Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

Nature Cell Biology

Volumn 2, Issue 6, 2000, Pages 346-351

  Burns, Kimberly ^a   Clatworthy, Jonathan ^b,c   Martin, Laurence ^a   Martinon, Fabio ^a   Plumpton, Chris ^b,d   Maschera, Barbara ^b,c   Lewis, Alan ^b,d   Ray, Keith ^b,d   Tschopp, Jürg ^a   Volpe, Filippo ^b,c,d  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b GLAXOSMITHKLINE   (United Kingdom)

^c Cell Biology Unit   (United Kingdom)

^d Molecular Pharmacology   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; IRAK PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN SERINE THREONINE KINASE; RECEPTOR SUBUNIT; TOLLIP PROTEIN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HOST RESISTANCE; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, DIFFERENTIATION; CARRIER PROTEINS; CELL LINE; CONSERVED SEQUENCE; ENZYME ACTIVATION; HUMANS; INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KINETICS; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN KINASES; RECEPTORS, IMMUNOLOGIC; RECEPTORS, INTERLEUKIN-1; RNA, MESSENGER; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0033776154     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35014038     Document Type: Article

References (19)

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2. Signalling pathways: A common theme in plants and animals?
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5. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
6. The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)
7. IRAK: A kinase associated with the interleukin-1 receptor
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