Smoothened antagonists: A promising new class of antitumor agents

Expert Opinion on Drug Discovery

Volumn 4, Issue 5, 2009, Pages 525-544

  Gallinari, Paola ^a   Filocamo, Gessica ^a   Jones, Philip ^a   Pazzaglia, Simonetta ^b   Steinkühler, Christian ^a  

^a IRBM   (Italy)

^b ENEA C R CASACCIA   (Italy)

Author keywords

Basal cell carcinoma; Cancer stem cells; Developmental pathways; Hedgehog; Medulloblastoma; Patched; Smoothened; Tumor stroma interactions

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; CYCLOPAMINE; DEXTRO HOMOCYCLOPAMINE 5; GDC 0449; IPI 609; JERVINE; LACTAM DERIVATIVE; METHANESULFONAMIDE DERIVATIVE; N (3 METHOXYBENZYL) 3,3 DIMETHYL N [1 (3,4 METHYLENEDIOXYBENZYL) 2 (1 PIPERAZINYLCARBONYL) 4 PYRROLIDINYL]BUTYRAMIDE; PYRAZOLE; SMOOTHENED ANTAGONIST; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ADVANCED CANCER; BASAL CELL CARCINOMA; CANCER CHEMOTHERAPY; CANCER RESEARCH; CARCINOGENESIS; CLINICAL TRIAL; COLORECTAL CANCER; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG HALF LIFE; DRUG INHIBITION; DRUG MECHANISM; DRUG SAFETY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG TARGETING; GENE MUTATION; HUMAN; MEDICAL LITERATURE; MEDULLOBLASTOMA; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; RHABDOMYOSARCOMA; SOLID TUMOR;

EID: 67649126684     PISSN: 17460441     EISSN: None     Source Type: Journal    
DOI: 10.1517/17460440902852686     Document Type: Review

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