Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Nature

Volumn 441, Issue 1, 2006, Pages 101-105

  Kato, Hiroki ^a,b   Takeuchi, Osamu ^a,b   Sato, Shintaro ^b   Yoneyama, Mitsutoshi ^c   Yamamoto, Masahiro ^a   Matsui, Kosuke ^a   Uematsu, Satoshi ^a   Jung, Andreas ^a   Kawai, Taro ^b   Ishii, Ken J ^b   Yamaguchi, Osamu ^d   Otsu, Kinya ^d   Tsujimura, Tohru ^e   Koh, Chang Sung ^f   Reis E Sousa, Caetano ^g   Matsuura, Yoshiharu ^a   Fujita, Takashi ^c   Akira, Shizuo ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e HYOGO COLLEGE OF MEDICINE   (Japan)

^f SHINSHU UNIVERSITY   (Japan)

^g THE FRANCIS CRICK INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; RNA; VIRUSES; BIODIVERSITY; GENES; IMMUNOLOGY; INTERFERONS; MICROORGANISMS; NATURAL RESOURCES; PROTEINS;

CYTOPLASMIC HELICASE PROTEINS; INFLUENZA VIRUS; PICORNAVIRUS; RNA VIRUSES; DSRNA DETECTORS; VIRAL INFECTION;

ENZYMES; RNA;

CYTOPLASM PROTEIN; DOUBLE STRANDED RNA; HELICASE; MELANOMA DIFFERENTIATION ASSOCIATED GENE 5; POLYINOSINIC POLYCYTIDYLIC ACID; RETINOIC ACID INDUCIBLE PROTEIN RIG I; UNCLASSIFIED DRUG; VIRUS RNA; DDX58 PROTEIN, MOUSE; DEAD BOX PROTEIN; IFIH1PROTEIN, MOUSE; RNA HELICASE; INTERFERON; MELANOMA DIFFERENTIATION ASSOCIATED GENE 5 PROTEIN; PROTEIN; RETINOIC ACID INDUCIBLE PROTEIN 1;

ENCEPHALITIS; IMMUNE SYSTEM; INFLUENZA; PROTEIN; RNA; RODENT; VIRUS; ENZYME ACTIVITY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; GENE; IMMUNE RESPONSE; INFECTION SENSITIVITY; MDA5 GENE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RIG I GENE; RNA VIRUS; VIRUS DETECTION; VIRUS INFECTION; VIRUS RESISTANCE; ANIMAL; CLASSIFICATION; ENCEPHALOMYOCARDITIS VIRUS; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; JAPANESE ENCEPHALITIS VIRUS; METABOLISM; EMBRYO; FEMALE; IN VITRO STUDY; INFLUENZA VIRUS; MALE; PARAMYXOVIRUS; PICORNAVIRUS;

JAPANESE ENCEPHALITIS VIRUS; ORTHOMYXOVIRIDAE; PICORNAVIRIDAE; RNA VIRUSES;

ANIMALS; DEAD-BOX RNA HELICASES; ENCEPHALITIS VIRUS, JAPANESE; ENCEPHALOMYOCARDITIS VIRUS; IMMUNITY, NATURAL; MICE; RNA HELICASES; RNA VIRUSES; RNA, DOUBLE-STRANDED; RNA, VIRAL;

EID: 33646342149     PISSN: 00280836     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/nature04734     Document Type: Article

References (28)

1. Akira, S., Uematsu, S. & Takeuchi, O. Pathogen recognition and innate immunity. Cell 124, 783-801 (2006).
2. Katze, M. G., He, Y. & Gale, M. Jr. Viruses and interferon: A fight for supremacy. Nature Rev. Immunol. 2, 675-687 (2002).
3. Yoneyama, M. et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nature Immunol. 5, 730-737 (2004).
4. Kang, D. C. et al. mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. Proc. Natl Acad. Sci. USA 99, 637-642 (2002).
5. Andrejeva, J. et al. The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-β promoter. Proc. Natl Acad. Sci. USA 101, 17264-17269 (2004).
6. Yoneyama, M. et al. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J. Immunol. 175, 2851-2858 (2005).
7. Rothenfusser, S. et al. The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J. Immunol. 175, 5260-5268 (2005).
8. Kato, H. et al. Cell type-specific involvement of RIG-I in antiviral response. Immunity 23, 19-28 (2005).
9. Iwasaki, A. & Medzhitov, R. Toll-like receptor control of the adaptive immune responses. Nature Immunol. 5, 987-995 (2004).
10. Beutler, B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 430, 257-263 (2004).
11. Alexopoulou, L., Holt, A. C., Medzhitov, R. & Flavell, R. A. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413, 732-738 (2001).
12. Yamamoto, M. et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301, 640-643 (2003).
13. Kovacsovics, M. et al. Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation. Curr. Biol. 12, 838-843 (2002).
14. Kawai, T. et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nature Immunol. 6, 981-988 (2005).
15. Seth, R. B., Sun, L., Ea, C. K. & Chen, Z. J. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF 3. Cell 122, 669-682 (2005).
16. Xu, L. G. et al. VISA is an adapter protein required for virus-triggered IFN-β signaling. Mol. Cell 19, 727-740 (2005).
17. Meylan, E. et al. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437, 1167-1172 (2005).
18. Fitzgerald, K. A. et al. IKKε and TBK1 are essential components of the IRF3 signaling pathway. Nature Immunol. 4, 491-496 (2003).
19. Sharma, S. et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 300, 1148-1151 (2003).
20. Hemmi, H. et al. The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J. Exp. Med. 199, 1641-1650 (2004).
21. Sato, M. et al. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-α/β gene induction. Immunity 13, 539-548 (2000).
22. Honda, K. et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434, 772-777 (2005).
23. Chang, T. H., Liao, C. L. & Lin, Y. L. Flavivirus induces interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-κB activation. Microbes Infect. 8, 157-171 (2006).
24. Melchjorsen, J. et al. Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner. J. Virol. 79, 12944-12951 (2005).
25. Hoshino, K., Kaisho, T., Iwabe, T., Takeuchi, O. & Akira, S. Differential involvement of IFN-β in Toll-like receptor-stimulated dendritic cell activation. Int. Immunol. 14, 1225-1231 (2002).
26. Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S. & Reis e Sousa, C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303, 1529-1531 (2004).
27. Mori, Y. et al. Nuclear localization of Japanese encephalitis virus core protein enhances viral replication. J. Virol. 79, 3448-3458 (2005).
28. Kato, A. et al. Characterization of the amino acid residues of sendai virus C protein that are critically involved in its interferon antagonism and RNA synthesis down-regulation. J. Virol. 78, 7443-7454 (2004).