Lipopolysaccharide stimulates the MyaD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

Journal of Immunology

Volumn 167, Issue 10, 2001, Pages 5887-5894

  Kawai, T ^a   Takeuchi, O ^a   Fujita, T ^a   Inoue, J I ^a   Muhlradt P F ^a   Sato, S ^a   Hoshino, K ^a   Akira, S ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYTOKINE; CYTOPLASM PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 1BETA; LIPID A; LIPOPEPTIDE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG; ALPHA CHEMOKINE; CELL SURFACE RECEPTOR; CXC CHEMOKINE IP 10; CXC CHEMOKINE IP-10; DIFFERENTIATION ANTIGEN; DNA BINDING PROTEIN; DROSOPHILA PROTEIN; IMMUNOGLOBULIN RECEPTOR; IRF3 PROTEIN, MOUSE; MEMBRANE PROTEIN; MESSENGER RNA; MYD88 PROTEIN, MOUSE; PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LYSATE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; EMBRYO; GENE EXPRESSION; GENE INDUCTION; IMMUNE RESPONSE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL CULTURE; DNA RESPONSIVE ELEMENT; DRUG EFFECT; GENE DELETION; GENETICS; MACROPHAGE; METABOLISM; PHYSIOLOGY; TRANSACTIVATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, DIFFERENTIATION; CELLS, CULTURED; CHEMOKINES, CXC; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; GENE DELETION; INTERFERON REGULATORY FACTOR-3; INTERFERONS; LIPID A; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MODELS, BIOLOGICAL; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RESPONSE ELEMENTS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 0035889228     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.10.5887     Document Type: Article

References (52)

1. Innate immunity: The virtues of a nonclonal system of recognition
2. Lipoproteins take their Toll on the host
3. Phylogenetic perspectives in innate immunity
4. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
5. A family of human receptors structurally related to Drosophila Toll
6. TLR6: A novel member of an expanding Toll-like receptor family
7. Cloning and characterization of a subfamily of human Toll-like receptors: hTLR7, hTLR8, and hTLR9
8. A Toll-like receptor recognizes bacterial DNA
9. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
10. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
11. TLR4-deficient mice are hyporesponsive to LPS: Evidence for TLR4 as the Lps gene product
12. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
13. Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a Toll-like receptor 2- and MyD88-dependent signaling pathway
14. The interleukin-1 receptor/Toll-like receptor superfamily: Signal generators for proinflammatory interleukins and microbial products
15. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
16. MyD88: An adaptor protein that recruits IRAK to the IL-1 receptor complex
17. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
18. IRAK: A kinase associated with the interleukin-1 receptor
19. TRAF6 is a signal transducer for interleukin-1
20. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
21. Unresponsiveness of MyD88-deficient mice to endotoxin
22. Direct triggering of the type I interferon system by virus infection: Activation of a transcription factor complex containing IRF-3 and CBP/p300
23. A novel lipopolysaccharide inducible C-C chemokine receptor related gene in murine macrophages
24. IFN-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element
25. Cooperative interaction between interferon (IFN) stimulus response element and κB sequence motifs controls IFN-γand lipopolysaccharide-stimulated transcription from the murine IP-10 promoter
26. Cloning and analysis of gene regulation of a novel LPS-inducible cDNA
27. The glucocorticoid-attenuated response genes GARG-16, GARG-39, and GARG-49/IRG2 encode inducible proteins containing multiple tetratricopeptide repeat domains
28. New inducers revealed by the promoter sequence analysis of two interferon-activated human genes
29. Regulation of two interferon-inducible human genes by interferon, poly(rI), poly(rC), and viruses
30. Regulation of macrophage chemokine expression by lipopolysaccharide in vitro and in vivo
31. Shared actions of endotoxin and Taxol on TNF receptors and TNF release
32. Taxol increases steady state levels of lipopolysaccharide-inducible genes and protein-tyrosine phosphorylation in murine macrophages
33. Mouse toll-like receptor 4: MD-2 complex mediates lipopolysaccharidemimetic signal transduction by Taxol
34. IP-10 gene transcription by virus in astrocytes requires cooperation of ISRE with adjacent κB site but not IRF-1 or viral transcription
35. Essential role of interferon regulatory factor-3 in direct activation of RANTES chemokine transcription
36. Activation of interferon regulatory factor-3 in response to DNA-damaging agents
37. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation
38. Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes
39. Cytomegalovirus activates interferon immediate early response gene expression and an interferon regulatory factor-3 containing interferon-stimulated response element-binding complex
40. p38-dependent activation of interferon regulatory factor-3 by lipopolysaccharide
41. Gene induction pathways mediated by distinct IRFs during viral infection
42. Signaling by Toll-like receptors 2 and 4 agonists results in differential gene expression in murine macrophages
43. CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression
44. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
45. Severe osteopetrosis, defective interleukin-1 signalling, and lymph node organogenesis in TRAF6-deficient mice
46. Protein kinase Cε is required for the induction of mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages
47. Rho proteins and the p38-MAPK pathway are important mediators for LPS-induced interleukin-8 expression in human endothelial cells
48. lyn and phosphatidylinositol 3-kinase in human monocytes
49. Activation of phosphatidylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: Differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production
50. The kinase TAK1 can activate the NIK-I κB as well as the MAP kinase cascade in the IL-1 signaling pathway
51. TAK1 mediates an activation signal from Toll-like receptor(s) to nuclear factor-κB in lipopolysaccharide-stimulated macrophages
52. Central role of double-stranded RNA-activated protein kinase in microbial induction of nitric oxide synthase