The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors

Nature Medicine

Volumn 7, Issue 6, 2001, Pages 706-711

  Pola, Roberto ^a   Ling, Leona E ^b   Silver, Marcy ^a   Corbley, Michael J ^b   Kearney, Marianne ^a   Blake Pepinsky, R ^b   Shapiro, Renee ^b   Taylor, Frederick R ^b   Baker, Darren P ^b   Asahara, Takayuki ^a   Isner, Jeffrey M ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BIOGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; ANGIOPEPTIN; CYTOKINE; GROWTH FACTOR; ISOPROTEIN; MORPHOGEN; SONIC HEDGEHOG PROTEIN; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL DIAMETER; CARDIOVASCULAR SYSTEM; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; FEMALE; IN VIVO STUDY; MALE; MESENCHYME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ANGIOPOIETIN-1; ANGIOPOIETIN-2; ANIMALS; BLOOD VESSELS; CORNEAL NEOVASCULARIZATION; ENDOTHELIAL GROWTH FACTORS; FEMALE; GENES, REPORTER; HEDGEHOG PROTEINS; HINDLIMB; HUMANS; IMMUNOHISTOCHEMISTRY; ISCHEMIA; LYMPHOKINES; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEINS; RECEPTORS, CELL SURFACE; RECOMBINANT FUSION PROTEINS; REGIONAL BLOOD FLOW; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

ANIMALIA; ERINACEIDAE;

EID: 0034960583     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/89083     Document Type: Article

References (45)

1. Cyclopia and defective axial patterning in mice lacking sonic hedgehog gene function
2. Molecular models for vertebrate limb development
3. Sonic hedgehog regulates branching morphogenesis in the mammalian lung
4. Hedgehog signals regulate multiple aspects of gastrointestinal development
5. Sonic hedgehog signaling is essential for hair development
6. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
7. Sertoli cell signaling by Desert hedgehog regulates the male germline
8. Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths
9. Cholesterol modification of hedgehog signaling proteins in animal development
10. Identification of a palmitic acid-modified form of human Sonic hedgehog
11. Sonic hedgehog signals not as a hydrolytic enzyme but as an apparent ligand for patched
12. Evolution and orthology of hedgehog genes
13. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo
14. Transducing hedgehog: The story so far
15. Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli
16. Mammalian Suppressor-of-Fused modulates nuclear-cytoplasmic shuttling of Gli-1
17. Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli
18. Suppressor of fused links fused and Cubitus interruptus on the hedgehog signaling pathway
19. Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway
20. Hedgehog elicits signal transduction by means of a large complex containing the kinesis-related protein costal2
21. Hedgehog signalling: Ci complex cuts and clasps
22. Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development
23. Regulation of patched by sonic hedgehog in the developing neural tube
24. Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells
25. Insights in to early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in type and mutant zebrafish embryos
26. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
27. Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I
28. Active hair growth (anagen) is associated with angiogenesis
29. Conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration
30. Age-dependent impairment of angiogenesis
31. Hypoxia-regulated gene expression in fetal wound regeneration and adult wound repair
32. Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity
33. Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptor in human skin
34. CD40 engagement on synovial fibroblasts up-regulates production of vascular endothelial growth factor
35. Indirect angiogenesis cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, while hypoxia upregulates VEGF expression only
36. Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization
37. Increased vascularization in mice overexpressing angiopoietin-1
38. Vascular endothelial growth factor (VEGF) mRNA isoforms expression pattern is correlated with liver metastasis and poor prognosis in colon cancer
39. Growth factors acting via endothelail cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development
40. New model of tumor angiogenesis: Dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
41. Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase
42. The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development
43. Mapping sonic hedgehog-receptor interactions by steric interference
44. A mouse model of angiogenesis
45. Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity