID; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; NUCLEOSIDE; OLIGONUCLEOTIDE; PHOSPHOROTHIOIC ACID; PHOSPHOTRANSFERASE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 8; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; CPG OLIGONUCLEOTIDE; CPG-OLIGONUCLEOTIDE; DIFFERENTIATION ANTIGEN; IMMUNOGLOBULIN RECEPTOR; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; IRAK4 PROTEIN, HUMAN; IRAK4 PROTEIN, MOUSE; MEMBRANE PROTEIN; MYD88 PROTEIN, HUMAN; MYD88 PROTEIN, MOUSE; OLIGODEOXYRIBONUCLEOTIDE; POLYGUANYLIC ACID; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TLR8 PROTEIN, HUMAN;

IMMUNE RESPONSE;

ADOPTIVE TRANSFER; ARTICLE; CANCER INHIBITION; CYTOKINE RELEASE; DENDRITIC CELL; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; IMMUNE RESPONSE; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TUMOR IMMUNITY; ANIMAL; CANCER TRANSPLANTATION; CD4+ T LYMPHOCYTE; CELL LINE; EXPERIMENTAL NEOPLASM; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MOUSE; NATURAL KILLER CELL; PATHOLOGY; PHYSIOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, DIFFERENTIATION; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CELL LINE, TUMOR; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; KILLER CELLS, NATURAL; LIGANDS; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MYELOID DIFFERENTIATION FACTOR 88; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; OLIGODEOXYRIBONUCLEOTIDES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); POLY G; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RNA INTERFERENCE; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; TOLL-LIKE RECEPTOR 8; TOLL-LIKE RECEPTORS;

EID: 23944509107     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1113401     Document Type: Article

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27. We thank D. Golenbock for the gift of MyD88 and TLR9 cDNAs, L. Old and E. M. Shevach for discussion, M. Cubbage and C. Threeton for their assistance in FACS sorting, J. Gilbert for his assistance in the preparation of this manuscript, and anonymous reviewers for useful comments on the manuscript. Supported by grants from NIH (nos. R01CA90327, R01CA101795, P50CA58204, P50CA093459, and PO1CA94237) and from the Cancer Research Institute.