N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons

Development

Volumn 128, Issue 12, 2001, Pages 2351-2363

  Kohtz, J D ^a   Lee, H Y ^a   Gaiano, N ^a   Segal, J ^a   Ng, E ^a   Larson, T ^a   Baker, D P ^a   Garber, E A ^a   Williams, K P ^a   Fishell, G ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Fatty acylation; Forebrain; Rat; Sonic hedgehog; Telecephalon

Indexed keywords

SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR;

ACYLATION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BRAIN DEVELOPMENT; BRAIN MALFORMATION; BRAIN NERVE CELL; CELL POPULATION; CONTROLLED STUDY; EMBRYO CELL; EMBRYONIC STRUCTURES; FOREBRAIN; HOMEOBOX; MORPHOLOGY; NERVE CELL DIFFERENTIATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETROVIRUS; SIGNAL TRANSDUCTION; TELENCEPHALON;

ANIMALS; CELL MEMBRANE; CELLS, CULTURED; FATTY ACIDS; GENE EXPRESSION; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; MICE; MYRISTIC ACID; NEURONS; PALMITIC ACID; POINT MUTATION; RATS; SIGNAL TRANSDUCTION; TELENCEPHALON; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0034931149     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons
2. Immunohistochemical localization of DARPP-32 in striatal projection neurons and striatal interneurons: Implications for the localization of D1-like dopamine receptors on different types of striatal neurons
3. A role for N-myristosylation in protein targeting: NADH-cytochrome b5 reductase requires myristic acid for association with outer mitochondrial but not ER membranes
4. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
5. Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-ras
6. Molecular cloning and expression of palmitoly-protein thioesterase
7. Protein lipidation in cell signaling
8. MASH-1 regulates neurogenesis in the ventral telencephalon
9. Cyclopia and defective axial patterning in mice lacking Sonic Hedgehog gene function
10. The Gsh-2 homeodomain gene controls multiple aspects of telencephalic development
11. Cooperation of BMP-7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm
12. Palmitoylation of a G protein a1 subunit requires membrane localization not myristoylation
13. Sonic Hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube
14. Two critical periods of long-range Sonic Hedgehog signaling required for the specification of motor neuron identity
15. Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube
16. Regionalization in the mammalian telencephalon
17. A method for rapid gain-of-function studies in the mouse embryonic nervous system
18. Regulation of the mevalonate pathway
19. Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system
20. Sonic hedgehog signaling at gastrula stages specifies ventral telencephalic cells in the chick embryo
21. Gsh-2, a murine homeobox gene expressed in the developing brain
22. Induction of midbrain dopaminergic neurons by Sonic Hedgehog
23. Transducing Hedgehog: The story so far
24. Genetic and biochemical studies of protein N-myristoylation
25. Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation
26. Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Shh
27. The transcription factor TTF-1 is expressed at the onset at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain
28. An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development
29. Alteration of limb and brain patterning in early mouse embryos by ultrasound-guided injection of Shh-expressing cells
30. Biochemical evidence that patched is the Hedgehog receptor
31. Origin and specification of striatal interneurons
32. Distribution of Sonic Hedgehog peptides in the developing chick and mouse embryo
33. Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants
34. More surprises in the Hedgehog signaling pathway
35. Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain
36. Specification of mouse telecephalic and mid-hindbrain progenitors following heterotopic ultrasound-guided embryonic transplantation
37. The development of crustacean limbs and the evolution of arthropods
38. Identification of a palmitic acid-modified form of human sonic hedgehog
39. Mesodermal control of neural cell identity: Floor plate induction by the notochord
40. Induction of floor plate differentiation by contact-dependent, homogenetic signals
41. Cholesterol modification of hedgehog signaling proteins in animal development
42. DLX-2, MASH-1, MAP-2 expression and bromodeoxyuridine incorporation define molecularly distinct cell populations in the embryonic mouse forebrain
43. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic Hedgehog autoproteolysis
44. A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells; in situ hybridization using digoxigenin-labeled cRNA probes
45. Longitudinal organization of the anterior neural plate and neural tube
46. Inductive interactions direct early regionalization of the mouse forebrain
47. Multipotential neural cell lines can engraft and participate in development of mouse cerebellum
48. The tumor suppressor gene patched encodes a candidate receptor for Sonic Hedgehog
49. Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: Evidence for a transformation of the pallidum into the striatum
50. Altered forebrain and hindbrain development in mice mutant for the Gsh-2 homeobox gene
51. Enhanced potency of human Sonic Hedgehog by hydrophobic modification
52. The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat
53. Genetic control of dorsal-ventral identity in the telencephalon: Opposing roles of Gsh2 and Pax6
54. Effect of the notochord on the differentiation of a floor plate area in the neural tube of the chick embryo
55. Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity
56. Control of cell pattern in the developing nervous system: Polarizing activity of the floor plate-notocord
57. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate
58. Gsh2 and Pax6 play complementary roles in dorsal ventral patterning of the mammalian telencephalon
59. Post-translational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis