Small-molecule modulators of Hedgehog signaling: Identification and characterization of Smoothened agonists and antagonists

Journal of Biology

Volumn 1, Issue 2, 2002, Pages

  Frank Kamenetsky, Maria ^a   Zhang, Xiaoyan M ^a   Bottega, Steve ^a   Guicherit, Oivin ^a   Wichterle, Hynek ^b   Dudek, Henryk ^a   Bumcrot, David ^a   Wang, Frank Y ^a   Jones, Simon ^a   Shulok, Janine ^a   Rubin, Lee L ^a   Porter, Jeffery A ^a  

^a CURIS INC   (United States)

^b College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; CYCLOPAMINE; G PROTEIN COUPLED RECEPTOR; N (3 METHOXYBENZYL) 3,3 DIMETHYL N [1 (3,4 METHYLENEDIOXYBENZYL) 2 (1 PIPERAZINYLCARBONYL) 4 PYRROLIDINYL]BUTYRAMIDE; PROTEIN PATCHED; PROTEIN SMOOTHENED; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; ANTIBODY; ANTIGEN ANTIBODY COMPLEX; CELL SURFACE RECEPTOR; MEMBRANE PROTEIN; PATCHED RECEPTORS; PEPTIDE; SHH PROTEIN, HUMAN; SIGNAL PEPTIDE; SMO PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TYPE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; EMBRYO; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; ANTIGEN ANTIBODY COMPLEX; BINDING COMPETITION; C3H MOUSE; CELL CULTURE; CELL LINE; CELL MEMBRANE; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CHEMICAL STRUCTURE; CHEMISTRY; CHICK EMBRYO; CYTOLOGY; DRUG EFFECTS; FEMALE; IMMUNOLOGY; MAMMALIAN EMBRYO; METABOLISM; NERVE CELL; ORGAN CULTURE TECHNIQUE; PHARMACOLOGY; PHYSIOLOGY; PREGNANCY; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALIA; ERINACEIDAE;

ANIMALS; ANTIBODIES; ANTIGEN-ANTIBODY COMPLEX; BINDING, COMPETITIVE; CELL DIFFERENTIATION; CELL LINE; CELL MEMBRANE; CELL PROLIFERATION; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CHICK EMBRYO; EMBRYO, MAMMALIAN; FEMALE; HEDGEHOG PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, INBRED C3H; MOLECULAR STRUCTURE; NEURONS; ORGAN CULTURE TECHNIQUES; PEPTIDES; PREGNANCY; RATS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATORS;

EID: 18644368453     PISSN: 14785854     EISSN: 14754924     Source Type: Journal    
DOI: 10.1186/1475-4924-1-10     Document Type: Article

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