The immunobiology of the TLR9 subfamily

Trends in Immunology

Volumn 25, Issue 7, 2004, Pages 381-386

  Wagner, Hermann ^a  

^a Inst Med Microbiol Immunol Hyg   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; IMIQUIMOD; LOXORIBINE; NUCLEIC ACID; QUINOLINE; QUINOLINE DERIVATIVE; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 9; VACCINE;

ANTIGEN PRESENTING CELL; CELL ACTIVATION; DENDRITIC CELL; ENDOSOME; HELPER CELL; IMMUNOBIOLOGY; MOLECULE; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN MOTIF; REVIEW;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, DIFFERENTIATION; AUTOIMMUNE DISEASES; DENDRITIC CELLS; DNA-BINDING PROTEINS; ENDOSOMES; HUMANS; IMMUNITY, NATURAL; MEMBRANE GLYCOPROTEINS; MICE; MYELOID DIFFERENTIATION FACTOR 88; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 9; TOLL-LIKE RECEPTORS;

EID: 2942679083     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2004.04.011     Document Type: Review

References (72)

1. Janeway C.A. Jr, Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 20:2002;197-216
2. Agrawal A., et al. Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system. Nature. 394:1998;744-751
3. Hoffmann J.A., et al. Phylogenetic perspectives in innate immunity. Science. 284:1999;1313-1318
4. Takeda K., et al. Toll-like receptors. Annu. Rev. Immunol. 21:2003;335-376
5. Hoffmann J.A., Reichhart J.M. Drosophila innate immunity: an evolutionary perspective. Nat. Immunol. 3:2002;121-126
6. Fearon D.T., Locksley R.M. The instructive role of innate immunity in the acquired immune response. Science. 272:1996;50-53
7. Belvin M.P., Anderson K.V. A conserved signaling pathway: the Drosophila Toll-dorsal pathway. Annu. Rev. Cell Dev. Biol. 12:1996;393-416
8. St Johnston D., Nusslein-Volhard C. The origin of pattern and polarity in the Drosophila embryo. Cell. 68:1992;201-219
9. Lemaitre B., et al. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 86:1996;973-983
10. Medzhitov R., et al. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 388:1997;394-397
11. Poltorak A., et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 282:1998;2085-2088
12. Rock F.L., et al. A family of human receptors structurally related to Drosophila Toll. Proc. Natl. Acad. Sci. U. S. A. 95:1998;588-593
13. Chuang T.H., Ulevitch R.J. Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur. Cytokine Netw. 11:2000;372-378
14. Beutler B., Rehli M. Evolution of the TIR, Tolls and TLRs: functional inferences from computational biology. Curr. Top. Microbiol. Immunol. 270:2002;1-21
15. Underhill D.M., et al. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature. 401:1999;811-815
16. Hayashi F., et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 410:2001;1099-1103
17. Smith K.D., et al. Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility. Nat. Immunol. 4:2003;1247-1253
18. Kawasaki K., et al. Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol. J. Biol. Chem. 275:2000;2251-2254
19. Kurt-Jones E.A., et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat. Immunol. 1:2000;398-401
20. Vabulas R.M., et al. Heat shock proteins as ligands of Toll-like receptors. Curr. Top. Microbiol. Immunol. 270:2002;169-184
21. Tokunaga T., et al. How BCG led to the discovery of immunostimulatory DNA. Jpn. J. Infect. Dis. 52:1999;1-11
22. Krieg A.M. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20:2002;709-760
23. Stacey K.J., et al. Macrophages ingest and are activated by bacterial DNA. J. Immunol. 157:1996;2116-2122
24. Sparwasser T., et al. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-α-mediated shock. Eur. J. Immunol. 27:1997;1671-1679
25. Sparwasser T., et al. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 28:1998;2045-2054
26. Klinman D.M., et al. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ Proc. Natl. Acad. Sci. U. S. A. 93:1996;2879-2883
27. Lipford G.B., et al. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur. J. Immunol. 27:1997;2340-2344
28. Wagner H. Bacterial CpG DNA activates immune cells to signal infectious danger. Adv. Immunol. 73:1999;329-368
29. Hacker H., et al. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 17:1998;6230-6240
30. Hacker H., et al. Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J. Exp. Med. 192:2000;595-600
31. Hemmi H., et al. A Toll-like receptor recognizes bacterial DNA. Nature. 408:2000;740-745
32. Bauer S., et al. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. U. S. A. 98:2001;9237-9242
33. Hajjar A.M., et al. Human Toll-like receptor 4 recognizes host-specific LPS modifications. Nat. Immunol. 3:2002;354-359
34. Ahmad-Nejad P., et al. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. 32:2002;1958-1968
35. Jurk M., et al. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat. Immunol. 3:2002;499
36. Heil F., et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur. J. Immunol. 33:2003;2987-2997
37. Lee J., et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc. Natl. Acad. Sci. U. S. A. 100:2003;6646-6651
38. Hornef M.W., et al. Intracellular recognition of lipopolysaccharide by Toll-like receptor 4 in intestinal epithelial cells. J. Exp. Med. 198:2003;1225-1235
39. Hornung V., et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 168:2002;4531-4537
40. + dendritic cells. J. Immunol. 166:2001;5000-5007
41. Kadowaki N., et al. Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens. J. Exp. Med. 194:2001;863-869
42. Cella M., et al. Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization. Nat. Immunol. 1:2000;305-310
43. Krug A., et al. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur. J. Immunol. 31:2001;3026-3037
44. Verthelyi D., et al. Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. J. Immunol. 166:2001;2372-2377
45. Tough D.F., et al. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science. 272:1996;1947-1950
46. + T-cell responses in vitro. Blood (in press).
47. Zheng M., et al. DNA containing CpG motifs induces angiogenesis. Proc. Natl. Acad. Sci. U. S. A. 99:2002;8944-8949
48. Krug, A., et al. Herpes simplex virus type 1 (HSV-1) activates murine natural interferon-producing cells (IPC) through Toll-like receptor 9. Blood (in press).
49. Lund J., et al. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198:2003;513-520
50. Latz E., et al. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat. Immunol. 5:2004;190-198
51. Heil F., et al. Species specific recognition of single stranded RNA via Toll-like receptor 7 and 8. Science. 303:2004;1526-1529
52. Scheel B., et al. Immunostimulating capacities of stabilized RNA molecules. Eur. J. Immunol. 34:2004;537-547
53. Diebold S.S., et al. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science. 303:2004;1529-1531
54. Nishiya, T. and DeFranco, A.L. Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the toll-like receptors. J. Biol. Chem. (in press).
55. Guermonprez P., et al. ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells. Nature. 425:2003;397-402
56. Yamamoto M., et al. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature. 420:2002;324-329
57. Yamamoto M., et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 301:2003;640-643
58. Hoebe K., et al. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat. Immunol. 4:2003;1223-1229
59. Horng T., et al. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature. 420:2002;329-333
60. Hoebe K., et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature. 424:2003;743-748
61. Schwarz K., et al. Role of Toll-like receptors in costimulating cytotoxic T cell responses. Eur. J. Immunol. 33:2003;1465-1470
62. Tighe H., et al. Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity. Eur. J. Immunol. 30:2000;1939-1947
63. Maurer T., et al. CpG-DNA aided cross-presentation of soluble antigens by dendritic cells. Eur. J. Immunol. 32:2002;2356-2364
64. Heit A., et al. Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cells. J. Immunol. 170:2003;2802-2805
65. Heit A., et al. CpG-DNA aided cross-priming by cross-presenting B cells. J. Immunol. 172:2004;1501-1507
66. Leadbetter E.A., et al. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature. 416:2002;603-607
67. Viglianti G.A., et al. Activation of autoreactive B cells by CpG dsDNA. Immunity. 19:2003;837-847
68. Fukao T., Koyasu S. PI3K and negative regulation of TLR signaling. Trends Immunol. 24:2003;358-363
69. Veillette A., et al. Negative regulation of immunoreceptor signaling. Annu. Rev. Immunol. 20:2002;669-707
70. Kinjyo I., et al. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity. 17:2002;583-591
71. Kobayashi K., et al. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell. 110:2002;191-202
72. Vabulas R.M., et al. CpG-DNA activates in vivo T cell epitope presenting dendritic cells to trigger protective antiviral cytotoxic T cell responses. J. Immunol. 164:2000;2372-2378