Achieving stability of lipopolysaccharide-induced NF-κB activation

Science

Volumn 309, Issue 5742, 2005, Pages 1854-1857

  Covert, Markus W ^a   Leung, Thomas H ^a   Gaston, Jahllonais E ^a   Baltimore, David ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHEMICAL ACTIVATION; SYNTHESIS (CHEMICAL);

ACTIVATION DYNAMICS; LIPOPOLYSACCHARIDE (LPS); PATHWAYS; TOLL-LIKE RECEPTOR 4 (TLR4);

POLYSACCHARIDES;

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

BIOLOGY;

ARTICLE; CELL STIMULATION; MATHEMATICAL MODEL; OSCILLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN SYNTHESIS; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; ANTIGENS, DIFFERENTIATION; CELL LINE; CELLS, CULTURED; COMPUTER SIMULATION; CYCLOHEXIMIDE; DNA-BINDING PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; I-KAPPA B KINASE; I-KAPPA B PROTEINS; INTERFERON REGULATORY FACTOR-3; KINETICS; LIPOPOLYSACCHARIDES; MICE; MODELS, BIOLOGICAL; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN SYNTHESIS INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TIME FACTORS; TOLL-LIKE RECEPTOR 4; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 24944586285     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1112304     Document Type: Article

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28. We thank M. Yamamoto and S. Akira for generously providing the MEFs; M. Boldin, M. Meffert, and A. Hoffmann for valuable discussions; and the Millard and Muriel Jacobs Genetics and Genomics Laboratory at the California Institute of Technology for assistance with the gene expression study. This work was funded by the NIH (GM039458-21). M.W.C. is a Robert Black Fellow supported by the Damon Runyon Cancer Research Foundation (DRG-#1835-04). T.H.L. is a student in the UCLA-California Institute of Technology Medical Scientist Training Program and supported by the Achievement Rewards for College Scientists foundation.