The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis

Development

Volumn 128, Issue 24, 2001, Pages 5201-5212

  Dahmane, Nadia ^a   Sánchez, Pilar ^a   Gitton, Yorick ^a   Palma, Verónica ^a   Sun, Tao ^a   Beyna, Mercedes ^a   Weiner, Howard ^a   Ruiz i Altaba, Ariel ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain; CNS; GLI; Growth; Mouse; Neocortex; SHH; Tectum; Tumor; Xenopus

Indexed keywords

ANTIMITOTIC AGENT; CYLOPAMINE; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ARTICLE; ASSAY; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN GROWTH; BRAIN TUMOR; CARCINOGENESIS; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; GENE TARGETING; IN VITRO STUDY; IN VIVO STUDY; MITOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; STEM CELL; TADPOLE; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BRAIN; BRAIN NEOPLASMS; CELL COMMUNICATION; CELL DIVISION; CORPORA QUADRIGEMINA; HEDGEHOG PROTEINS; HUMANS; MICE; NEOCORTEX; ONCOGENE PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; VERATRUM ALKALOIDS;

ERINACEIDAE; MAMMALIA;

EID: 0035691884     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (73)

1. Sonic hedgehog control of size and shape in midbrain pattern formation
2. Gli/Zic factors pattern the neural plate by defining domains of cell differentiation
3. Altaba Gli2 functions in FGF signaling during antero-posterior patterning
4. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
5. Teratogen-mediated inhibition of target tissue response to Shh signaling
6. Sonic hedgehog regulates the growth and patterning of the cerebellum
7. Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
8. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
9. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
10. Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube
11. Two critical periods of sonic hedgehog signaling required for the specification of motor neuron identity
12. Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway
13. Extra-toes (Xt) homoxygous mice demonstrate a role for the Gli3 gene in the development of the forebrain
14. Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
15. Altered neural cell fates and medulloblastoma in mouse patched mutants
16. Basal cell carcinomas in mice overexpressing gli2 in skin
17. Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
18. Beta-catenin signaling activity dissected in the early Xenopus embryo: A novel antisense approach
19. Identification of major cell classes in the developing mammalian nervous system
20. Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development
21. Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1
22. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction
23. Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture
24. The regulation of neural precursor cells within the mammalian brain Mol.
25. Identification of an amplified, highly expressed gene in a human glioma
26. Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog
27. Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
28. CNS stem cells express a new class of intermediate filament protein
29. Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP
30. Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3
31. Multiple roles of bone morphogenetic protein signaling in the regulation of cortical cell number and phenotype
32. Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult in vitro
33. Sonic hedgehog contributes to oligodendrocyte specification in the mammalian telencephalon
34. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing Gli1
35. Cooperation of intrinsic and extrinsic signals in the elaboration of regional identity in the posterior cerebral cortex
36. Modulation of early but not later stages of programmed cell death in embryonic avian spinal cord by sonic hedgehog
37. Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors
38. FGF-2 activates a latent neurogenic program on neural stem cells from diverse regions of the adult CNS
39. Mouse Gli mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
40. Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched
41. Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium
42. Induction of oligodendrocyte progenitors in the trunk neural tube by ventralizing signals: Effects of notochord and floor plate grafts, and of sonic hedgehog
43. A singularity of PDGF alpha-receptor expression in the dorsoventral axis of the neural tube may define the origin of the oligodendrocyte lineage
44. Determination of neuroepithelial cell fate: Induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog
45. Radial unit hypothesis of neocortical expansion
46. Sporadic medulloblastomas contain PTCH mutations
47. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
48. Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord
49. Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells
50. Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog
51. Gli proteins and Hedgehog signaling: Development and cancer
52. Restrictions to floor plate induction by hedgehog and winged-helix genes in the neural tube of frog embryos
53. The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A
54. Situ hybridization with single-stranded RNA probes to demonstrate infrequently elevated gli mRNA and no increased ras mRNA levels in meningiomas and astrocytomas
55. Platelet-derived growth factor (PDGF) in primary brain tumours of neuroglial origin
56. Sonic hedgehog signaling is essential for hair development
57. PACAP is an anti-mitogenic signal in developing cerebral cortex
58. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
59. Cloning of novel isoforms of the human Gli2 oncogene and their activities to enhance Tax-dependent transcription of the human T-cell leukemia virus type I genome
60. Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon
61. Gli3 is required for Emx gene expression during dorsal telencephalon development
62. Dorsoventral patterning of the mouse telencephalon is disrupted in the mouse mutant extra-toes
63. Discrete localizations of hedgehog signalling components in the developing and adult nervous system
64. Somatic mutations on the human homologue of Drosophila patched in primitive neuroectodermal tumors
65. Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum
66. p53 activity is essential for normal development in Xenopus
67. Control of chick tectum territory along the dorsoventral axis by Sonic hedgehog
68. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog
69. Consistent and selective expression of the DDR1 tyrosine kinase in human brain tumors
70. Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
71. A search for gli expression in tumors of the central nervous system
72. Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors
73. Sonic hedgehog and BMP2 exert opposing actions on proliferation and differentiation of embryonic neural progenitor cells