An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development

Developmental Biology

Volumn 233, Issue 1, 2001, Pages 122-136

  Lee, Jeffrey D ^a,b   Kraus, Petra ^a   Gaiano, Nicholas ^a,b   Nery, Susana ^a,b   Kohtz, Jhumku ^a,b   Fishell, Gord ^a,b   Loomis, Cynthia A ^a,b   Treisman, Jessica E ^a,b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Cell Biology ^*  (United States)

Author keywords

Acylation; Evolution; Hedgehog; Limb; Wing

Indexed keywords

CHOLESTEROL; CYSTEINE; SONIC HEDGEHOG PROTEIN;

ACYLATION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA; EMBRYO; EMBRYO SEGMENTATION; GENE OVEREXPRESSION; IN VIVO STUDY; LIMB DEVELOPMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; TISSUE SPECIFICITY;

EID: 0035337027     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2001.0218     Document Type: Article

References (82)

1. Hedgehog and its patched-smoothened receptor complex: A novel signalling mechanism at the cell surface
2. Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interrruptus protein, a member of the GLI family of zinc finger DNA-binding proteins
3. Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
4. Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein
5. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
6. An extensive 3′ cis-regulatory region directs the imaginal disc expression of decapentaplegic, a member of the TGF-β family in Drosophila
7. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
8. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
9. Genetic analysis of viable and lethal fused mutants of Drosophila melanogaster
10. In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex
11. Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression
12. Production and design of more effective avian replication-incompetent retroviral vectors
13. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
14. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
15. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
16. Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation
17. A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling
18. Activation of Fgf-4 and HoxD gene expression by BMP-2 expressing cells in the developing chick limb
19. Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway
20. The hedgehog gene family in Drosophila and vertebrate development
21. Secretion of the amino-terminal fragment of the hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila
22. Chorion villus sampling and limb deficiency - Cause or coincidence?
23. Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb
24. Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched
25. A method for rapid gain-of-function studies in the mouse embryonic nervous system
26. Control of the gene optomotor-blind in Drosophila wing development by decapentaplegic and wingless
27. Decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc
28. Three distinct roles for the engrailed gene in Drosophila wing development
29. Pattern formation: Hedgehog points the way
30. Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing
31. Patched overexpression alters wing disc size and pattern: Transcriptional and post-transcriptional effects on hedgehog targets
32. The NH2-terminal region of the active domain of sonic hedgehog is necessary for its signal transduction
33. Some distal limb structures develop in mice lacking Sonic hedgehog signaling
34. Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud
35. Two distinct mechanisms for long-range patterning by decapentaplegic in the Drosophila wing
36. Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
37. Autoproteolysis in hedgehog protein biogenesis
38. Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development
39. Alteration of limb and brain patterning in early mouse embryos by ultrasound-guided injection of Shh-expressing cells
40. Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs
41. Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene
42. The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye
43. Teratogenic effects of amniotic sac puncture: A mouse model
44. Biochemical evidence that patched is the Hedgehog receptor
45. Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of cubitus interruptus
46. Activation of knot (kn) specifies the 3-4 intervein region in the Drosophila wing
47. The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways
48. Hedgehog activity, independent of decapentaplegic, participates in wing disc patterning
49. Sonic hedgehog signaling by the patched-smoothened receptor complex
50. Direct and long-range action of a dpp morphogen gradient
51. Role of knot (kn) in wing patterning in Drosophila
52. Hedgehog stimulates maturation of cubitus interruptus into a labile transcriptional activator
53. Identification of a palmitic acid-modified form of human Sonic hedgehog
54. Mapping sonic hedgehog-receptor interactions by steric interference
55. The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
56. Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain
57. Cholesterol modification of hedgehog signaling proteins in animal development
58. Fatty acylation of proteins: New insights into membrane targeting of myristoylated and palmitoylated proteins
59. Sonic hedgehog mediates the polarizing activity of the ZPA
60. Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains
61. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
62. Hedgehog, wingless and orthodenticle specify adult head development in Drosophila
63. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of shh signaling
64. Analysis of cubitus interruptus regulation in Drosophila embryos and imaginal disks
65. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
66. A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
67. Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
68. Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan
69. Phosphorylation of the fused protein kinase in response to signaling from hedgehog
70. Ultrasound backscatter microscope analysis of early mouse embryonic brain development
71. The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing
72. Antagonists go out on a limb
73. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
74. Tissue-specific regulation of vein/EGF receptor signaling in Drosophila
75. Dual functions of wingless in the Drosophila leg imaginal disc
76. Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity
77. Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila
78. Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposteriot polarity in the chick limb
79. Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing
80. Targeted misexpression of constitutively active BMP receptor-IB causes bifurcation, duplication, and posterior transformation of digit in mouse limb
81. Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds