Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

Developmental Cell

Volumn 14, Issue 4, 2008, Pages 624-632

  Zhu, Jianjian ^a   Nakamura, Eiichiro ^a   Nguyen, Minh Thanh ^a   Bao, Xiaozhong ^a   Akiyama, Haruhiko ^b   Mackem, Susan ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

DEVBIO

Indexed keywords

CRE RECOMBINASE; SONIC HEDGEHOG PROTEIN; TAMOXIFEN;

ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL EXPANSION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EMBRYO PATTERN FORMATION; GROWTH REGULATION; LIMB BUD; LIMB DEVELOPMENT; MESENCHYME; MORPHOGENESIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; TISSUE SPECIFICITY;

ANIMALS; BODY PATTERNING; EMBRYO, MAMMALIAN; EXTREMITIES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, REPORTER; HEDGEHOG PROTEINS; LIMB BUDS; MICE; MICE, TRANSGENIC; MORPHOGENESIS; PHENOTYPE; TAMOXIFEN;

ERINACEIDAE; MAMMALIA;

EID: 41649094573     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.devcel.2008.01.008     Document Type: Article

References (38)

1. Ahn S., and Joyner A.L. Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. Cell 118 (2004) 505-516
2. Barna M., and Niswander L. Visualization of cartilage formation: insight into cellular properties of skeletal progenitors and chondrodysplasia syndromes. Dev. Cell 12 (2007) 931-941
3. Beachy P.A., Karhadkar S.S., and Berman D.M. Tissue repair and stem cell renewal in carcinogenesis. Nature 432 (2004) 324-331
4. Bi W., Deng J.M., Zhang Z., Behringer R.R., and de Crombrugghe B. Sox9 is required for cartilage formation. Nat. Genet. 22 (1999) 85-89
5. Brunet L.J., McMahon J.A., McMahon A.P., and Harland R.M. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science 280 (1998) 1455-1457
6. Buscher D., Bosse B., Heymer J., and Ruther U. Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mech. Dev. 62 (1997) 175-182
7. Chen M.H., Li Y.J., Kawakami T., Xu S.M., and Chuang P.T. Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 18 (2004) 641-659
8. Chiang C., Litingtung Y., Harris M.P., Simandl B.K., Li Y., Beachy P.A., and Fallon J.F. Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev. Biol. 236 (2001) 421-435
9. Dahn R.D., and Fallon J.F. Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling. Science 289 (2000) 438-441
10. Drossopoulou G., Lewis K.E., Sanz-Ezquerro J.J., Nikbakht N., McMahon A.P., Hofmann C., and Tickle C. A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signaling and Bmp signaling. Development 127 (2000) 1337-1348
11. Harfe B.D., Scherz P.J., Nissim S., Tian H., McMahon A.P., and Tabin C.J. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 118 (2004) 517-528
12. Hasson P., Del Buono J., and Logan M.P.O. Tbx5 is dispensable for forelimb outgrowth. Development 134 (2007) 85-92
13. Hornbruch A., and Wolpert L. Cell division in the early growth and morphogenesis of the chick limb. Nature 226 (1970) 764-766
14. Ingham P.W., and McMahon A.P. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15 (2001) 3059-3087
15. Lewis P.M., Dunn M.P., McMahon J.A., Logan M., Martin J.F., St-Jacques B., and McMahon A.P. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 105 (2001) 599-612
16. Li Y., Zhang H.M., Litingtung Y., and Chiang C. Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proc. Natl. Acad. Sci. USA 103 (2006) 6548-6553
17. Litingtung Y., Dahn R.D., Li Y.N., Fallon J.F., and Chiang C. Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature 418 (2002) 979-983
18. Mariani F.V., and Martin G.R. Deciphering skeletal patterning: clues from the limb. Nature 423 (2003) 319-325
19. Marigo V., Johnson R.L., Vortkamp A., and Tabin C.J. Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev. Biol. 180 (1996) 273-283
20. Michos O., Panman L., Vintersten K., Beier K., Zeller R., and Zuniga A. Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development 131 (2004) 3401-3410
21. Nakamura E., Nguyen M.T., and Mackem S. Kinetics of tamoxifen-regulated Cre activity in mice using a cartilage-specific CreER(T) to assay temporal activity windows along the proximodistal limb skeleton. Dev. Dyn. 235 (2006) 2603-2612
22. Pacifici M., Koyama E., and Iwamoto M. Mechanisms of synovial joint and articular cartilage formation: recent advances, but many lingering mysteries. Birth Defects Res. C Embryo Today 75 (2005) 237-248
23. Panman L., Galli A., Lagarde N., Michos O., Soete G., Zuniga A., and Zeller R. Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling. Development 133 (2006) 3419-3428
24. Parr B.A., and McMahon A.P. Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature 374 (1995) 350-353
25. Platt K.A., Michaud J., and Joyner A.L. Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice. Mech. Dev. 62 (1997) 121-135
26. Scherz P.J., McGlinn E., Nissim S., and Tabin C.J. Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb. Dev. Biol. 308 (2007) 343-354
27. Schughart K., Bieberich C.J., Eid R., and Ruddle F.H. A regulatory region from the mouse Hox-2.2 promoter directs gene-expression into developing limbs. Development 112 (1991) 807-811
28. Shapiro M.D., Hanken J., and Rosenthal N. Developmental basis of evolutionary digit loss in the Australian lizard Hemiergis. J. Exp. Zoolog. B Mol. Dev. Evol. 297 (2003) 48-56
29. Shubin N.H., and Alberch P. A morphogenetic approach to the origin and basic organization of the tetrapod limb. In: Hecht M.K., Wallace B., and Prance G.I. (Eds). Evolutionary Biology Volume 20 (1986), Plenum Press, New York 319-387
30. Stopper G.F., and Wagner G.P. Inhibition of Sonic hedgehog signaling leads to posterior digit loss in Ambystoma mexicanum: parallels to natural digit reduction in urodeles. Dev. Dyn. 236 (2007) 321-331
31. Sun X., Mariani F.V., and Martin G.R. Functions of FGF signalling from the apical ectodermal ridge in limb development. Nature 418 (2002) 501-508
32. Suzuki T., Takeuchi J., Koshiba-Takeuchi K., Koshiba-Takeuchi K., and Ogura T. Tbx genes specify posterior digit identity through Shh and BMP signaling. Dev. Cell 6 (2004) 43-53
33. te Welscher P., Zuniga A., Kuijper S., Drenth T., Goedemans H.J., Meijlink F., and Zeller R. Progression of vertebrate limb development through SHH-mediated counteraction of GLI3. Science 298 (2002) 827-830
34. Tickle C. Making digit patterns in the vertebrate limb. Nat. Rev. Mol. Cell Biol. 7 (2006) 45-53
35. Verheyden J.M., Lewandoski M., Deng C., Harfe B.D., and Sun X. Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development 132 (2005) 4235-4245
36. Yang Y., Drossopoulou G., Chuang P.T., Duprez D., Marti E., Bumcrot D., Vargesson N., Clarke J., Niswander L., McMahon A., et al. Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. Development 124 (1997) 4393-4404
37. Zakany J., and Duboule D. Synpolydactyly in mice with a targeted deficiency in the HoxD complex. Nature 384 (1996) 69-71
38. Zeller R. It takes time to make a pinky: unexpected insights into how SHH patterns vertebrate digits. Sci. STKE 259 (2004) pe53