Severe impairment of interleukin-1 and toll-like receptor signalling in mice lacking IRAK-4

Nature

Volumn 416, Issue 6882, 2002, Pages 750-754

  Suzuki, Nobutaka ^a   Suzuki, Shinobu ^a   Duncan, Gordon S ^a   Millar, Douglas G ^b   Wada, Teiji ^a   Mirtsos, Christine ^a   Takada, Hidetoshi ^a   Wakeham, Andrew ^a   Itie, Annick ^a   Li, Shyun ^c   Penninger, Josef M ^a   Wesche, Holger ^c   Ohashi, Pamela S ^b   Mak, Tak W ^a   Yeh, Wen Chen ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c Tularik Incorporation   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CELL CULTURE; ENZYMES; PHYSIOLOGY; POLYSACCHARIDES; SIGNAL PROCESSING; VIRUSES;

HOMOLOGY;

GENES;

INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN; PROTEIN PELLE; PROTEIN SERINE THREONINE KINASE INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; PROTEIN SERINE THREONINE KINASE INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 2; PROTEIN SERINE THREONINE KINASE INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; PROTEIN SERINE THREONINE KINASE INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE M; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

IMMUNITY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; DROSOPHILA; GENE TARGETING; IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION; VIRUS INFECTION;

ANIMALS; ARENAVIRIDAE INFECTIONS; B-LYMPHOCYTES; CELLS, CULTURED; DROSOPHILA PROTEINS; GENE DELETION; IMMUNITY, NATURAL; INTERFERON TYPE II; INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KILLER CELLS, NATURAL; LIGANDS; LIPOPOLYSACCHARIDES; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASES; RECEPTORS, CELL SURFACE; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0037129212     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature736     Document Type: Article

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