Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

Nature

Volumn 434, Issue 7030, 2005, Pages 243-249

  Takaoka, Akinori ^a   Yanai, Hideyuki ^a   Kondo, Seiji ^b   Duncan, Gordon ^b   Negishi, Hideo ^a   Mizutani, Tatsuaki ^a   Kano, Shin Ichi ^a   Honda, Kenya ^a   Ohba, Yusuke ^a,c   Mak, Tak W ^b,c   Taniguchi, Tadatsugu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TORONTO   (Canada)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; IMMUNOLOGY; POLYSACCHARIDES; PROTEINS; TUMORS;

CYTOKINES; GENE INDUCTION; THERAPEUCTIC INTERVENTION; TOLL-LIKE RECEPTORS (TLR);

GENES;

ALPHA INTERFERON; DNA; INTERLEUKIN 12; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR IRF 5; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; CYTOKINE; DIFFERENTIATION ANTIGEN; IMMUNOGLOBULIN RECEPTOR; INTERFERON REGULATORY FACTOR; IRF5 PROTEIN, MOUSE; MEMBRANE PROTEIN; MESSENGER RNA; MYD88 PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

MEDICINE;

ANIMAL CELL; ARTICLE; GENE INDUCTION; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; HEMATOPOIETIC CELL; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN INDUCTION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; GENE DELETION; GENETICS; INFLAMMATION; METABOLISM; PROMOTER REGION; SEPTIC SHOCK; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, DIFFERENTIATION; CYTOKINES; GENE DELETION; INFLAMMATION; INTERFERON REGULATORY FACTORS; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MICE; MYELOID DIFFERENTIATION FACTOR 88; PROMOTER REGIONS (GENETICS); RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RNA, MESSENGER; SHOCK, SEPTIC; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6; TOLL-LIKE RECEPTORS; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 15044345461     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03308     Document Type: Article

References (30)

1. Medzhitov, R. Toll-like receptors and innate immunity. Nature Rev. Immunol. 1, 135-145 (2001).
2. O'Neill, L. A., Fitzgerald, K. A. & Bowie, A. G. The Toll-IL-1 receptor adaptor family grows to five members. Trends Immunol. 24, 286-290 (2003).
3. Akira, S. & Takeda, K. Toll-like receptor signalling. Nature Rev. Immunol. 4, 499-511 (2004).
4. Medzhitov, R. et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 2, 253-258 (1998).
5. Taniguchi, T., Ogasawara, K., Takaoka, A. & Tanaka, N. IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol. 19, 623-655 (2001).
6. Levy, D. E., Marie, I. & Prakash, A. Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity. Curr. Opin. Immunol. 15, 52-58 (2003).
7. Barnes, B., Lubyova, B. & Pitha, P. M. On the role of IRF in host defense. J. Interferon Cytokine Res. 22, 59-71 (2002).
8. Lin, R., Yang, L., Arguello, M., Penafuerte, C. & Hiscott, J. A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization. J. Biol. Chem. (in the press).
9. Barnes, B. J., Moore, P. A. & Pitha, P. M. Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon a genes. J. Biol. Chem. 276, 23382-23390 (2001).
10. Honda, K. et al. Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc. Natl Acad. Sci. USA 101, 15416-15421 (2004).
11. Kawai, T. et al. Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nature Immunol. 5, 1061-1068 (2004).
12. Verthelyi, D., Ishii, K. J., Gursel, M., Takeshita, F. & Klinman, D. M. Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. J. Immunol. 166, 2372-2377 (2001).
13. Krieg, A. M. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20, 709-760 (2002).
14. Krug, A. et al. Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells. Eur. J. Immunol. 31, 2154-2163 (2001).
15. Colonna, M., Trinchieri, G. & Liu, Y. J. Plasmacytoid dendritic cells in immunity. Nature Immunol. 5, 1219-1226 (2004).
16. Alexopoulou, L., Holt, A. C., Medzhitov, R. & Flavell, R. A. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413, 732-738 (2001).
17. Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085-2088 (1998).
18. Hayashi, F. et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410, 1099-1103 (2001).
19. Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S. Reis e Sousa, C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303, 1529-1531 (2004).
20. Heil, F. et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303, 1526-1529 (2004).
21. Lund, J. M. et al. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc. Natl Acad. Sci. USA 101, 5598-5603 (2004).
22. Darnell, J. E. Jr, Kerr, I. M. & Stark, G. R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421 (1994).
23. Alvarez, M., Rhodes, S. J. & Bidwell, J. P. Context-dependent transcription: all politics is local. Gene 313, 43-57 (2003).
24. Yamamoto, M. et al. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ. Nature 430, 218-222 (2004).
25. Cowdery, J. S., Boerth, N. J., Norian, L. A., Myung, P. S. & Koretzky, G. A. Differential regulation of the IL-12 p40 promoter and of p40 secretion by CpG DNA and lipopolysaccharide. J. Immunol. 162, 6770-6775 (1999).
26. Hacker, H. et al. Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J. Exp. Med. 192, 595-600 (2000).
27. Sparwasser, T. et al. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-α-mediated shock. Eur. J. Immunol. 27, 1671-1679 (1997).
28. Cao, Z., Xiong, J., Takeuchi, M., Kurama, T. & Goeddel, D. V. TRAF6 is a signal transducer for interleukin-1. Nature 383, 443-446 (1996).
29. Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S. & Cao, Z. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7, 837-847 (1997).
30. Takaoka, A. et al. Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence. Nature 424, 516-523 (2003).