The dorsoventral regulatory gene cassette spatzle/Toll/Cactus controls the potent antifungal response in Drosophila adults

Cell

Volumn 86, Issue 6, 1996, Pages 973-983

  Lemaitre, Bruno ^a   Nicolas, Emmanuelle ^a   Michaut, Lydia ^a   Reichhart, Jean Marc ^a   Hoffmann, Jules A ^a  

^a INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL ACTIVITY; ARTICLE; DROSOPHILA; GENE CONTROL; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; REGULATOR GENE; SIGNAL TRANSDUCTION;

CACTACEAE; MAMMALIA;

EID: 0030595339     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80172-5     Document Type: Article

References (56)

1. Anderson, K.V., and Nüsslein-Volhard, C. (1984). Information for the dorso-ventral pattern of the Drosophila embryo is stored as maternal mRNA. Nature 311, 223-227.
2. Anderson, K.V., and Nüsslein-Volhard, C. (1986). Dorsal-group genes of Drosophila. In Gametogenesis and the Early Embryo, J. Gall, ed. (New York: Alan R. Liss), pp. 177-194.
3. Asling, B., Dushay, M., and Hultmark, D. (1995). Identification of early genes in the Drosophila immune response by PCR-based differential display: the Attacin A gene and the evolution of attach-like proteins. Insect Biochem. Mol. Biol. 25, 511-518.
4. Baeuerle, P.A., and Henkel, T. (1994). Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12, 141-179.
5. Beg, A.A., Sha, W.C., Bronson, S., and Baltimore, D. (1995). Constitutive NF-κB activation, enhanced granulopoiesis, and neonatal lethality in IκBα-deficient mice. Genes Dev. 9, 2736-2746.
6. Boman, H.G. (1995). Peptide antibiotics and their role in innate immunity. Annu. Rev. Immunol. 13, 61-92.
7. Broekaert, W.F., Terras, F.R.G., Cammue, B.P.A., and Osborn, R.W. (1995). Plant defensins: novel antimicrobial peptides as components of the host defense systeme. Plant Physiol. 108, 1353-1358.
8. Bulet, P., Dimarcq, J.L., Hetru, C., Lagueux, M., Charlet, M., Hegy, G., Van Dorsselaer, A., and Hoffmann, J.A. (1993). A novel inducible antibacterial peptide Drosophila carries an O-glycosylated substitution. J. Biol. Chem. 268, 14893-14897.
9. Cao, Z., Henzel, W.J., and Gao, X. (1996). IRAK: a kinase associated with the interleukin-1 receptor. Science 271, 1128-1131.
10. Chasan, N., and Anderson, K.V. (1989). Activation of easter, an apparent serine protease, in organizing the dorsal-ventral axis of the Drosophila embryo. Cell 56, 391-400.
11. DeLotto, R., and Spierer, P. (1986). A gene required for the specification of the dorsal-ventral pattern in Drosophila appears to encode a serine protease. Nature 323, 688-692.
12. Dimarcq, J.L., Hoffmann, D., Meister, M., Bulet, P., Lanot, R., Reichhart, J.M., and Hoffmann, J.A. (1994). Characterization and transcriptional profiles of a Drosophila gene encoding an insect defensin: a study in insect immunity. Eur. J. Biochem. 221, 201-209.
13. Dinesh-Kumar, S.P., Whitham, S., Choi, D., Hehl, R., Corr, C., and Baker, B. (1995). Transposon tagging of tobacco mosaic virus resistance gene W: its possible role in the TMV-W-mediated signal transduction pathway. Proc. Natl. Acad. Sci. USA 92, 4175-4180.
14. Engström, Y., Kadalayil, L., Sun, S.C., Samakovlis, C., Hultmark, D., and Faye, I. (1993). κB-like motifs regulate the induction of immune genes in Drosophila. J. Mol. Biol. 232, 327-333.
15. Fehlbaum, P., Bulet, P., Michaut, L., Lagueux, M., Broekaert, W., Hetru, C., and Hoffmann, J.A. (1994). Insect immunity: septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides. J. Biol. Chem. 269, 33159-33163.
16. Flyg, C., and Boman, H.G. (1988). Drosophila genes cut and miniature are associated with the susceptibility to infection by Serratia marcescens. Genet. Res. 52, 51-56.
17. Gay, N.J., and Keith, F.J. (1991). Drosophila Toll and IL-1 receptor. Nature 357, 355-356.
18. Geisler, R., Bergmann, A., Hiromi, Y., and Nüsslein-Volhard, C. (1992). cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates. Cell 71, 613-621.
19. Gertulla, S., Jin, Y., and Anderson, K.V. (1988). Zygotic expression and activity of the Drosophila Toll gene, a gene required maternally for embryonic dorsal-ventral pattern formation. Genetics 119, 123-133.
20. Gross, I., Georgel, P., Kappler C., Reichhart J.M., and Hoffmann, J.A. (1996). Drosophila immunity: a comparative analysis of the Rel proteins dorsal and Dif in the induction of the genes encoding diptericin and cecropin. Nucl. Acids Res. 24, 1238-1245.
21. Hashimoto, C., Hudson, K.L., and Anderson, K.V. (1988). The Toll gene of Drosophila, required for dorso-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 52, 269-279.
22. Hecht, P.M., and Anderson, K.V. (1992). Extracellular proteases and embryonic pattern formation. Trends Cell Biol. 2, 197-202.
23. Hecht, P.M., and Anderson, K.V. (1993). Genetic characterization of tube and pelle genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo. Genetics 735, 405-417.
24. Heguy, A., Baldari, C.T., Macchia, G., Telford, J.L., and Melli, M. (1992). Amino acids conserved in interleukin-1 receptor (IL-1R) and the Drosophila Toll protein are essential for IL-1R signal transduction. J. Biol. Chem. 267, 2604-2609.
25. Hetru, C., Bulet, P., Cociancich, S., Dimarq, J.L., Hoffmann, D., and Hoffmann, J.A. (1994). Antibacterial peptides/polypeptides in the insect host defense. In Perspectives in Immunity: The Insect Host Defense, J.A. Hoffmann, C. Janeway, and S. Natori, eds. (Austin, Texas: R.G. Landes Company), pp. 167-181.
26. Hoffmann, J.A. (1995). Innate immunity of insects. Curr. Opin. Immunol. 7, 4-10.
27. Hultmark, D. (1993). Immune reactions in Drosophila and other insects: a model for innate immunity. Trends Genet. 9, 178-183.
28. Ip, T.Y., Reach, M., Engström, Y., Kadalayil, L, Cai, H., Gonzalez-Crespo, S., Tatei, K., and Levine, M. (1993). Dif, a dorsal-related gene that mediates an immune response in Drosophila. Cell 75, 753-763.
29. Iwanaga, S. (1993). The limulus clotting reaction. Curr. Opin. Immunol. 5, 74-82.
30. Jin, Y., and Anderson, K.V. (1990). Dominant and recessive alleles of the Drosophila easter gene are point mutations at conserved sites in the serine protease catalytic domain. Cell 60, 873-881.
31. Kappler, C., Meister, M., Lagueux, M.,Gateff, E., Hoffmann, J.A., and Reichhart, J.M. (1993). Insect immunity: two 17 bp repeats nesting a κB-related sequence confer inducibility to the diptericin gene and bind a polypeptide in bacteria-challenged Drosophila. EMBO J. 72, 1561-1568.
32. Kidd, S. (1992). Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins. Cell 71, 623-635.
33. Kylsten, P., Samakovlis, C., and Hultmark, D. (1990). The cecropin locus in Drosophila: a compact gene cluster involved in the response to infection. EMBO J. 9, 217-224.
34. Lemaitre, B., Kromer-Metzger, E., Michaut, L., Nicolas, E., Meister, M., Georgel, P., Reichhart, J.M., and Hoffmann, J.A. (1995a). A novel mutation, immune deficiency, defines two distinct control pathways in the Drosophila host defense. Proc. Natl. Acad. Sci. USA 92, 9465-9469.
35. Lemaitre, B., Meister, M., Govind, S., Georgel, P., Steward, R., Reichhart, J.M., and Hoffmann, J.A. (1995b). Functional analysis and regulation of nuclear import of dorsal during the immune response of Drosphila. EMBO J. 14, 536-545.
36. Letsou, A., Alexander, S., Orth, K., and Wasserman, S.A. (1991). Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity. Proc. Natl. Acad. Sci. USA 88, 810-814.
37. Lindsley, D.L., and Zimm, G.G. (1992). The Genome of Drosophila melanogaster (San Diego, California: Academic Press).
38. Morisato, D., and Anderson, K.V. (1994). The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsoventral pattern of the Drosophila embryo. Cell 76, 677-688.
39. Morisato, D., and Anderson, K.V. (1995). Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo. Annu. Rev. Genet. 29, 371-399.
40. O'Connell, P., and Rosbach, M. (1984). Sequence, structure and codon preference of the Drosophila ribosomal protein 49 gene. Nucl. Acids Res. 72, 5495-5513.
41. Petersen, U.M., Björklund, G., Ip, T.Y., and Engström, Y. (1995). The dorsal-related immunity factor, Dif is a sequence-specific transactivator of Drosophila Cecropin gene expression. EMBO J. 14, 3146-3158.
42. Reichhart, J.M., Georgel, P., Meister, M., Lemaitre, B., Kappler, C., and Hoffmann, J.A. (1993). Expression and nuclear translocation of the rel/NF-κB-related morphogen dorsal during the immune response of Drosophila. CR Acad. Sci. (Paris) 376, 1207-1217.
43. Rosetto, M., Engström, Y., Baldari, C.T., Telford, J.L., and Hultmark, D. (1995). Signals from the IL-1 receptor homolog, Toll, can activate an immune response in a Drosophila hemocyte cell line. Biochem. Biophys. Res. Commun. 209, 111-116.
44. Roth, S., Hiromi, Y., Godt, D., and Nüsslein-Volhard, C. (1991). cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos. Development 112, 371-388.
45. Schneider, D.S., Jin, Y., Morisato, D., and Anderson, K.V. (1994). A processed form of spätzle protein defines dorso-ventral polarity in the Drosophila embryo. Development 120, 1243-1250.
46. Shelton, C.A., and Wasserman, S.A. (1993). pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo. Cell 72, 515-525.
47. Siebenlist, U., Franzoso, G., and Brown, K. (1994). Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 70, 405-455.
48. Smith, C., Giordano, H., and DeLotto, R. (1994). Mutational analysis of the Drosophila snake protease: an essential role for domains within the proenzyme polypeptide chain. Genetics 136, 1355-1365.
49. Steward, R. (1987). Dorsal, an embryonic polarity gene in Drosophila is homologous to the vertebrate proto-oncogene,c-rel. Science 238, 692-694.
50. Sun, S.C., Lindström, I., Lee, J.Y., and Faye, I. (1991). Structure and expression of the attach genes in Hyalophora cecropia. Eur. J. Biochem. 196, 247-254.
51. Tatei, K., and Levine, M. (1995). Specificity of Rel-inhibitor interactions in Drosophila embryos. Mol. Cell. Biol. 15, 3627-3634.
52. Tryselius Y., Samakovlis C., Kimbrell, D.A., and Hultmark, D. (1992). CecC, a cecropin gene expressed during metamorphosis in Drosophila pupae. Eur. J. Biochem. 204, 395-399.
53. Vey A., and Götz P. (1986). Antifungal cellular defense mechanisms in insects. In Hemocytic and Humoral Immunity in Athropods, A.P. Gupta, ed. (New York: John Wiley & Sons, Inc.), pp. 89-115.
54. Wasserman, S.A. (1993). A conserved signal transduction pathway regulating the activity of the Rel-like proteins dorsal and NF-κB. Mol. Biol. Cell 4, 767-771.
55. Whitham, S., Dinesh-Kumar, S.P., Choi, D., Hehl, R., Corr, C., and Baker, B. (1994). The product of the tobacco mosaic virus resistance gene N: similarity to Toll and the interleukin-1 receptor. Cell 78, 1101-1115.
56. Wicker, C., Reichhart, J.M., Hoffmann, D., Hultmark, D., Samakovlis, C., and Hoffmann, J.A. (1990). Insect immunity: characterization of a Drosophila cDNA encoding a novel member of the diptericin family of immune peptides. J. Biol. Chem. 265, 22493-22498.