General microwave-assisted protocols for the expedient synthesis of quinoxalines and heterocyclic pyrazines

Tetrahedron Letters

Volumn 45, Issue 25, 2004, Pages 4873-4876

  Zhao, Zhijian ^a   Wisnoski, David D ^a   Wolkenberg, Scott E ^a   Leister, William H ^a   Wang, Yi ^a   Lindsley, Craig W ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Microwave; Pyrazine; Quinoxaline

Indexed keywords

DIAMINE DERIVATIVE; DIKETONE; POLYMER; PYRAZINE DERIVATIVE; QUINOXALINE DERIVATIVE;

ARTICLE; CHEMICAL MODIFICATION; MICROWAVE IRRADIATION; MICROWAVE RADIATION; THERMODYNAMICS;

EID: 2942519827     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.04.144     Document Type: Article

References (21)

1. For an excellent review of MAOS see: Lidstrom P., Wathey B., Westman J. Tetrahedron. 57:2001;9225
2. Furka A. Drug Discovery Today. 7:2002;1
3. Lindsley C.W., Zhao Z., Leister W.H. Tetrahderon Lett. 43:2002;4225
4. Leister W., Struass K., Wisniski D., Zhao Z., Lindsley C. J. Comb. Chem. 5:2003;322
5. Zhao Z., Leister W.H., Strauss K.A., Wisnoski D.D., Lindsley C.W. Tetrahderon Lett. 44:2003;1123
6. Wolkenberg S.E., Wisnoski D.D., Leister W.H., Wang Y., Zhao Z., Lindsley C.W. Org. Lett. 6:2004;1453
7. Sakata G., Makino K., Kurasawa Y. Heterocycles. 27:1988;2481
8. He W., Meyers M.R., Hanney B., Spada A., Bilder G., Galzcinski H., Amin D., Needle S., Page K., Jayyosi Z., Perrone H. Bioorg. Med. Chem. Lett. 13:2003;3097
9. Kim Y.B., Kim Y.H., Park J.Y., Kim S.K. Bioorg. Med. Chem. Lett. 14:2004;541
10. Porter A.E.A. Katritsky A.R., Rees C.W. Comprehensive Heterocyclic Chemistry. 1984;157-197 Pergamon, Oxford
11. Woo G.H.C., Snyder J.K., Wan Z.-K. Prog. Heterocycl. Chem. 14:2002;279
12. Brown D.J. Quinoxalines: Supplement II. Taylor E.C., Wipf P. The Chemistry of Heterocyclic Compounds. 2004;John Wiley & Sons, New Jersey
13. The single-mode microwave synthesizer employed for this work was an Emrys Liberator™ by Personal Chemistry. For more information, see: www.personalchemistry.com
14. 2 (M+H); found: 341.1295
15. Kaye I.A. J. Med. Chem. 7:1964;240
16. Katritzky A.R., Pozharskii A.F. Handbook of Heterocyclic Chemistry. 2nd ed. 2000;Pergamon, New York
17. 2 (M+H); 264.0768, found: 264.0767
18. Kenning D.D., Mitchell K.A., Calhoun T.R., Funfar M.R., Sattler D.J., Rasmussen S.C. J. Org. Chem. 67:2002;9073
19. Garbacia S., Desai B., Lavastre O., Knappe O. J. Org. Chem. 68:2003;9136
20. Willis R.C. Today's Chem. Work. 2004;47
21. 4S (M+H); 291.0626; found 291.0630