IRAK-M is a negative regulator of Toll-like receptor signaling

Cell

Volumn 110, Issue 2, 2002, Pages 191-202

  Kobayashi, Koichi ^a   Hernandez, Lorraine D ^b   Galán, Jorge E ^b   Janeway Jr , Charles A ^a   Medzhitov, Ruslan ^a   Flavell, Richard A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN IRAK M; PROTEIN SERINE THREONINE KINASE; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HOMEOSTASIS; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROVOCATION TEST;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0037178785     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(02)00827-9     Document Type: Article

References (55)

1. Toll-like receptors: Critical proteins linking innate and acquired immunity
2. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
3. Tolerance to bacterial pyrogens. I. Factors influencing its development
4. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin
5. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
6. Irak: A kinase associated with the interleukin-1 receptor
7. Evidence for a gamma-interferon receptor that regulates macrophage tumoricidal activity
8. Salmonella spp. are cytotoxic for cultured macrophages
9. The importance of a lipopolysaccharide-initiated, cytokine-mediated host defense mechanism in mice against extraintestinally invasive Escherichia coli
10. Endotoxemia in human septic shock
11. Host resistance to mucosal gram-negative infection. Susceptibility of lipopolysaccharide nonresponder mice
12. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
13. Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells
14. Hyporesponsiveness to lipopolysaccharide alters the composition of NF-kappaB binding to the regulatory regions of inducible nitric oxide synthase gene
15. Mechanisms of endotoxin tolerance. IV. Specificity of the pyrogenic refractory state during continuous intravenous infusions of endotoxin
16. Monophosphoryl lipid A as a prophylactic for sepsis and septic shock
17. Difference in susceptibility to gram-negative urinary tract infection between C3H/HeJ and C3H/HeN mice
18. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
19. A Toll-like receptor recognizes bacterial DNA
20. Differential cytokine induction by doses of lipopolysaccharide and monophosphoryl lipid A that result in equivalent early endotoxin tolerance
21. Tirap: An adapter molecule in the toll signaling pathway
22. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide; Evidence for TLR4 as the Lps gene product
23. Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production
24. The Salmonella typhimurium invasion genes invF and invG encode homologues of the AraC and PulD family of proteins
25. NF-kappaB1 (p50) is upregulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expression
26. Unresponsiveness of MyD88-deficient mice to endotoxin
27. Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity
28. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation
29. Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells
30. Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase
31. IRAK-4: A novel member of the irak family with the properties of an irak-kinase
32. Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB
33. A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types
34. Innate immunity: The virtues of a nonclonal system of recognition
35. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
36. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
37. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: Selective expression of TLR3 in dendritic cells
38. Cutting edge: Endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression
39. Non-invasive Salmonella typhimurium mutants are avirulent because of an inability to enter and destroy M cells of ileal Peyer's patches
40. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
41. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
42. Pulmonary and hepatic gene expression following cecal ligation and puncture: Monophosphoryl lipid A prophylaxis attenuates sepsis-induced cytokine and chemokine expression and neutrophil infiltration
43. Toll-like receptors control activation of adaptive immune responses
44. Neutrophil recruitment and bacterial clearance correlated with LPS responsiveness in local gram-negative infection
45. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
46. IL-1 receptor-associated kinase modulates host responsiveness to endotoxin
47. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
48. Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase
49. Crohn's disease: Genetic susceptibility, bacteria, and innate immunity
50. MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
51. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
52. The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation
53. Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes
54. Molecular mechanism in tolerance to lipopolysaccharide
55. Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers