메뉴 건너뛰기




Volumn 60, Issue 8, 2000, Pages 2239-2246

The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; GENE MUTATION; MEDULLOBLASTOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0034655270     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (179)

References (48)
  • 3
    • 0031416280 scopus 로고    scopus 로고
    • Genetics of pediatric central nervous system tumors
    • Biegel, J. A. Genetics of pediatric central nervous system tumors. J. Pediatr. Hematol./Oncol., 19: 492-501, 1997.
    • (1997) J. Pediatr. Hematol./oncol. , vol.19 , pp. 492-501
    • Biegel, J.A.1
  • 6
    • 0030874617 scopus 로고    scopus 로고
    • Somatic mutations in the human homologue of drosophila patched in primitive neuroectodermal tumours
    • Vorechovsky, I., Tingby, O., Hartman, M., Stromberg, B., Nister, M., Collins, V. P., and Toftgard, R. Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours. Oncogene, 15: 361-366, 1997.
    • (1997) Oncogene , vol.15 , pp. 361-366
    • Vorechovsky, I.1    Tingby, O.2    Hartman, M.3    Stromberg, B.4    Nister, M.5    Collins, V.P.6    Toftgard, R.7
  • 7
    • 0030738693 scopus 로고    scopus 로고
    • Mutations in the human homologue of the drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
    • Wolter, M., Reifenherger, J., Sommer, C., Ruzicka, T., and Reifenberger, G. Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res., 57: 2581-2585, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 2581-2585
    • Wolter, M.1    Reifenherger, J.2    Sommer, C.3    Ruzicka, T.4    Reifenberger, G.5
  • 11
    • 0029944362 scopus 로고    scopus 로고
    • Tumor suppressor genes and medulloblastoma
    • Cogen, P. H., and McDonald, J. D. Tumor suppressor genes and medulloblastoma. J. Neuro-Oncol., 29: 103-112, 1996.
    • (1996) J. Neuro-oncol. , vol.29 , pp. 103-112
    • Cogen, P.H.1    McDonald, J.D.2
  • 12
    • 0030913738 scopus 로고    scopus 로고
    • The gene for the naevoid basal cell carcinoma syndrome acts as a tumour-suppressor gene in medulloblastoma
    • Cowan, R., Hoban, P., Kelsey, A., Birch, J. M., Gattamaneni, R., and Evans, D. G. The gene for the naevoid basal cell carcinoma syndrome acts as a tumour-suppressor gene in medulloblastoma. Br. J. Cancer, 76: 141-145, 1997.
    • (1997) Br. J. Cancer , vol.76 , pp. 141-145
    • Cowan, R.1    Hoban, P.2    Kelsey, A.3    Birch, J.M.4    Gattamaneni, R.5    Evans, D.G.6
  • 13
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in drosophila
    • Nusslein-Volhard, C., and Wieschaus, E. Mutations affecting segment number and polarity in Drosophila. Nature (Lond.), 287: 795-801, 1980.
    • (1980) Nature (Lond.) , vol.287 , pp. 795-801
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 14
    • 0024468746 scopus 로고
    • The drosophila patched gene encodes a putative membrane protein required for segmental patterning
    • Hooper, J. E., and Scott, M. P. The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell, 59: 751-765, 1989.
    • (1989) Cell , vol.59 , pp. 751-765
    • Hooper, J.E.1    Scott, M.P.2
  • 15
    • 0009603803 scopus 로고    scopus 로고
    • Sonic hedgehog signaling by the patched-smoothencd receptor complex
    • Murone, M., Rosenthal, A., and de Sauvage, F. J. Sonic hedgehog signaling by the patched-smoothencd receptor complex. Curr. Biol., 9: 76-84, 1999.
    • (1999) Curr. Biol. , vol.9 , pp. 76-84
    • Murone, M.1    Rosenthal, A.2    De Sauvage, F.J.3
  • 16
    • 0032126734 scopus 로고    scopus 로고
    • Transducing hedgehog: The story so far
    • Ingham, P. W. Transducing Hedgehog: the story so far. EMBO J., 17: 3505-3511, 1998.
    • (1998) EMBO J. , vol.17 , pp. 3505-3511
    • Ingham, P.W.1
  • 17
    • 0030869843 scopus 로고    scopus 로고
    • Recent advances in hedgehog signalling
    • Tabin, C. J., and McMahon, A. P. Recent advances in hedgehog signalling. Trends Cell Biol., 7: 442-446, 1997.
    • (1997) Trends Cell Biol. , vol.7 , pp. 442-446
    • Tabin, C.J.1    McMahon, A.P.2
  • 19
    • 0032409157 scopus 로고    scopus 로고
    • Hedgehog and patched in neural development and disease
    • Goodrich, L. V., and Scott, M. P. Hedgehog and patched in neural development and disease. Neuron, 21: 1243-1257, 1998.
    • (1998) Neuron , vol.21 , pp. 1243-1257
    • Goodrich, L.V.1    Scott, M.P.2
  • 21
    • 0023930186 scopus 로고
    • The GLI gene is a member of the kruppel family of zinc finger proteins
    • Kinzler, K. W., Ruppert, J. M., Bigner, S. H., and Vogelstein, B. The GLI gene is a member of the Kruppel family of zinc finger proteins. Nature (Lond.), 332: 371-374, 1988.
    • (1988) Nature (Lond.) , vol.332 , pp. 371-374
    • Kinzler, K.W.1    Ruppert, J.M.2    Bigner, S.H.3    Vogelstein, B.4
  • 22
    • 0023222358 scopus 로고
    • Nevoid basal-cell carcinoma syndrome
    • Gorlin, R. J. Nevoid basal-cell carcinoma syndrome. Medicine, 66: 98-113, 1987.
    • (1987) Medicine , vol.66 , pp. 98-113
    • Gorlin, R.J.1
  • 24
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • (Washington DC)
    • Goodrich, L. V., Milenkovic, L., Higgins, K. M., and Scott, M. P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science (Washington DC), 277: 1109-1113, 1997.
    • (1997) Science , vol.277 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3    Scott, M.P.4
  • 25
    • 0031837454 scopus 로고    scopus 로고
    • Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of gorlin syndrome
    • Hahn, H., Wojnowski, L., Zimmer, A. M., Hall, J., Miller, G., and Zimmer, A. Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome [see comments]. Nat. Med., 4: 619-622, 1998.
    • (1998) Nat. Med. , vol.4 , pp. 619-622
    • Hahn, H.1    Wojnowski, L.2    Zimmer, A.M.3    Hall, J.4    Miller, G.5    Zimmer, A.6
  • 26
  • 27
    • 0028281306 scopus 로고
    • Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm-and mesoderm-derived tissues suggests multiple roles during postimplantation development
    • Hui, C. C., Slusarski, D., Platt, K. A., Holmgren, R., and Joyner, A. L. Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm-and mesoderm-derived tissues suggests multiple roles during postimplantation development. Dev. Biol., 162: 402-413, 1994.
    • (1994) Dev. Biol. , vol.162 , pp. 402-413
    • Hui, C.C.1    Slusarski, D.2    Platt, K.A.3    Holmgren, R.4    Joyner, A.L.5
  • 28
    • 0028940096 scopus 로고
    • A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
    • D'Arcangelo, G., Miao, G. G., Chen, S. C., Soares, H. D., Morgan, J. I., and Curran, T. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler [see comments]. Nature (Lond.), 374: 719-723, 1995.
    • (1995) Nature (Lond.) , vol.374 , pp. 719-723
    • D'Arcangelo, G.1    Miao, G.G.2    Chen, S.C.3    Soares, H.D.4    Morgan, J.I.5    Curran, T.6
  • 29
    • 0025944524 scopus 로고
    • TrkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3
    • Lamballe, F., Klein, R., and Barbacid, M. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell, 66: 967-979, 1991.
    • (1991) Cell , vol.66 , pp. 967-979
    • Lamballe, F.1    Klein, R.2    Barbacid, M.3
  • 30
    • 0030844141 scopus 로고    scopus 로고
    • Activation of the transcription factor gli1 and the sonic hedgehog signalling pathway in skin tumours
    • [published erratum appears in Nature (Lond.), 390: 536, 1997].
    • Dahmane, N., Lee, J., Robins, P., Heller, P., and Ruiz i Altaba, A. Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours [published erratum appears in Nature (Lond.), 390: 536, 1997]. Nature (Lond.)., 389: 876-881, 1997.
    • (1997) Nature (Lond.). , vol.389 , pp. 876-881
    • Dahmane, N.1    Lee, J.2    Robins, P.3    Heller, P.4    Ruiz, I.5    Altaba, A.6
  • 32
    • 0026714672 scopus 로고
    • Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme
    • Xanthoudakis, S., Miao, G., Wang, F., Pan, Y. C., and Curran, T. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J., 11: 3323-3335, 1992.
    • (1992) EMBO J. , vol.11 , pp. 3323-3335
    • Xanthoudakis, S.1    Miao, G.2    Wang, F.3    Pan, Y.C.4    Curran, T.5
  • 33
    • 0028568009 scopus 로고
    • Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma
    • Segal, R. A., Goumnerova, L. C., Kwon, Y. K., Stiles, C. D., and Pomeroy, S. L. Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma. Proc. Natl. Acad. Sci. USA, 91: 12867-12871, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12867-12871
    • Segal, R.A.1    Goumnerova, L.C.2    Kwon, Y.K.3    Stiles, C.D.4    Pomeroy, S.L.5
  • 35
    • 0032959871 scopus 로고    scopus 로고
    • Control of neuronal precursor proliferation in the cerebellum by sonic hedgehog
    • Wechsler-Reya, R. J., and Scott, M. P. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog [see comments]. Neuron, 22: 103-114, 1999.
    • (1999) Neuron , vol.22 , pp. 103-114
    • Wechsler-Reya, R.J.1    Scott, M.P.2
  • 36
    • 0033570359 scopus 로고    scopus 로고
    • Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells
    • Rowitch, D. H., St-Jacques, B., Lee, S. M. K., Flax, J. D., Snyder, E. Y., and McMahon, A. P. Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J. Neurosci., 19: 8954-8965, 1999.
    • (1999) J. Neurosci. , vol.19 , pp. 8954-8965
    • Rowitch, D.H.1    St-Jacques, B.2    Lee, S.M.K.3    Flax, J.D.4    Snyder, E.Y.5    McMahon, A.P.6
  • 37
    • 0028956797 scopus 로고
    • Mechanisms of neural patterning and specification in the developing cerebellum
    • Hatten, M. E., and Heintz, N. Mechanisms of neural patterning and specification in the developing cerebellum. Annu. Rev. Neurosci., 18: 385-408, 1995.
    • (1995) Annu. Rev. Neurosci. , vol.18 , pp. 385-408
    • Hatten, M.E.1    Heintz, N.2
  • 39
    • 0030802458 scopus 로고    scopus 로고
    • Induction of basal cell carcinoma features in transgenic human skin expressing sonic Hedgehog
    • Fan, H., Oro, A. E., Scott, M. P., and Khavari, P. A. Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog. Nat. Med., 3: 788-792, 1997.
    • (1997) Nat. Med. , vol.3 , pp. 788-792
    • Fan, H.1    Oro, A.E.2    Scott, M.P.3    Khavari, P.A.4
  • 40
    • 0032796826 scopus 로고    scopus 로고
    • Sonic hedgehog regulates the growth and patterning of the cerebellum
    • (Camb.)
    • Dahmane, N., and Ruiz-i-Altaba, A. Sonic hedgehog regulates the growth and patterning of the cerebellum. Development (Camb.), 126: 3089-3100, 1999.
    • (1999) Development , vol.126 , pp. 3089-3100
    • Dahmane, N.1    Ruiz-I-Altaba, A.2
  • 41
    • 0030955557 scopus 로고    scopus 로고
    • Basal cell carcinomas in mice overexpressing sonic hedgehog
    • (Washington DC)
    • Oro, A. E., Higgins, K. M., Hu, Z., Bonifas, J. M., Epstein, E. H., Jr., and Scott, M. P. Basal cell carcinomas in mice overexpressing sonic hedgehog. Science (Washington DC), 276: 817-821, 1997.
    • (1997) Science , vol.276 , pp. 817-821
    • Oro, A.E.1    Higgins, K.M.2    Hu, Z.3    Bonifas, J.M.4    Epstein E.H., Jr.5    Scott, M.P.6
  • 42
    • 0028032065 scopus 로고
    • The drosophila segment polarity gene patched interacts with decapentaplegic in wing development
    • Capdevila, J., Estrada, M. P., Sanchez-Herrero, E., and Guerrero, I. The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. EMBO J., 13: 71-82, 1994.
    • (1994) EMBO J. , vol.13 , pp. 71-82
    • Capdevila, J.1    Estrada, M.P.2    Sanchez-Herrero, E.3    Guerrero, I.4
  • 43
    • 0029843937 scopus 로고    scopus 로고
    • Regulation of patched by sonic hedgehog in the developing neural tube
    • Marigo, V., and Tabin, C. J. Regulation of patched by sonic hedgehog in the developing neural tube. Proc. Natl. Acad. Sci. USA, 93: 9346-9351, 1996.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9346-9351
    • Marigo, V.1    Tabin, C.J.2
  • 44
    • 0030027059 scopus 로고    scopus 로고
    • Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
    • Goodrich, L. V., Johnson, R. L., Milenkovic, L., McMahon, J. A., and Scott, M. P. Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev., 10: 301-312, 1996.
    • (1996) Genes Dev. , vol.10 , pp. 301-312
    • Goodrich, L.V.1    Johnson, R.L.2    Milenkovic, L.3    McMahon, J.A.4    Scott, M.P.5
  • 46
    • 0030902872 scopus 로고    scopus 로고
    • Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice
    • Simpson, E. M., Linder, C. C., Sargent, E. E., Davisson, M. T., Mobraaten, L. E., and Sharp, J. J. Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice. Nat. Genet., 16: 19-27, 1997.
    • (1997) Nat. Genet. , vol.16 , pp. 19-27
    • Simpson, E.M.1    Linder, C.C.2    Sargent, E.E.3    Davisson, M.T.4    Mobraaten, L.E.5    Sharp, J.J.6
  • 47
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for patched in sequestering and transducing hedgehog
    • Chen, Y., and Struhl, G. Dual roles for patched in sequestering and transducing Hedgehog. Cell, 87: 553-563, 1996.
    • (1996) Cell , vol.87 , pp. 553-563
    • Chen, Y.1    Struhl, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.