Controlled microwave heating in modern organic synthesis

Angewandte Chemie - International Edition

Volumn 43, Issue 46, 2004, Pages 6250-6284

  Kappe, C Oliver ^a,b,c,d  

^a UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c EMORY UNIVERSITY   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Combinatorial chemistry; High temperature chemistry; High throughput synthesis; Microwave irradiation; Synthetic methods

Indexed keywords

BUNSEN BURNER; ORGANIC SYNTHESIS; REACTION VESSEL;

CHEMICAL REACTIONS; RESEARCH LABORATORIES; SYNTHESIS (CHEMICAL);

MICROWAVE HEATING;

CARBON; FLUORINE DERIVATIVE; HETEROCYCLIC COMPOUND; POLYMER; REAGENT; SCAVENGER; TRANSITION ELEMENT;

ALKYLATION; CARBONYLATION; CHEMICAL BOND; CLAISEN REARRANGEMENT; COMBINATORIAL CHEMISTRY; CYCLOADDITION; EQUIPMENT; GLYCOSYLATION; HECK REACTION; HIGH THROUGHPUT SCREENING; INTERMETHOD COMPARISON; LIQUID; MICROWAVE COOKING; MITSUNOBU REACTION; ORGANIC CHEMISTRY; OXIDATION; POLYMERIZATION; REACTION ANALYSIS; REACTION TIME; REPRODUCIBILITY; REVIEW; SOLVENT EFFECT; SONOGASHIRA REACTION; STILLE REACTION; SUBSTITUTION REACTION; SUZUKI REACTION; SYNTHESIS;

CHEMISTRY, ORGANIC; COMBINATORIAL CHEMISTRY TECHNIQUES; HEAT; MICROWAVES; PHARMACEUTICAL PREPARATIONS;

EID: 11144325118     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200400655     Document Type: Review

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26. Combinatorial chemistry: a) A. Lew, P. O. Krutznik, M. E. Hart, A. R. Chamberlin, J. Comb. Chem. 2002, 4, 95-105; b) C. O. Kappe, Curr. Opin. Chem. Biol. 2002, 6, 314-320; c) P. Lidström, J. Westman, A. Lewis, Comb. Chem. High Through-put Screening 2002, 5, 441-458; d)H. E. Blackwell, Org. Biomol. Chem. 2003, 1, 1251-1255; e) F. Al-Obeidi, R. E. Austin, J. F. Okonya, D. R. S. Bond, Mini-Rev. Med. Chem. 2003, 3, 449-460; f) K. M. K. Swamy, W.-B. Yeh, M.-J. Lin, C.-M. Sun, Curr. Med. Chem. 2003, 10, 2403-2423; g) Microwaves in Combinatorial and High-Throughput Synthesis (Ed.: C. O. Kappe), Kluwer, Dordrecht, 2003 (a special issue of Mol. Diversity 2003, 7, pp. 95-307); h) A. Stadler, C. O. Kappe in Microwave-Assisted Organic Synthesis (Eds. : P. Lidström, J. P. Tierney), Blackwell, Oxford, 2004, Chapter 7.
27. Combinatorial chemistry: a) A. Lew, P. O. Krutznik, M. E. Hart, A. R. Chamberlin, J. Comb. Chem. 2002, 4, 95-105; b) C. O. Kappe, Curr. Opin. Chem. Biol. 2002, 6, 314-320; c) P. Lidström, J. Westman, A. Lewis, Comb. Chem. High Through-put Screening 2002, 5, 441-458; d)H. E. Blackwell, Org. Biomol. Chem. 2003, 1, 1251-1255; e) F. Al-Obeidi, R. E. Austin, J. F. Okonya, D. R. S. Bond, Mini-Rev. Med. Chem. 2003, 3, 449-460; f) K. M. K. Swamy, W.-B. Yeh, M.-J. Lin, C.-M. Sun, Curr. Med. Chem. 2003, 10, 2403-2423; g) Microwaves in Combinatorial and High-Throughput Synthesis (Ed.: C. O. Kappe), Kluwer, Dordrecht, 2003 (a special issue of Mol. Diversity 2003, 7, pp. 95-307); h) A. Stadler, C. O. Kappe in Microwave-Assisted Organic Synthesis (Eds. : P. Lidström, J. P. Tierney), Blackwell, Oxford, 2004, Chapter 7.
28. Combinatorial chemistry: a) A. Lew, P. O. Krutznik, M. E. Hart, A. R. Chamberlin, J. Comb. Chem. 2002, 4, 95-105; b) C. O. Kappe, Curr. Opin. Chem. Biol. 2002, 6, 314-320; c) P. Lidström, J. Westman, A. Lewis, Comb. Chem. High Through-put Screening 2002, 5, 441-458; d)H. E. Blackwell, Org. Biomol. Chem. 2003, 1, 1251-1255; e) F. Al-Obeidi, R. E. Austin, J. F. Okonya, D. R. S. Bond, Mini-Rev. Med. Chem. 2003, 3, 449-460; f) K. M. K. Swamy, W.-B. Yeh, M.-J. Lin, C.-M. Sun, Curr. Med. Chem. 2003, 10, 2403-2423; g) Microwaves in Combinatorial and High-Throughput Synthesis (Ed.: C. O. Kappe), Kluwer, Dordrecht, 2003 (a special issue of Mol. Diversity 2003, 7, pp. 95-307); h) A. Stadler, C. O. Kappe in Microwave-Assisted Organic Synthesis (Eds. : P. Lidström, J. P. Tierney), Blackwell, Oxford, 2004, Chapter 7.
29. Combinatorial chemistry: a) A. Lew, P. O. Krutznik, M. E. Hart, A. R. Chamberlin, J. Comb. Chem. 2002, 4, 95-105; b) C. O. Kappe, Curr. Opin. Chem. Biol. 2002, 6, 314-320; c) P. Lidström, J. Westman, A. Lewis, Comb. Chem. High Through-put Screening 2002, 5, 441-458; d)H. E. Blackwell, Org. Biomol. Chem. 2003, 1, 1251-1255; e) F. Al-Obeidi, R. E. Austin, J. F. Okonya, D. R. S. Bond, Mini-Rev. Med. Chem. 2003, 3, 449-460; f) K. M. K. Swamy, W.-B. Yeh, M.-J. Lin, C.-M. Sun, Curr. Med. Chem. 2003, 10, 2403-2423; g) Microwaves in Combinatorial and High-Throughput Synthesis (Ed.: C. O. Kappe), Kluwer, Dordrecht, 2003 (a special issue of Mol. Diversity 2003, 7, pp. 95-307); h) A. Stadler, C. O. Kappe in Microwave-Assisted Organic Synthesis (Eds. : P. Lidström, J. P. Tierney), Blackwell, Oxford, 2004, Chapter 7.
30. Combinatorial chemistry: a) A. Lew, P. O. Krutznik, M. E. Hart, A. R. Chamberlin, J. Comb. Chem. 2002, 4, 95-105; b) C. O. Kappe, Curr. Opin. Chem. Biol. 2002, 6, 314-320; c) P. Lidström, J. Westman, A. Lewis, Comb. Chem. High Through-put Screening 2002, 5, 441-458; d)H. E. Blackwell, Org. Biomol. Chem. 2003, 1, 1251-1255; e) F. Al-Obeidi, R. E. Austin, J. F. Okonya, D. R. S. Bond, Mini-Rev. Med. Chem. 2003, 3, 449-460; f) K. M. K. Swamy, W.-B. Yeh, M.-J. Lin, C.-M. Sun, Curr. Med. Chem. 2003, 10, 2403-2423; g) Microwaves in Combinatorial and High-Throughput Synthesis (Ed.: C. O. Kappe), Kluwer, Dordrecht, 2003 (a special issue of Mol. Diversity 2003, 7, pp. 95-307); h) A. Stadler, C. O. Kappe in Microwave-Assisted Organic Synthesis (Eds. : P. Lidström, J. P. Tierney), Blackwell, Oxford, 2004, Chapter 7.
31. Combinatorial chemistry: a) A. Lew, P. O. Krutznik, M. E. Hart, A. R. Chamberlin, J. Comb. Chem. 2002, 4, 95-105; b) C. O. Kappe, Curr. Opin. Chem. Biol. 2002, 6, 314-320; c) P. Lidström, J. Westman, A. Lewis, Comb. Chem. High Through-put Screening 2002, 5, 441-458; d)H. E. Blackwell, Org. Biomol. Chem. 2003, 1, 1251-1255; e) F. Al-Obeidi, R. E. Austin, J. F. Okonya, D. R. S. Bond, Mini-Rev. Med. Chem. 2003, 3, 449-460; f) K. M. K. Swamy, W.-B. Yeh, M.-J. Lin, C.-M. Sun, Curr. Med. Chem. 2003, 10, 2403-2423; g) Microwaves in Combinatorial and High-Throughput Synthesis (Ed.: C. O. Kappe), Kluwer, Dordrecht, 2003 (a special issue of Mol. Diversity 2003, 7, pp. 95-307); h) A. Stadler, C. O. Kappe in Microwave-Assisted Organic Synthesis (Eds. : P. Lidström, J. P. Tierney), Blackwell, Oxford, 2004, Chapter 7.
32. Combinatorial chemistry: a) A. Lew, P. O. Krutznik, M. E. Hart, A. R. Chamberlin, J. Comb. Chem. 2002, 4, 95-105; b) C. O. Kappe, Curr. Opin. Chem. Biol. 2002, 6, 314-320; c) P. Lidström, J. Westman, A. Lewis, Comb. Chem. High Through-put Screening 2002, 5, 441-458; d)H. E. Blackwell, Org. Biomol. Chem. 2003, 1, 1251-1255; e) F. Al-Obeidi, R. E. Austin, J. F. Okonya, D. R. S. Bond, Mini-Rev. Med. Chem. 2003, 3, 449-460; f) K. M. K. Swamy, W.-B. Yeh, M.-J. Lin, C.-M. Sun, Curr. Med. Chem. 2003, 10, 2403-2423; g) Microwaves in Combinatorial and High-Throughput Synthesis (Ed.: C. O. Kappe), Kluwer, Dordrecht, 2003 (a special issue of Mol. Diversity 2003, 7, pp. 95-307); h) A. Stadler, C. O. Kappe in Microwave-Assisted Organic Synthesis (Eds. : P. Lidström, J. P. Tierney), Blackwell, Oxford, 2004, Chapter 7.
33. Combinatorial chemistry: a) A. Lew, P. O. Krutznik, M. E. Hart, A. R. Chamberlin, J. Comb. Chem. 2002, 4, 95-105; b) C. O. Kappe, Curr. Opin. Chem. Biol. 2002, 6, 314-320; c) P. Lidström, J. Westman, A. Lewis, Comb. Chem. High Through-put Screening 2002, 5, 441-458; d)H. E. Blackwell, Org. Biomol. Chem. 2003, 1, 1251-1255; e) F. Al-Obeidi, R. E. Austin, J. F. Okonya, D. R. S. Bond, Mini-Rev. Med. Chem. 2003, 3, 449-460; f) K. M. K. Swamy, W.-B. Yeh, M.-J. Lin, C.-M. Sun, Curr. Med. Chem. 2003, 10, 2403-2423; g) Microwaves in Combinatorial and High-Throughput Synthesis (Ed.: C. O. Kappe), Kluwer, Dordrecht, 2003 (a special issue of Mol. Diversity 2003, 7, pp. 95-307); h) A. Stadler, C. O. Kappe in Microwave-Assisted Organic Synthesis (Eds. : P. Lidström, J. P. Tierney), Blackwell, Oxford, 2004, Chapter 7.
34. Combinatorial chemistry: a) A. Lew, P. O. Krutznik, M. E. Hart, A. R. Chamberlin, J. Comb. Chem. 2002, 4, 95-105; b) C. O. Kappe, Curr. Opin. Chem. Biol. 2002, 6, 314-320; c) P. Lidström, J. Westman, A. Lewis, Comb. Chem. High Through-put Screening 2002, 5, 441-458; d)H. E. Blackwell, Org. Biomol. Chem. 2003, 1, 1251-1255; e) F. Al-Obeidi, R. E. Austin, J. F. Okonya, D. R. S. Bond, Mini-Rev. Med. Chem. 2003, 3, 449-460; f) K. M. K. Swamy, W.-B. Yeh, M.-J. Lin, C.-M. Sun, Curr. Med. Chem. 2003, 10, 2403-2423; g) Microwaves in Combinatorial and High-Throughput Synthesis (Ed.: C. O. Kappe), Kluwer, Dordrecht, 2003 (a special issue of Mol. Diversity 2003, 7, pp. 95-307); h) A. Stadler, C. O. Kappe in Microwave-Assisted Organic Synthesis (Eds. : P. Lidström, J. P. Tierney), Blackwell, Oxford, 2004, Chapter 7.
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