Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists

Journal of Medicinal Chemistry

Volumn 51, Issue 21, 2008, Pages 6646-6649

  Tremblay, Martin R ^a   Nevalainen, Marta ^a   Nair, Somarajan J ^a   Porter, James R ^a   Castro, Alfredo C ^a   Behnke, Mark L ^a   Yu, Lin Chen ^a   Hagel, Margit ^a,b   White, Kerry ^a   Faia, Kerrie ^a   Grenier, Louis ^a   Campbell, Matthew J ^a   Cushing, Jill ^a   Woodward, Caroline N ^a,c   Hoyt, Jennifer ^a   Foley, Michael A ^a,d   Read, Margaret A ^a   Sydor, Jens R ^a   Tong, Jeffrey K ^a   Palombella, Vito J ^a   McGovern, Karen ^a   Adams, Julian ^a   more..

^a Infinity Pharmaceuticals Inc   (United States)

^b Avila Therapeutics Inc   (United States)

^c Epix Pharmaceuticals   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 EN 3 ONE CYCLOPAMINE; ALLYL COMPOUND; ANTINEOPLASTIC AGENT; CYCLOPAMINE; CYCLOPROPYLCYCLOPAMINE; DEXTRO HOMOCYCLOPAMINE DERIVATIVE; IPI 269609; KETONE; UNCLASSIFIED DRUG; VERATRAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CATALYSIS; CONTROLLED STUDY; CYCLOPROPANATION; DRUG ELIMINATION; DRUG POTENCY; DRUG SYNTHESIS; MOUSE; NONHUMAN; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; HEDGEHOG PROTEINS; MOLECULAR STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; VERATRUM ALKALOIDS;

EID: 56249121238     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8008508     Document Type: Article

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