Dectin-1 mediates the biological effects of β-glucans

Journal of Experimental Medicine

Volumn 197, Issue 9, 2003, Pages 1119-1124

  Brown, Gordon D ^a   Herre, Jurgen ^a   Williams, David L ^b   Willment, Janet A ^a   Marshall, Andrew S J ^a   Gordon, Siamon ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b East Tennessee State University   (United States)

Author keywords

glucan receptor; Candida; Inflammation; Macrophages; Tumor necrosis factor

Indexed keywords

BETA GLUCAN; CELL PROTEIN; DECTIN 1; LECTIN; MYD 88 PROTEIN; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL CELL; ARTICLE; CANDIDA ALBICANS; CELL SURFACE; CYTOKINE PRODUCTION; IMMUNOMODULATION; INFLAMMATION; LEUKOCYTE ACTIVATION; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF;

ANIMALS; CANDIDA ALBICANS; GLUCANS; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; TUMOR NECROSIS FACTOR-ALPHA; ZYMOSAN;

EID: 0038558248     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20021890     Document Type: Article

References (29)

1. Czop, J.K. 1986. The role of beta-glucan receptors on blood and tissue leukocytes in phagocytosis and metabolic activation. Pathol. Immunopathol. Res. 5:286-296.
2. Williams, D.L. 1997. Overview of (1,3)-beta-D-glucan immunobiology. Mediators Inflamm. 6:247-250.
3. Ross, G.D., V. Vetvicka, J. Yan, Y. Xia, and J. Vetvickova. 1999. Therapeutic intervention with complement and betaglucan in cancer. Immunopharmacology. 42:61-74.
4. Williams, D.L., A. Mueller, and W. Browder. 1996. Glucan-based macrophage stimulators. Clinical Immunotherapy. 5:392-399.
5. Riggi, S.J., and N.R. Di Luzio. 1961. Identification of a reticuloendothelial stimulating agent in zymosan. Am. J. Physiol. 200:297-300.
6. Benacerraf, B., and M.M. Sebestyen. 1957. Effect of bacterial endotoxins on the reticuloendothelial system. Fed. Proc. 16: 860-867.
7. Ariizumi, K., G.L. Shen, S. Shikano, S. Xu, R. Ritter III, T. Kumamoto, D. Edelbaum, A. Morita, P.R. Bergstresser, and A. Takashima. 2000. Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. J. Biol. Chem. 275:20157-20167.
8. Brown, G.D., and S. Gordon. 2001. Immune recognition: a new receptor for beta-glucans. Nature. 413:36-37.
9. Taylor, P.R., G.D. Brown, D.M. Reid, J.A. Willment, L. Martinez-Pomares, S. Gordon, and S.Y.C. Wong. 2002. The beta-glucan receptor, Dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. J. Immunol. 269:3876-3882.
10. Willment, J.A., S. Gordon, and G.D. Brown. 2001. Characterisation of the human beta-glucan receptor and its alternatively spliced isoforms. J. Biol. Chem. 276:43818-43823.
11. Brown, G.D., P.R. Taylor, D.M. Reid, J.A. Willment, D.L. Williams, L. Martinez-Pomares, S.Y.C. Wong, and S. Gordon. 2002. Dectin-1 is a major beta-glucan receptor on macrophages. J. Exp. Med. 296:407-412.
12. Ozinsky, A., D.M. Underhill, J.D. Fontenot, A.M. Hajjar, K.D. Smith, C.B. Wilson, L. Schroeder, and A. Aderem. 2000. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc. Natl. Acad. Sci. USA. 97:13766-13771.
13. Takeuchi, O., K. Hoshino, T. Kawai, H. Sanjo, H. Takada, T. Ogawa, K. Takeda, and S. Akira. 1999. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity. 11: 443-451.
14. Adachi, O., T. Kawai, K. Takeda, M. Matsumoto, H. Tsutsui, M. Sakagami, K. Nakanishi, and S. Akira. 1998. Targeted disruption of the MyD88 gene results in loss of IL-1-and IL-18-mediated function. Immunity. 9:143-150.
15. +, and adherence. J. Cell. Physiol. 117:189-194.
16. Muller, A., P.J. Rice, H.E. Ensley, P.S. Coogan, J.H. Kalbfleish, J.L. Kelley, E.J. Love, C.A. Portera, T. Ha, I.W. Browder, et al. 1996. Receptor binding and internalization of a water-soluble (1→3)-beta-D-glucan biologic response modifier in two monocyte/macrophage cell lines. J. Immunol. 156:3418-3425.
17. Underhill, D.M., A. Ozinsky, K.D. Smith, and A. Aderem. 1999. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc. Natl. Acad. Sci. USA. 96:14459-14463.
18. Stein, M., and S. Gordon. 1991. Regulation of tumor necrosis factor (TNF) release by murine peritoneal macrophages: role of cell stimulation and specific phagocytic plasma membrane receptors. Eur. J. Immunol. 21:431-437.
19. Tapper, H., and R. Sundler. 1995. Glucan receptor and zymosan-induced lysosomal enzyme secretion in macrophages. Biochem. J. 306:829-835.
20. Kawakami, K., X. Qifeng, M. Tohyama, M.H. Qureshi, and A. Saito. 1996. Contribution of tumour necrosis factor-alpha (TNF-alpha) in host defence mechanism against Cryptococcus neoformans. Clin. Exp. Immunol. 106:468-474.
21. Netea, M.G., L.J. van Tits, J.H. Curfs, F. Amiot, J.F. Meis, J.W. van der Meer, and B.J. Kullberg. 1999. Increased susceptibility of TNF-alpha lymphotoxin-alpha double knockout mice to systemic candidiasis through impaired recruitment of neutrophils and phagocytosis of Candida albicans. J. Immunol. 163:1498-1505.
22. Mehrad, B., R.M. Strieter, and T.J. Standiford. 1999. Role of TNF-alpha in pulmonary host defense in murine invasive aspergillosis. J. Immunol. 162:1633-1640.
23. Allendoeffer, R., and G.S. Deepe, Jr. 1998. Blockade of endogenous TNF-alpha exacerbates primary and secondary pulmonary histoplasmosis by differential mechanisms. J. Immunol. 160:6072-6082.
24. Klis, F.M., P. de Groot, and K. Hellingwerf. 2001. Molecular organization of the cell wall of Candida albicans. Med. Mycol. 39:1-8.
25. Borges-Walmsley, M.I., D. Chen, X. Shu, and A.R. Walmsley. 2002. The pathobiology of Paracoccidioides brasiliensis. Trends Microbiol. 10:80-87.
26. Netea, M.G., C.A. Van Der Graaf, A.G. Vonk, I. Verschueren, J.W. Van Der Meer, and B.J. Kullberg. 2002. The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. J. Infect. Dis. 185: 1483-1489.
27. Underhill, D.M., A. Ozinsky, A.M. Hajjar, A. Stevens, C.B. Wilson, M. Bassetti, and A. Aderem. 1999. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature. 401:811-815.
28. Kataoka, K., T. Muta, S. Yamazaki, and K. Takeshige. 2002. Activation of macrophages by linear (1,3)-beta-D-glucans. J. Biol. Chem. 277:36825-36831.
29. Lombard, Y., J. Giaimis, M. Makaya-Kumba, P. Fonteneau, and P. Poindron. 1994. A new method for studying the binding and ingestion of zymosan particles by macrophages. J. Immunol. Methods. 174:155-165.