메뉴 건너뛰기




Volumn 2, Issue 8, 2001, Pages 675-680

Toll-like receptors: Critical proteins linking innate and acquired immunity

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BLOOD CLOTTING FACTOR 6; CYTOPLASM PROTEIN; INTERLEUKIN 1 RECEPTOR; LIGAND; MICROORGANISM PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN KINASE; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

EID: 0034886143     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/90609     Document Type: Review
Times cited : (4114)

References (84)
  • 9
    • 0033614428 scopus 로고    scopus 로고
    • TLR6: A novel member of an expanding toll-like receptor family
    • (1999) Gene , vol.231 , pp. 59-65
    • Takeuchi, O.1
  • 11
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1
  • 13
    • 0034123135 scopus 로고    scopus 로고
    • Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: Selective expression of TLR3 in dendritic cells
    • (2000) J. Immunol. , vol.164 , pp. 5998-6004
    • Muzio, M.1
  • 14
    • 0035164253 scopus 로고    scopus 로고
    • Regulation of Toll-like receptors in human monocytes and dendritic cells
    • (2001) J. Immunol. , vol.166 , pp. 249-255
    • Visintin, A.1
  • 16
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
    • (1998) Science , vol.282 , pp. 2085-2088
    • Poltorak, A.1
  • 17
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
    • (1999) J. Immunol. , vol.162 , pp. 3749-3752
    • Hoshino, K.1
  • 18
    • 0034084438 scopus 로고    scopus 로고
    • TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
    • (2000) Nature Genet. , vol.25 , pp. 187-191
    • Arbour, N.C.1
  • 19
    • 0033532629 scopus 로고    scopus 로고
    • MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    • (1999) J. Exp. Med. , vol.189 , pp. 1777-1782
    • Shimazu, R.1
  • 20
    • 0032541661 scopus 로고    scopus 로고
    • Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
    • (1998) Nature , vol.395 , pp. 284-288
    • Yang, R.B.1
  • 22
    • 0033564325 scopus 로고    scopus 로고
    • Cutting edge: Cells that carry a null allele for toll-like receptor 2 are capable of responding to endotoxin
    • (1999) J. Immunol. , vol.162 , pp. 6971-6975
    • Heine, H.1
  • 23
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1
  • 24
    • 0033592748 scopus 로고    scopus 로고
    • The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
    • (1999) Nature , vol.401 , pp. 811-815
    • Underhill, D.M.1
  • 25
    • 0034646695 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharide activates NF-κB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells
    • (2000) J. Biol. Chem. , vol.275 , pp. 11058-11063
    • Faure, E.1
  • 27
    • 5944225473 scopus 로고    scopus 로고
    • Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
    • (2001) Nature Immunol. , vol.2 , pp. 346-352
    • Werts, C.1
  • 28
    • 0035115080 scopus 로고    scopus 로고
    • Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages
    • (2001) Infect. Immun. , vol.69 , pp. 1477-1482
    • Hirschfeld, M.1
  • 29
    • 0034723186 scopus 로고    scopus 로고
    • Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol
    • (2000) J. Biol. Chem. , vol.275 , pp. 2251-2254
    • Kawasaki, K.1
  • 30
    • 0033618630 scopus 로고    scopus 로고
    • Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
    • (1999) Science , vol.285 , pp. 736-739
    • Aliprantis, A.O.1
  • 31
    • 0033618562 scopus 로고    scopus 로고
    • Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
    • (1999) Science , vol.285 , pp. 732-736
    • Brightbill, H.D.1
  • 32
    • 0033198204 scopus 로고    scopus 로고
    • Cutting edge: Inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2
    • (1999) J. Immunol. , vol.163 , pp. 2382-2386
    • Hirschfeld, M.1
  • 33
    • 0034650420 scopus 로고    scopus 로고
    • Cutting edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway
    • (2000) J. Immunol. , vol.164 , pp. 554-557
    • Takeuchi, O.1
  • 34
    • 0033585011 scopus 로고    scopus 로고
    • Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products
    • (1999) J. Biol. Chem. , vol.274 , pp. 33419-33425
    • Lien, E.1
  • 35
    • 0033168728 scopus 로고    scopus 로고
    • Cutting edge: Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
    • (1999) J. Immunol. , vol.163 , pp. 1-5
    • Yoshimura, A.1
  • 37
    • 0033215123 scopus 로고    scopus 로고
    • Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis
    • (1999) J. Immunol. , vol.163 , pp. 3920-3927
    • Means, T.K.1
  • 38
    • 0034651729 scopus 로고    scopus 로고
    • Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide
    • (2000) J. Immunol. , vol.164 , pp. 2064-2069
    • Flo, T.H.1
  • 39
    • 0033968625 scopus 로고    scopus 로고
    • Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades
    • (2000) Int. Immunol. , vol.12 , pp. 113-117
    • Takeuchi, O.1
  • 40
    • 0001701294 scopus 로고    scopus 로고
    • Toll-like receptor (TLR)-2 mediates Treponema Glycolipid and lipoteichoic acid (LTA)-induced NF-κB translocation
    • (2001) J. Biol. Chem. , vol.276 , pp. 22041-22047
    • Opitz, B.1
  • 41
    • 0035399862 scopus 로고    scopus 로고
    • Activation of toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite
    • (2001) J. Immunol. , vol.167 , pp. 416-423
    • Marco, A.S.1
  • 42
    • 0034610291 scopus 로고    scopus 로고
    • The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 13766-13771
    • Ozinsky, A.1
  • 43
    • 0034922923 scopus 로고    scopus 로고
    • Discrimination of bacterial lipoproteins by Toll-like receptor 6
    • (2001) Int. Immunol. , vol.13 , pp. 933-940
    • Takeuchi, O.1
  • 45
    • 0035863730 scopus 로고    scopus 로고
    • Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: IκBα degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction
    • (2001) J. Immunol. , vol.166 , pp. 1248-1260
    • Eaves-Pyles, T.1
  • 46
    • 0035953543 scopus 로고    scopus 로고
    • The innate immune response to bacterial flagellin is mediated by Toll-like receptor-5
    • (2001) Nature , vol.410 , pp. 1099-1103
    • Hayashi, F.1
  • 49
    • 0034698739 scopus 로고    scopus 로고
    • Immune Cell Activation by Bacterial CpG-DNA through Myeloid Differentiation Marker 88 and Tumor Necrosis Factor Receptor-Associated Factor (TRAF)6
    • (2000) J. Exp. Med. , vol.192 , pp. 595-600
    • Hacker, H.1
  • 50
    • 0033637315 scopus 로고    scopus 로고
    • DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA
    • (2000) Cell , vol.103 , pp. 909-918
    • Chu, W.1
  • 51
    • 0343114462 scopus 로고    scopus 로고
    • Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells
    • (1999) EMBO J. , vol.18 , pp. 6973-6982
    • Hacker, H.1
  • 52
    • 0027931646 scopus 로고
    • The product of the tobacco mosaic virus resistance gene N: Similarity to toll and the interleukin-1 receptor
    • (1994) Cell , vol.78 , pp. 1101-1115
    • Whitham, S.1
  • 53
    • 5944261457 scopus 로고    scopus 로고
    • Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
    • (2000) Nature Immunol. , vol.1 , pp. 398-401
    • Kurt-Jones, E.A.1
  • 54
    • 0034730146 scopus 로고    scopus 로고
    • A46R and A52R from vaccinia virus are antagonists of host IL-I and toll-like receptor signaling
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 10162-10167
    • Bowie, A.1
  • 55
    • 0033578917 scopus 로고    scopus 로고
    • Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila
    • (1999) Science , vol.285 , pp. 1917-1919
    • Levashina, E.A.1
  • 57
    • 0034002247 scopus 로고    scopus 로고
    • Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
    • (2000) J. Clin. Invest. , vol.105 , pp. 497-504
    • Lien, E.1
  • 61
    • 0034663808 scopus 로고    scopus 로고
    • Oligosaccharides of hyaluronan are potent activators of dendritic cells
    • (2000) J. Immunol. , vol.165 , pp. 1863-1870
    • Termeer, C.C.1
  • 63
    • 0035971217 scopus 로고    scopus 로고
    • The EDA domain of fibronectin activates toll-like receptor 4
    • (2001) J. Biol. Chem. , vol.276 , pp. 10229-10233
    • Okamura, Y.1
  • 66
    • 0032133278 scopus 로고    scopus 로고
    • MyD88 is an adaptor protein in the hToll/IL-I receptor family signaling pathways
    • (1998) Mol. Cell , vol.2 , pp. 253-258
    • Medzhitov, R.1
  • 67
    • 0032127279 scopus 로고    scopus 로고
    • Targeted disruption of the MyD88 gene results in loss of IL-I- and IL- 18-mediated function
    • (1998) Immunity , vol.9 , pp. 143-150
    • Adachi, O.1
  • 69
    • 0034175632 scopus 로고    scopus 로고
    • Severe liver degeneration and lack of NF-κB activation in NEMO/IKKγ-deficient mice
    • (2000) Genes Dev. , vol.14 , pp. 854-862
    • Rudolph, D.1
  • 71
    • 0033257795 scopus 로고    scopus 로고
    • JNK2 and IKKβ are required for activating the innate response to viral infection
    • (1999) Immunity , vol.11 , pp. 721-731
    • Chu, W.M.1
  • 72
    • 0035865249 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced IL-18 secretion from murine kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1β
    • (2001) J. Immunol. , vol.166 , pp. 2651-2657
    • Seki, E.1
  • 80
    • 0035871737 scopus 로고    scopus 로고
    • Bacterial CpG-DNA triggers activation and maturation of human CD11c(-), CD123(+) dendritic cells
    • (2001) J. Immunol. , vol.166 , pp. 5000-5007
    • Bauer, M.1
  • 83
    • 0035865228 scopus 로고    scopus 로고
    • Distinct CpG DNA and polyinosinic-polycytidylic acid double-stranded RNA, respectively, stimulate CD11c(-) type 2 dendritic cell precursors and CD11c(+) dendritic cells to produce type I IFN
    • (2001) J. Immunol. , vol.166 , pp. 2291-2295
    • Kadowaki, N.1    Antonenko, S.2    Liu Y., J.3
  • 84
    • 0035936836 scopus 로고    scopus 로고
    • Induction of direct antimicrobial activity through mammalian toll-like receptors
    • (2001) Science , vol.291 , pp. 1544-1547
    • Thoma-Uszynski, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.