메뉴 건너뛰기




Volumn 22, Issue , 2006, Pages 409-437

Recognition and signaling by toll-like receptors

Author keywords

Innate immunity; Leucine rich repeat; MyD88; Signal transaction; TIR domain; TRIF

Indexed keywords

LEUCINE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9;

EID: 33751172758     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.cellbio.21.122303.115827     Document Type: Review
Times cited : (592)

References (171)
  • 1
    • 0032127279 scopus 로고    scopus 로고
    • Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    • Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, et al. 1998. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9:143-50
    • (1998) Immunity , vol.9 , pp. 143-150
    • Adachi, O.1    Kawai, T.2    Takeda, K.3    Matsumoto, M.4    Tsutsui, H.5
  • 2
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4:499-511
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 3
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • Akira S, Takeda K, Kaisho T. 2001. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2:675-80
    • (2001) Nat. Immunol. , vol.2 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 4
    • 1642527864 scopus 로고    scopus 로고
    • Toll-like receptors differentially induce nucleosome remodelling at the IL-12p40 promoter
    • Albrecht I, Tapmeier T, Zimmermann S, Frey M, Heeg K, Dalpke A. 2004. Toll-like receptors differentially induce nucleosome remodelling at the IL-12p40 promoter. EMBO Rep. 5:172-77
    • (2004) EMBO Rep. , vol.5 , pp. 172-177
    • Albrecht, I.1    Tapmeier, T.2    Zimmermann, S.3    Frey, M.4    Heeg, K.5    Dalpke, A.6
  • 5
    • 0036595049 scopus 로고    scopus 로고
    • Suppressors of cytokine signalling (SOCS) in the immune system
    • Alexander WS. 2002. Suppressors of cytokine signalling (SOCS) in the immune system. Nat. Rev. Immunol. 2:410-16
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 410-416
    • Alexander, W.S.1
  • 6
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. 2001. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413:732-38
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 7
    • 10344259136 scopus 로고    scopus 로고
    • The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-β promoter
    • Andrejeva J, Childs KS, Young DF, Carlos TS, Stock N, et al. 2004. The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-β promoter. Proc. Natl. Acad. Sci. USA 101:17264-69
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 17264-17269
    • Andrejeva, J.1    Childs, K.S.2    Young, D.F.3    Carlos, T.S.4    Stock, N.5
  • 8
    • 11144233242 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells
    • Baetz A, Frey M, Heeg K, Dalpke AH. 2004. Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells. J. Biol. Chem. 279:54708-15
    • (2004) J. Biol. Chem. , vol.279 , pp. 54708-54715
    • Baetz, A.1    Frey, M.2    Heeg, K.3    Dalpke, A.H.4
  • 9
    • 29244450802 scopus 로고    scopus 로고
    • Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
    • Barton GM, Kagan JC, Medzhitov R. 2006. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat. Immunol. 7:49-56
    • (2006) Nat. Immunol. , vol.7 , pp. 49-56
    • Barton, G.M.1    Kagan, J.C.2    Medzhitov, R.3
  • 12
    • 3142654210 scopus 로고    scopus 로고
    • Inferences, questions and possibilities in Toll-like receptor signalling
    • Beutler B. 2004. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 430:257-63
    • (2004) Nature , vol.430 , pp. 257-263
    • Beutler, B.1
  • 13
    • 20344364201 scopus 로고    scopus 로고
    • Genetic analysis of innate immunity: Identification and function of the TIR adapter proteins
    • Beutler B, Hoebe K, Georgel P, Tabeta K, Du X. 2005. Genetic analysis of innate immunity: identification and function of the TIR adapter proteins. Adv. Exp. Med. Biol. 560:29-39
    • (2005) Adv. Exp. Med. Biol. , vol.560 , pp. 29-39
    • Beutler, B.1    Hoebe, K.2    Georgel, P.3    Tabeta, K.4    Du, X.5
  • 14
    • 2942721674 scopus 로고    scopus 로고
    • ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
    • Brint EK, Xu D, Liu H, Dunne A, McKenzie AN, et al. 2004. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat. Immunol. 5:373-79
    • (2004) Nat. Immunol. , vol.5 , pp. 373-379
    • Brint, E.K.1    Xu, D.2    Liu, H.3    Dunne, A.4    McKenzie, A.N.5
  • 15
    • 0035817818 scopus 로고    scopus 로고
    • Immune recognition. A new receptor for beta-glucans
    • Brown GD, Gordon S. 2001. Immune recognition. A new receptor for beta-glucans. Nature 413:36-37
    • (2001) Nature , vol.413 , pp. 36-37
    • Brown, G.D.1    Gordon, S.2
  • 17
    • 0035879283 scopus 로고    scopus 로고
    • Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: Role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling
    • Bulut Y, Faure E, Thomas L, Equils O, Arditi M. 2001. Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. J. Immunol. 167:987-94
    • (2001) J. Immunol. , vol.167 , pp. 987-994
    • Bulut, Y.1    Faure, E.2    Thomas, L.3    Equils, O.4    Arditi, M.5
  • 18
    • 0033776154 scopus 로고    scopus 로고
    • Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
    • Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, et al. 2000. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat. Cell. Biol. 2:346-51
    • (2000) Nat. Cell. Biol. , vol.2 , pp. 346-351
    • Burns, K.1    Clatworthy, J.2    Martin, L.3    Martinon, F.4    Plumpton, C.5
  • 19
    • 0037454946 scopus 로고    scopus 로고
    • Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4
    • Burns K, Janssens S, Brissoni B, Olivos N, Beyaert R, Tschopp J. 2003. Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J. Exp. Med. 197:263-68
    • (2003) J. Exp. Med. , vol.197 , pp. 263-268
    • Burns, K.1    Janssens, S.2    Brissoni, B.3    Olivos, N.4    Beyaert, R.5    Tschopp, J.6
  • 20
    • 0035399862 scopus 로고    scopus 로고
    • Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite
    • Campos MA, Almeida IC, Takeuchi O, Akira S, Valente EP, et al. 2001. Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite. J. Immunol. 167:416-23
    • (2001) J. Immunol. , vol.167 , pp. 416-423
    • Campos, M.A.1    Almeida, I.C.2    Takeuchi, O.3    Akira, S.4    Valente, E.P.5
  • 21
    • 0037204948 scopus 로고    scopus 로고
    • TNF-R1 signaling: A beautiful pathway
    • Chen G, Goeddel DV. 2002. TNF-R1 signaling: a beautiful pathway. Science 296:1634-33
    • (2002) Science , vol.296 , pp. 1634-1733
    • Chen, G.1    Goeddel, D.V.2
  • 22
    • 23144449789 scopus 로고    scopus 로고
    • Ubiquitin signalling in the NF-κB pathway
    • Chen ZJ. 2005. Ubiquitin signalling in the NF-κB pathway. Nat. Cell. Biol. 7:758-65
    • (2005) Nat. Cell. Biol. , vol.7 , pp. 758-765
    • Chen, Z.J.1
  • 23
    • 23044445303 scopus 로고    scopus 로고
    • Crystal structure of human toll-like receptor 3 (TLR3) ectodomain
    • Choe J, Kelker MS, Wilson IA. 2005. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science 309:581-85
    • (2005) Science , vol.309 , pp. 581-585
    • Choe, J.1    Kelker, M.S.2    Wilson, I.A.3
  • 24
    • 19944430901 scopus 로고    scopus 로고
    • Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
    • Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, et al. 2005. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J. Exp. Med. 201:19-25
    • (2005) J. Exp. Med. , vol.201 , pp. 19-25
    • Coban, C.1    Ishii, K.J.2    Kawai, T.3    Hemmi, H.4    Sato, S.5
  • 25
    • 24944586285 scopus 로고    scopus 로고
    • Achieving stability of lipopolysaccharide-induced NF-kappaB activation
    • Covert MW, Leung TH, Gaston JE, Baltimore D. 2005. Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science 309:1854-57
    • (2005) Science , vol.309 , pp. 1854-1857
    • Covert, M.W.1    Leung, T.H.2    Gaston, J.E.3    Baltimore, D.4
  • 26
    • 27744561393 scopus 로고    scopus 로고
    • Rip1 mediates the Trif-dependent Toll-like receptor 3 and 4-induced NF-κ B activation but does not contribute to IRF-3 activation
    • Cusson-Hermance N, Lee TH, Fitzgerald KA, Kelliher MA. 2005. Rip1 mediates the Trif-dependent Toll-like receptor 3 and 4-induced NF-κ B activation but does not contribute to IRF-3 activation. J. Biol. Chem, 280:36560-66
    • (2005) J. Biol. Chem , vol.280 , pp. 36560-36566
    • Cusson-Hermance, N.1    Lee, T.H.2    Fitzgerald, K.A.3    Kelliher, M.A.4
  • 27
    • 0034644474 scopus 로고    scopus 로고
    • Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
    • Deng L, Wang C, Spencer E, Yang L, Braun A, et al. 2000. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103:351-61
    • (2000) Cell , vol.103 , pp. 351-361
    • Deng, L.1    Wang, C.2    Spencer, E.3    Yang, L.4    Braun, A.5
  • 28
    • 31344444906 scopus 로고    scopus 로고
    • Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide
    • Didierlaurent A, Brissoni B, Velin D, Aebi N, Tardivel A, et al. 2006. Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Mol. Cell. Biol. 26:735-42
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 735-742
    • Didierlaurent, A.1    Brissoni, B.2    Velin, D.3    Aebi, N.4    Tardivel, A.5
  • 29
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. 2004. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303:1529-31
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis E Sousa, C.5
  • 32
    • 0141959224 scopus 로고    scopus 로고
    • LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the Toll adapters TRAM and TRIF
    • Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, et al. 2003b. LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the Toll adapters TRAM and TRIF. J. Exp. Med. 198:1043-55
    • (2003) J. Exp. Med. , vol.198 , pp. 1043-1055
    • Fitzgerald, K.A.1    Rowe, D.C.2    Barnes, B.J.3    Caffrey, D.R.4    Visintin, A.5
  • 33
    • 33744464740 scopus 로고    scopus 로고
    • Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1 β in salmonella-infected macrophages
    • Franchi L, Amer A, Body-Malapel M, Kanneganti TD, Ozoren N, et al. 2006. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1 β in salmonella-infected macrophages. Nat. Immunol. 7:576-82
    • (2006) Nat. Immunol. , vol.7 , pp. 576-582
    • Franchi, L.1    Amer, A.2    Body-Malapel, M.3    Kanneganti, T.D.4    Ozoren, N.5
  • 34
    • 12144287484 scopus 로고    scopus 로고
    • Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family
    • Garlanda C, Riva F, Polentarutti N, Buracchi C, Sironi M, et al. 2004. Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. Proc. Natl. Acad. Sci. USA 101:3522-26
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 3522-3526
    • Garlanda, C.1    Riva, F.2    Polentarutti, N.3    Buracchi, C.4    Sironi, M.5
  • 35
    • 33646547951 scopus 로고    scopus 로고
    • Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4
    • Gilchrist M, Thorsson V, Li B, Rust AG, Korb M, et al. 2006. Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Nature 441:173-78
    • (2006) Nature , vol.441 , pp. 173-178
    • Gilchrist, M.1    Thorsson, V.2    Li, B.3    Rust, A.G.4    Korb, M.5
  • 36
    • 11144224785 scopus 로고    scopus 로고
    • Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of Toll-like receptor signaling
    • Gingras S, Parganas E, de Pauw A, Ihle JN, Murray PJ. 2004. Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of Toll-like receptor signaling. J. Biol. Chem. 279:54702-7
    • (2004) J. Biol. Chem. , vol.279 , pp. 54702-54707
    • Gingras, S.1    Parganas, E.2    De Pauw, A.3    Ihle, J.N.4    Murray, P.J.5
  • 37
    • 4344613405 scopus 로고    scopus 로고
    • Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not Toll/IL-1 receptor domain-containing adaptor-inducing IFN-β (TRIF)-dependent pathway in TLR signaling
    • Gohda J, Matsumura T, Inoue J. 2004. Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not Toll/IL-1 receptor domain-containing adaptor-inducing IFN-β (TRIF)-dependent pathway in TLR signaling. J. Immunol. 173:2913-17
    • (2004) J. Immunol. , vol.173 , pp. 2913-2917
    • Gohda, J.1    Matsumura, T.2    Inoue, J.3
  • 38
    • 9144233004 scopus 로고    scopus 로고
    • Human but not murine Toll-like receptor 2 discriminates between tri-palmitoylated and tri-lauroylated peptides
    • Grabiec A, Meng G, Fichte S, Bessler W, Wagner H, Kirschning CJ. 2004. Human but not murine Toll-like receptor 2 discriminates between tri-palmitoylated and tri-lauroylated peptides. J. Biol. Chem. 279:48004-12
    • (2004) J. Biol. Chem. , vol.279 , pp. 48004-48012
    • Grabiec, A.1    Meng, G.2    Fichte, S.3    Bessler, W.4    Wagner, H.5    Kirschning, C.J.6
  • 39
    • 30544451546 scopus 로고    scopus 로고
    • Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
    • Hacker H, Redecke V, Blagoev B, Kratchmarova I, Hsu LC, et al. 2006. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 439:204-7
    • (2006) Nature , vol.439 , pp. 204-207
    • Hacker, H.1    Redecke, V.2    Blagoev, B.3    Kratchmarova, I.4    Hsu, L.C.5
  • 40
    • 15544380329 scopus 로고    scopus 로고
    • Toll-like receptor 2 mediates cellular activation by the B subunits of type II heat-labile enterotoxins
    • Hajishengallis G, Tapping RI, Martin MH, Nawar H, Lyle EA, et al. 2005. Toll-like receptor 2 mediates cellular activation by the B subunits of type II heat-labile enterotoxins. Infect. Immunol. 73:1343-49
    • (2005) Infect. Immunol. , vol.73 , pp. 1343-1349
    • Hajishengallis, G.1    Tapping, R.I.2    Martin, M.H.3    Nawar, H.4    Lyle, E.A.5
  • 41
    • 0035953543 scopus 로고    scopus 로고
    • The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    • Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, et al. 2001. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410:1099-103
    • (2001) Nature , vol.410 , pp. 1099-1103
    • Hayashi, F.1    Smith, K.D.2    Ozinsky, A.3    Hawn, T.R.4    Yi, E.C.5
  • 42
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-κB
    • Hayden MS, Ghosh S. 2004. Signaling to NF-κB. Genes Dev. 18:2195-224
    • (2004) Genes Dev. , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 43
    • 0029919991 scopus 로고    scopus 로고
    • Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice
    • Haziot A, Ferrero E, Kontgen F, Hijiya N, Yamamoto S, et al. 1996. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity 4:407-14
    • (1996) Immunity , vol.4 , pp. 407-414
    • Haziot, A.1    Ferrero, E.2    Kontgen, F.3    Hijiya, N.4    Yamamoto, S.5
  • 44
    • 0242391997 scopus 로고    scopus 로고
    • The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily
    • Heil F, Ahmad-Nejad P, Hemmi H, Hochrein H, Ampenberger F, et al. 2003. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur. J. Immunol. 33:2987-97
    • (2003) Eur. J. Immunol. , vol.33 , pp. 2987-2997
    • Heil, F.1    Ahmad-Nejad, P.2    Hemmi, H.3    Hochrein, H.4    Ampenberger, F.5
  • 45
    • 0036008014 scopus 로고    scopus 로고
    • Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    • Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, et al. 2002. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 3:196-200
    • (2002) Nat. Immunol. , vol.3 , pp. 196-200
    • Hemmi, H.1    Kaisho, T.2    Takeuchi, O.3    Sato, S.4    Sanjo, H.5
  • 46
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, et al. 2000. A Toll-like receptor recognizes bacterial DNA. Nature 408:740-45
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1    Takeuchi, O.2    Kawai, T.3    Kaisho, T.4    Sato, S.5
  • 47
    • 4344566281 scopus 로고    scopus 로고
    • The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection
    • Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, et al. 2004. The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J. Exp. Med. 199:1641-50
    • (2004) J. Exp. Med. , vol.199 , pp. 1641-1650
    • Hemmi, H.1    Takeuchi, O.2    Sato, S.3    Yamamoto, M.4    Kaisho, T.5
  • 48
    • 0042679529 scopus 로고    scopus 로고
    • Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
    • Hoebe K, Du X, Georgel P, Janssen E, Tabeta K, et al. 2003. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424:743-48
    • (2003) Nature , vol.424 , pp. 743-748
    • Hoebe, K.1    Du, X.2    Georgel, P.3    Janssen, E.4    Tabeta, K.5
  • 51
    • 0141703238 scopus 로고    scopus 로고
    • Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection
    • Honda K, Sakaguchi S, Nakajima C, Watanabe A, Yanai H, et al. 2003. Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc. Natl. Acad. Sci. USA 100:10872-77
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 10872-10877
    • Honda, K.1    Sakaguchi, S.2    Nakajima, C.3    Watanabe, A.4    Yanai, H.5
  • 52
    • 17144404177 scopus 로고    scopus 로고
    • IRF-7 is the master regulator of type-I interferon-dependent immune responses
    • Honda K, Yanai H, Negishi H, Asagiri M, Sato M, et al. 2005. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434:772-77
    • (2005) Nature , vol.434 , pp. 772-777
    • Honda, K.1    Yanai, H.2    Negishi, H.3    Asagiri, M.4    Sato, M.5
  • 53
    • 0037153130 scopus 로고    scopus 로고
    • The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
    • Horng T, Barton GM, Flavell RA, Medzhitov R. 2002. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 420:329-33
    • (2002) Nature , vol.420 , pp. 329-333
    • Horng, T.1    Barton, G.M.2    Flavell, R.A.3    Medzhitov, R.4
  • 54
    • 0035555301 scopus 로고    scopus 로고
    • TIRAP: An adapter molecule in the Toll signaling pathway
    • Horng T, Barton GM, Medzhitov R. 2001. TIRAP: an adapter molecule in the Toll signaling pathway. Nat. Immunol. 2:835-41
    • (2001) Nat. Immunol. , vol.2 , pp. 835-841
    • Horng, T.1    Barton, G.M.2    Medzhitov, R.3
  • 55
    • 0036796384 scopus 로고    scopus 로고
    • Differential involvement of IFN-β in Toll-like receptor-stimulated dendritic cell activation
    • Hoshino K, Kaisho T, Iwabe T, Takeuchi O, Akira S. 2002. Differential involvement of IFN-β in Toll-like receptor-stimulated dendritic cell activation. Int. Immunol. 14:1225-31
    • (2002) Int. Immunol. , vol.14 , pp. 1225-1231
    • Hoshino, K.1    Kaisho, T.2    Iwabe, T.3    Takeuchi, O.4    Akira, S.5
  • 56
    • 33645841633 scopus 로고    scopus 로고
    • IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9
    • Hoshino K, Sugiyama T, Matsumoto M, Tanaka T, Saito M, et al. 2006. IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9. Nature 440:949-53
    • (2006) Nature , vol.440 , pp. 949-953
    • Hoshino, K.1    Sugiyama, T.2    Matsumoto, M.3    Tanaka, T.4    Saito, M.5
  • 57
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
    • Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, et al. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162:3749-52
    • (1999) J. Immunol. , vol.162 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3    Sanjo, H.4    Ogawa, T.5
  • 58
    • 0346496017 scopus 로고    scopus 로고
    • Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3
    • Huang Q, Yang J, Lin Y, Walker C, Cheng J, et al. 2004. Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. Nat. Immunol. 5:98-103
    • (2004) Nat. Immunol. , vol.5 , pp. 98-103
    • Huang, Q.1    Yang, J.2    Lin, Y.3    Walker, C.4    Cheng, J.5
  • 59
    • 29244471275 scopus 로고    scopus 로고
    • A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    • Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, et al. 2006. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat. Immunol. 7:40-48
    • (2006) Nat. Immunol. , vol.7 , pp. 40-48
    • Ishii, K.J.1    Coban, C.2    Kato, H.3    Takahashi, K.4    Torii, Y.5
  • 60
    • 0037025399 scopus 로고    scopus 로고
    • The extracellular Toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus
    • Iwaki D, Mitsuzawa H, Murakami S, Sano H, Konishi M, et al. 2002. The extracellular Toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus. J. Biol. Chem. 277:24315-20
    • (2002) J. Biol. Chem. , vol.277 , pp. 24315-24320
    • Iwaki, D.1    Mitsuzawa, H.2    Murakami, S.3    Sano, H.4    Konishi, M.5
  • 61
    • 9144234252 scopus 로고    scopus 로고
    • Comparative analysis of IRF and IFN-α expression in human plasmacytoid and monocyte-derived dendritic cells
    • Izaguirre A, Barnes BJ, Amrute S, Yeow WS, Megjugorac N, et al. 2003. Comparative analysis of IRF and IFN-α expression in human plasmacytoid and monocyte-derived dendritic cells. J. Leukoc. Biol. 74:1125-38
    • (2003) J. Leukoc. Biol. , vol.74 , pp. 1125-1138
    • Izaguirre, A.1    Barnes, B.J.2    Amrute, S.3    Yeow, W.S.4    Megjugorac, N.5
  • 62
    • 0024955886 scopus 로고
    • Approaching the asymptote? Evolution and revolution in immunology
    • Janeway CA Jr. 1989. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 54(Pt. 1):1-13
    • (1989) Cold Spring Harb. Symp. Quant. Biol. , vol.54 , Issue.PART 1 , pp. 1-13
    • Janeway Jr., C.A.1
  • 63
    • 0036088492 scopus 로고    scopus 로고
    • Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
    • Jurk M, Heil F, Vollmer J, Schetter C, Krieg AM, et al. 2002. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat. Immunol. 3:499
    • (2002) Nat. Immunol. , vol.3 , pp. 499
    • Jurk, M.1    Heil, F.2    Vollmer, J.3    Schetter, C.4    Krieg, A.M.5
  • 64
    • 0035339861 scopus 로고    scopus 로고
    • Endotoxin-induced maturation of MyD88-deficient dendritic cells
    • Kaisho T, Takeuchi O, Kawai T, Hoshino K, Akira S. 2001. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J. Immunol. 166:5688-94
    • (2001) J. Immunol. , vol.166 , pp. 5688-5694
    • Kaisho, T.1    Takeuchi, O.2    Kawai, T.3    Hoshino, K.4    Akira, S.5
  • 65
    • 23844464444 scopus 로고    scopus 로고
    • Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA
    • Kariko K, Buckstein M, Ni H, Weissman D. 2005. Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23:165-75
    • (2005) Immunity , vol.23 , pp. 165-175
    • Kariko, K.1    Buckstein, M.2    Ni, H.3    Weissman, D.4
  • 66
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-κB activity
    • Karin M, Ben-Neriah Y. 2000. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol. 18:621-63
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 67
    • 0037184115 scopus 로고    scopus 로고
    • Activation of macrophages by linear (1 → 3)-β-D-glucans. Implications for the recognition of fungi by innate immunity
    • Kataoka K, Muta T, Yamazaki S, Takeshige K. 2002. Activation of macrophages by linear (1 → 3)-β-D-glucans. Implications for the recognition of fungi by innate immunity. J. Biol. Chem. 277:36825-31
    • (2002) J. Biol. Chem. , vol.277 , pp. 36825-36831
    • Kataoka, K.1    Muta, T.2    Yamazaki, S.3    Takeshige, K.4
  • 68
    • 22544455673 scopus 로고    scopus 로고
    • Cell type-specific involvement of RIG-I in antiviral response
    • Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, et al. 2005. Cell type-specific involvement of RIG-I in antiviral response. Immunity 23:19-28
    • (2005) Immunity , vol.23 , pp. 19-28
    • Kato, H.1    Sato, S.2    Yoneyama, M.3    Yamamoto, M.4    Uematsu, S.5
  • 69
    • 33646342149 scopus 로고    scopus 로고
    • Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    • Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, et al. 2006. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441:101-5
    • (2006) Nature , vol.441 , pp. 101-105
    • Kato, H.1    Takeuchi, O.2    Sato, S.3    Yoneyama, M.4    Yamamoto, M.5
  • 70
    • 0033166472 scopus 로고    scopus 로고
    • Unresponsiveness of MyD88-deficient mice to endotoxin
    • Kawai T, Adachi O, Ogawa T, Takeda K, Akira S. 1999. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11:115-22
    • (1999) Immunity , vol.11 , pp. 115-122
    • Kawai, T.1    Adachi, O.2    Ogawa, T.3    Takeda, K.4    Akira, S.5
  • 71
    • 5444274514 scopus 로고    scopus 로고
    • Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
    • Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, et al. 2004. Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat. Immunol. 5:1061-68
    • (2004) Nat. Immunol. , vol.5 , pp. 1061-1068
    • Kawai, T.1    Sato, S.2    Ishii, K.J.3    Coban, C.4    Hemmi, H.5
  • 72
    • 27144440523 scopus 로고    scopus 로고
    • IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
    • Kawai T, Takahashi K, Sato S, Coban C, Kumar H, et al. 2005. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat. Immunol. 6:981-88
    • (2005) Nat. Immunol. , vol.6 , pp. 981-988
    • Kawai, T.1    Takahashi, K.2    Sato, S.3    Coban, C.4    Kumar, H.5
  • 73
    • 0035889228 scopus 로고    scopus 로고
    • Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
    • Kawai T, Takeuchi O, Fujita T, Inoue J, Muhlradt PF, et al. 2001. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J. Immunol. 167:5887-94
    • (2001) J. Immunol. , vol.167 , pp. 5887-5894
    • Kawai, T.1    Takeuchi, O.2    Fujita, T.3    Inoue, J.4    Muhlradt, P.F.5
  • 74
    • 0037407691 scopus 로고    scopus 로고
    • Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells
    • Kerkmann M, Rothenfusser S, Hornung V, Towarowski A, Wagner M, et al. 2003. Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells. J. Immunol. 170:4465-74
    • (2003) J. Immunol. , vol.170 , pp. 4465-4474
    • Kerkmann, M.1    Rothenfusser, S.2    Hornung, V.3    Towarowski, A.4    Wagner, M.5
  • 75
    • 0036850946 scopus 로고    scopus 로고
    • SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
    • Kinjyo I, Hanada T, Inagaki-Ohara K, Mori H, Aki D, et al. 2002. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17:583-91
    • (2002) Immunity , vol.17 , pp. 583-591
    • Kinjyo, I.1    Hanada, T.2    Inagaki-Ohara, K.3    Mori, H.4    Aki, D.5
  • 77
    • 0035692811 scopus 로고    scopus 로고
    • The leucine-rich repeat as a protein recognition motif
    • Kobe B, Kajava AV. 2001. The leucine-rich repeat as a protein recognition motif. Curr. Opin. Struct. Biol. 11:725-32
    • (2001) Curr. Opin. Struct. Biol. , vol.11 , pp. 725-732
    • Kobe, B.1    Kajava, A.V.2
  • 78
    • 0033567388 scopus 로고    scopus 로고
    • ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
    • Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, et al. 1999. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev. 13:2059-71
    • (1999) Genes Dev. , vol.13 , pp. 2059-2071
    • Kopp, E.1    Medzhitov, R.2    Carothers, J.3    Xiao, C.4    Douglas, I.5
  • 79
    • 0842328805 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 activates murine natural interferon-producing cells through Toll-like receptor 9
    • Krug A, Luker GD, Barchet W, Leib DA, Akira S, Colonna M. 2004. Herpes simplex virus type 1 activates murine natural interferon-producing cells through Toll-like receptor 9. Blood 103:1433-37
    • (2004) Blood , vol.103 , pp. 1433-1437
    • Krug, A.1    Luker, G.D.2    Barchet, W.3    Leib, D.A.4    Akira, S.5    Colonna, M.6
  • 80
    • 5944261457 scopus 로고    scopus 로고
    • Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
    • Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, et al. 2000. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat. Immunol. 1:398-401
    • (2000) Nat. Immunol. , vol.1 , pp. 398-401
    • Kurt-Jones, E.A.1    Popova, L.2    Kwinn, L.3    Haynes, L.M.4    Jones, L.P.5
  • 82
    • 32244432768 scopus 로고    scopus 로고
    • Double-stranded RNA-mediated TLR3 activation is enhanced by CD14
    • Lee HK, Dunzendorfer S, Soldau K, Tobias PS. 2006. Double-stranded RNA-mediated TLR3 activation is enhanced by CD14. Immunity 24:153-63
    • (2006) Immunity , vol.24 , pp. 153-163
    • Lee, H.K.1    Dunzendorfer, S.2    Soldau, K.3    Tobias, P.S.4
  • 83
    • 0035976968 scopus 로고    scopus 로고
    • Identification and characterization of the DNA binding domain of CpG-binding protein
    • Lee JH, Voo KS, Skalnik DG. 2001. Identification and characterization of the DNA binding domain of CpG-binding protein. J. Biol. Chem. 276:44669-76
    • (2001) J. Biol. Chem. , vol.276 , pp. 44669-44676
    • Lee, J.H.1    Voo, K.S.2    Skalnik, D.G.3
  • 84
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. 1996. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86:973-83
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 85
    • 0034002247 scopus 로고    scopus 로고
    • Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
    • Lien E, Means TK, Heine H, Yoshimura A, Kusumoto S, et al. 2000. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. J. Clin. Invest. 105:497-504
    • (2000) J. Clin. Invest. , vol.105 , pp. 497-504
    • Lien, E.1    Means, T.K.2    Heine, H.3    Yoshimura, A.4    Kusumoto, S.5
  • 86
    • 20644450804 scopus 로고    scopus 로고
    • Negative regulation of Toll-like receptor-mediated immune responses
    • Liew FY, Xu D, Brint EK, O'Neill LA. 2005. Negative regulation of Toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 5:446-58
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 446-458
    • Liew, F.Y.1    Xu, D.2    Brint, E.K.3    O'Neill, L.A.4
  • 87
    • 0042123694 scopus 로고    scopus 로고
    • Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    • Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A. 2003. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198:513-20
    • (2003) J. Exp. Med. , vol.198 , pp. 513-520
    • Lund, J.1    Sato, A.2    Akira, S.3    Medzhitov, R.4    Iwasaki, A.5
  • 90
    • 4444258208 scopus 로고    scopus 로고
    • Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-κB activation by Toll-like receptor (TLR)-2 and TLR4-7
    • Mansell A, Brint E, Gould JA, O'Neill LA, Hertzog PJ. 2004. Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-κB activation by Toll-like receptor (TLR)-2 and TLR4-7. J. Biol. Chem. 279:37227-30
    • (2004) J. Biol. Chem. , vol.279 , pp. 37227-37230
    • Mansell, A.1    Brint, E.2    Gould, J.A.3    O'Neill, L.A.4    Hertzog, P.J.5
  • 91
    • 31344467156 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation
    • Mansell A, Smith R, Doyle SL, Gray P, Fenner JE, et al. 2006. Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat. Immunol. 7:148-55
    • (2006) Nat. Immunol. , vol.7 , pp. 148-155
    • Mansell, A.1    Smith, R.2    Doyle, S.L.3    Gray, P.4    Fenner, J.E.5
  • 92
    • 0037083638 scopus 로고    scopus 로고
    • Cutting edge: Immune stimulation by neisserial porins is Toll-like receptor 2 and MyD88 dependent
    • Massari P, Henneke P, Ho Y, Latz E, Golenbock DT, Wetzler LM. 2002. Cutting edge: immune stimulation by neisserial porins is Toll-like receptor 2 and MyD88 dependent. J. Immunol. 168:1533-37
    • (2002) J. Immunol. , vol.168 , pp. 1533-1537
    • Massari, P.1    Henneke, P.2    Ho, Y.3    Latz, E.4    Golenbock, D.T.5    Wetzler, L.M.6
  • 94
    • 0033215123 scopus 로고    scopus 로고
    • Human Toll-like receptors mediate cellular activation by Mycobacterium tuberculosis
    • Means TK, Wang S, Lien E, Yoshimura A, Golenbock DT, Fenton MJ. 1999. Human Toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J. Immunol. 163:3920-27
    • (1999) J. Immunol. , vol.163 , pp. 3920-3927
    • Means, T.K.1    Wang, S.2    Lien, E.3    Yoshimura, A.4    Golenbock, D.T.5    Fenton, M.J.6
  • 95
    • 0030666222 scopus 로고    scopus 로고
    • Innate immunity: The virtues of a nonclonal system of recognition
    • Medzhitov R, Janeway CA Jr. 1997. Innate immunity: the virtues of a nonclonal system of recognition. Cell. 91:295-98
    • (1997) Cell , vol.91 , pp. 295-298
    • Medzhitov, R.1    Janeway Jr., C.A.2
  • 96
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388:394-97
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr., C.A.3
  • 97
    • 0032133278 scopus 로고    scopus 로고
    • MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
    • Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, et al. 1998. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 2:253-58
    • (1998) Mol. Cell , vol.2 , pp. 253-258
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Kopp, E.3    Stadlen, A.4    Chen, C.5
  • 98
    • 0030666222 scopus 로고    scopus 로고
    • Innate immunity: The virtues of a nonclonal system of recognition
    • Medzhitov RJ, Janeway CA Jr. 2001. Innate immunity: the virtues of a nonclonal system of recognition. Cell. 91:295-98
    • (2001) Cell , vol.91 , pp. 295-298
    • Medzhitov, R.J.1    Janeway Jr., C.A.2
  • 99
    • 0141994786 scopus 로고    scopus 로고
    • Cellular recognition of tri-/dipalmitoylated peptides is independent from a domain encompassing the N-terminal seven leucine-rich repeat (LRR)/LRR-like motifs of TLR2
    • Meng G, Grabiec A, Vallon M, Ebe B, Hampel S, et al. 2003. Cellular recognition of tri-/dipalmitoylated peptides is independent from a domain encompassing the N-terminal seven leucine-rich repeat (LRR)/LRR-like motifs of TLR2. J. Biol. Chem. 278:39822-29
    • (2003) J. Biol. Chem. , vol.278 , pp. 39822-39829
    • Meng, G.1    Grabiec, A.2    Vallon, M.3    Ebe, B.4    Hampel, S.5
  • 100
    • 2442642691 scopus 로고    scopus 로고
    • RIP1 is an essential mediator of Toll-like receptor 3-induced NF-κB activation
    • Meylan E, Burns K, Hofmann K, Blancheteau V, Martinon F, et al. 2004. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-κB activation. Nat. Immunol. 5:503-7
    • (2004) Nat. Immunol. , vol.5 , pp. 503-507
    • Meylan, E.1    Burns, K.2    Hofmann, K.3    Blancheteau, V.4    Martinon, F.5
  • 101
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    • Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, et al. 2005. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437:1167-72
    • (2005) Nature , vol.437 , pp. 1167-1172
    • Meylan, E.1    Curran, J.2    Hofmann, K.3    Moradpour, D.4    Binder, M.5
  • 102
    • 33744493091 scopus 로고    scopus 로고
    • Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf
    • Miao EA, Alpuche-Aranda CM, Dors M, Clark AE, Bader MW, et al. 2006. Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf. Nat. Immunol. 7:569-75
    • (2006) Nat. Immunol. , vol.7 , pp. 569-575
    • Miao, E.A.1    Alpuche-Aranda, C.M.2    Dors, M.3    Clark, A.E.4    Bader, M.W.5
  • 103
    • 0035798654 scopus 로고    scopus 로고
    • Extracellular Toll-like receptor 2 region containing Ser40-Ile64 but not Cys30-Ser39 is critical for the recognition of Staphylococcus aureus peptidoglycan
    • Mitsuzawa H, Wada I, Sano H, Iwaki D, Murakami S, et al. 2001. Extracellular Toll-like receptor 2 region containing Ser40-Ile64 but not Cys30-Ser39 is critical for the recognition of Staphylococcus aureus peptidoglycan. J. Biol. Chem. 276:41350-56
    • (2001) J. Biol. Chem. , vol.276 , pp. 41350-41356
    • Mitsuzawa, H.1    Wada, I.2    Sano, H.3    Iwaki, D.4    Murakami, S.5
  • 104
    • 1642384019 scopus 로고    scopus 로고
    • Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2
    • Miyake K. 2004. Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. Trends Microbiol. 12:186-92
    • (2004) Trends Microbiol. , vol.12 , pp. 186-192
    • Miyake, K.1
  • 105
    • 0037604765 scopus 로고    scopus 로고
    • Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes
    • Mizel SB, Honko AN, Moors MA, Smith PS, West AP. 2003a. Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes. J. Immunol. 170:6217-23
    • (2003) J. Immunol. , vol.170 , pp. 6217-6223
    • Mizel, S.B.1    Honko, A.N.2    Moors, M.A.3    Smith, P.S.4    West, A.P.5
  • 106
    • 0038607406 scopus 로고    scopus 로고
    • Identification of a sequence in human Toll-like receptor 5 required for the binding of Gram-negative flagellin
    • Mizel SB, West AP, Hantgan RR. 2003b. Identification of a sequence in human Toll-like receptor 5 required for the binding of Gram-negative flagellin. J. Biol. Chem. 278:23624-29
    • (2003) J. Biol. Chem. , vol.278 , pp. 23624-23629
    • Mizel, S.B.1    West, A.P.2    Hantgan, R.R.3
  • 107
    • 0030694108 scopus 로고    scopus 로고
    • IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    • Muzio M, Ni J, Feng P, Dixit VM. 1997. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278:1612-15
    • (1997) Science , vol.278 , pp. 1612-1615
    • Muzio, M.1    Ni, J.2    Feng, P.3    Dixit, V.M.4
  • 108
    • 0036301797 scopus 로고    scopus 로고
    • Essential role of MD-2 in LPS responsiveness and TLR4 distribution
    • Nagai Y, Akashi S, Nagafuku M, Ogata M, Iwakura Y, et al. 2002. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat. Immunol. 3:667-72
    • (2002) Nat. Immunol. , vol.3 , pp. 667-672
    • Nagai, Y.1    Akashi, S.2    Nagafuku, M.3    Ogata, M.4    Iwakura, Y.5
  • 109
    • 18744371050 scopus 로고    scopus 로고
    • SOCS-1 participates in negative regulation of LPS responses
    • Nakagawa R, Naka T, Tsutsui H, Fujimoto M, Kimura A, et al. 2002. SOCS-1 participates in negative regulation of LPS responses. Immunity 17:677-87
    • (2002) Immunity , vol.17 , pp. 677-687
    • Nakagawa, R.1    Naka, T.2    Tsutsui, H.3    Fujimoto, M.4    Kimura, A.5
  • 110
    • 30544447047 scopus 로고    scopus 로고
    • Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
    • Oganesyan G, Saha SK, Guo B, He JQ, Shahangian A, et al. 2006. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature 439:208-11
    • (2006) Nature , vol.439 , pp. 208-211
    • Oganesyan, G.1    Saha, S.K.2    Guo, B.3    He, J.Q.4    Shahangian, A.5
  • 111
    • 27744456905 scopus 로고    scopus 로고
    • Domain exchange between human Toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination
    • Omueti KO, Beyer JM, Johnson CM, Lyle EA, Tapping RI. 2005. Domain exchange between human Toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination. J. Biol. Chem. 280:36616-25
    • (2005) J. Biol. Chem. , vol.280 , pp. 36616-36625
    • Omueti, K.O.1    Beyer, J.M.2    Johnson, C.M.3    Lyle, E.A.4    Tapping, R.I.5
  • 112
    • 0037320451 scopus 로고    scopus 로고
    • TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction
    • Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T. 2003a. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat. Immunol. 4:161-67
    • (2003) Nat. Immunol. , vol.4 , pp. 161-167
    • Oshiumi, H.1    Matsumoto, M.2    Funami, K.3    Akazawa, T.4    Seya, T.5
  • 113
    • 0345991221 scopus 로고    scopus 로고
    • TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces Interferon-β
    • Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T. 2003b. TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces Interferon-β. J. Biol. Chem. 278:49751-62
    • (2003) J. Biol. Chem. , vol.278 , pp. 49751-49762
    • Oshiumi, H.1    Sasai, M.2    Shida, K.3    Fujita, T.4    Matsumoto, M.5    Seya, T.6
  • 114
    • 0034610291 scopus 로고    scopus 로고
    • The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
    • Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, et al. 2000. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. Proc. Natl. Acad. Sci. USA 97:13766-71
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 13766-13771
    • Ozinsky, A.1    Underhill, D.M.2    Fontenot, J.D.3    Hajjar, A.M.4    Smith, K.D.5
  • 115
    • 0035173628 scopus 로고    scopus 로고
    • CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression
    • Perera PY, Mayadas TN, Takeuchi O, Akira S, Zaks-Zilberman M, et al. 2001. CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression. J. Immunol. 166:574-81
    • (2001) J. Immunol. , vol.166 , pp. 574-581
    • Perera, P.Y.1    Mayadas, T.N.2    Takeuchi, O.3    Akira, S.4    Zaks-Zilberman, M.5
  • 116
    • 3042647375 scopus 로고    scopus 로고
    • Differential requirement for TANK-binding kinase-1 in type I Interferon responses to Toll-like receptor activation and viral infection
    • Perry AK, Chow EK, Goodnough JB, Yeh WC, Cheng G. 2004. Differential requirement for TANK-binding kinase-1 in type I Interferon responses to Toll-like receptor activation and viral infection. J. Exp. Med. 199:1651-58
    • (2004) J. Exp. Med. , vol.199 , pp. 1651-1658
    • Perry, A.K.1    Chow, E.K.2    Goodnough, J.B.3    Yeh, W.C.4    Cheng, G.5
  • 117
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
    • Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, et al. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-88
    • (1998) Science , vol.282 , pp. 2085-2088
    • Poltorak, A.1    He, X.2    Smirnova, I.3    Liu, M.Y.4    Van Huffel, C.5
  • 118
    • 0034007076 scopus 로고    scopus 로고
    • Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation
    • Poltorak A, Ricciardi-Castagnoli P, Citterio S, Beutler B. 2000. Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation. Proc. Natl. Acad. Sci. USA 97:2163-67
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2163-2167
    • Poltorak, A.1    Ricciardi-Castagnoli, P.2    Citterio, S.3    Beutler, B.4
  • 119
    • 33646567507 scopus 로고    scopus 로고
    • The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction
    • Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, et al. 2006. The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc. Natl. Acad. Sci. USA 103:6299-304
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 6299-6304
    • Rowe, D.C.1    McGettrick, A.F.2    Latz, E.3    Monks, B.G.4    Gay, N.J.5
  • 120
    • 0033680737 scopus 로고    scopus 로고
    • Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-α/β gene induction
    • Sato M, Suemori H, Hata N, Asagiri M, Ogasawara K, et al. 2000. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-α/β gene induction. Immunity 13:539-48
    • (2000) Immunity , vol.13 , pp. 539-548
    • Sato, M.1    Suemori, H.2    Hata, N.3    Asagiri, M.4    Ogasawara, K.5
  • 121
    • 27544434183 scopus 로고    scopus 로고
    • Essential function for the kinase TAK1 in innate and adaptive immune responses
    • Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, et al. 2005. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat. Immunol. 6:1087-95
    • (2005) Nat. Immunol. , vol.6 , pp. 1087-1095
    • Sato, S.1    Sanjo, H.2    Takeda, K.3    Ninomiya-Tsuji, J.4    Yamamoto, M.5
  • 122
    • 0141923690 scopus 로고    scopus 로고
    • Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-κ B and IFN-regulatory factor-3, in the Toll-like receptor signaling
    • Sato S, Sugiyama M, Yamamoto M, Watanabe Y, Kawai T, et al. 2003. Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-κ B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J. Immunol. 171:4304-10
    • (2003) J. Immunol. , vol.171 , pp. 4304-4310
    • Sato, S.1    Sugiyama, M.2    Yamamoto, M.3    Watanabe, Y.4    Kawai, T.5
  • 123
    • 20444380445 scopus 로고    scopus 로고
    • The interferon regulatory factor, IRF5, is a central mediator of Toll-like receptor 7 signaling
    • Schoenemeyer A, Barnes BJ, Mancl ME, Latz E, Goutagny N, et al. 2005. The interferon regulatory factor, IRF5, is a central mediator of Toll-like receptor 7 signaling. J. Biol. Chem. 280:17005-12
    • (2005) J. Biol. Chem. , vol.280 , pp. 17005-17012
    • Schoenemeyer, A.1    Barnes, B.J.2    Mancl, M.E.3    Latz, E.4    Goutagny, N.5
  • 124
    • 15444352709 scopus 로고    scopus 로고
    • Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytic cells via a CD14-dependent pathway distinct from that used by lipopolysaccharide
    • Sellati TJ, Bouis DA, Kitchens RL, Darveau RP, Pugin J, et al. 1998. Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytic cells via a CD14-dependent pathway distinct from that used by lipopolysaccharide. J. Immunol. 160:5455-64
    • (1998) J. Immunol. , vol.160 , pp. 5455-5464
    • Sellati, T.J.1    Bouis, D.A.2    Kitchens, R.L.3    Darveau, R.P.4    Pugin, J.5
  • 125
    • 24144461689 scopus 로고    scopus 로고
    • Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF 3
    • Seth RB, Sun L, Ea CK, Chen ZJ. 2005. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF 3. Cell 122:669-82
    • (2005) Cell , vol.122 , pp. 669-682
    • Seth, R.B.1    Sun, L.2    Ea, C.K.3    Chen, Z.J.4
  • 126
    • 0029940355 scopus 로고    scopus 로고
    • TAB1: An activator of the TAK1 MAPKKK in TGF-beta signal transduction
    • Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, et al. 1996. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science 272:1179-82
    • (1996) Science , vol.272 , pp. 1179-1182
    • Shibuya, H.1    Yamaguchi, K.2    Shirakabe, K.3    Tonegawa, A.4    Gotoh, Y.5
  • 127
    • 27744577296 scopus 로고    scopus 로고
    • TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
    • Shim JH, Xiao C, Paschal A, Bailey S, Rao P, et al. 2005. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 19:2668-81
    • (2005) Genes Dev. , vol.19 , pp. 2668-2681
    • Shim, J.H.1    Xiao, C.2    Paschal, A.3    Bailey, S.4    Rao, P.5
  • 128
    • 0033532629 scopus 로고    scopus 로고
    • MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    • Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, et al. 1999. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189:1777-82
    • (1999) J. Exp. Med. , vol.189 , pp. 1777-1782
    • Shimazu, R.1    Akashi, S.2    Ogata, H.3    Nagai, Y.4    Fukudome, K.5
  • 129
    • 0035313274 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates intracellular signaling without TNF-α release in response to Cryptococcus neoformans polysaccharide capsule
    • Shoham S, Huang C, Chen JM, Golenbock DT, Levitz SM. 2001. Toll-like receptor 4 mediates intracellular signaling without TNF-α release in response to Cryptococcus neoformans polysaccharide capsule. J. Immunol. 166:4620-26
    • (2001) J. Immunol. , vol.166 , pp. 4620-4626
    • Shoham, S.1    Huang, C.2    Chen, J.M.3    Golenbock, D.T.4    Levitz, S.M.5
  • 130
    • 0037234680 scopus 로고    scopus 로고
    • Darwinism and immunology: From Metchnikoff to Burnet
    • Silverstein AM. 2003. Darwinism and immunology: from Metchnikoff to Burnet. Nat. Immunol. 4:3-6
    • (2003) Nat. Immunol. , vol.4 , pp. 3-6
    • Silverstein, A.M.1
  • 131
    • 0037152173 scopus 로고    scopus 로고
    • Yersinia V-antigen exploits Toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression
    • Sing A, Rost D, Tvardovskaia N, Roggenkamp A, Wiedemann A, et al. 2002. Yersinia V-antigen exploits Toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression. J. Exp. Med. 196:1017-24
    • (2002) J. Exp. Med. , vol.196 , pp. 1017-1024
    • Sing, A.1    Rost, D.2    Tvardovskaia, N.3    Roggenkamp, A.4    Wiedemann, A.5
  • 132
    • 0347776208 scopus 로고    scopus 로고
    • Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility
    • Smith KD, Andersen-Nissen E, Hayashi F, Strobe K, Bergman MA, et al. 2003. Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility. Nat. Immunol. 4:1247-53
    • (2003) Nat. Immunol. , vol.4 , pp. 1247-1253
    • Smith, K.D.1    Andersen-Nissen, E.2    Hayashi, F.3    Strobe, K.4    Bergman, M.A.5
  • 133
    • 30444450839 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    • Stetson DB, Medzhitov R. 2006. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24:93-103
    • (2006) Immunity , vol.24 , pp. 93-103
    • Stetson, D.B.1    Medzhitov, R.2
  • 134
    • 2342629277 scopus 로고    scopus 로고
    • The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
    • Sun L, Deng L, Ea CK, Xia ZP, Chen ZJ. 2004. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol. Cell. 14:289-301
    • (2004) Mol. Cell , vol.14 , pp. 289-301
    • Sun, L.1    Deng, L.2    Ea, C.K.3    Xia, Z.P.4    Chen, Z.J.5
  • 135
    • 33646592188 scopus 로고    scopus 로고
    • The specific and essential role of MAVS in antiviral innate immune responses
    • Sun Q, Sun L, Liu HH, Chen X, Seth RB, et al. 2006. The specific and essential role of MAVS in antiviral innate immune responses. Immunity 24:633-42
    • (2006) Immunity , vol.24 , pp. 633-642
    • Sun, Q.1    Sun, L.2    Liu, H.H.3    Chen, X.4    Seth, R.B.5
  • 136
    • 0037129212 scopus 로고    scopus 로고
    • Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
    • Suzuki N, Suzuki S, Duncan GS, Millar DG, Wada T, et al. 2002. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature 416:750-56
    • (2002) Nature , vol.416 , pp. 750-756
    • Suzuki, N.1    Suzuki, S.2    Duncan, G.S.3    Millar, D.G.4    Wada, T.5
  • 137
    • 0033634977 scopus 로고    scopus 로고
    • TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
    • Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, et al. 2000. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell. 5:649-58
    • (2000) Mol. Cell , vol.5 , pp. 649-658
    • Takaesu, G.1    Kishida, S.2    Hiyama, A.3    Yamaguchi, K.4    Shibuya, H.5
  • 138
    • 15044345461 scopus 로고    scopus 로고
    • Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
    • Takaoka A, Yanai H, Kondo S, Duncan G, Negishi H, et al. 2005. Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature 434:243-49
    • (2005) Nature , vol.434 , pp. 243-249
    • Takaoka, A.1    Yanai, H.2    Kondo, S.3    Duncan, G.4    Negishi, H.5
  • 139
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • Takeda K, Akira S. 2005. Toll-like receptors in innate immunity. Int. Immunol. 17:1-14
    • (2005) Int. Immunol. , vol.17 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 141
    • 0035477969 scopus 로고    scopus 로고
    • Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells
    • Takeshita F, Leifer CA, Gursel I, Ishii KJ, Takeshita S, et al. 2001. Cutting edge: role of Toll-like receptor 9 in CpG DNA-induced activation of human cells. J. Immunol. 167:3555-58
    • (2001) J. Immunol. , vol.167 , pp. 3555-3558
    • Takeshita, F.1    Leifer, C.A.2    Gursel, I.3    Ishii, K.J.4    Takeshita, S.5
  • 142
    • 0034669910 scopus 로고    scopus 로고
    • Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection
    • Takeuchi O, Hoshino K, Akira S. 2000. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J. Immunol. 165:5392-96
    • (2000) J. Immunol. , vol.165 , pp. 5392-5396
    • Takeuchi, O.1    Hoshino, K.2    Akira, S.3
  • 144
    • 0036644042 scopus 로고    scopus 로고
    • Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
    • Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, et al. 2002. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 169:10-14
    • (2002) J. Immunol. , vol.169 , pp. 10-14
    • Takeuchi, O.1    Sato, S.2    Horiuchi, T.3    Hoshino, K.4    Takeda, K.5
  • 145
    • 0033151633 scopus 로고    scopus 로고
    • Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily
    • Thomassen E, Renshaw BR, Sims JE. 1999. Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. Cytokine 11:389-99
    • (1999) Cytokine , vol.11 , pp. 389-399
    • Thomassen, E.1    Renshaw, B.R.2    Sims, J.E.3
  • 146
    • 20244388983 scopus 로고    scopus 로고
    • Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction
    • Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, et al. 2005. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction. J. Exp. Med. 201:915-23
    • (2005) J. Exp. Med. , vol.201 , pp. 915-923
    • Uematsu, S.1    Sato, S.2    Yamamoto, M.3    Hirotani, T.4    Kato, H.5
  • 147
    • 0027291534 scopus 로고
    • Recognition of bacterial endotoxins by receptor-dependent mechanisms
    • Ulevitch RJ. 1993. Recognition of bacterial endotoxins by receptor-dependent mechanisms. Adv. Immunol. 53:267-89
    • (1993) Adv. Immunol. , vol.53 , pp. 267-289
    • Ulevitch, R.J.1
  • 148
    • 0033592748 scopus 로고    scopus 로고
    • The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
    • Underhill DM, Ozinsky A, Hajjar AM, Stevens A, Wilson CB, et al. 1999a. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401:811-15
    • (1999) Nature , vol.401 , pp. 811-815
    • Underhill, D.M.1    Ozinsky, A.2    Hajjar, A.M.3    Stevens, A.4    Wilson, C.B.5
  • 149
    • 0033458799 scopus 로고    scopus 로고
    • Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages
    • Underhill DM, Ozinsky A, Smith KD, Aderem A. 1999b. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc. Natl. Acad. Sci. USA 96:14459-63
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 14459-14463
    • Underhill, D.M.1    Ozinsky, A.2    Smith, K.D.3    Aderem, A.4
  • 150
    • 10344222956 scopus 로고    scopus 로고
    • TLR2 recognizes a bacterial lipopeptide through direct binding
    • Vasselon T, Detmers PA, Charron D, Haziot A. 2004. TLR2 recognizes a bacterial lipopeptide through direct binding. J. Immunol. 173:7401-5
    • (2004) J. Immunol. , vol.173 , pp. 7401-7405
    • Vasselon, T.1    Detmers, P.A.2    Charron, D.3    Haziot, A.4
  • 152
    • 0042733592 scopus 로고    scopus 로고
    • SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling
    • Wald D, Qin J, Zhao Z, Qian Y, Naramura M, et al. 2003. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 4:920-27
    • (2003) Nat. Immunol. , vol.4 , pp. 920-927
    • Wald, D.1    Qin, J.2    Zhao, Z.3    Qian, Y.4    Naramura, M.5
  • 154
    • 0035221154 scopus 로고    scopus 로고
    • Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event
    • Weinmann AS, Mitchell DM, Sanjabi S, Bradley MN, Hoffmann A, et al. 2001. Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event. Nat. Immunol. 2:51-57
    • (2001) Nat. Immunol. , vol.2 , pp. 51-57
    • Weinmann, A.S.1    Mitchell, D.M.2    Sanjabi, S.3    Bradley, M.N.4    Hoffmann, A.5
  • 155
    • 24944489952 scopus 로고    scopus 로고
    • Stimulus specificity of gene expression programs determined by temporal control of IKK activity
    • Werner SL, Barken D, Hoffmann A. 2005. Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science 309:1857-61
    • (2005) Science , vol.309 , pp. 1857-1861
    • Werner, S.L.1    Barken, D.2    Hoffmann, A.3
  • 156
    • 0033516561 scopus 로고    scopus 로고
    • IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
    • Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z. 1999. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J. Biol. Chem. 274:19403-10
    • (1999) J. Biol. Chem. , vol.274 , pp. 19403-19410
    • Wesche, H.1    Gao, X.2    Li, X.3    Kirschning, C.J.4    Stark, G.R.5    Cao, Z.6
  • 157
    • 0031423761 scopus 로고    scopus 로고
    • MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
    • Wesche H, Henzel WJ, Shillinglaw W, Li S, Cao Z. 1997. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7:837-47
    • (1997) Immunity , vol.7 , pp. 837-847
    • Wesche, H.1    Henzel, W.J.2    Shillinglaw, W.3    Li, S.4    Cao, Z.5
  • 158
    • 0038664380 scopus 로고    scopus 로고
    • The role of Toll-like receptor 2 in microbial disease and immunity
    • Wetzler LM. 2003. The role of Toll-like receptor 2 in microbial disease and immunity. Vaccine 21(Suppl. 2):S55-60
    • (2003) Vaccine , vol.21 , Issue.SUPPL. 2
    • Wetzler, L.M.1
  • 159
    • 0032103093 scopus 로고    scopus 로고
    • The role of CD14 in signaling mediated by outer membrane lipoproteins of Borrelia burgdorferi
    • Wooten RM, Morrison TB, Weis JH, Wright SD, Thieringer R, Weis JJ. 1998. The role of CD14 in signaling mediated by outer membrane lipoproteins of Borrelia burgdorferi. J. Immunol. 160:5485-92
    • (1998) J. Immunol. , vol.160 , pp. 5485-5492
    • Wooten, R.M.1    Morrison, T.B.2    Weis, J.H.3    Wright, S.D.4    Thieringer, R.5    Weis, J.J.6
  • 160
    • 0025166114 scopus 로고
    • CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
    • Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC. 1990. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431-33
    • (1990) Science , vol.249 , pp. 1431-1433
    • Wright, S.D.1    Ramos, R.A.2    Tobias, P.S.3    Ulevitch, R.J.4    Mathison, J.C.5
  • 161
    • 0034671803 scopus 로고    scopus 로고
    • Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses
    • Wyllie DH, Kiss-Toth E, Visintin A, Smith SC, Boussouf S, et al. 2000. Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses. J. Immunol. 165:7125-32
    • (2000) J. Immunol. , vol.165 , pp. 7125-7132
    • Wyllie, D.H.1    Kiss-Toth, E.2    Visintin, A.3    Smith, S.C.4    Boussouf, S.5
  • 162
    • 10744224961 scopus 로고    scopus 로고
    • Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis
    • Xiao C, Shim JH, Kluppel M, Zhang SS, Dong C, et al. 2003. Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev. 17:2933-49
    • (2003) Genes Dev. , vol.17 , pp. 2933-2949
    • Xiao, C.1    Shim, J.H.2    Kluppel, M.3    Zhang, S.S.4    Dong, C.5
  • 163
    • 24944538819 scopus 로고    scopus 로고
    • VISA is an adapter protein required for virus-triggered IFN-β signaling
    • Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB. 2005. VISA is an adapter protein required for virus-triggered IFN-β signaling. Mol. Cell 19:727-40
    • (2005) Mol. Cell , vol.19 , pp. 727-740
    • Xu, L.G.1    Wang, Y.Y.2    Han, K.J.3    Li, L.Y.4    Zhai, Z.5    Shu, H.B.6
  • 164
    • 0043176281 scopus 로고    scopus 로고
    • Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway
    • Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, et al. 2003a. Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway. Science 301:640-43
    • (2003) Science , vol.301 , pp. 640-643
    • Yamamoto, M.1    Sato, S.2    Hemmi, H.3    Hoshino, K.4    Kaisho, T.5
  • 165
    • 0037153191 scopus 로고    scopus 로고
    • Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
    • Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, et al. 2002a. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 420:324-29
    • (2002) Nature , vol.420 , pp. 324-329
    • Yamamoto, M.1    Sato, S.2    Hemmi, H.3    Sanjo, H.4    Uematsu, S.5
  • 166
    • 0242624622 scopus 로고    scopus 로고
    • TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
    • Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, et al. 2003b. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat. Immunol. 4:1144-50
    • (2003) Nat. Immunol. , vol.4 , pp. 1144-1150
    • Yamamoto, M.1    Sato, S.2    Hemmi, H.3    Uematsu, S.4    Hoshino, K.5
  • 167
    • 0037114185 scopus 로고    scopus 로고
    • Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling
    • Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, et al. 2002b. Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling. J. Immunol. 169:6668-72
    • (2002) J. Immunol. , vol.169 , pp. 6668-6672
    • Yamamoto, M.1    Sato, S.2    Mori, K.3    Hoshino, K.4    Takeuchi, O.5
  • 168
    • 20644433342 scopus 로고    scopus 로고
    • TLR11 activation of dendritic cells by a protozoan profilin-like protein
    • Yarovinsky F, Zhang D, Andersen JF, Bannenberg GL, Serhan CN, et al. 2005. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 308:1626-29
    • (2005) Science , vol.308 , pp. 1626-1629
    • Yarovinsky, F.1    Zhang, D.2    Andersen, J.F.3    Bannenberg, G.L.4    Serhan, C.N.5
  • 169
    • 3242813113 scopus 로고    scopus 로고
    • The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
    • Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, et al. 2004. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 5:730-37
    • (2004) Nat. Immunol. , vol.5 , pp. 730-737
    • Yoneyama, M.1    Kikuchi, M.2    Natsukawa, T.3    Shinobu, N.4    Imaizumi, T.5
  • 170
    • 1542377424 scopus 로고    scopus 로고
    • A Toll-like receptor that prevents infection by uropathogenic bacteria
    • Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, et al. 2004. A Toll-like receptor that prevents infection by uropathogenic bacteria. Science 303:1522-26
    • (2004) Science , vol.303 , pp. 1522-1526
    • Zhang, D.1    Zhang, G.2    Hayden, M.S.3    Greenblatt, M.B.4    Bussey, C.5
  • 171
    • 0036510366 scopus 로고    scopus 로고
    • Negative regulation of toll-like receptor-mediated signaling by Tollip
    • Zhang G, Ghosh S. 2002. Negative regulation of toll-like receptor-mediated signaling by Tollip. J. Biol. Chem. 277:7059-65
    • (2002) J. Biol. Chem. , vol.277 , pp. 7059-7065
    • Zhang, G.1    Ghosh, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.