Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

Nature

Volumn 420, Issue 6913, 2002, Pages 324-329

  Yamamoto, Masahiro ^a   Sato, Shintaro ^a   Hemmi, Hiroaki ^a   Sanjo, Hideki ^a   Uematsu, Satoshi ^a,b   Kaisho, Tsuneyasu ^a   Hoshino, Katsuaki ^a   Takeuchi, Osamu ^a   Kobayashi, Masaya ^a   Fujita, Takashi ^c   Takeda, Kiyoshi ^a   Akira, Shizuo ^a  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c RIKEN   (Japan)

^d TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CLONING; GENES; LIVING SYSTEMS STUDIES; POLYSACCHARIDES;

CYTOKINES;

PROTEINS;

ADAPTOR PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERLEUKIN 1 RECEPTOR; LIGAND; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TIRAP; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

PROTEIN; SIGNAL;

ANIMAL CELL; ARTICLE; CELL MATURATION; CELL PROLIFERATION; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME ACTIVATION; GENE EXPRESSION; GENE INDUCTION; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DOMAIN; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SPLEEN CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, DIFFERENTIATION; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; DROSOPHILA PROTEINS; ENZYME ACTIVATION; GENE DELETION; LIGANDS; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; SPLEEN; SUBSTRATE SPECIFICITY; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTORS;

ANIMALIA;

EID: 0037153191     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01182     Document Type: Article

References (19)

1. Akira, S., Takeda, K. & Kaisho, T. Toll-like receptors: Critical proteins linking innate and acquired immunity. Nature Immunol. 2, 675-680 (2001).
2. Imer, I. L. & Hoffmann, J. A. Toll-like receptors in innate immunity. Trends Cell Biol. 11, 304-311 (2001).
3. Medzhitov, R. Toll-like receptors and innate immunity. Nature Rev. Immunol. 1, 135-145 (2002).
4. Janeway, C. A. Jr & Medzhitov, R. Innate immune recognition. Annu. Rev. Immunol. 20, 197-216 (2002).
5. Kawai, T., Adachi, O., Ogawa, T., Takeda, K. & Akira, S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11, 115-122 (1999).
6. Kaisho, T., Takeuchi, O., Kawai, T., Hoshino, K. & Akira, S. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J. Immunol. 166, 5688-5694 (2001).
7. Kawai, T. et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IRF-3 and the expression of a subset of LPS-inducible genes. J. Immunol. 167, 5887-5894 (2001).
8. Horng, T., Barton, G. M. & Medzhitov, R. TIRAP: an adapter molecule in the Toll signaling pathway. Nature Immunol, 2, 835-841 (2001).
9. Fitzgerald, K. A. et al. Mal (MyD88-adaptor-like) is required for Toll-like receptor-4 signal transduction. Nature 413, 78-83 (2001).
10. Adachi, O. et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9, 143-150 (1998).
11. Hemmi, H. et al. A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745 (2000).
12. Hemmi, H. et al. Small anti-viral compounds activate immune cells via the TLR7-MyD88-dependent signaling pathway. Nature Immunol. 3, 196-200 (2002).
13. Alexopoulou, L., Holt, A. C., Medzhitov, R. & Flavell, R. A. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413, 732-738 (2001).
14. Takeuchi, O. et al. Cutting edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway. J. Immunol. 164, 554-557 (2000).
15. Takeuchi, O. et al. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 11, 443-451 (1999).
16. Toshchakov, V. et al. TLR4, but not TLR2, mediates IFN-β-induced STAT1α/β-induced STAT1α-dependent gene expression in macrophages. Nature Immunol. 3, 392-398 (2002).
17. O'Neill, L. A. Toll-like receptor signal transduction and the tailoring of innate immunity: A role for Mal? Trends Immunol. 23, 296-300 (2002).
18. Sato, S. et al. A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways. Int. Immunol. 14, 783-791 (2002).
19. Iwamura, T. et al. Induction of IRF-3/-7 kinase and NF-κB in response to double-stranded RNA and virus infection: Common and unique pathways. Genes Cells 6, 375-388 (2001).