Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide

Journal of Clinical Investigation

Volumn 105, Issue 4, 2000, Pages 497-504

  Lien, Egil ^a,b   Means, Terry K ^c   Heine, Holger ^a   Yoshimura, Atsutoshi ^a   Kusumoto, Shoichi ^d   Fukase, Koichi ^d   Fenton, Matthew J ^c   Oikawa, Masato ^d   Qureshi, Nilofer ^e   Monks, Brian ^a   Finberg, Robert W ^f   Ingalls, Robin R ^a   Golenbock, Douglas T ^a,g  

^a BOSTON MEDICAL CENTER   (United States)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d OSAKA UNIVERSITY   (Japan)

^e WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

^f DANA FARBER CANCER INSTITUTE   (United States)

^g Maxwell Finland Lab Infect Dis   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD14 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; RECEPTOR; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; GRAM NEGATIVE SEPSIS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0034002247     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI8541     Document Type: Article

References (42)

1. Sands, K.E., et al. 1997. Epidemiology of sepsis syndrome in 8 academic medical centers. Academic Medical Center Consortium Sepsis Project Working Group. JAMA. 278:234-240.
2. Raetz, C.R., et al. 1991. Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J. 5:2652-2660.
3. Fenton, M.J., and Golenbock, D.T. 1998. LPS-binding proteins and receptors. J. Leukoc. Biol. 64:25-32.
4. Kitchens, R.L., and Munford, R.S. 1995. Enzymatically deacylated lipopolysaccharide (LPS) can antagonize LPS at multiple sites in the LPS recognition pathway. J. Biol. Chem 270:9904-9910.
5. Kitchens, R.L., Ulevitch, R.J., and Munford, R.S. 1992. Lipopolysaccharide (LPS) partial structures inhibit responses to LPS in a human macrophage cell line without inhibiting LPS uptake by a CD14-mediated pathway. J. Exp. Med. 176:485-494.
6. Delude, R., et al. 1995. CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition. Proc. Natl. Acad. Sci. USA. 92:9288-9292.
7. Ingalls, R.R., Monks, B.G., and Golenbock, D.T. 1999. Membrane expression of soluble endotoxin-binding proteins permits lipopolysaccharide signaling in Chinese hamster ovary fibroblasts independently of CD14. J. Biol. Chem. 274:13993-13998.
8. Ulevitch, R.J., and Tobias, P.S. 1994. Recognition of endotoxin by cells leading to transmembrane signaling. Curr. Opin. Immunol. 6:125-130.
9. Lynn, W.A., and Golenbock, D.T. 1992. Lipopolysaccharide antagonists. Immunol. Today. 13:271-276.
10. Golenbock, D.T., Hampton, R.Y., Qureshi, N., Takayama, K., and Raetz, C.R.H. 1991. Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes. J. Biol. Chem. 266:19490-19498.
11. Belvin, M.P., and Anderson, K.V. 1996. A conserved signaling pathway: the Drosophila Toll-dorsal pathway Annu. Rev. Cell Dev. Biol. 12:393-416.
12. Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.M., and Hoffmann, J.A. 1996. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 86:973-983.
13. Williams, M.J., Rodriguez, A., Kimbrell, D.A., and Eldon, E.D. 1997. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. EMBO J. 16:6120-6130.
14. Rock, F.L. Hardiman, G., Timans, J.C., Kastelein, R.A., and Bazan, J.F. 1998. A family of human receptors structurally related to Drosophila Toll. Proc. Natl. Acad. Sci. USA. 95:588-593.
15. Yang, R.B., et al. 1998. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature. 395:284-288.
16. Kirschning, C.J., Wesche, H., Ayres, T.M., and Rothe, M. 1998. Human Toll-like receptor 2 confers rcsponsiveness to bacterial lipopolysaccharide. J. Exp. Med. 188:2091-2097.
17. Poltorak, A., et al. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 282:2085-2088.
18. Hoshino, K., et al. 1999. Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162:3749-3752.
19. Qureshi, S.T. et al. 1999. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J. Exp. Med. 189:615-625.
20. Chow, J.C., Young, D.W., Golenbock, D.T., Christ, W.J., and Gusovsky, F. 1999. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J. Biol. Chem. 274:10689-10692.
21. Liu, W.-C., Oikawa, M., Fukase, K., Suda, Y., and Kusumoto, S. 1999. A divergent synthesis of lipid A and its chemically stable unnatural analogues. Bull. Chem. Soc. Jpn. 72:1377-1385.
22. Lien, E., et al. 1999 Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial cell wall products. J. Biol. Chem. 274:33419-33425.
23. Shimazu, R., et al. 1999. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189:1777-1782.
24. Heine, H., et al. 1999. Cutting edge: cells that carry a null allele for Toll-like receptor 2 are capable of responding to endotoxin. J. Immunol. 162:6971-6975.
25. Medzhitov, R., Preston-Hurlburt, P., and Janeway, C.A., Jr. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 388:394-397.
26. Delude, R.L., Yoshimura, A., Ingalls, R.R., and Golenbock, D.T. 1998. Construction of a lipopolysaccharide reporter cell line and its use in identifying mutants defective in endotoxin, but not TNF-alpha, signal transduction. J. Immunol. 161:3001-3009.
27. Schindler, U., and Baichwal, V.R. 1994. Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression. Mol. Cell. Biol. 14:5820-5831.
28. Golenbock, D., Liu, Y., Millham, F., Freeman, M., and Zoeller, R. 1993. Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin. J. Biol. Chem. 268:22055-22059.
29. Yoshimura, A., et al. 1999. Cutting edge: recognition of gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J. Immunol. 163:1-5.
30. Aarden, L.A., De Groot, E.R., Schaap, O.L., and Lansdorp, P.M. 1987. Production of hybridoma growth factor by human monocytes. Eur. J. Immunol. 17:1411-1416.
31. Heine, H., Delude, R.L., Monks, B.G., Espevik, T., and Golenbock, D.T. 1999. Bacterial lipopolysaccharide induces expression of the stress response genes hop and H411. J. Biol. Chem. 274:21049-21055.
32. Schwandner, R., Dziarski, R., Wesche, H., Rothe, M., and Kirschning, C.J. 1999. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor 2. J. Biol. Chem. 274:17406-17409.
33. Hirschfeld, M. ,et al. 1999. Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by Toll-like receptor 2. J. Immunol. 163:2382-2386.
34. Brightbill, H.D., et al. 1999. Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors. Science. 285:732-736.
35. Means, T.K., et al. 1999. The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receprors. J. Immunol. 163:6748-6755.
36. Means, T.K., et al. 1999. Human Toll-like receptors rediate cellular activarion by M. tuberculosis. J. Immunol. 163:3920-3927.
37. Vogel, S.N., Moore, R.N., Sipe, J.D., and Rosenstreich, D.L. 1980. BCG-induced enhancement of endotoxin sensitivity in C3H/HeJ mice. I. In vivo studies. J. Immunol. 124:2004-2009.
38. DeLotto, Y., and DeLotto, R. 1998. Proteolytic processing of the Drosophila Spatzle protein by easter generates a dimeric NGF-like molecule with ventralising activiry. Mech. Dev. 72:141-148.
39. Monsato, D., and Anderson, K.V. 1994. The spatzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo. Cell. 76:677-688.
40. Medzhitov, R., and Janeway, C.A., Jr. 1998. Self-defense: the fruit fly style. Proc. Natl. Acad. Sci. USA. 95-429-430.
41. Wright, S.D. 1999. Toll, a new piece in the puzzle of innate immunity. J. Exp. Med. 189:605-609.
42. Lynn, W.A., Raetz, C.R., Qureshi, N., and Golenbock, D.T. 1991. Lipopolysaccharide-indticed stimulation of CD11b/CD18 expression on neutrophils. Evidence of specific receptor-based response and inhibition by lipid A-based antagonists. J. Immunol. 147:3072-3079.