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Volumn 12, Issue 5, 2007, Pages 767-778

The Graded Response to Sonic Hedgehog Depends on Cilia Architecture

Author keywords

CELLBIO; DEVBIO; SIGNALING

Indexed keywords

ARF PROTEIN; GENE PRODUCT; GUANOSINE TRIPHOSPHATASE; HENNIN; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI3; TRANSCRIPTION FACTOR PAX6; UNCLASSIFIED DRUG;

EID: 34247558062     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.devcel.2007.03.004     Document Type: Article
Times cited : (593)

References (72)
  • 1
    • 1842839986 scopus 로고    scopus 로고
    • Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site
    • Agren M., Kogerman P., Kleman M.I., Wessling M., and Toftgard R. Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site. Gene 330 (2004) 101-114
    • (2004) Gene , vol.330 , pp. 101-114
    • Agren, M.1    Kogerman, P.2    Kleman, M.I.3    Wessling, M.4    Toftgard, R.5
  • 2
    • 0036106384 scopus 로고    scopus 로고
    • The C. elegans evl-20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis
    • Antoshechkin I., and Han M. The C. elegans evl-20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis. Dev. Cell 2 (2002) 579-591
    • (2002) Dev. Cell , vol.2 , pp. 579-591
    • Antoshechkin, I.1    Han, M.2
  • 3
    • 0347764480 scopus 로고    scopus 로고
    • All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
    • Bai C.B., Stephen D., and Joyner A.L. All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev. Cell 6 (2004) 103-115
    • (2004) Dev. Cell , vol.6 , pp. 103-115
    • Bai, C.B.1    Stephen, D.2    Joyner, A.L.3
  • 4
    • 0014099286 scopus 로고
    • Evidence for four classes of microtubules in individual cells
    • Behnke O., and Forer A. Evidence for four classes of microtubules in individual cells. J. Cell Sci. 2 (1967) 169-192
    • (1967) J. Cell Sci. , vol.2 , pp. 169-192
    • Behnke, O.1    Forer, A.2
  • 5
    • 0034729382 scopus 로고    scopus 로고
    • ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin
    • Bhamidipati A., Lewis S.A., and Cowan N.J. ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin. J. Cell Biol. 149 (2000) 1087-1096
    • (2000) J. Cell Biol. , vol.149 , pp. 1087-1096
    • Bhamidipati, A.1    Lewis, S.A.2    Cowan, N.J.3
  • 7
    • 0034640087 scopus 로고    scopus 로고
    • A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
    • Briscoe J., Pierani A., Jessell T.M., and Ericson J. A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube. Cell 101 (2000) 435-445
    • (2000) Cell , vol.101 , pp. 435-445
    • Briscoe, J.1    Pierani, A.2    Jessell, T.M.3    Ericson, J.4
  • 9
  • 11
    • 0034084213 scopus 로고    scopus 로고
    • LdARL-3A, a Leishmania promastigote-specific ADP-ribosylation factor-like protein, is essential for flagellum integrity
    • Cuvillier A., Redon F., Antoine J.C., Chardin P., DeVos T., and Merlin G. LdARL-3A, a Leishmania promastigote-specific ADP-ribosylation factor-like protein, is essential for flagellum integrity. J. Cell Sci. 113 (2000) 2065-2074
    • (2000) J. Cell Sci. , vol.113 , pp. 2065-2074
    • Cuvillier, A.1    Redon, F.2    Antoine, J.C.3    Chardin, P.4    DeVos, T.5    Merlin, G.6
  • 12
    • 0033583035 scopus 로고    scopus 로고
    • Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3
    • Dai P., Akimaru H., Tanaka Y., Maekawa T., Nakafuku M., and Ishii S. Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem. 274 (1999) 8143-8152
    • (1999) J. Biol. Chem. , vol.274 , pp. 8143-8152
    • Dai, P.1    Akimaru, H.2    Tanaka, Y.3    Maekawa, T.4    Nakafuku, M.5    Ishii, S.6
  • 13
    • 33745496759 scopus 로고    scopus 로고
    • The emerging complexity of the vertebrate cilium: new functional roles for an ancient organelle
    • Davis E.E., Brueckner M., and Katsanis N. The emerging complexity of the vertebrate cilium: new functional roles for an ancient organelle. Dev. Cell 11 (2006) 9-19
    • (2006) Dev. Cell , vol.11 , pp. 9-19
    • Davis, E.E.1    Brueckner, M.2    Katsanis, N.3
  • 14
    • 0035899865 scopus 로고    scopus 로고
    • Localization of intraflagellar transport protein IFT52 identifies basal body transitional fibers as the docking site for IFT particles
    • Deane J.A., Cole D.G., Seeley E.S., Diener D.R., and Rosenbaum J.L. Localization of intraflagellar transport protein IFT52 identifies basal body transitional fibers as the docking site for IFT particles. Curr. Biol. 11 (2001) 1586-1590
    • (2001) Curr. Biol. , vol.11 , pp. 1586-1590
    • Deane, J.A.1    Cole, D.G.2    Seeley, E.S.3    Diener, D.R.4    Rosenbaum, J.L.5
  • 15
    • 0031855859 scopus 로고    scopus 로고
    • Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
    • Ding Q., Motoyama J., Gasca S., Mo R., Sasaki H., Rossant J., and Hui C.C. Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 125 (1998) 2533-2543
    • (1998) Development , vol.125 , pp. 2533-2543
    • Ding, Q.1    Motoyama, J.2    Gasca, S.3    Mo, R.4    Sasaki, H.5    Rossant, J.6    Hui, C.C.7
  • 16
    • 0038813753 scopus 로고    scopus 로고
    • Characterization of the physical interaction of Gli proteins with SUFU proteins
    • Dunaeva M., Michelson P., Kogerman P., and Toftgard R. Characterization of the physical interaction of Gli proteins with SUFU proteins. J. Biol. Chem. 278 (2003) 5116-5122
    • (2003) J. Biol. Chem. , vol.278 , pp. 5116-5122
    • Dunaeva, M.1    Michelson, P.2    Kogerman, P.3    Toftgard, R.4
  • 17
    • 0027756145 scopus 로고
    • Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
    • Echelard Y., Epstein D.J., St-Jacques B., Shen L., Mohler J., McMahon J.A., and McMahon A.P. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75 (1993) 1417-1430
    • (1993) Cell , vol.75 , pp. 1417-1430
    • Echelard, Y.1    Epstein, D.J.2    St-Jacques, B.3    Shen, L.4    Mohler, J.5    McMahon, J.A.6    McMahon, A.P.7
  • 18
    • 0034669084 scopus 로고    scopus 로고
    • Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene
    • Eggenschwiler J.T., and Anderson K.V. Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene. Dev. Biol. 227 (2000) 648-660
    • (2000) Dev. Biol. , vol.227 , pp. 648-660
    • Eggenschwiler, J.T.1    Anderson, K.V.2
  • 19
    • 30544448979 scopus 로고    scopus 로고
    • Mouse Rab23 regulates Hedgehog signaling from Smoothened to Gli proteins
    • Eggenschwiler J.T., Bulgakov O.V., Qin J., Li T., and Anderson K.V. Mouse Rab23 regulates Hedgehog signaling from Smoothened to Gli proteins. Dev. Biol. 290 (2006) 1-12
    • (2006) Dev. Biol. , vol.290 , pp. 1-12
    • Eggenschwiler, J.T.1    Bulgakov, O.V.2    Qin, J.3    Li, T.4    Anderson, K.V.5
  • 20
    • 0035849901 scopus 로고    scopus 로고
    • Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway
    • Eggenschwiler J.T., Espinoza E., and Anderson K.V. Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature 412 (2001) 194-198
    • (2001) Nature , vol.412 , pp. 194-198
    • Eggenschwiler, J.T.1    Espinoza, E.2    Anderson, K.V.3
  • 24
    • 33845354764 scopus 로고    scopus 로고
    • Three types of cilia including a novel 9+4 axoneme on the notochordal plate of the rabbit embryo
    • Feistel K., and Blum M. Three types of cilia including a novel 9+4 axoneme on the notochordal plate of the rabbit embryo. Dev. Dyn. 235 (2006) 3348-3358
    • (2006) Dev. Dyn. , vol.235 , pp. 3348-3358
    • Feistel, K.1    Blum, M.2
  • 26
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse Patched mutants
    • Goodrich L.V., Milenkovic L., Higgins K.M., and Scott M.P. Altered neural cell fates and medulloblastoma in mouse Patched mutants. Science 277 (1997) 1109-1113
    • (1997) Science , vol.277 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3    Scott, M.P.4
  • 27
    • 40749144679 scopus 로고    scopus 로고
    • Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
    • Haycraft C.J., Banizs B., Aydin-Son Y., Zhang Q., Michaud E.J., and Yoder B.K. Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet. 1 (2005) e53
    • (2005) PLoS Genet. , vol.1
    • Haycraft, C.J.1    Banizs, B.2    Aydin-Son, Y.3    Zhang, Q.4    Michaud, E.J.5    Yoder, B.K.6
  • 29
    • 0025174216 scopus 로고
    • Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes
    • Hoyt M.A., Stearns T., and Botstein D. Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes. Mol. Cell. Biol. 10 (1990) 223-234
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 223-234
    • Hoyt, M.A.1    Stearns, T.2    Botstein, D.3
  • 30
    • 23844485210 scopus 로고    scopus 로고
    • Cilia and Hedgehog responsiveness in the mouse
    • Huangfu D., and Anderson K.V. Cilia and Hedgehog responsiveness in the mouse. Proc. Natl. Acad. Sci. USA 102 (2005) 11325-11330
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 11325-11330
    • Huangfu, D.1    Anderson, K.V.2
  • 31
  • 32
    • 0027478216 scopus 로고
    • A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene
    • Hui C.C., and Joyner A.L. A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat. Genet. 3 (1993) 241-246
    • (1993) Nat. Genet. , vol.3 , pp. 241-246
    • Hui, C.C.1    Joyner, A.L.2
  • 33
    • 33644526287 scopus 로고    scopus 로고
    • Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins
    • Kahn R.A., Cherfils J., Elias M., Lovering R.C., Munro S., and Schurmann A. Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins. J. Cell Biol. 172 (2006) 645-650
    • (2006) J. Cell Biol. , vol.172 , pp. 645-650
    • Kahn, R.A.1    Cherfils, J.2    Elias, M.3    Lovering, R.C.4    Munro, S.5    Schurmann, A.6
  • 34
    • 4444220296 scopus 로고    scopus 로고
    • Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord
    • Lei Q., Zelman A.K., Kuang E., Li S., and Matise M.P. Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord. Development 131 (2004) 3593-3604
    • (2004) Development , vol.131 , pp. 3593-3604
    • Lei, Q.1    Zelman, A.K.2    Kuang, E.3    Li, S.4    Matise, M.P.5
  • 35
    • 10044297008 scopus 로고    scopus 로고
    • Functional genomic analysis of the ADP-ribosylation factor family of GTPases: phylogeny among diverse eukaryotes and function in C. elegans
    • Li Y., Kelly W.G., Logsdon Jr. J.M., Schurko A.M., Harfe B.D., Hill-Harfe K.L., and Kahn R.A. Functional genomic analysis of the ADP-ribosylation factor family of GTPases: phylogeny among diverse eukaryotes and function in C. elegans. FASEB J. 18 (2004) 1834-1850
    • (2004) FASEB J. , vol.18 , pp. 1834-1850
    • Li, Y.1    Kelly, W.G.2    Logsdon Jr., J.M.3    Schurko, A.M.4    Harfe, B.D.5    Hill-Harfe, K.L.6    Kahn, R.A.7
  • 36
    • 0242540472 scopus 로고    scopus 로고
    • Protofilament ribbon compartments of ciliary and flagellar microtubules
    • Linck R.W., and Norrander J.M. Protofilament ribbon compartments of ciliary and flagellar microtubules. Protist 154 (2003) 299-311
    • (2003) Protist , vol.154 , pp. 299-311
    • Linck, R.W.1    Norrander, J.M.2
  • 37
    • 34247558998 scopus 로고    scopus 로고
    • Functional Protofilament Numbering of Ciliary, Flagellar and Centriolar Microtubules
    • 10.1002/cm.20202 in press. Published online March 15, 2007
    • Linck R.W., and Stephens R.E. Functional Protofilament Numbering of Ciliary, Flagellar and Centriolar Microtubules. Cell Motil. Cytoskeleton (2007) 10.1002/cm.20202 in press. Published online March 15, 2007
    • (2007) Cell Motil. Cytoskeleton
    • Linck, R.W.1    Stephens, R.E.2
  • 38
    • 0033808256 scopus 로고    scopus 로고
    • Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3
    • Litingtung Y., and Chiang C. Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. Nat. Neurosci. 3 (2000) 979-985
    • (2000) Nat. Neurosci. , vol.3 , pp. 979-985
    • Litingtung, Y.1    Chiang, C.2
  • 39
    • 0037194765 scopus 로고    scopus 로고
    • Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity
    • Litingtung Y., Dahn R.D., Li Y., Fallon J.F., and Chiang C. Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature 418 (2002) 979-983
    • (2002) Nature , vol.418 , pp. 979-983
    • Litingtung, Y.1    Dahn, R.D.2    Li, Y.3    Fallon, J.F.4    Chiang, C.5
  • 40
    • 23144466931 scopus 로고    scopus 로고
    • Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
    • Liu A., Wang B., and Niswander L.A. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 132 (2005) 3103-3111
    • (2005) Development , vol.132 , pp. 3103-3111
    • Liu, A.1    Wang, B.2    Niswander, L.A.3
  • 41
    • 0029948270 scopus 로고    scopus 로고
    • Biochemical evidence that patched is the Hedgehog receptor
    • Marigo V., Davey R.A., Zuo Y., Cunningham J.M., and Tabin C.J. Biochemical evidence that patched is the Hedgehog receptor. Nature 384 (1996) 176-179
    • (1996) Nature , vol.384 , pp. 176-179
    • Marigo, V.1    Davey, R.A.2    Zuo, Y.3    Cunningham, J.M.4    Tabin, C.J.5
  • 42
    • 0031679850 scopus 로고    scopus 로고
    • Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
    • Matise M.P., Epstein D.J., Park H.L., Platt K.A., and Joyner A.L. Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125 (1998) 2759-2770
    • (1998) Development , vol.125 , pp. 2759-2770
    • Matise, M.P.1    Epstein, D.J.2    Park, H.L.3    Platt, K.A.4    Joyner, A.L.5
  • 43
    • 27744484694 scopus 로고    scopus 로고
    • Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
    • May S.R., Ashique A.M., Karlen M., Wang B., Shen Y., Zarbalis K., Reiter J., Ericson J., and Peterson A.S. Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev. Biol. 287 (2005) 378-389
    • (2005) Dev. Biol. , vol.287 , pp. 378-389
    • May, S.R.1    Ashique, A.M.2    Karlen, M.3    Wang, B.4    Shen, Y.5    Zarbalis, K.6    Reiter, J.7    Ericson, J.8    Peterson, A.S.9
  • 44
    • 0038784537 scopus 로고    scopus 로고
    • Two populations of node monocilia initiate left-right asymmetry in the mouse
    • McGrath J., Somlo S., Makova S., Tian X., and Brueckner M. Two populations of node monocilia initiate left-right asymmetry in the mouse. Cell 114 (2003) 61-73
    • (2003) Cell , vol.114 , pp. 61-73
    • McGrath, J.1    Somlo, S.2    Makova, S.3    Tian, X.4    Brueckner, M.5
  • 46
    • 0037706929 scopus 로고    scopus 로고
    • Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification
    • Motoyama J., Milenkovic L., Iwama M., Shikata Y., Scott M.P., and Hui C.C. Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification. Dev. Biol. 259 (2003) 150-161
    • (2003) Dev. Biol. , vol.259 , pp. 150-161
    • Motoyama, J.1    Milenkovic, L.2    Iwama, M.3    Shikata, Y.4    Scott, M.P.5    Hui, C.C.6
  • 49
    • 0033964053 scopus 로고    scopus 로고
    • A conserved small GTP-binding protein Alp41 is essential for the cofactor-dependent biogenesis of microtubules in fission yeast
    • Radcliffe P.A., Vardy L., and Toda T. A conserved small GTP-binding protein Alp41 is essential for the cofactor-dependent biogenesis of microtubules in fission yeast. FEBS Lett. 468 (2000) 84-88
    • (2000) FEBS Lett. , vol.468 , pp. 84-88
    • Radcliffe, P.A.1    Vardy, L.2    Toda, T.3
  • 50
    • 0031820135 scopus 로고    scopus 로고
    • Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog
    • Ruiz i Altaba A. Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog. Development 125 (1998) 2203-2212
    • (1998) Development , vol.125 , pp. 2203-2212
    • Ruiz i Altaba, A.1
  • 51
    • 0030891148 scopus 로고    scopus 로고
    • A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
    • Sasaki H., Hui C., Nakafuku M., and Kondoh H. A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 124 (1997) 1313-1322
    • (1997) Development , vol.124 , pp. 1313-1322
    • Sasaki, H.1    Hui, C.2    Nakafuku, M.3    Kondoh, H.4
  • 53
    • 33646164168 scopus 로고    scopus 로고
    • Intraflagellar transport and cilium-based signaling
    • Scholey J.M., and Anderson K.V. Intraflagellar transport and cilium-based signaling. Cell 125 (2006) 439-442
    • (2006) Cell , vol.125 , pp. 439-442
    • Scholey, J.M.1    Anderson, K.V.2
  • 54
    • 3042733150 scopus 로고    scopus 로고
    • The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling
    • Sekimizu K., Nishioka N., Sasaki H., Takeda H., Karlstrom R.O., and Kawakami A. The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling. Development 131 (2004) 2521-2532
    • (2004) Development , vol.131 , pp. 2521-2532
    • Sekimizu, K.1    Nishioka, N.2    Sasaki, H.3    Takeda, H.4    Karlstrom, R.O.5    Kawakami, A.6
  • 56
    • 14644401158 scopus 로고    scopus 로고
    • A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube
    • Stamataki D., Ulloa F., Tsoni S.V., Mynett A., and Briscoe J. A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube. Genes Dev. 19 (2005) 626-641
    • (2005) Genes Dev. , vol.19 , pp. 626-641
    • Stamataki, D.1    Ulloa, F.2    Tsoni, S.V.3    Mynett, A.4    Briscoe, J.5
  • 57
    • 0014944479 scopus 로고
    • Thermal fractionation of outer fiber doublet microtubules into A- and B-subfiber components. A- and B-tubulin
    • Stephens R.E. Thermal fractionation of outer fiber doublet microtubules into A- and B-subfiber components. A- and B-tubulin. J. Mol. Biol. 47 (1970) 353-363
    • (1970) J. Mol. Biol. , vol.47 , pp. 353-363
    • Stephens, R.E.1
  • 58
    • 0033820225 scopus 로고    scopus 로고
    • Preferential incorporation of tubulin into the junctional region of ciliary outer doublet microtubules: a model for treadmilling by lattice dislocation
    • Stephens R.E. Preferential incorporation of tubulin into the junctional region of ciliary outer doublet microtubules: a model for treadmilling by lattice dislocation. Cell Motil. Cytoskeleton 47 (2000) 130-140
    • (2000) Cell Motil. Cytoskeleton , vol.47 , pp. 130-140
    • Stephens, R.E.1
  • 59
    • 33747088253 scopus 로고    scopus 로고
    • Molecular architecture of axonemal microtubule doublets revealed by cryo-electron tomography
    • Sui H., and Downing K.H. Molecular architecture of axonemal microtubule doublets revealed by cryo-electron tomography. Nature 442 (2006) 475-478
    • (2006) Nature , vol.442 , pp. 475-478
    • Sui, H.1    Downing, K.H.2
  • 60
    • 4544383179 scopus 로고    scopus 로고
    • A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney
    • Sun Z., Amsterdam A., Pazour G.J., Cole D.G., Miller M.S., and Hopkins N. A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. Development 131 (2004) 4085-4093
    • (2004) Development , vol.131 , pp. 4085-4093
    • Sun, Z.1    Amsterdam, A.2    Pazour, G.J.3    Cole, D.G.4    Miller, M.S.5    Hopkins, N.6
  • 61
    • 0033577894 scopus 로고    scopus 로고
    • Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis
    • Takeda S., Yonekawa Y., Tanaka Y., Okada Y., Nonaka S., and Hirokawa N. Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis. J. Cell Biol. 145 (1999) 825-836
    • (1999) J. Cell Biol. , vol.145 , pp. 825-836
    • Takeda, S.1    Yonekawa, Y.2    Tanaka, Y.3    Okada, Y.4    Nonaka, S.5    Hirokawa, N.6
  • 62
    • 0035159015 scopus 로고    scopus 로고
    • Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia
    • Taulman P.D., Haycraft C.J., Balkovetz D.F., and Yoder B.K. Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia. Mol. Biol. Cell 12 (2001) 589-599
    • (2001) Mol. Biol. Cell , vol.12 , pp. 589-599
    • Taulman, P.D.1    Haycraft, C.J.2    Balkovetz, D.F.3    Yoder, B.K.4
  • 64
    • 0035933796 scopus 로고    scopus 로고
    • ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins
    • Van Valkenburgh H., Shern J.F., Sharer J.D., Zhu X., and Kahn R.A. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. J. Biol. Chem. 276 (2001) 22826-22837
    • (2001) J. Biol. Chem. , vol.276 , pp. 22826-22837
    • Van Valkenburgh, H.1    Shern, J.F.2    Sharer, J.D.3    Zhu, X.4    Kahn, R.A.5
  • 65
    • 0032555120 scopus 로고    scopus 로고
    • Localization of ADP-ribosylation factor domain protein 1 (ARD1) in lysosomes and Golgi apparatus
    • Vitale N., Horiba K., Ferrans V.J., Moss J., and Vaughan M. Localization of ADP-ribosylation factor domain protein 1 (ARD1) in lysosomes and Golgi apparatus. Proc. Natl. Acad. Sci. USA 95 (1998) 8613-8618
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8613-8618
    • Vitale, N.1    Horiba, K.2    Ferrans, V.J.3    Moss, J.4    Vaughan, M.5
  • 66
    • 0034681266 scopus 로고    scopus 로고
    • Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
    • Wang B., Fallon J.F., and Beachy P.A. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 100 (2000) 423-434
    • (2000) Cell , vol.100 , pp. 423-434
    • Wang, B.1    Fallon, J.F.2    Beachy, P.A.3
  • 67
    • 0029586470 scopus 로고
    • Primary cilia in normal and pathological tissues
    • Wheatley D.N. Primary cilia in normal and pathological tissues. Pathobiology 63 (1995) 222-238
    • (1995) Pathobiology , vol.63 , pp. 222-238
    • Wheatley, D.N.1
  • 69
    • 0037111827 scopus 로고    scopus 로고
    • A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord
    • Wijgerde M., McMahon J.A., Rule M., and McMahon A.P. A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev. 16 (2002) 2849-2864
    • (2002) Genes Dev. , vol.16 , pp. 2849-2864
    • Wijgerde, M.1    McMahon, J.A.2    Rule, M.3    McMahon, A.P.4
  • 70
    • 3042740428 scopus 로고    scopus 로고
    • iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo
    • Wolff C., Roy S., Lewis K.E., Schauerte H., Joerg-Rauch G., Kirn A., Weiler C., Geisler R., Haffter P., and Ingham P.W. iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. Genes Dev. 18 (2004) 1565-1576
    • (2004) Genes Dev. , vol.18 , pp. 1565-1576
    • Wolff, C.1    Roy, S.2    Lewis, K.E.3    Schauerte, H.4    Joerg-Rauch, G.5    Kirn, A.6    Weiler, C.7    Geisler, R.8    Haffter, P.9    Ingham, P.W.10
  • 71
    • 0035958941 scopus 로고    scopus 로고
    • Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node
    • Zhang X.M., Ramalho-Santos M., and McMahon A.P. Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell 106 (2001) 781-792
    • (2001) Cell , vol.106 , pp. 781-792
    • Zhang, X.M.1    Ramalho-Santos, M.2    McMahon, A.P.3
  • 72
    • 33745752819 scopus 로고    scopus 로고
    • Arl2 and Arl3 regulate different microtubule-dependent processes
    • Zhou C., Cunningham L., Marcus A.I., Li Y., and Kahn R.A. Arl2 and Arl3 regulate different microtubule-dependent processes. Mol. Biol. Cell 17 (2006) 2476-2487
    • (2006) Mol. Biol. Cell , vol.17 , pp. 2476-2487
    • Zhou, C.1    Cunningham, L.2    Marcus, A.I.3    Li, Y.4    Kahn, R.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.