Gli proteins and the control of spinal-cord patterning

EMBO Reports

Volumn 4, Issue 8, 2003, Pages 761-765

  Jacob, John ^a   Briscoe, James ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SONIC HEDGEHOG PROTEIN; ZINC FINGER PROTEIN;

BRAIN NERVE CELL; EMBRYO PATTERN FORMATION; GENETIC TRANSCRIPTION; INFORMATION PROCESSING; NERVOUS SYSTEM DEVELOPMENT; NEURAL TUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; REVIEW; SIGNAL TRANSDUCTION; SPINAL CORD;

ANIMALS; BODY PATTERNING; CENTRAL NERVOUS SYSTEM; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; ONCOGENE PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SPINAL CORD; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ERINACEIDAE; VERTEBRATA;

EID: 0041852606     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.embor.embor896     Document Type: Review

References (45)

1. Aza-Blanc, P., Ramirez-Weber, F.A., Laget, M.P., Schwartz, C. & Kornberg, T.B. (1997) Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell, 89, 1043-1053.
2. Aza-Blanc, P., Lin, H.Y., Ruiz i Altaba, A. & Kornberg, T.B. (2000) Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities. Development, 127, 4293-4301.
3. Bai, C.B. & Joyner, A.L. (2001) Gli1 can rescue the in vivo function of Gli2. Development, 128, 5161-5172.
4. Bai, C.B., Auerbach, W., Lee, J.S., Stephen, D. & Joyner, A.L. (2002) Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development, 129, 4753-4761.
5. Barth, K.A., Kishimoto, Y., Rohr, K.B., Seydler, C., Schulte-Merker, S. & Wilson, S.W. (1999) Bmp activity establishes a gradient of positional information throughout the entire neural plate. Development, 126, 4977-4987.
6. Böse, J., Grotewold, L. & Rüther, U. (2002) Pallister-Hall syndrome phenotype in mice mutant for Gli3. Hum. Mol. Genet., 11, 1129-1135.
7. Chen, C.H., von Kessler, D.P., Park, W., Wang, B., Ma, Y. & Beachy, P.A. (1999) Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell, 98, 305-316.
8. Cheng, S.Y. & Bishop, J.M. (2002) Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex. Proc. Natl Acad. Sci. USA, 99, 5442-5447.
9. Dai, P., Akimaru, H., Tanaka, Y., Maekawa, T., Nakafuku, M. & Ishii, S. (1999) Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem., 274, 8143-8152.
10. Ding, Q., Motoyama, J., Gasca, S., Mo, R., Sasaki, H., Rossant, J. & Hui, C.C. (1998) Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development, 125, 2533-2543.
11. Hui, C.C., Slusarski, D., Platt, K.A., Holmgren, R. & Joyner, A.L. (1994) Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development. Dev. Biol., 162, 402-413.
12. Hynes, M., Stone, D.M., Dowd, M., Pitts-Meek, S., Goddard, A., Gurney, A. & Rosenthal, A. (1997) Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron, 19, 15-26.
13. Ingham, P.W. & McMahon, A.P. (2001) Hedgehog signaling in animal development: paradigms and principles. Genes Dev., 15, 3059-3087.
14. Jessell, T.M. (2000) Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nature Rev. Genet., 1, 20-29.
15. Jia, J., Amanai, K., Wang, G., Tang, J., Wang, B. & Jiang, J. (2002) Shaggy/GSK3 antagonizes Hedgehog signaling by regulating Cubitus interruptus. Nature, 416, 548-552.
16. Jiang, J. (2002) Degrading Ci: who is Cul-pable? Genes Dev., 16, 2315-2321.
17. Karlstrom, R.O., Tyurina, O.V., Kawakami, A., Nishioka, N., Talbot, W.S., Sasaki, H. & Schier, A.F. (2003) Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development. Development, 130, 1549-1564.
18. Lee, J., Platt, K.A., Censullo, P. & Ruiz i Altaba, A. (1997) Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development, 124, 2537-2552.
19. Lee, K.J. & Jessell, T.M. (1999) The specification of dorsal cell fates in the vertebrate central nervous system. Annu. Rev. Neurosci., 22, 261-294.
20. Liem, K.F., Jessell, T.M. & Briscoe, J. (2000) Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites. Development, 127, 4855-4866.
21. Litingtung, Y. & Chiang, C. (2000) Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. Nature Neurosci., 3, 979-985.
22. Litingtung, Y., Dahn, R.D., Li, Y., Fallon, J.F. & Chiang, C. (2002) Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature, 418, 979-983.
23. Liu, F., Massague J. & Ruiz i Altaba, A. (1998) Carboxy-terminally truncated Gli3 proteins associate with Smads. Nature Genet., 20, 325-326.
24. Matise, M.P., Epstein, D.J., Park, H.L., Platt, K.A. & Joyner, A.L. (1998) Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development, 125, 2759-2770.
25. McMahon, J.A., Takada, S., Zimmerman, L.B., Fan, C.M., Harland, R.M. & McMahon, A.P. (1998) Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev., 12, 1438-1452.
26. Methot, N. & Basler, K. (1999) Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell, 96, 819-831.
27. Methot, N. & Basler, K. (2001) An absolute requirement for Cubitus interruptus in Hedgehog signaling. Development, 128, 733-742.
28. Mullor, J.L., Dahmane, N., Sun, T. & Ruiz i Altaba, A. (2001) Wnt signals are targets and mediators of Gli function. Curr. Biol., 11, 769-773.
29. Muroyama, Y., Fujihara, M., Ikeya, M., Kondoh, H. & Takada, S. (2002) Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes Dev., 16, 548-553.
30. Ohlmeyer, J.T. & Kalderon, D. (1998) Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature, 396, 749-753.
31. Park, H.L., Bai, C., Platt, K.A., Matise, M.P., Beeghly, A., Hui, C.C., Nakashima, M. & Joyner, A.L. (2000) Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development, 127, 1593-1605.
32. Patten, I. & Placzek, M. (2002) Opponent activities of Shh and BMP signaling during floor plate induction in vivo. Curr. Biol., 12, 47-52.
33. Persson, M., Stamataki, D., te Welscher, P., Andersson, E., Bose, J., Ruther, U., Ericson, J. & Briscoe, J. (2002) Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev., 16, 2865-2878.
34. Pierani, A., Brenner-Morton, S., Chiang, C. & Jessell, T.M. (1999) A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Cell, 97, 903-915.
35. Price, M.A. & Kalderon, D. (2002) Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Cell, 108, 823-835.
36. Robbins, D.J., Nybakken, K.E., Kobayashi, R., Sisson, J.C., Bishop, J.M. & Therond, P.P. (1997) Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Cell, 90, 225-234.
37. Ruiz i Altaba, A. (1997) Catching a Gli-mpse of Hedgehog. Cell, 90, 193-196.
38. Ruiz i Altaba, A. (1998) Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic Hedgehog. Development, 125, 2203-2212.
39. Ruiz i Altaba, A. (1999) Gli proteins encode context-dependent positive and negative functions: implications for development and disease. Development, 126, 3205-3216.
40. Sasaki, H., Hui, C., Nakafuku, M. & Kondoh, H. (1997) A binding site for Gli proteins is essential for HNF-3β floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development, 124, 1313-1322.
41. Sasaki, H., Nishizaki, Y., Hui, C., Nakafuku, M. & Kondoh, H. (1999) Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development, 126, 3915-3924.
42. Wang, B., Fallon, J.F. & Beachy, P.A. (2000) Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell, 100, 423-434.
43. Wang, Q.T. & Holmgren, R.A. (2000) Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation. Development, 127, 3131-3139.
44. Wijgerde, M., McMahon, J.A., Rule, M. & McMahon, A.P. (2002) A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev., 16, 2849-2864.
45. Yoon, J.W., Kita, Y., Frank, D.J., Majewski, R.R., Konicek, B.A., Nobrega, M.A., Jacob, H., Walterhouse, D. & Iannaccone, P. (2002) Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J. Biol. Chem., 277, 5548-5555.