Stimulus specificity of gene expression programs determined by temporal control of IKK activity

Science

Volumn 309, Issue 5742, 2005, Pages 1857-1861

  Werner, Shannon L ^a   Barken, Derren ^a   Hoffmann, Alexander ^a  

^a Signaling Systems Laboratory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; FEEDBACK; MOLECULAR DYNAMICS; PHYSIOLOGY;

BIOLOGICAL RESPONSES; LIPOPOLYSACCHARIDE (LPS); MAMMALIAN SIGNALING; TEMPORAL CONTROL;

GENES;

CYTOKINE; I KAPPA B; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

BIOLOGY;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; GENE ACTIVATION; GENE EXPRESSION; INFLAMMATION; MAMMAL; MOLECULAR MECHANICS; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ALGORITHMS; ANIMALS; AUTOCRINE COMMUNICATION; CELL LINE; CELLS, CULTURED; COMPUTER SIMULATION; CYTOKINES; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; I-KAPPA B KINASE; I-KAPPA B PROTEINS; LIPOPOLYSACCHARIDES; MICE; MODELS, BIOLOGICAL; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

MAMMALIA;

EID: 24944489952     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1113319     Document Type: Article

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20. We thank C. Huang for excellent technical assistance; A. Ma for A20-deficient 3T3 cells; T. Huxford for GST-IκBa(1-54); Santa-Cruz Biotechnology for antibodies; and A. Levchenko, G. Ghosh, S. Subramaniam, and D. Baltimore for insightful discussions. This study was supported by NIH grants GM72024 and GM071573.